Full Text Journal Articles by
Author Jonathan M Chemouny

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

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Unexpected overdose of oral cyclosporine in a kidney transplant patient: a case report.

Astrid Bacle, Roxane Lhermitte, Brendan Le Daré, Marion Mercerolle, Cécile Vigneau, Pascal Le Corre, Jonathan M Chemouny,

Cyclosporine is a widely used immunosuppressive agent to prevent rejection of solid organ transplant. Here, we describe the case of a 71-year-old man who received the prescribed dose of cyclosporine 10 times 6 days after a kidney transplantation because of a concentration miscalculation involving two galenic forms. The patient presented gastrointestinal ... Read more >>

Eur J Hosp Pharm (European journal of hospital pharmacy : science and practice)
[2021, :]

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Occurrence of severe COVID-19 in vaccinated transplant patients.

Sophie Caillard, Nathalie Chavarot, Dominique Bertrand, Nassim Kamar, Olivier Thaunat, Valerie Moal, Christophe Masset, Marc Hazzan, Philippe Gatault, Antoine Sicard, Jonathan M Chemouny, Jean Philippe Rerolle, Charlotte Colosio, Hélène Francois, Jamal Bamoulid, Nicolas Bouvier, Agnès Duveau, Dany Anglicheau, Gilles Blancho, ,

Kidney Int (Kidney international)
[2021, :]

Cited: 0 times

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Kidney Biopsy in Type 2 Diabetes: A Multicenter Cross-Sectional Study.

Jonathan M Chemouny, Mickaël Bobot, Aurélie Sannier, Valentin Maisons, Noémie Jourde-Chiche, Elsa Ferriere, Dominique Joly, Cécile Vigneau, Nathalie Rioux-Leclercq, Christophe Barba, Laurent Daniel, Jean-Michel Halimi, Francois Vrtovsnik,

<h4>Introduction</h4>Kidney biopsies (KBs) are performed in patients with type 2 diabetes (T2D) to diagnose non-diabetic or hypertensive kidney disease (NDHKD) potentially requiring specific management compared to diabetic and or hypertensive nephropathy (absence of NDHKD). Indications for KB are based on the presence of atypical features compared to the typical course ... Read more >>

Am J Nephrol (American journal of nephrology)
[2021, 52(2):131-140]

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Belatacept as maintenance therapy in kidney transplant recipients with ANCA-associated vasculitis.

Manon Martins, Antoine Morel, Charlotte Laurent, Nassim Kamar, Dany Anglicheau, Marie Matignon, Cécile Vigneau, Dominique Guerrot, Nathalie Chavarot, Jonathan M Chemouny,

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2021, 39 Suppl 129(2):194-195]

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Volumetric absorptive microsampling for the quantification of tacrolimus in capillary blood by high performance liquid chromatography-tandem mass spectrometry.

Camille Tron, Marie-José Ferrand-Sorre, Julie Querzerho-Raguideau, Jonathan M Chemouny, Pauline Houssel-Debry, Marie-Clémence Verdier, Eric Bellissant, Florian Lemaitre,

Volumetric absorptive microsampling (VAMS) is an innovative alternative strategy to venipuncture for monitoring tacrolimus levels in transplant recipients. In this study, we aimed to validate a new high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for quantifying tacrolimus in blood collected by VAMS. Tacrolimus was extracted from dried blood tips ... Read more >>

J Chromatogr B Analyt Technol Biomed Life Sci (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2021, 1165:122521]

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Is COVID-19 infection more severe in kidney transplant recipients?

Sophie Caillard, Nathalie Chavarot, Hélène Francois, Marie Matignon, Clarisse Greze, Nassim Kamar, Philippe Gatault, Olivier Thaunat, Tristan Legris, Luc Frimat, Pierre F Westeel, Valentin Goutaudier, Mariam Jdidou, Renaud Snanoudj, Charlotte Colosio, Antoine Sicard, Dominique Bertrand, Christiane Mousson, Jamal Bamoulid, Christophe Masset, Antoine Thierry, Lionel Couzi, Jonathan M Chemouny, Agnes Duveau, Valerie Moal, Gilles Blancho, Philippe Grimbert, Antoine Durrbach, Bruno Moulin, Dany Anglicheau, Dany Anglicheau, Yvon Ruch, Charlotte Kaeuffer, Ilies Benotmane, Morgane Solis, Yannick LeMeur, Marc Hazzan, Marc Hazzan, Francois Danion, ,

There are no studies which have compared the risk of severe COVID-19 and related mortality between transplant recipients and nontransplant patients. We enrolled two groups of patients hospitalized for COVID-19, that is, kidney transplant recipients (KTR) from the French Registry of Solid Organ Transplant (n = 306) and a single-center cohort of ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(3):1295-1303]

Cited: 4 times

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An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants.

