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New insights into atypical Alzheimer's disease in the era of biomarkers.

Jonathan Graff-Radford, Keir X X Yong, Liana G Apostolova, Femke H Bouwman, Maria Carrillo, Bradford C Dickerson, Gil D Rabinovici, Jonathan M Schott, David T Jones, Melissa E Murray,

Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction. In the past, these individuals often received a late diagnosis; however, availability of CSF and PET biomarkers of Alzheimer's disease pathologies ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):222-234]

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Tau and Amyloid Relationships with Resting-state Functional Connectivity in Atypical Alzheimer's Disease.

Irene Sintini, Jonathan Graff-Radford, David T Jones, Hugo Botha, Peter R Martin, Mary M Machulda, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwell,

The mechanisms through which tau and amyloid-beta (Aβ) accumulate in the brain of Alzheimer's disease patients may differ but both are related to neuronal networks. We examined such mechanisms on neuroimaging in 58 participants with atypical Alzheimer's disease (posterior cortical atrophy or logopenic progressive aphasia). Participants underwent Aβ-PET, longitudinal tau-PET, ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(3):1693-1706]

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Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population.

Konstantinos Poulakis, Robert I Reid, Scott A Przybelski, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Michelle M Mielke, Mary M Machulda, Clifford R Jack, Ronald C Petersen, Eric Westman, Prashanthi Vemuri,

Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters ... Read more >>

Brain Commun (Brain communications)
[2021, 3(1):fcaa238]

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Cognitive Impairment in Patients with Stroke.

Caitlin E D'Souza, Melanie R F Greenway, Jonathan Graff-Radford, James F Meschia,

Despite substantial advances in stroke care, vascular cognitive impairment remains a prominent source of disability. Unlike sensorimotor impairments, cognition often continues to decline after stroke. An aging population will increase the prevalence of vascular cognitive impairment, with stroke playing an important role. Ten percent of patients presenting with stroke have ... Read more >>

Semin Neurol (Seminars in neurology)
[2021, 41(1):75-84]

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β-Amyloid PET and 123I-FP-CIT SPECT in Mild Cognitive Impairment at Risk for Lewy Body Dementia.

Qin Chen, Val J Lowe, Bradley F Boeve, Scott A Przybelski, Toji Miyagawa, Matthew L Senjem, Clifford R Jack, Timothy G Lesnick, Walter K Kremers, Julie A Fields, Hoon-Ki Min, Christopher G Schwarz, Jeffrey L Gunter, Jonathan Graff-Radford, Rodolfo Savica, David S Knopman, David Jones, Tanis J Ferman, Neill R Graff-Radford, Ronald C Petersen, Kejal Kantarci,

<h4>Objective</h4>To determine the clinical phenotypes associated with the amyloid-β PET and dopamine transporter imaging (<sup>123</sup>I-FP-CIT SPECT) findings in mild cognitive impairment (MCI) with the core clinical features of dementia with Lewy bodies (DLB; MCI-LB).<h4>Methods</h4>Patients with MCI who had at least one core clinical feature of DLB (n=34) were grouped into ... Read more >>

Neurology (Neurology)
[2021, :]

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The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia.

Toji Miyagawa, Scott A Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica, David Knopman, Ronald Petersen, Walter K Kremers, Leah K Forsberg, Julie A Fields, Tanis J Ferman, Laura Allen, Joseph Parisi, R Ross Reichard, Melissa Murray, Dennis Dickson, Bradley F Boeve, Kejal Kantarci, Val J Lowe,

Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[<sup>123</sup>I]iodophenyl) nortropane (<sup>123</sup>I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well <sup>123</sup>I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alzheimer's disease dementia (ADem) and whether multimodal imaging provides additional value. <sup>123</sup>I-FP-CIT SPECT, magnetic resonance imaging, ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2021, 99:11-18]

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Lewy Body Disease is a Contributor to Logopenic Progressive Aphasia Phenotype.

Marina Buciuc, Jennifer L Whitwell, Koji Kasanuki, Jonathan Graff-Radford, Mary M Machulda, Joseph R Duffy, Edythe A Strand, Val J Lowe, Neill R Graff-Radford, Beth K Rush, Malgorzata B Franczak, Margaret E Flanagan, Matthew C Baker, Rosa Rademakers, Owen A Ross, Bernardino F Ghetti, Joseph E Parisi, Aditya Raghunathan, R Ross Reichard, Eileen H Bigio, Dennis W Dickson, Keith A Josephs,

<h4>Objective</h4>The objective of this study was to describe clinical features, [<sup>18</sup> F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET) metabolism and digital pathology in patients with logopenic progressive aphasia (LPA) and pathologic diagnosis of diffuse Lewy body disease (DLBD) and compare to patients with LPA with other pathologies, as well as patients with ... Read more >>

Ann Neurol (Annals of neurology)
[2021, 89(3):520-533]

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Artificial Intelligence-Electrocardiography to Predict Incident Atrial Fibrillation: A Population-Based Study.

