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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

Cited: 0 times

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

Cited: 0 times

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Any Role of High-Dose Vitamin C for Septic Shock in 2021?

Ankita Agarwal, David N Hager, Jonathan E Sevransky,

While the use of vitamin C as a therapeutic agent has been investigated since the 1950s, there has been substantial recent interest in the role of vitamin C supplementation in critical illness and particularly, sepsis and septic shock. Humans cannot synthesize vitamin C and rely on exogenous intake to maintain ... Read more >>

Semin Respir Crit Care Med (Seminars in respiratory and critical care medicine)
[2021, 42(5):672-682]

Cited: 0 times

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21st Century Evidence: Randomized Controlled Trials Versus Systematic Reviews and Meta-Analyses.

Ankita Agarwal, Bram Rochwerg, Jonathan E Sevransky,

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.

Jonathan E Sevransky, Richard E Rothman, David N Hager, Gordon R Bernard, Samuel M Brown, Timothy G Buchman, Laurence W Busse, Craig M Coopersmith, Christine DeWilde, E Wesley Ely, Lindsay M Eyzaguirre, Alpha A Fowler, David F Gaieski, Michelle N Gong, Alex Hall, Jeremiah S Hinson, Michael H Hooper, Gabor D Kelen, Akram Khan, Mark A Levine, Roger J Lewis, Chris J Lindsell, Jessica S Marlin, Anna McGlothlin, Brooks L Moore, Katherine L Nugent, Samuel Nwosu, Carmen C Polito, Todd W Rice, Erin P Ricketts, Caroline C Rudolph, Fred Sanfilippo, Kert Viele, Greg S Martin, David W Wright, ,

<h4>Importance</h4>Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.<h4>Objective</h4>To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo ... Read more >>

JAMA (JAMA)
[2021, 325(8):742-750]

Cited: 9 times

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Standardized Care Is Better Than Individualized Care for the Majority of Critically Ill Patients.

Jonathan E Sevransky, Ankita Agarwal, Craig S Jabaley, Bram Rochwerg,

Crit Care Med (Critical care medicine)
[2021, 49(1):151-155]

Cited: 1 time

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Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study.

Jen-Ting Chen, Russel Roberts, Melissa J Fazzari, Kianoush Kashani, Nida Qadir, Charles B Cairns, Kusum Mathews, Pauline Park, Akram Khan, James F Gilmore, Anne Rain T Brown, Betty Tsuei, Michele Handzel, Alfredo Lee Chang, Abhijit Duggal, Michael Lanspa, James Taylor Herbert, Anthony Martinez, Joseph Tonna, Mahmoud A Ammar, Drayton Hammond, Lama H Nazer, Mojdeh Heavner, Erin Pender, Lauren Chambers, Michael T Kenes, David Kaufman, April Downey, Brent Brown, Darlene Chaykosky, Armand Wolff, Michael Smith, Katie Nault, Jonathan Sevransky, Michelle N Gong, ,

<h4>Objectives</h4>To characterize the association between the use of physiologic assessment (central venous pressure, pulmonary artery occlusion pressure, stroke volume variation, pulse pressure variation, passive leg raise test, and critical care ultrasound) with fluid and vasopressor administration 24 hours after shock onset and with in-hospital mortality.<h4>Design</h4>Multicenter prospective cohort study between September ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(10):1436-1444]

Cited: 0 times

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Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock.

Russel J Roberts, Todd A Miano, Drayton A Hammond, Gourang P Patel, Jen-Ting Chen, Kristy M Phillips, Natasha Lopez, Kianoush Kashani, Nida Qadir, Charles B Cairns, Kusum Mathews, Pauline Park, Akram Khan, James F Gilmore, Anne Rain Tanner Brown, Betty Tsuei, Michele Handzel, Alfredo Lee Chang, Abhijit Duggal, Michael Lanspa, James Taylor Herbert, Anthony Martinez, Joseph Tonna, Mahmoud A Ammar, Lama H Nazer, Mojdeh Heavner, Erin Pender, Lauren Chambers, Michael T Kenes, David Kaufman, April Downey, Brent Brown, Darlene Chaykosky, Armand Wolff, Michael Smith, Katie Nault, Michelle N Gong, Jonathan E Sevransky, Ishaq Lat, ,

<h4>Objectives</h4>The objectives of this study were to: 1) determine the association between vasopressor dosing intensity during the first 6 hours and first 24 hours after the onset of septic shock and 30-day in-hospital mortality; 2) determine whether the effect of vasopressor dosing intensity varies by fluid resuscitation volume; and 3) ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(10):1445-1453]

Cited: 3 times

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Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise.

