Full Text Journal Articles by
Author Jonathan B McHugh

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Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma.

Molly E Heft Neal, Apurva D Bhangale, Andrew C Birkeland, Jonathan B McHugh, Andrew G Shuman, Andrew J Rosko, Paul L Swiecicki, Matthew E Spector, J Chad Brenner,

Organ preservation protocols are commonly used as first line therapy for advanced laryngeal cancer. Recurrence thereafter is associated with poor survival. The aim of this study is to identify genetic alterations associated with survival among patients with recurrent laryngeal cancer undergoing salvage laryngectomy. Sixty-two patients were sequenced using a targeted ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.

Nicole C Panarelli, Suntrea T G Hammer, Jingmei Lin, Purva Gopal, ILKe Nalbantoglu, Lili Zhao, Jerome Cheng, Adam J Gersten, Jonathan B McHugh, Vinita Parkash, Elena Lucas, Maria Westerhoff,

The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1381-1388]

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Tumor infiltrating lymphocytes after neoadjuvant IRX-2 immunotherapy in oral squamous cell carcinoma: Interim findings from the INSPIRE trial.

Gregory T Wolf, Siyu Liu, Emily Bellile, Maureen Sartor, Laura Rozek, Dafydd Thomas, Ariane Nguyen, Katie Zarins, Jonathan B McHugh, ,

OBJECTIVES:IRX-2 is a primary-cell-derived immune-restorative consisting of multiple human cytokines that act to overcome tumor-mediated immunosuppression and provide an in vivo tumor vaccination to increase tumor infiltrating lymphocytes (TILs). A randomized phase II trial was conducted of the IRX regimen 3 weeks prior to surgery consisting of an initial dose of ... Read more >>

Oral Oncol (Oral oncology)
[2020, 111:104928]

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Impact of extrinsic tongue muscle invasion on stage migration in AJCC 8th edition staging of oral cavity carcinoma.

Emily J Marchiano, Noah J Mathis, Emily L Bellile, Remy Lobo, Mohannad Ibrahim, Joshua D Smith, Andrew C Birkeland, Keith A Casper, Kelly M Malloy, Paul L Swiecicki, Francis P Worden, Michelle L Mierzwa, J Chad Brenner, Carol R Bradford, Chaz L Stucken, Mark E Prince, Andrew J Rosko, Andrew G Shuman, Jonathan B McHugh, Matthew E Spector, Steven B Chinn,

Oral Oncol (Oral oncology)
[2020, 110:104888]

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A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations.

Timothy I Miller, Nicholas A Zoumberos, Bryan Johnson, Daniel R Rhodes, Scott A Tomlins, May P Chan, Aleodor A Andea, David R Lucas, Jonathan B McHugh, Noah Smith, Kelly L Harms, Chad Brewer, Jasmine Saleh, Rajiv M Patel, Paul W Harms,

Sarcomas on photodamaged skin vary in prognosis and management, but can display overlapping microscopic and immunophenotypic features. Improved understanding of molecular alterations in these tumors may provide diagnostic and therapeutic insights. We characterized 111 cutaneous sarcomatoid malignancies and their counterparts, including primary cutaneous angiosarcoma (n = 7), atypical fibroxanthoma (AFX) (n = 21), pleomorphic ... Read more >>

Hum. Pathol. (Human pathology)
[2020, 102:60-69]

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Sinonasal Papillomas and Carcinomas: A Contemporary Update With Review of an Emerging Molecular Classification.

Steven C Weindorf, Noah A Brown, Jonathan B McHugh, Aaron M Udager,

CONTEXT.—:Sinonasal papillomas and carcinomas are uncommon head and neck neoplasms that comprise a broad clinicopathologic and morphologic spectrum, and thus frequently represent a diagnostic challenge for surgical pathologists. Recent molecular interrogation of these tumors has delineated a number of recurrent alterations that correspond to distinct entities with potential diagnostic and/or ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2019, 143(11):1304-1316]

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Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma.

