Full Text Journal Articles by
Author John Wright

Advertisement

Find full text journal articles






Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I.

John J Wright, Justin G Fedor, Judy Hirst, Maxie M Roessler,

BACKGROUND:For decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic proton-pumping enzymes, respiratory complex I, and different mechanisms have been proposed on their basis. However, the difficulty in investigating complex I semiquinones, due to the many different enzymes embedded in ... Read more >>

BMC Biol. (BMC biology)
[2020, 18(1):54]

Cited: 0 times

View full text PDF listing >>



Letter to the Editor: Time to update the language of genetics from the nineteenth to the twenty-first century: a response to Schmidtke and Cornel.

Neil Small, Dan Mason, John Wright,

J Community Genet (Journal of community genetics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Factors associated with the uptake of the UK routine childhood immunization schedule in a bi-ethnic population.

Gillian Santorelli, Dan Mason, Chris Cartwright, Leena Inamdar, Caroline Tomes, John Wright,

BACKGROUND:Various factors associated with vaccination uptake in children have been identified, but no study has examined their overall immunization status and individual vaccine coverage at 1, 2 and 5 years in the UK. METHODS:Data from 6977 participants in the Born in Bradford cohort were linked to primary care records. Overall immunization ... Read more >>

Eur J Public Health (European journal of public health)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Medication Order Errors at Hospital Admission Among Children With Medical Complexity.

Kevin Blaine, John Wright, Amy Pinkham, Margaret O'Neill, Sarah Wilkerson, Jayne Rogers, Sarah McBride, Charis Crofton, Sarah Grodsky, David Hall, Sangeeta Mauskar, Vinita Akula, Alisa Khan, Alexandra Mercer, Jay G Berry,

OBJECTIVES:We sought to characterize the nature and prevalence of medication order errors (MOEs) occurring at hospital admission for children with medical complexity (CMC), as well as identify the demographic and clinical risk factors for CMC experiencing MOEs. METHODS:Prospective cohort study of 1233 hospitalizations for CMC from November 1, 2015, to ... Read more >>

J Patient Saf (Journal of patient safety)
[2020, :]

Cited: 0 times

View full text PDF listing >>



COVID-19 in-patient hospital mortality by ethnicity

Gillian Santorelli, Trevor Sheldon, Jane West, Chris Cartwright, John Wright,

There is debate about the extent to which COVID-19 affects ethnic groups differently. We explored if there was variation in hospital mortality in patients with COVID. Mortality rates in 1,276 inpatients in Bradford with test results for COVID-19 were analysed by ethnic group. The age-adjusted risk of dying from COVID-19 ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



HDL-apoA-I kinetics in response to 16 wk of exercise training in men with nonalcoholic fatty liver disease.

Martin B Whyte, Fariba Shojaee-Moradie, Sharaf E Sharaf, Daniel J Cuthbertson, Graham J Kemp, Mark Barrett, Nicola C Jackson, Roselle A Herring, John Wright, E Louise Thomas, Jimmy Bell, A Margot Umpleby,

Nonalcoholic fatty liver disease (NAFLD) is characterized by low-circulating concentration of high-density lipoprotein cholesterol (HDL-C) and raised triacylglycerol (TAG). Exercise reduces hepatic fat content, improves insulin resistance and increases clearance of very-low-density lipoprotein-1 (VLDL1). However, the effect of exercise on TAG and HDL-C metabolism is unknown. We randomized male participants ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2020, 318(6):E839-E847]

Cited: 0 times

View full text PDF listing >>



Clinical label-free biochemical and metabolic fluorescence lifetime endoscopic imaging of precancerous and cancerous oral lesions.

Elvis Duran-Sierra, Shuna Cheng, Rodrigo Cuenca-Martinez, Bilal Malik, Kristen C Maitland, Y S Lisa Cheng, John Wright, Beena Ahmed, Jim Ji, Mathias Martinez, Moustafa Al-Khalil, Hussain Al-Enazi, Javier A Jo,

INTRODUCTION:Incomplete head and neck cancer resection occurs in up to 85% of cases, leading to increased odds of local recurrence and regional metastases; thus, image-guided surgical tools for accurate, in situ and fast detection of positive margins during head and neck cancer resection surgery are urgently needed. Oral epithelial dysplasia ... Read more >>

Oral Oncol. (Oral oncology)
[2020, 105:104635]

Cited: 0 times

View full text PDF listing >>



Multidimensional Harmonic Generation Determines Halide Perovskite Crystal Symmetry: Disentangling Second Harmonic Generation from Multiphoton Photoluminescence

Darien Morrow, Matthew Hautzinger, David Lafayette, Jason Scheeler, Lianna Dang, Meiying Leng, Daniel Kohler, Amelia Wheaton, yongping fu, Ilia Guzei, Jiang Tang, Song Jin, John Wright,

<div>Metal halide perovskites are an intriguing class of semiconductor materials being explored for their linear and non-linear optical, and potentially ferroelectric properties. In particular, layered two-dimensional Ruddlesden-Popper (RP) halide perovskites have shown ferroelectric properties. Optical second harmonic generation (SHG) is commonly used to screen for ferroelectric materials, however, SHG measurements ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease.

