Full Text Journal Articles by
Author Jonathan H Chow

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Effects of a single bolus of hydroxocobalamin on hemodynamics in vasodilatory shock.

Lindsay A Ritter, Mary Maldarelli, Michael T McCurdy, David P Yamane, Danielle Davison, Christopher Parrino, David N Yim, Myounghee Lee, Michael A Mazzeffi, Jonathan H Chow,

<h4>Purpose</h4>Hydroxocobalamin has been observed to cause transient hypertension in healthy subjects, but rigorous studies examining its efficacy are lacking.<h4>Materials and methods</h4>Adults in shock who received hydroxocobalamin from 2017 to 2021 were analyzed retrospectively. Hourly hemodynamics from 24 h before and after treatment were collected, and the difference and hourly change of ... Read more >>

J Crit Care (Journal of critical care)
[2021, 67:66-71]

Cited: 0 times

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The Algorithm Examining the Risk of Massive Transfusion (ALERT) Score Accurately Predicts Massive Transfusion at the Scene of Injury and on Arrival to the Trauma Bay: A Retrospective Analysis.

Jonathan H Chow, Justin E Richards, Samuel M Galvagno, Patrick J Coleman, Allison S Lankford, Cheralyn Hendrix, Jackson Dunitz, Ikeoluwapo Ibrahim, Mira Ghneim, Kenichi A Tanaka, Thomas M Scalea, Michael A Mazzeffi, Peter Hu,

<h4>Background</h4>Massive transfusion (MT) is required to resuscitate traumatically injured patients with complex derangements. Scoring systems for MT typically require laboratory values and radiological imaging that may delay the prediction of MT.<h4>Study design</h4>The Trauma ALgorithm Examining the Risk of massive Transfusion (Trauma ALERT) study was an observational cohort study. Prehospital and ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(4):529-536]

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Association of prehospital antiplatelet therapy with survival in patients hospitalized with COVID-19: A propensity score-matched analysis.

Jonathan H Chow, Ying Yin, David P Yamane, Danielle Davison, Ryan J Keneally, Katrina Hawkins, K Gage Parr, Mustafa Al-Mashat, Jeffery S Berger, Reamer L Bushardt, Michael A Mazzeffi, Stuart J Nelson,

<h4>Purpose</h4>Coronavirus disease 2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk. The impact of prehospital antiplatelet therapy on in-hospital mortality is uncertain.<h4>Methods</h4>This was an observational cohort study of 34 675 patients ≥50 years old from 90 health systems in the United States. Patients were hospitalized with laboratory-confirmed COVID-19 between February 2020 and ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2021, 19(11):2814-2824]

Cited: 1 time

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The Impact of Corticosteroids on Secondary Infection and Mortality in Critically Ill COVID-19 Patients.

Lindsay A Ritter, Noel Britton, Emily L Heil, William A Teeter, Sarah B Murthi, Jonathan H Chow, Emily Ricotta, Daniel S Chertow, Alison Grazioli, Andrea R Levine,

<h4>Background</h4>Corticosteroids are part of the treatment guidelines for COVID-19 and have been shown to improve mortality. However, the impact corticosteroids have on the development of secondary infection in COVID-19 is unknown. We sought to define the rate of secondary infection in critically ill patients with COVID-19 and determine the effect ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2021, 36(10):1201-1208]

Cited: 0 times

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Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Maniraj Jeyaraju, Michael T McCurdy, Andrea R Levine, Prasad Devarajan, Michael A Mazzeffi, Kristin E Mullins, Michaella Reif, David N Yim, Christopher Parrino, Allison S Lankford, Jonathan H Chow,

<h4>Objectives</h4>Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospital mortality in hypotensive patients on vasopressors.<h4>Design</h4>Prospective, observational cohort study.<h4>Setting</h4>Tertiary academic ICU.<h4>Patients</h4>Adult patients ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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In Response.

Jonathan H Chow, Michael A Mazzeffi,

Anesth Analg (Anesthesia and analgesia)
[2021, 132(5):e90]

Cited: 0 times

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Seven-Year Follow-Up of an Online Critical Care Curriculum.

Ali Tabatabai, John C Greenwood, James H Lantry, Andrea R Levine, Nirav G Shah, William C Chiu, Nicholas A Morris, Jonathan H Chow, Samuel A Tisherman, Michael T McCurdy,

<b>Background:</b> In July of 2013, the University of Maryland launched MarylandCCProject.com. This free-access educational website delivers asynchronous high-quality multidisciplinary critical care education targeted at critical care trainees. The lectures, presented in real time on-site, are recorded and available on the website or as a podcast on iTunes or Android. Thus, ... Read more >>

ATS Sch (ATS scholar)
[2021, 2(2):224-235]

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Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With Coronavirus Disease 2019.