Thomas P Bleck, Timothy G Buchman, R Phillip Dellinger, Clifford S Deutschman, John C Marshall, David M Maslove, Henry Masur, Margaret M Parker, Donald S Prough, Aarti Sarwal, Jonathan E Sevransky, Jean-Louis Vincent, Jerry J Zimmerman,

Crit Care Med (Critical care medicine)
[2020, 48(8):1099-1102]

Cited: 3 times

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In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol.

Christopher J Lindsell, Anna McGlothlin, Samuel Nwosu, Todd W Rice, Alex Hall, Gordon R Bernard, Laurence W Busse, E Wesley Ely, Alpha A Fowler, David F Gaieski, Jeremiah S Hinson, Michael H Hooper, James C Jackson, Gabor D Kelen, Mark Levine, Greg S Martin, Richard E Rothman, Jonathan E Sevransky, Kert Viele, David W Wright, David N Hager,

<h4>Trial registration</h4>ClinicalTrials.gov: NCT03509350. Registered on 26 April 2018. ... Read more >>

Trials (Trials)
[2020, 21(1):351]

Cited: 0 times

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Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise.

Bram Rochwerg, Rachael Parke, Srinivas Murthy, Shannon M Fernando, Jeanna Parsons Leigh, John Marshall, Neill K J Adhikari, Kirsten Fiest, Rob Fowler, François Lamontagne, Jonathan E Sevransky,

Although the amount of information generated during this most recent coronavirus disease 2019 pandemic is enormous, much is of uncertain trustworthiness. This review summaries the many potential sources of information that clinicians turn to during pandemic illness, the challenges associated with performing methodologically sound research in this setting and potential ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(4):e0098]

Cited: 13 times

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Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

Christopher J Lindsell, Anna McGlothlin, Samuel Nwosu, Todd W Rice, Alex Hall, Gordon R Bernard, Laurence W Busse, E Wesley Ely, Alpha A Fowler, David F Gaieski, Jeremiah S Hinson, Michael H Hooper, James C Jackson, Gabor D Kelen, Mark Levine, Greg S Martin, Richard E Rothman, Jonathan E Sevransky, Kert Viele, David W Wright, David N Hager,

<h4>Background</h4>Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.<h4>Methods and design</h4>The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with ... Read more >>

Trials (Trials)
[2019, 20(1):670]

Cited: 3 times

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Toward Increased Understanding of the Steroid Controversy in Septic Shock.

James A Russell, Jonathan Sevransky,

Crit Care Med (Critical care medicine)
[2019, 47(12):1677-1679]

Cited: 0 times

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Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: a prospective cohort study.

Sarina K Sahetya, Christopher Mallow, Jonathan E Sevransky, Greg S Martin, Timothy D Girard, Roy G Brower, William Checkley, ,

<h4>Background</h4>Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well investigated in patients without ARDS. We hypothesized that higher driving pressures (ΔP) and plateau pressures (Pplat) are associated with worse patient-centered outcomes in ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):367]

Cited: 3 times

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Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.

Alpha A Fowler, Jonathon D Truwit, R Duncan Hite, Peter E Morris, Christine DeWilde, Anna Priday, Bernard Fisher, Leroy R Thacker, Ramesh Natarajan, Donald F Brophy, Robin Sculthorpe, Rahul Nanchal, Aamer Syed, Jamie Sturgill, Greg S Martin, Jonathan Sevransky, Markos Kashiouris, Stella Hamman, Katherine F Egan, Andrei Hastings, Wendy Spencer, Shawnda Tench, Omar Mehkri, James Bindas, Abhijit Duggal, Jeanette Graf, Stephanie Zellner, Lynda Yanny, Catherine McPolin, Tonya Hollrith, David Kramer, Charles Ojielo, Tessa Damm, Evan Cassity, Aleksandra Wieliczko, Matthew Halquist,

<h4>Importance</h4>Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS).<h4>Objective</h4>To determine the effect of intravenous vitamin C infusion on organ failure scores and biological markers of inflammation and vascular injury in patients with sepsis and ARDS.<h4>Design, setting, and ... Read more >>

JAMA (JAMA)
[2019, 322(13):1261-1270]

Cited: 164 times

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The authors reply.

Samuel A Tisherman, Antionette Spevetz, Sandralee A Blosser, Daniel Brown, Cherylee Chang, Philip A Efron, Michael O'Connor, Jonathan E Sevransky, Brian T Wessman,

Crit Care Med (Critical care medicine)
[2019, 47(5):e429]

Cited: 0 times

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The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

David N Hager, Michael H Hooper, Gordon R Bernard, Laurence W Busse, E Wesley Ely, Alpha A Fowler, David F Gaieski, Alex Hall, Jeremiah S Hinson, James C Jackson, Gabor D Kelen, Mark Levine, Christopher J Lindsell, Richard E Malone, Anna McGlothlin, Richard E Rothman, Kert Viele, David W Wright, Jonathan E Sevransky, Greg S Martin,

<h4>Background</h4>Sepsis accounts for 30% to 50% of all in-hospital deaths in the United States. Other than antibiotics and source control, management strategies are largely supportive with fluid resuscitation and respiratory, renal, and circulatory support. Intravenous vitamin C in conjunction with thiamine and hydrocortisone has recently been suggested to improve outcomes ... Read more >>

Trials (Trials)
[2019, 20(1):197]

Cited: 19 times

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Typologies of Decision-Makers in the ICU: A Qualitative Study of Patients With Acute Respiratory Distress Syndrome and Sepsis and Their Surrogates.