Ryan C Ungaro, Clara Yzet, Peter Bossuyt, Filip J Baert, Thomas Vanasek, Geert R D'Haens, Vincent Wilhelmus Joustra, Remo Panaccione, Gottfried Novacek, Walter Reinisch, Alessandro Armuzzi, Oleksandr Golovchenko, Olga Prymak, Adrian Goldis, Simon P Travis, Xavier Hébuterne, Marc Ferrante, Gerhard Rogler, Mathurin Fumery, Silvio Danese, Grazyna Rydzewska, Benjamin Pariente, Erik Hertervig, Carol Stanciu, Melanie Serrero, Mircea Diculescu, Laurent Peyrin-Biroulet, David Laharie, John P Wright, Fernando Gomollón, Irina Gubonina, Stefan Schreiber, Satoshi Motoya, Per M Hellström, Jonas Halfvarson, James W Butler, Joel Petersson, Francesca Petralia, Jean-Frederic Colombel,

BACKGROUND & AIMS:We investigated the effects of inducing deep remission in patients with early Crohn's disease (CD). METHODS:We collected follow-up data from 122 patients (mean age, 31.2±11.3 y) with early, moderate to severe CD (median duration 0.2 y; interquartile range, 0.1-0.5 y) who participated in the effect of tight control ... Read more >>

Gastroenterology (Gastroenterology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Starting School: a large-scale start of school assessment within the ‘Born in Bradford’ longitudinal cohort

Katy Shire, Elizabeth Andrews, Sally Barber, Alison Bruce, John Corkett, Liam Hill, Brian Kelly, Rosemary McEachan, Mark Mon-Williams, Louise Tracey, Amanda Waterman, John Wright,

The Born in Bradford (BiB) cohort of 13,776 children born between 2007-2011 and their parents provides a rich data resource for researchers exploring protective and risk factors influencing long-term developmental and health outcomes. Educational attainment is a critical factor related to later health. Literacy and communication, fine motor skills and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Using methylome data to inform exposome-health association studies: An application to the identification of environmental drivers of child body mass index.

Solène Cadiou, Mariona Bustamante, Lydiane Agier, Sandra Andrusaityte, Xavier Basagaña, Angel Carracedo, Leda Chatzi, Regina Grazuleviciene, Juan R Gonzalez, Kristine B Gutzkow, Léa Maitre, Dan Mason, Frédéric Millot, Mark Nieuwenhuijsen, Eleni Papadopoulou, Gillian Santorelli, Pierre-Jean Saulnier, Marta Vives, John Wright, Martine Vrijheid, Rémy Slama,

BACKGROUND:The exposome is defined as encompassing all environmental exposures one undergoes from conception onwards. Challenges of the application of this concept to environmental-health association studies include a possibly high false-positive rate. OBJECTIVES:We aimed to reduce the dimension of the exposome using information from DNA methylation as a way to more ... Read more >>

Environ Int (Environment international)
[2020, 138:105622]

Cited: 0 times

View full text PDF listing >>



Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria.

Tracy L McGregor, Karen A Hunt, Elaine Yee, Dan Mason, Paul Nioi, Simina Ticau, Marissa Pelosi, Perry R Loken, Sarah Finer, Deborah A Lawlor, Eric B Fauman, Qin Qin Huang, Christopher J Griffiths, Daniel G MacArthur, Richard C Trembath, Devin Oglesbee, John C Lieske, David V Erbe, John Wright, David A van Heel,

By sequencing autozygous human populations, we identified a healthy adult woman with lifelong complete knockout of HAO1 (expected ~1 in 30 million outbred people). HAO1 (glycolate oxidase) silencing is the mechanism of lumasiran, an investigational RNA interference therapeutic for primary hyperoxaluria type 1. Her plasma glycolate levels were 12 times, ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 0 times

View full text PDF listing >>



Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children.

Nikos Stratakis, David V Conti, Eva Borras, Eduardo Sabido, Theano Roumeliotaki, Eleni Papadopoulou, Lydiane Agier, Xavier Basagana, Mariona Bustamante, Maribel Casas, Shohreh F Farzan, Serena Fossati, Juan R Gonzalez, Regina Grazuleviciene, Barbara Heude, Lea Maitre, Rosemary R C McEachan, Ioannis Theologidis, Jose Urquiza, Marina Vafeiadi, Jane West, John Wright, Rob McConnell, Anne-Lise Brantsaeter, Helle-Margrete Meltzer, Martine Vrijheid, Leda Chatzi,

Importance:The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. Objective:To assess the associations of fish intake and mercury exposure during pregnancy with metabolic syndrome in children and alterations in biomarkers of inflammation in children. Design, Setting, ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e201007]

Cited: 0 times

View full text PDF listing >>



Dictionary learning in Fourier-transform scanning tunneling spectroscopy.