Georgios Christopoulos, Jonathan Graff-Radford, Camden L Lopez, Xiaoxi Yao, Zachi I Attia, Alejandro A Rabinstein, Ronald C Petersen, David S Knopman, Michelle M Mielke, Walter Kremers, Prashanthi Vemuri, Konstantinos C Siontis, Paul A Friedman, Peter A Noseworthy,

<h4>Background</h4>An artificial intelligence (AI) algorithm applied to electrocardiography during sinus rhythm has recently been shown to detect concurrent episodic atrial fibrillation (AF). We sought to characterize the value of AI-enabled electrocardiography (AI-ECG) as a predictor of future AF and assess its performance compared with the CHARGE-AF score (Cohorts for Aging ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2020, 13(12):e009355]

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CSF dynamics disorders: Association of brain MRI and nuclear medicine cisternogram findings.

Petrice M Cogswell, Jonathan Graff-Radford, Lincoln I Wurtz, Neill R Graff-Radford, Derek R Johnson, Christopher H Hunt, Jeffrey L Gunter, Jeremy K Cutsforth-Gregory, David T Jones, Benjamin D Elder, John Huston Iii, Clifford R Jack,

Disproportionately enlarged subarachnoid space hydrocephalus (DESH), characterized by ventriculomegaly, high convexity/midline tight sulci, and enlarged sylvian fissures on brain MRI has been increasingly recognized as a distinct diagnostic imaging entity that falls within the larger category of idiopathic normal pressure hydrocephalus. Normal pressure hydrocephalus has been previously characterized as a ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 28:102481]

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Author response: Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition.

Jonathan Graff-Radford, David Knopman, David Jones,

Neurology (Neurology)
[2020, 95(18):846]

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Network Localization of Alien Limb in Patients with Corticobasal Syndrome.

Aaron M Tetreault, Tony Phan, Kalen J Petersen, Daniel O Claassen, Byran J Neth, Jonathan Graff-Radford, Franziska Albrecht, Klaus Fliessbach, Anja Schneider, Matthis Synofzik, Janine Diehl-Schmid, Markus Otto, Matthias L Schroeter, Richard Ryan Darby, ,

<h4>Objective</h4>Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS-specific symptoms. In prior work, we used a wiring ... Read more >>

Ann Neurol (Annals of neurology)
[2020, 88(6):1118-1131]

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β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies.

Daniel Ferreira, Scott A Przybelski, Timothy G Lesnick, Afina W Lemstra, Elisabet Londos, Frederic Blanc, Zuzana Nedelska, Christopher G Schwarz, Jonathan Graff-Radford, Matthew L Senjem, Julie A Fields, David S Knopman, Rodolfo Savica, Tanis J Ferman, Neill R Graff-Radford, Val J Lowe, Clifford R Jack, Ronald C Petersen, Brit Mollenhauer, Sara Garcia-Ptacek, Carla Abdelnour, Jakub Hort, Laura Bonanni, Ketil Oppedal, Milica G Kramberger, Bradley F Boeve, Dag Aarsland, Eric Westman, Kejal Kantarci,

<h4>Objective</h4>In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases with age, which is modified by <i>APOE</i> genotype and sex, and that there are isolated and synergistic associations with the clinical phenotype.<h4>Methods</h4>We included 417 patients with DLB (age ... Read more >>

Neurology (Neurology)
[2020, 95(24):e3257-e3268]

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Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers.

Petrice M Cogswell, Heather J Wiste, Matthew L Senjem, Jeffrey L Gunter, Stephen D Weigand, Christopher G Schwarz, Arvin Arani, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Kejal Kantarci, Prashanthi Vemuri, Bradley F Boeve, Michelle M Mielke, Ronald C Petersen, Clifford R Jack,

Altered iron metabolism has been hypothesized to be associated with Alzheimer's disease pathology, and prior work has shown associations between iron load and beta amyloid plaques. Quantitative susceptibility mapping (QSM) is a recently popularized MR technique to infer local tissue susceptibility secondary to the presence of iron as well as ... Read more >>

Neuroimage (NeuroImage)
[2021, 224:117433]

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Functional outcome after critical illness in older patients: a population-based study.