Michael S Lava, Neal W Dickert, Paula M Frew, Gregory S Martin, Jonathan E Sevransky,

To develop hypotheses of patient and surrogate's rationale for decision-making. Design:We pursued a qualitative study of patients with acute respiratory distress syndrome or sepsis and their surrogates. Fourteen patients and 28 surrogates were given semistructured interviews while in the ICU and again 30 days later. The interviews focused on goal ... Read more >>

Crit Care Explor (Critical care explorations)
[2019, 1(5):e0011]

Cited: 0 times

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Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome-More Research Is Needed.

Bram Rochwerg, Waleed Alhazzani, Jonathan E Sevransky,

Crit Care Med (Critical care medicine)
[2019, 47(1):118-120]

Cited: 0 times

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A Case for Change in Adult Critical Care Training for Physicians in the United States: A White Paper Developed by the Critical Care as a Specialty Task Force of the Society of Critical Care Medicine.

Samuel A Tisherman, Antoinette Spevetz, Sandralee A Blosser, Daniel Brown, Cherylee Chang, Philip A Efron, Michael O'Connor, Jonathan E Sevransky, Brian T Wessman,

<h4>Objectives</h4>In the United States, physician training in Critical Care Medicine has developed as a subspecialty of different primary boards, despite significant commonality in knowledge and skills. The Society of Critical Care Medicine appointed a multidisciplinary Task Force to examine alternative approaches for future training.<h4>Design</h4>The Task Force reviewed the literature and ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(10):1577-1584]

Cited: 4 times

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Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis.

Bram Rochwerg, Simon J Oczkowski, Reed A C Siemieniuk, Thomas Agoritsas, Emilie Belley-Cote, Frédérick D'Aragon, Erick Duan, Shane English, Kira Gossack-Keenan, Mashari Alghuroba, Wojciech Szczeklik, Kusum Menon, Waleed Alhazzani, Jonathan Sevransky, Per Olav Vandvik, Djillali Annane, Gordon Guyatt,

<h4>Objective</h4>This systematic review and meta-analysis addresses the efficacy and safety of corticosteroids in critically ill patients with sepsis.<h4>Data sources</h4>We updated a comprehensive search of MEDLINE, EMBASE, CENTRAL, and LILACS, and unpublished sources for randomized controlled trials that compared any corticosteroid to placebo or no corticosteroid in critically ill children and ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(9):1411-1420]

Cited: 51 times

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Glucometry When Using Vitamin C in Sepsis: A Note of Caution.

David N Hager, Greg S Martin, Jonathan E Sevransky, Michael H Hooper,

Chest (Chest)
[2018, 154(1):228-229]

Cited: 3 times

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Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis.

Djillali Annane, Jean-Paul Mira, Lorraine B Ware, Anthony C Gordon, Charles J Hinds, David C Christiani, Jonathan Sevransky, Kathleen Barnes, Timothy G Buchman, Patrick J Heagerty, Robert Balshaw, Nadia Lesnikova, Karen de Nobrega, Hugh F Wellman, Mauricio Neira, Alexandra D J Mancini, Keith R Walley, James A Russell,

PURPOSE:To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was designed to validate whether previously identified improved response polymorphisms (IRPs A and B) were associated with an improved response to DrotAA in severe sepsis. ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2018, 8(1):16]

Cited: 0 times

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A Survey of Corticosteroid Dosing for Exacerbations of Chronic Obstructive Pulmonary Disease Requiring Assisted Ventilation.

Tyree H Kiser, Jonathan E Sevransky, Jerry A Krishnan, James Tonascia, Robert A Wise, William Checkley, John Walsh, Jamie B Sullivan, Kevin C Wilson, Alan Barker, Marc Moss, R William Vandivier,

<b>Background:</b> For over 40 years, systemic corticosteroids have been a mainstay of treatment for patients with exacerbations of chronic obstructive pulmonary disease (COPD). Surprisingly, the optimal dosage of corticosteroids is unknown in critically ill patients requiring assisted ventilation, a group with high morbidity and mortality. <b>Methods:</b> We surveyed 39 academic ... Read more >>

Chronic Obstr Pulm Dis (Chronic obstructive pulmonary diseases (Miami, Fla.))
[2017, 4(3):186-193]

Cited: 2 times

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