Sky C Cheung, John Y Shin, Yenson Lau, Zhengyu Chen, Ju Sun, Yuqian Zhang, Marvin A Müller, Ilya M Eremin, John N Wright, Abhay N Pasupathy,

Modern high-resolution microscopes are commonly used to study specimens that have dense and aperiodic spatial structure. Extracting meaningful information from images obtained from such microscopes remains a formidable challenge. Fourier analysis is commonly used to analyze the structure of such images. However, the Fourier transform fundamentally suffers from severe phase ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):1081]

Cited: 0 times

View full text PDF listing >>



Associations of Pregnancy Physical Activity with Maternal Cardiometabolic Health, Neonatal Delivery Outcomes and Body Composition in a Biethnic Cohort of 7305 Mother-Child Pairs: The Born in Bradford Study.

Paul J Collings, Diane Farrar, Joanna Gibson, Jane West, Sally E Barber, John Wright,

OBJECTIVE:Physical activity is advocated for a range of benefits to the uncomplicated pregnancy. We investigated associations of mid-pregnancy physical activity with maternal and neonatal health in white British and Pakistani-origin women from a deprived urban setting. METHODS:The study was performed in 6921 pregnant women (53% Pakistani-origin) who contributed data for ... Read more >>

Sports Med (Sports medicine (Auckland, N.Z.))
[2020, 50(3):615-628]

Cited: 0 times

View full text PDF listing >>



Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial.

Antoine Italiano, Olivier Mir, Simone Mathoulin-Pelissier, Nicolas Penel, Sophie Piperno-Neumann, Emmanuelle Bompas, Christine Chevreau, Florence Duffaud, Natacha Entz-Werlé, Esma Saada, Isabelle Ray-Coquard, Cyril Lervat, Nathalie Gaspar, Perrine Marec-Berard, Hélène Pacquement, John Wright, Maud Toulmonde, Alban Bessede, Amandine Crombe, Michèle Kind, Carine Bellera, Jean-Yves Blay,

BACKGROUND:Patients with Ewing sarcoma or osteosarcoma have a median overall survival of less than 12 months after diagnosis, and a standard treatment strategy has not yet been established. Pharmacological inhibition of MET signalling and aberrant angiogenesis has shown promising results in several preclinical models of Ewing sarcoma and osteosarcoma. We ... Read more >>

Lancet Oncol. (The Lancet. Oncology)
[2020, 21(3):446-455]

Cited: 0 times

View full text PDF listing >>



Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people.

Sarah Finer, Hilary C Martin, Ahsan Khan, Karen A Hunt, Beverley MacLaughlin, Zaheer Ahmed, Richard Ashcroft, Ceri Durham, Daniel G MacArthur, Mark I McCarthy, John Robson, Bhavi Trivedi, Chris Griffiths, John Wright, Richard C Trembath, David A van Heel,

Int J Epidemiol (International journal of epidemiology)
[2020, 49(1):20-21i]

Cited: 1 time

View full text PDF listing >>



Phase II Trial of Cabozantinib in Recurrent/Metastatic Endometrial Cancer: A Study of the Princess Margaret, Chicago and California Consortia (NCI9322/PHL86).

Neesha C Dhani, Hal W Hirte, Lisa Wang, Julia V Burnier, Angela Jain, Marcus O Butler, Stephen Welch, Gini F Fleming, Jean Hurteau, Koji Matsuo, Daniela Matei, Waldo Jimenez, Carolyn Johnston, Mihaela Cristea, Katia Tonkin, Prafull Ghatage, Stephanie Lheureux, Anjali Mehta, Judy Quintos, Qian Tan, Suzanne Kamel-Reid, Olga Ludkovski, Ming-Sound Tsao, John J Wright, Amit M Oza,

PURPOSE:The relevance of the MET/Hepatocyte Growth Factor (HGF) pathway in endometrial cancer tumor biology supports the clinical evaluation of cabozantinib in this disease. PATIENTS & METHODS:PHL86/NCI#9322 (NCT01935934) is a single arm study that evaluated cabozantinib in women with endometrial cancer with progression after chemotherapy. Co-primary endpoints were response rate and ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Occupational chemical exposures in pregnancy and fetal growth: evidence from the Born in Bradford Study.