Mania Hajeb, Tarun D Singh, Amra Sakusic, Jonathan Graff-Radford, Ognjen Gajic, Alejandro A Rabinstein,

<h4>Purpose</h4>To determine the prevalence of disability among ICU survivors one year after admission, and which factors influence functional outcome.<h4>Methods</h4>We examined consecutive patients enrolled in the population-based Mayo Clinic Olmsted Study of Aging and then admitted to medical or surgical adult ICUs at Mayo Clinic, Rochester between January 1, 2006, and ... Read more >>

Neurol Res (Neurological research)
[2021, 43(2):103-109]

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Predicting future rates of tau accumulation on PET.

Clifford R Jack, Heather J Wiste, Stephen D Weigand, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Tanis J Ferman, Bradley F Boeve, Kejal Kantarci, Prashanthi Vemuri, Michelle M Mielke, Jennifer Whitwell, Keith Josephs, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Petersen,

Clinical trials with anti-tau drugs will need to target individuals at risk of accumulating tau. Our objective was to identify variables available in a research setting that predict future rates of tau PET accumulation separately among individuals who were either cognitively unimpaired or cognitively impaired. All 337 participants had: a ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(10):3136-3150]

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Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition.

Vijay K Ramanan, Xuewei Wang, Scott A Przybelski, Sheelakumari Raghavan, Michael G Heckman, Anthony Batzler, Matthew L Kosel, Timothy J Hohman, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Michelle M Mielke, Clifford R Jack, Ronald C Petersen, Owen A Ross, Prashanthi Vemuri,

Tau deposition is a key biological feature of Alzheimer's disease that is closely related to cognitive impairment. However, it remains poorly understood why certain individuals may be more susceptible to tau deposition while others are more resistant. The recent availability of <i>in vivo</i> assessment of tau burden through positron emission ... Read more >>

Brain Commun (Brain communications)
[2020, 2(2):fcaa159]

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Prevalence and Trends in Management of Idiopathic Normal Pressure Hydrocephalus in the United States: Insights from the National Inpatient Sample.

Mohammed Ali Alvi, Desmond Brown, Yagiz Yolcu, Jad Zreik, Saad Javeed, Mohamad Bydon, Jeremy K Cutsforth-Gregory, Jonathan Graff-Radford, David T Jones, Neill R Graff-Radford, Petrice M Cogswell, Benjamin D Elder,

<h4>Background</h4>Over the past 2 decades, management of idiopathic normal pressure hydrocephalus (iNPH) has evolved significantly. In the current study, we sought to evaluate the national prevalence and management trends of iNPH in the United States using a national database.<h4>Methods</h4>The National Inpatient Sample was queried for patients with an International Classification ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 145:e38-e52]

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Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI.

Sheelakumari Raghavan, Scott A Przybelski, Robert I Reid, Jonathan Graff-Radford, Timothy G Lesnick, Samantha M Zuk, David S Knopman, Mary M Machulda, Michelle M Mielke, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri,

Our goal was to evaluate the utility of diffusion tensor imaging (DTI) for predicting future cognitive decline in mild cognitive impairment (MCI) in conjunction with Alzheimer's disease (AD) biomarkers (amyloid positron emission tomography and AD signature neurodegeneration) in 132 MCI individuals ≥60 year old with structural magnetic resonance imaging, DTI, amyloid ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2020, 96:176-183]

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Associations Between Plasma Ceramides and Cerebral Microbleeds or Lacunes.

Eseosa T Ighodaro, Jonathan Graff-Radford, Jeremy A Syrjanen, Hai H Bui, Ronald C Petersen, David S Knopman, Clifford R Jack, Samantha M Zuk, Prashanthi Vemuri, Michelle M Mielke,

<h4>Objective</h4>High plasma ceramide levels and ratios are associated with poor outcomes in individuals with cardiovascular disease; less is known about their relation to cerebral small vessel disease. We examined whether high plasma ceramide levels or ratios were associated with cerebral microbleeds (CMBs) and lacunes and whether associations differ by sex. ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(11):2785-2793]

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Predictors of adverse outcomes and cost after surgical management for idiopathic normal pressure hydrocephalus: Analyses from a national database.

Mohammed Ali Alvi, Desmond Brown, Yagiz Ugur Yolcu, Jad Zreik, Mohamad Bydon, Jeremy K Cutsforth-Gregory, Jonathan Graff-Radford, David T Jones, Neill R Graff-Radford, Benjamin D Elder,

<h4>Introduction</h4>We utilized a national administrative database to investigate drivers of immediate adverse economic and hospital outcomes, including non-routine discharge, prolonged length of stay (LOS), and admission costs among patients undergoing surgery for idiopathic normal pressure hydrocephalus (iNPH).<h4>Methods</h4>The National Inpatient Sample (NIS) was queried from 2007 to 2017 for patients aged ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 197:106178]

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Utility of HAS-BLED and CHA2DS2-VASc Scores Among Patients With Atrial Fibrillation and Imaging Evidence of Cerebral Amyloid Angiopathy.