Matthew E Spector, Emily Bellile, Lahin Amlani, Katie Zarins, Joshua Smith, J Chad Brenner, Laura Rozek, Ariane Nguyen, Daffyd Thomas, Jonathan B McHugh, Jeremy M G Taylor, Gregory T Wolf, ,

Importance:Biomarkers that reflect prognosis and cellular immunity in patients with head and neck squamous cell carcinoma (HNSCC) are a prerequisite for improving individualized treatment that limits the intensity and morbidity of conventional treatment and may be useful in the introduction of new immunotherapy regimens. Objective:To determine if specific classes of ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2019, :]

Cited: 4 times

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EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor.

Grace Y Wang, Dafydd G Thomas, Jessica L Davis, Tony Ng, Rajiv M Patel, Paul W Harms, Bryan L Betz, Scott M Schuetze, Jonathan B McHugh, Andrew E Horvai, Soo-Jin Cho, David R Lucas,

In recent years, a novel small round cell sarcoma harboring EWSR1-NFATC2 translocation with immunomorphologic overlap with Ewing sarcoma (ES), myoepithelial tumors, and extraskeletal myxoid chondrosarcoma has emerged. There has not been a case series devoted to describing its detailed clinicopathologic and immunohistochemical characteristics. Six sarcomas harboring EWSR1-NFATC2 fusion transcripts by ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2019, 43(8):1112-1122]

Cited: 1 time

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Institutional Experience of Treatment and Outcomes for Cutaneous Periauricular Squamous Cell Carcinoma.

Kevin J Kovatch, Joshua D Smith, Andrew C Birkeland, John E Hanks, Rasha Jawad, Scott A McLean, Alison B Durham, Ashok Srinivasan, Jonathan B McHugh, Gregory J Basura,

Objectives:To report our institutional experience, management, and outcomes of cutaneous periauricular squamous cell carcinoma (SCC). Study Design:Retrospective chart review. Setting:Tertiary academic center. Subjects:Patients undergoing treatment of cutaneous periauricular SCC from 2000 to 2016. Results:A total of 112 patients had a median follow-up of 24.5 months, a mean ± SD age ... Read more >>

(OTO open)
[2019, 3(3):2473974X19875077]

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Primary Cardiac Sarcoma: A Rare, Aggressive Malignancy with a High Propensity for Brain Metastases.

Brittany L Siontis, Lili Zhao, Monika Leja, Jonathan B McHugh, Maryann M Shango, Laurence H Baker, Scott M Schuetze, Rashmi Chugh,

Introduction:Primary cardiac sarcoma (PCS) has a poor prognosis compared to other sarcomas due to late presentation, challenging resection, incidence of metastases, and limited efficacy of systemic therapies. Methods:A medical record search engine was queried to identify patients diagnosed with PCS from 1992 to 2017 at the University of Michigan. Results:Thirty-nine ... Read more >>

(Sarcoma)
[2019, 2019:1960593]

Cited: 1 time

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Intraoperative Depth of Invasion Is Accurate in Early-Stage Oral Cavity Squamous Cell Carcinoma.

Justine Moe, Jonathan B McHugh, Aaron M Udager, Thomas M Braun, Joseph I Helman, Brent B Ward,

PURPOSE:Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early-stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI in ... Read more >>

J. Oral Maxillofac. Surg. (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons)
[2019, 77(8):1704-1712]

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Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana.

Lauren E Merz, Osei Afriyie, Evelyn Jiagge, Ernest Adjei, Susan K Foltin, Megan L Ludwig, Jonathan B McHugh, J Chad Brenner, Sofia D Merajver,

Background and aims:Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of ... Read more >>

(Health science reports)
[2019, 2(2):e108]

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Canonical Wnt/β-catenin signaling activation in soft-tissue sarcomas: A comparative study of synovial sarcoma and leiomyosarcoma.