Adeleh Shirangi, John Wright, Eve M Blair, Rosemary Rc McEachan, Mark J Nieuwenhuijsen,

Objectives This prospective birth cohort study evaluated the effect of occupational exposure to endocrine disrupting chemicals (EDC) during pregnancy on inadequate fetal growth as measured by small-for-gestational age (SGA) and inadequate fetal growth measured by percentage of optimal birth weight (POBW). The study also identified the maternal characteristics associated with ... Read more >>

Scand J Work Environ Health (Scandinavian journal of work, environment & health)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Maternal Physical Activity and Neonatal Cord Blood Lipid Levels: Findings From a Prospective Pregnancy Cohort.

Paul J Collings, Diane Farrar, Joanna Gibson, Jane West, Sally E Barber, John Wright,

BACKGROUND:Physical activity performed while pregnant is beneficially associated with maternal cardiovascular health. It is unknown if benefits extend to neonatal cardiovascular health. This study investigated associations of maternal physical activity with neonatal cord blood lipid and lipoprotein concentrations. METHODS:Cord blood lipids were measured at birth in a pseudorandomly selected subgroup ... Read more >>

J Phys Act Health (Journal of physical activity & health)
[2020, 17(2):236-241]

Cited: 0 times

View full text PDF listing >>



Trametinib Activity in Patients with Solid Tumors and Lymphomas Harboring BRAF Non-V600 Mutations or Fusions: Results from NCI-MATCH (EAY131).

Douglas B Johnson, Fengmin Zhao, Marcus Noel, Gregory J Riely, Edith P Mitchell, John J Wright, Helen X Chen, Robert J Gray, Shuli Li, Lisa M McShane, Larry V Rubinstein, David Patton, P Mickey Williams, Stanly R Hamilton, Barbara A Conley, Carlos L Arteaga, Lyndsay N Harris, Peter J O'Dwyer, Alice P Chen, Keith T Flaherty,

PURPOSE:Substantial preclinical evidence and case reports suggest that MEK inhibition is an active approach in tumors with BRAF mutations outside the V600 locus, and in BRAF fusions. Thus, Subprotocol R of the NCI-MATCH study tested the MEK inhibitor trametinib in this population. PATIENTS AND METHODS:The NCI-MATCH study performed genomic profiling ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(8):1812-1819]

Cited: 0 times

View full text PDF listing >>



NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma.

Ana M Molina, Johannes C van der Mijn, Paul Christos, John Wright, Charlene Thomas, Janice P Dutcher, David M Nanus, Scott T Tagawa, Lorraine J Gudas,

Preclinical studies suggest that histone deacetylase (HDAC) inhibitors may restore tumor sensitivity to retinoids and have synergistic anti-tumor activity when combined. We performed a Phase I clinical trial to evaluate the safety and preliminary efficacy of combining the oral HDAC inhibitor vorinostat and isotretinoin in patients with advanced renal cell ... Read more >>

Invest New Drugs (Investigational new drugs)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Obesity is associated with shorter telomeres in 8 year-old children.

Diana B P Clemente, Lea Maitre, Mariona Bustamante, Leda Chatzi, Theano Roumeliotaki, Serena Fossati, Regina Grazuleviciene, Kristine B Gützkow, Johanna Lepeule, Dries S Martens, Rosie R C McEachan, Helle M Meltzer, Inga Petraviciene, Rémy Slama, Ibon Tamayo-Uria, Jose Urquiza, Marina Vafeiadi, John Wright, Tim S Nawrot, Martine Vrijheid,

Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18739]

Cited: 0 times

View full text PDF listing >>



Early life tobacco exposure and children's telomere length: The HELIX project.

Citlalli Osorio-Yáñez, Diana B P Clemente, Lea Maitre, Martha Vives-Usano, Mariona Bustamante, David Martinez, Maribel Casas, Jan Alexander, Cathrine Thomsen, Leda Chatzi, Kristine B Gützkow, Regina Grazuleviciene, Dries S Martens, Michelle Plusquin, Remy Slama, Rosemary C McEachan, John Wright, Tiffany C Yang, Jose Urquiza, Ibon Tamayo, Jordi Sunyer, Marina Vafeiadi, Tim S Nawrot, Martine Vrijheid,

Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated ... Read more >>

Sci. Total Environ. (The Science of the total environment)
[2020, 711:135028]

Cited: 0 times

View full text PDF listing >>



Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies.

Judith S Brand, Romy Gaillard, Jane West, Rosemary R C McEachan, John Wright, Ellis Voerman, Janine F Felix, Kate Tilling, Deborah A Lawlor,

BACKGROUND:Maternal smoking during pregnancy is an established risk factor for low infant birth weight, but evidence on critical exposure windows and timing of fetal growth restriction is limited. Here we investigate the associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth by triangulating evidence from ... Read more >>

PLoS Med. (PLoS medicine)
[2019, 16(11):e1002972]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0329 s