Robert Ward, Shiva Ponamgi, Christopher V DeSimone, Stephen English, David O Hodge, Joshua P Slusser, Jonathan Graff-Radford, Alejandro A Rabinstein, Samuel J Asirvatham, David Holmes,

<h4>Objective</h4>To determine the utility of the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol concomitantly) and CHA<sub>2</sub>DS<sub>2</sub>-VASc (Congestive heart failure, Hypertension, Age, Diabetes, previous Stroke/transient ischemic attack-VAScular disease) scores among patients on anticoagulation (AC) therapy for atrial fibrillation (AF) who have evidence ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2020, 95(10):2090-2098]

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High prevalence of cervical myelopathy in patients with idiopathic normal pressure hydrocephalus.

Ryan M Naylor, Karina A Lenartowicz, Jonathan Graff-Radford, David T Jones, Jeremy K Cutsforth-Gregory, Neill R Graff-Radford, Benjamin D Elder,

<h4>Background</h4>Both idiopathic normal pressure hydrocephalus (iNPH) and cervical myelopathy may result in progressive gait impairment. Some patients who do not respond to shunting despite a positive tap test may have gait dysfunction from cervical myelopathy. The objective of this study was to determine the prevalence of cervical myelopathy in patients ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 197:106099]

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Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia.

Samuel Boes, Hugo Botha, Mary Machulda, Val Lowe, Jonathan Graff-Radford, Jennifer L Whitwell, Rene L Utianski, Joseph R Duffy, Keith A Josephs,

We report a patient presenting with clinical features of logopenic variant primary progressive aphasia (lvPPA) who was later diagnosed with probable dementia with Lewy bodies. LvPPA is a neurodegenerative disease that is characterized by anomia, word-finding difficulty, impaired comprehension, and phonological errors. The most common underlying pathology for lvPPA is ... Read more >>

Neurocase (Neurocase)
[2020, 26(5):259-263]

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High Mortality Rates Among Patients With Non-Traumatic Intracerebral Hemorrhage and Atrial Fibrillation on Antithrombotic Therapy Are Independent of the Presence of Cerebral Amyloid Angiopathy: Insights From a Population-Based Study.

Shiva P Ponamgi, Robert Ward, Christopher V DeSimone, Stephen English, David O Hodge, Joshua P Slusser, Jonathan Graff-Radford, Alejandro A Rabinstein, Samuel J Asirvatham, David Holmes,

Background Intracerebral hemorrhage (ICH) risk is higher in elderly patients with atrial fibrillation on antithrombotic therapy as well as those with cerebral amyloid angiopathy (CAA). We investigated if mortality among patients with atrial fibrillation on antithrombotic therapy presenting with non-traumatic ICH was influenced by underlying CAA. Methods and Results We ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(15):e016893]

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Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.

Melanie T Gentry, Maria I Lapid, Jeremy Syrjanen, Kendrick Calvert, Samantha Hughes, Danielle Brushaber, Walter Kremers, Jessica Bove, Patrick Brannelly, Giovanni Coppola, Christina Dheel, Bradley Dickerson, Susan Dickinson, Kelley Faber, Julie Fields, Jamie Fong, Tatiana Foroud, Leah Forsberg, Ralitza Gavrilova, Deb Gearhart, Nupur Ghoshal, Jill Goldman, Jonathan Graff-Radford, Neill Graff-Radford, Murray Grossman, Dana Haley, Hilary Heuer, Ging-Yuek Hsiung, Edward Huey, David Irwin, David Jones, Lynne Jones, Kejal Kantarci, Anna Karydas, David Knopman, John Kornak, Joel Kramer, Walter Kukull, Diane Lucente, Codrin Lungu, Ian Mackenzie, Masood Manoochehri, Scott McGinnis, Bruce Miller, Rodney Pearlman, Len Petrucelli, Madeline Potter, Rosa Rademakers, Eliana Marisa Ramos, Katherine Rankin, Katya Rascovsky, Pheth Sengdy, Leslie Shaw, Nadine Tatton, Joanne Taylor, Arthur Toga, John Trojanowski, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Bradley F Boeve, Adam Boxer, Howard Rosen, ,

<h4>Objective</h4>The Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects evaluates familial frontotemporal lobar degeneration (FTLD) kindreds with MAPT, GRN, or C9orf72 mutations. Objectives were to examine whether health-related quality of life (HRQoL) correlates with clinical symptoms and caregiver burden, and whether self-rated and informant-rated HRQoL would correlate with each other.<h4>Methods</h4>Individuals were ... Read more >>

Alzheimers Dement (Alzheimer's & dementia : the journal of the Alzheimer's Association)
[2020, 16(8):1115-1124]

Cited: 1 time

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