Laurence M Briski, Dafydd G Thomas, Rajiv M Patel, Elizabeth R Lawlor, Rashmi Chugh, Jonathan B McHugh, David R Lucas,

Background:Previous studies have shown that aberrant activation of the Wnt/β-catenin pathway is associated with many malignant neoplasms. This includes some soft-tissue sarcoma phenotypes, most notably synovial sarcoma, implicating potential targets for novel molecular therapies. Objective:We investigate the level of Wnt/β-catenin pathway activation present in leiomyosarcomas relative to synovial sarcomas, using ... Read more >>

(Rare tumors)
[2018, 10:2036361318813431]

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Differential Outcomes and Biologic Markers of Radiation-Associated vs. Sporadic Osteosarcoma: A Single-Institution Experience.

Brittany L Siontis, Jonathan B McHugh, Emily Roberts, Lily Zhao, Dafydd G Thomas, Dawn Owen, Laurence H Baker, J Sybil Biermann, Scott M Schuetze, Rashmi Chugh,

Background: Radiation-associated osteosarcoma (RAO) is a rare, life-threatening complication from radiation. Many physicians presume RAO has a worse prognosis than sporadic osteosarcoma (SO), although limited objective data exist. We conducted a retrospective study comparing these entities. Methods: We identified adults treated at our institution with osteosarcoma (1990-2016) and categorized tumors ... Read more >>

Front Oncol (Frontiers in oncology)
[2019, 9:1523]

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Correction: Expression of immunohistochemical markers in non-oropharyngeal head and neck squamous cell carcinoma in Ghana.

Osei Owusu-Afriyie, W K B A Owiredu, Kwabena Owusu-Danquah, Christine Komarck, Susan K Foltin, Rita Larsen-Reindorf, Emmanuel Acheampong, Solomon E Quayson, Mark E Prince, Jonathan B McHugh, Peter Donkor, Sofia D Merajver, J Chad Brenner,

[This corrects the article DOI: 10.1371/journal.pone.0202790.]. ... Read more >>

PLoS ONE (PloS one)
[2018, 13(12):e0209696]

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Analysis of tumor-infiltrating CD103 resident memory T-cell content in recurrent laryngeal squamous cell carcinoma.

Jacqueline E Mann, Joshua D Smith, Andrew C Birkeland, Emily Bellile, Paul Swiecicki, Michelle Mierzwa, Steven B Chinn, Andrew G Shuman, Kelly M Malloy, Keith A Casper, Scott A McLean, Jeffery S Moyer, Gregory T Wolf, Carol R Bradford, Mark E Prince, Thomas E Carey, Jonathan B McHugh, Matthew E Spector, J Chad Brenner,

BACKGROUND:Recurrent laryngeal squamous cell carcinomas (LSCCs) are associated with poor outcomes, without reliable biomarkers to identify patients who may benefit from adjuvant therapies. Given the emergence of tumor-infiltrating lymphocytes (TIL) as a biomarker in head and neck squamous cell carcinoma, we generated predictive models to understand the utility of CD4+, ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2019, 68(2):213-220]

Cited: 2 times

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Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

Gregory T Wolf, William Winter, Emily Bellile, Ariane Nguyen, C R Donnelly, Jonathan B McHugh, Dafydd Thomas, Lahin Amlani, Laura Rozek, Yu L Lei, ,

INTRODUCTION:Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immune response, expression of these markers and correlations ... Read more >>

Oral Oncol (Oral oncology)
[2018, 87:29-35]

Cited: 1 time

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A Slow-Growing Fibrous Parapharyngeal Mass.

Janice L Farlow, Jonathan B McHugh, Matthew E Spector,

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2018, 144(10):944-945]

Cited: 0 times

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Biphenotypic Sinonasal Sarcoma: A Review and Update.