Sophie Caillard, Dany Anglicheau, Marie Matignon, Antoine Durrbach, Clarisse Greze, Luc Frimat, Olivier Thaunat, Tristan Legris, Valerie Moal, Pierre Francois Westeel, Nassim Kamar, Philippe Gatault, Renaud Snanoudj, Antoine Sicard, Dominique Bertrand, Charlotte Colosio, Lionel Couzi, Jonathan M Chemouny, Christophe Masset, Gilles Blancho, Jamal Bamoulid, Agnes Duveau, Nicolas Bouvier, Nathalie Chavarot, Philippe Grimbert, Bruno Moulin, Yannick Le Meur, Marc Hazzan, ,

Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in recipients of a kidney transplant remain scanty. The aim of this registry-based observational study was to explore characteristics and clinical outcomes of recipients of kidney transplants included in the French nationwide Registry of Solid Organ ... Read more >>

Kidney Int (Kidney international)
[2020, 98(6):1549-1558]

Cited: 28 times

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2658. Meningitis in Kidney Transplant Recipients: TransMéninges, a French Multicentric Retrospective Cohort Study

Yanis Tamzali, Anne Scemla, Pierre Taupin, Sunny Randhawa, Valérie Moal, Claire Garandeau, Charlène Levi, Marie Matignon, Vincent Fihman, Moglie Le Quintrec, Yosu Luque, Aurelia Retbi, Dominique Bertrand, Eric Thervet, Ilham Cherrak, Jonathan M Chemouny, Benoît Barrou, Jerôme Tourret-Arnaud,

Abstract Background The management of meningitis requires the prompt introduction of high-dose probabilistic anti-infectious therapy. The literature reporting on meningitis in kidney transplant recipients (KTR) is scarce and no recommendation exists for this specific population. Methods We retrospectively included all adult KTRs diagnosed with meningitis (cerebro-spinal fluid (CSF) cell count ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S930-S930]

Cited: 0 times

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Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice.

Jonathan M Chemouny, Patrick J Gleeson, Lilia Abbad, Gabriella Lauriero, Erwan Boedec, Karine Le Roux, Céline Monot, Maxime Bredel, Julie Bex-Coudrat, Aurélie Sannier, Eric Daugas, Francois Vrtovsnik, Loreto Gesualdo, Marion Leclerc, Laureline Berthelot, Sanae Ben Mkaddem, Patricia Lepage, Renato C Monteiro,

<h4>Background</h4>Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. We aimed to determine if an intervention targeting the gut microbiota could impact the ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(7):1135-1144]

Cited: 13 times

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Basophil involvement in lupus nephritis: a basis for innovation in daily care.

Nicolas Charles, Jonathan M Chemouny, Eric Daugas,

Lupus nephritis (LN) affects a large proportion of patients with systemic lupus erythematosus (SLE). LN can lead to end-stage renal disease depending on when it is diagnosed and on the adequacy of the treatment administered to the patient based on the class of LN. Determination of the class and activity ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2019, 34(5):750-756]

Cited: 0 times

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Value of biomarkers for predicting immunoglobulin A vasculitis nephritis outcome in an adult prospective cohort.

Laureline Berthelot, Agnès Jamin, Denis Viglietti, Jonathan M Chemouny, Hamza Ayari, Melissa Pierre, Pierre Housset, Virginia Sauvaget, Margarita Hurtado-Nedelec, François Vrtovsnik, Eric Daugas, , Renato C Monteiro, Evangeline Pillebout, ,

<h4>Background</h4>Henoch-Schönlein purpura, more recently renamed immunoglobulin A vasculitis (IgAV), is a systemic vasculitis characterized by IgA deposits. The current markers used to assess IgAV inaccurately evaluate the risk of nephritis occurrence and its long-term outcomes. The current study assessed biomarkers of nephritis outcomes.<h4>Methods</h4>This French multicentre prospective study enrolled 85 adult ... Read more >>

Nephrol Dial Transplant (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2018, 33(9):1579-1590]

Cited: 10 times

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Minimal Change Disease Induced by Lorlatinib.

Maureen Betton, Valérie Gounant, Aurélie Sannier, Guillaume Hanouna, Jean-Michel Goujon, Solenn Brosseau, Gérard Zalcman, Jonathan M Chemouny,

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2018, 13(8):e154-e156]

Cited: 0 times

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IgA kappa light and heavy chain deposition disease in multiple myeloma.

Aurélie Sannier, Guillaume Hanouna, Eric Daugas, Francois Vrtovsnik, Jean-Michel Goujon, Jonathan M Chemouny,

Br J Haematol (British journal of haematology)
[2018, 183(1):13]

Cited: 0 times

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Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice.

Agnès Jamin, Laureline Berthelot, Anne Couderc, Jonathan M Chemouny, Erwan Boedec, Laurène Dehoux, Lilia Abbad, Claire Dossier, Eric Daugas, Renato C Monteiro, Georges Deschênes,

Idiopathic steroid sensitive nephrotic syndrome (INS), the most frequent childhood nephropathy, is thought to be mediated by a circulating soluble factor that reversibly affects the renal protein sieving. The efficiency of rituximab therapy recently highlighted the involvement of B cells. Here we studied the involvement of a specific immunoglobulin G ... Read more >>

J Autoimmun (Journal of autoimmunity)
[2018, 89:149-161]

Cited: 6 times

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Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs.