Jonathan H Chow, Ashish K Khanna, Shravan Kethireddy, David Yamane, Andrea Levine, Amanda M Jackson, Michael T McCurdy, Ali Tabatabai, Gagan Kumar, Paul Park, Ivy Benjenk, Jay Menaker, Nayab Ahmed, Evan Glidewell, Elizabeth Presutto, Shannon Cain, Naeha Haridasa, Wesley Field, Jacob G Fowler, Duy Trinh, Kathleen N Johnson, Aman Kaur, Amanda Lee, Kyle Sebastian, Allison Ulrich, Salvador Peña, Ross Carpenter, Shruti Sudhakar, Pushpinder Uppal, Benjamin T Fedeles, Aaron Sachs, Layth Dahbour, William Teeter, Kenichi Tanaka, Samuel M Galvagno, Daniel L Herr, Thomas M Scalea, Michael A Mazzeffi,

<h4>Background</h4>Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality.<h4>Methods</h4>A retrospective, observational cohort study of adult patients admitted with ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(4):930-941]

Cited: 83 times

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COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management.

Michael A Mazzeffi, Jonathan H Chow, Kenichi Tanaka,

<h4>Abstract</h4>Patients with severe coronavirus disease-2019 (COVID-19) frequently have hypercoagulability caused by the immune response to the severe acute respiratory syndrome coronavirus-2 infection. The pathophysiology of COVID-19 associated hypercoagulability is not fully understood, but characteristic changes include: increased fibrinogen concentration, increased Factor VIII activity, increased circulating von Willebrand factor, and exhausted ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(4):465-471]

Cited: 7 times

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Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients.

Jonathan H Chow, Erica D Wittwer, Patrick M Wieruszewski, Ashish K Khanna,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2021, :]

Cited: 0 times

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

Cited: 1 time

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High-Flow Nasal Cannula Oxygen in Patients Having Anesthesia for Advanced Esophagogastroduodenoscopy: HIFLOW-ENDO, a Randomized Clinical Trial.

Michael A Mazzeffi, Kendra M Petrick, Laurence Magder, Bruce D Greenwald, Peter Darwin, Eric M Goldberg, Paul Bigeleisen, Jonathan H Chow, Megan Anders, Cynthia M Boyd, Jeremy S Kaplowitz, Kai Sun, Michael Terrin, Peter Rock,

<h4>Background</h4>Over 6 million esophagogastroduodenoscopy (EGD) procedures are performed in the United States each year. Patients having anesthesia for advanced EGD procedures, such as interventional procedures, are at high risk for hypoxemia.<h4>Methods</h4>Our primary study aim was to evaluate whether high-flow nasal cannula (HFNC) oxygen reduces the incidence of hypoxemia during anesthesia ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):743-751]

Cited: 0 times

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Is Tranexamic Acid Associated With Mortality or Multiple Organ Failure Following Severe Injury?

Justin E Richards, Benjamin T Fedeles, Jonathan H Chow, Jonathan J Morrison, Corinne Renner, Anthony T Trinh, Caroline S Schlee, Ken Koerner, Thomas E Grissom, Richard D Betzold, Thomas M Scalea, Rosemary A Kozar,

<h4>Background</h4>Tranexamic acid (TXA) administration is recommended in severely injured trauma patients. We examined TXA administration, admission fibrinolysis phenotypes, and clinical outcomes following traumatic injury and hypothesized that TXA was associated with increased multiple organ failure (MOF).<h4>Methods</h4>Two-year, single-center, retrospective investigation. Inclusion criteria were age ≥ 18 years, Injury Severity Score (ISS) >16, admitted ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 55(1):55-60]

Cited: 1 time

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Intraoperative hypotension and perioperative acute ischemic stroke in patients having major elective non-cardiovascular non-neurological surgery.

Michael Mazzeffi, Jonathan H Chow, Megan Anders, Miranda Gibbons, Uwagbale Okojie, Amber Feng, Ikeoluwapo Ibrahim, Nicholas A Morris, Douglas Martz, Peter Rock,

<h4>Purpose</h4>The association between intraoperative hypotension and perioperative acute ischemic stroke is not well described. We hypothesized that intraoperative hypotension would be associated with perioperative acute ischemic stroke.<h4>Methods</h4>Four-year retrospective cohort study of elective non-cardiovascular, non-neurological surgical patients. Characteristics of patients who had perioperative acute ischemic stroke were compared against those of ... Read more >>

J Anesth (Journal of anesthesia)
[2021, 35(2):246-253]

Cited: 0 times

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Impact of Preoperative Platelet Count on Bleeding Risk and Allogeneic Transfusion in Multilevel Spine Surgery.