Cody S Carter, Ellen G East, Jonathan B McHugh,

CONTEXT.—:Biphenotypic sinonasal sarcoma (BSNS) is a rare, slow-growing soft tissue sarcoma of the sinonasal tract, typically presenting with nonspecific obstructive nasal symptoms. Although recurrences are common, no metastases have been reported, and only 1 patient has died of disease thus far. It characteristically demonstrates rearrangements of PAX3 with multiple fusion ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2018, 142(10):1196-1201]

Cited: 1 time

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Clues to recognition of fumarate hydratase-deficient renal cell carcinoma: Findings from cytologic and limited biopsy samples.

Irene Shyu, Leili Mirsadraei, Xiaoyan Wang, Valentina Robila, Rohit Mehra, Jonathan B McHugh, Ying-Bei Chen, Aaron M Udager, Anthony J Gill, Liang Cheng, Mahul B Amin, Oscar Lin, Steven Christopher Smith,

BACKGROUND:Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is rare and highly aggressive and is believed to arise mostly in the setting of hereditary leiomyomatosis-RCC syndrome with a germline mutation of FH. Because of the aggressiveness of these tumors and a frequent lack of ascertainable family history, these tumors may first ... Read more >>

Cancer Cytopathol (Cancer cytopathology)
[2018, 126(12):992-1002]

Cited: 1 time

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Expressed HNSCC variants by HPV-status in a well-characterized Michigan cohort.

Tingting Qin, Yanxiao Zhang, Katie R Zarins, Tamara R Jones, Shama Virani, Lisa A Peterson, Jonathan B McHugh, Douglas Chepeha, Gregory T Wolf, Laura S Rozek, Maureen A Sartor,

While whole-exome DNA sequencing is the most common technology to study genetic variants in tumors in known exonic regions, RNA-seq is cheaper, covers most of the same exonic regions, and is often more readily available. In this study, we show the utility of mRNA-seq-based variant analysis combined with targeted gene ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):11458]

Cited: 1 time

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Expression of immunohistochemical markers in non-oropharyngeal head and neck squamous cell carcinoma in Ghana.

Osei Owusu-Afriyie, W K B A Owiredu, Kwabena Owusu-Danquah, Christine Komarck, Susan K Foltin, Rita Larsen-Reindorf, Emmanuel Acheampong, Solomon E Quayson, Mark E Prince, Jonathan B McHugh, Peter Donkor, Sofia D Merajver, J Chad Brenner,

BACKGROUND:Head and neck cancers include carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx. Studies on molecular expression of prognostic tumour markers in Ghana are scarce. The purpose of this study was to determine the expression of p53, p16, EGFR, Cyclin-D1 and HER2 among patients with non-oropharyngeal head and ... Read more >>

PLoS ONE (PloS one)
[2018, 13(8):e0202790]

Cited: 1 time

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Prospective Analysis of Surgical Bone Margins After Partial Foot Amputation in Diabetic Patients Admitted With Moderate to Severe Foot Infections.

Brian M Schmidt, Jonathan B McHugh, Rajiv M Patel, James S Wrobel,

BACKGROUND:Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims ... Read more >>

Foot Ankle Spec (Foot & ankle specialist)
[2019, 12(2):131-137]

Cited: 3 times

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A Pediatric Nasopharyngeal Mass.

Andrew C Birkeland, Jonathan B McHugh, Lauren A Bohm,

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2018, 144(4):371-372]

Cited: 0 times

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Dermatofibrosarcoma Protuberans of Distal Extremities and Acral Sites: A Clinicopathologic Analysis of 27 Cases.

Kabeer K Shah, Jonathan B McHugh, Andrew L Folpe, Rajiv M Patel,

Dermatofibrosarcoma protuberans (DFSP) of the distal extremities and acral sites are extremely rare and incompletely characterized. Twenty-seven DFSP occurring in these sites were retrieved from our collective archives and reevaluated. Tumors occurred in 16 males and 11 females. Median age at presentation was 42.5 years (range, 7 to 78 y). Lesions ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2018, 42(3):413-419]

Cited: 2 times

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