Christophe Pellefigues, Barbara Dema, Yasmine Lamri, Fanny Saidoune, Nathalie Chavarot, Charlotte Lohéac, Emeline Pacreau, Michael Dussiot, Caroline Bidault, Florian Marquet, Mathieu Jablonski, Jonathan M Chemouny, Fanny Jouan, Antoine Dossier, Marie-Paule Chauveheid, Delphine Gobert, Thomas Papo, Hajime Karasuyama, Karim Sacré, Eric Daugas, Nicolas Charles,

In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role for prostaglandin D2 (PGD2) in the pathophysiology of SLE. Patients with SLE have increased expression ... Read more >>

Nat Commun (Nature communications)
[2018, 9(1):725]

Cited: 13 times

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Persistent Hypokalemia With Renal Losses in a 31-Year-Old Pregnant Woman.

Juliette Gueguen, Guillaume Hanouna, Jonathan M Chemouny,

Gastroenterology (Gastroenterology)
[2018, 154(6):1580-1581]

Cited: 0 times

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Serum Iron Protects from Renal Postischemic Injury.

Céline Vaugier, Mariane T Amano, Jonathan M Chemouny, Michael Dussiot, Claire Berrou, Marie Matignon, Sanae Ben Mkaddem, Pamella H M Wang, Aurélie Fricot, Thiago T Maciel, Damien Grapton, Jacques R R Mathieu, Carole Beaumont, Marie-Noëlle Peraldi, Carole Peyssonnaux, Laurent Mesnard, Eric Daugas, François Vrtovsnik, Renato C Monteiro, Olivier Hermine, Yelena Z Ginzburg, Marc Benhamou, Niels O S Camara, Martin Flamant, Ivan C Moura,

Renal transplants remain a medical challenge, because the parameters governing allograft outcome are incompletely identified. Here, we investigated the role of serum iron in the sterile inflammation that follows kidney ischemia-reperfusion injury. In a retrospective cohort study of renal allograft recipients (<i>n</i>=169), increased baseline levels of serum ferritin reliably predicted ... Read more >>

J Am Soc Nephrol (Journal of the American Society of Nephrology : JASN)
[2017, 28(12):3605-3615]

Cited: 3 times

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Renal biopsies should be performed whenever treatment strategies depend on renal involvement.

Gillian Divard, Aurelie Sannier, Guillaume Hanouna, Eric Daugas, Francois Vrtovsnik, Jonathan M Chemouny,

Ann Rheum Dis (Annals of the rheumatic diseases)
[2017, 76(8):e27]

Cited: 1 time

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Role of IgA receptors in the pathogenesis of IgA nephropathy.

Sebastian M Lechner, Christina Papista, Jonathan M Chemouny, Laureline Berthelot, Renato C Monteiro,

Immunoglobulin A nephropathy (IgAN) or Berger's disease is the most common form of primary glomerulonephritis in the world and one of the first causes of end-stage renal failure. IgAN is characterized by the accumulation of immune complexes containing polymeric IgA1 in mesangial areas. The pathogenesis of this disease involves the ... Read more >>

J Nephrol (Journal of nephrology)
[2016, 29(1):5-11]

Cited: 10 times

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Gluten exacerbates IgA nephropathy in humanized mice through gliadin-CD89 interaction.

Christina Papista, Sebastian Lechner, Sanae Ben Mkaddem, Marie-Bénédicte LeStang, Lilia Abbad, Julie Bex-Coudrat, Evangéline Pillebout, Jonathan M Chemouny, Mathieu Jablonski, Martin Flamant, Eric Daugas, François Vrtovsnik, Minas Yiangou, Laureline Berthelot, Renato C Monteiro,

IgA1 complexes containing deglycosylated IgA1, IgG autoantibodies, and a soluble form of the IgA receptor (sCD89), are hallmarks of IgA nephropathy (IgAN). Food antigens, notably gluten, are associated with increased mucosal response and IgAN onset, but their implication in the pathology remains unknown. Here, an IgAN mouse model expressing human ... Read more >>

Kidney Int (Kidney international)
[2015, 88(2):276-285]

Cited: 22 times

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The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy.

Houda Tamouza, Jonathan M Chemouny, Leona Raskova Kafkova, Laureline Berthelot, Martin Flamant, Marie Demion, Laurent Mesnard, Etienne Paubelle, Francine Walker, Bruce A Julian, Emilie Tissandié, Meetu K Tiwari, Niels O S Camara, François Vrtovsnik, Marc Benhamou, Jan Novak, Renato C Monteiro, Ivan C Moura,

IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has significant morbidity and mortality as 20-40% of patients progress to end-stage renal disease within 20 years of onset. In order to gain insight into the molecular mechanisms involved in the progression of IgAN, we systematically evaluated renal biopsies from such ... Read more >>

Kidney Int (Kidney international)
[2012, 82(12):1284-1296]

Cited: 41 times

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