Jonathan H Chow, Zackary Chancer, Michael A Mazzeffi, John S McNeil, Michael J Sokolow, Tyler M Gaines, Michaella M Reif, Anthony T Trinh, Ian J Wellington, Jael E Camacho, Jacob J Bruckner, Kenichi A Tanaka, Steven Ludwig,

<h4>Study design</h4>This was an observational cohort study of patients receiving multilevel thoracic and lumbar spine surgery.<h4>Objective</h4>The aim of this study was to identify which patients are at high risk for allogeneic transfusion which may allow for better preoperative planning and employment of specific blood management strategies.<h4>Summary of background data</h4>Multilevel posterior ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, 46(1):E65-E72]

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A Multicenter Observational Cohort Study of Angiotensin II in Shock.

Susan E Smith, Andrea S Newsome, Yanglin Guo, Jason Hecht, Michael T McCurdy, Michael A Mazzeffi, Jonathan H Chow, Shravan Kethireddy,

<h4>Introduction</h4>Angiotensin II (Ang-2) is a non-catecholamine vasopressor that targets the renin-angiotensin-aldosterone system by agonism of the angiotensin type 1 receptor. Its utility as a vasopressor and a catecholamine-sparing agent was demonstrated in the pivotal ATHOS-3 trial, and numerous post-hoc analyses have shown reduced mortality in certain subsets of the population.<h4>Methods</h4>Consecutive ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2020, :885066620972943]

Cited: 0 times

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Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?

Michael Mazzeffi, Jonathan H Chow, Anthony Amoroso, Kenichi Tanaka,

Anesth Analg (Anesthesia and analgesia)
[2020, 131(3):690-693]

Cited: 5 times

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Anemia, sex, and race as predictors of morbidity or mortality after knee arthroplasty surgery.

Michael Mazzeffi, Monica Taneja, Steven Porter, Jonathan H Chow, Bryon Jackson, Magali Fontaine, Steven M Frank, Kenichi Tanaka,

<h4>Background</h4>Anemia is associated with poor outcome after major joint replacement surgery, but it is unclear whether sex and race modify its impact on outcome. We hypothesized that anemia would be associated with increased morbidity or mortality after knee arthroplasty surgery and that sex and race would be effect modifiers for ... Read more >>

Transfusion (Transfusion)
[2020, 60(12):2877-2885]

Cited: 0 times

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Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock.

Jonathan H Chow, Marianne Wallis, Allison S Lankford, Zackary Chancer, Rolf N Barth, Joseph R Scalea, John C LaMattina, Michael A Mazzeffi, Michael T McCurdy,

Endothelial dysfunction is common in septic shock and has been shown to impair angiotensin converting enzyme and the renin-angiotensin-aldosterone system (RAAS). Dysregulation of this pathway, which can be measured with plasma renin activity (PRA), is important not only because RAAS dysfunction is associated with increased mortality but also because treatment ... Read more >>

Semin Cardiothorac Vasc Anesth (Seminars in cardiothoracic and vascular anesthesia)
[2021, 25(1):67-73]

Cited: 0 times

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In Response.

Jonathan H Chow, Michael A Mazzeffi, Michael T McCurdy,

Anesth Analg (Anesthesia and analgesia)
[2020, 131(3):e171]

Cited: 0 times

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Angiotensin II and Vasoplegia in Cardiac Surgery: Paradigm Changer or Costly Contender?

Jonathan H Chow, Erik Strauss, Michael A Mazzeffi,

J Cardiothorac Vasc Anesth (Journal of cardiothoracic and vascular anesthesia)
[2021, 35(1):59-60]

Cited: 0 times

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Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series.

Ali Tabatabai, Joseph Rabin, Jay Menaker, Ronson Madathil, Samuel Galvagno, Ashley Menne, Jonathan H Chow, Alison Grazioli, Daniel Herr, Kenichi Tanaka, Thomas Scalea, Michael Mazzeffi,

Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor ... Read more >>

A A Pract (A&A practice)
[2020, 14(7):e01236]

Cited: 9 times

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Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle.

Michael A Mazzeffi, Jonathan H Chow, Zhongjun J Wu, Kenichi A Tanaka,

Crit Care Med (Critical care medicine)
[2020, 48(8):e732-e733]

Cited: 0 times

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Argument for Personalized Vasopressors in Septic Shock.

Andrea R Levine, Jonathan H Chow, Michael T McCurdy,

Crit Care Med (Critical care medicine)
[2020, 48(5):e439]

Cited: 0 times

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Angiotensin II for the Treatment of COVID-19-Related Vasodilatory Shock.

Jonathan H Chow, Michael A Mazzeffi, Michael T McCurdy,

Anesth Analg (Anesthesia and analgesia)
[2020, 131(1):102-105]

Cited: 13 times

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