Full Text Journal Articles by
Author Jonathan Hiller

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Anesthetic technique and cancer surgery outcomes.

Julia Dubowitz, Jonathan Hiller, Bernhard Riedel,

<h4>Purpose of review</h4>Surgery remains integral to treating solid cancers. However, the surgical stress response, characterized by physiologic perturbation of the adrenergic, inflammatory, and immune systems, may promote procancerous pathways. Anesthetic technique per se may attenuate/enhance these pathways and thereby could be implicated in long-term cancer outcomes.<h4>Recent findings</h4>To date, clinical studies ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):317-325]

Cited: 0 times

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Layered assemblers for scalable parallel integration.

Jonathan Hiller, Joni Mici, Hod Lipson,

Many complex natural and artificial systems are composed of large numbers of elementary building blocks, such as organisms made of many biological cells or processors made of many electronic transistors. This modular substrate is essential to the evolution of biological and technological complexity, but has been difficult to replicate for ... Read more >>

J R Soc Interface (Journal of the Royal Society, Interface)
[2020, 17(171):20200543]

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Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial.

Jonathan G Hiller, Steven W Cole, Elizabeth M Crone, David J Byrne, David M Shackleford, Jia-Min B Pang, Michael A Henderson, Sophie S Nightingale, Kwok M Ho, Paul S Myles, Stephen Fox, Bernhard Riedel, Erica K Sloan,

<h4>Purpose</h4>The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in preclinical studies. This phase II randomized controlled trial evaluated the effect of preoperative β-blockade with propranolol on biomarkers of metastatic potential and the immune cell profile within the primary tumor ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(8):1803-1811]

Cited: 13 times

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Modes of carbon dioxide delivery during laparoscopy generate distinct differences in peritoneal damage and hypoxia in a porcine model.

Shienny Sampurno, Timothy J Chittleborough, Sandra Carpinteri, Jonathan Hiller, Alexander Heriot, Andrew Craig Lynch, Robert George Ramsay,

<h4>Background</h4>Insufflation with CO<sub>2</sub> can employ continuous flow, recirculated gas and/or additional warming and humidification. The ability to compare these modes of delivery depends upon the assays employed and opportunities to minimize subject variation. The use of pigs to train colorectal surgeons provided an opportunity to compare three modes of CO<sub>2</sub> ... Read more >>

Surg Endosc (Surgical endoscopy)
[2020, 34(10):4395-4402]

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Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia.

Andrea Yap, Maria A Lopez-Olivo, Julia Dubowitz, Jonathan Hiller, Bernhard Riedel, ,

There was an isolated error relating to the Oh et al. study (1) within our recurrence-free survival analysis. When the reported estimates for Oh et al. are corrected, the pooled hazard ratio (HR) is now 0.87; 95% confidence interval (CI), 0.66 to 1.15; P=0.32. ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2019, 66(8):1007-1008]

Cited: 1 time

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In reply: Comment on "Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia".

Andrea Yap, Maria A Lopez-Olivo, Julia Dubowitz, Jonathan Hiller, Bernhard Riedel, ,

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2020, 67(1):152-153]

Cited: 0 times

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Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesia.

Andrea Yap, Maria A Lopez-Olivo, Julia Dubowitz, Jonathan Hiller, Bernhard Riedel, ,

PURPOSE:Cancer-related mortality, a leading cause of death worldwide, is often the result of metastatic disease recurrence. Anesthetic techniques have varying effects on innate and cellular immunity, activation of adrenergic-inflammatory pathways, and activation of cancer-promoting cellular signaling pathways; these effects may translate into an influence of anesthetic technique on long-term cancer ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2019, 66(5):546-561]

Cited: 17 times

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Perioperative events influence cancer recurrence risk after surgery.

Jonathan G Hiller, Nicholas J Perry, George Poulogiannis, Bernhard Riedel, Erica K Sloan,

Surgery is a mainstay treatment for patients with solid tumours. However, despite surgical resection with a curative intent and numerous advances in the effectiveness of (neo)adjuvant therapies, metastatic disease remains common and carries a high risk of mortality. The biological perturbations that accompany the surgical stress response and the pharmacological ... Read more >>

Nat Rev Clin Oncol (Nature reviews. Clinical oncology)
[2018, 15(4):205-218]

Cited: 51 times

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Improving trial design in cancer anesthesia (onco-anesthesia) research.

Jonathan G Hiller, Paul S Myles, Rob G Ramsay, Bernhard J Riedel,

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2017, 64(8):872-873]

Cited: 0 times

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Impact of celecoxib on inflammation during cancer surgery: a randomized clinical trial.

Jonathan G Hiller, Shienny Sampurno, Rosemary Millen, Niketh Kuruvilla, Kwok M Ho, Rob Ramsay, Bernhard Riedel,

<h4>Purpose</h4>During cancer surgery, prostaglandin-mediated inflammation may promote and activate micrometastatic disease with a consequent increase in long-term cancer recurrence. Cyclooxygenase-2 inhibitors, known to have anti-proliferative properties, may offset such perioperative perturbation. We investigated the effectiveness of these agents to minimize inflammatory changes during cancer surgery.<h4>Methods</h4>Following ethics approval, 32 patients who ... Read more >>

Can J Anaesth (Canadian journal of anaesthesia = Journal canadien d'anesthesie)
[2017, 64(5):497-505]

Cited: 6 times

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Neuraxial Anesthesia Reduces Lymphatic Flow: Proof-of-Concept in First In-Human Study.

Jonathan G Hiller, Hilmy M Ismail, Michael S Hofman, Kailash Narayan, Shakher Ramdave, Bernhard J Riedel,

Dilation of lymphatic vessels may contribute to iatrogenic dissemination of cancer cells during surgery. We sought to determine whether neuraxial anesthesia reduces regional lymphatic flow. Using nuclear lymphoscintigraphy, 5 participants receiving spinal anesthesia for brachytherapy had lower extremity lymph flow at rest compared with flow under conditions of spinal anesthesia. ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2016, 123(5):1325-1327]

Cited: 2 times

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The Combined Blockade of β-Adrenoceptor and COX-2 During the Perioperative Period to Improve Long-term Cancer Outcomes.

Itay Ricon, Jonathan G Hiller, Shamgar Ben-Eliyahu,

Int Anesthesiol Clin (International anesthesiology clinics)
[2016, 54(4):72-91]

Cited: 2 times

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Improved quality of anesthesia and cancer recurrence studies.

Jonathan Hiller, Hilmy Ismail, Bernhard Riedel,

Anesth Analg (Anesthesia and analgesia)
[2014, 119(3):751-752]

Cited: 5 times

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Understanding clinical strategies that may impact tumour growth and metastatic spread at the time of cancer surgery.

Jonathan Hiller, Gerhard Brodner, Antje Gottschalk,

The role of the perioperative period during cancer surgery and its impact on patients' long-term cancer outcomes are of increasing interest. Anticipation and prevention of perioperative immunosuppression and targeted therapeutic interventions that translate to reduced cancer recurrence are increasingly being explored. These interventions may focus on reducing the systemic inflammatory ... Read more >>

Best Pract Res Clin Anaesthesiol (Best practice & research. Clinical anaesthesiology)
[2013, 27(4):427-439]

Cited: 12 times

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