Full Text Journal Articles by
Author John W Davis

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Freehand Versus Grid-Based Transperineal Prostate Biopsy: A Comparison of Anatomic Region Yield and Complications.

Ahmet Urkmez, Cihan Demirel, Muammer Altok, Tharakeswara K Bathala, Daniel D Shapiro, John W Davis,

<h4>Purpose</h4>The freehand (FH) technique of transperineal (TP) prostate biopsy using commercialized needle access systems facilitates a reduction in anesthesia requirements from general to local or local/sedation. We sought to compare the efficacy and complication rates of the FH method with those of the standard grid-based (GB) method.<h4>Materials and methods</h4>The GB ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001902]

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Echocardiographic evaluation of the Athlete's heart.

Aiham Albaeni, John W Davis, Masood Ahmad,

Cardiac response to prolonged, intense exercise induces phenotypic and physiologic adaptive changes that improve myocardial ability to meet oxygen demands. These adaptations, termed "athletes' heart," have been extensively studied. The importance of this entity arises from the increasing numbers of athletes as well as the drive for physical fitness in ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2021, :]

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Optimizing the diagnosis and management of ductal prostate cancer.

Weranja Ranasinghe, Daniel D Shapiro, Miao Zhang, Tharakeswara Bathala, Nora Navone, Timothy C Thompson, Bradley Broom, Ana Aparicio, Shi-Ming Tu, Chad Tang, John W Davis, Louis Pisters, Brian F Chapin,

Ductal adenocarcinoma (DAC) is the most common variant histological subtype of prostate carcinoma and has an aggressive clinical course. DAC is usually characterized and treated as high-risk prostatic acinar adenocarcinoma (PAC). However, DAC has a different biology to that of acinar disease, which often poses a challenge for both diagnosis ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2021, 18(6):337-358]

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Therapeutic Consequences of Omitting a Pelvic Lymph Node Dissection at Radical Prostatectomy when Grade and/or Stage Increase.

Muammer Altok, Brian F Chapin, Surena F Matin, Mary F Achim, Justin R Gregg, John W Davis,

<h4>Objective</h4>To analyze the effect on biochemical recurrence (BCR) of omitting PLND in subsequently upgraded/upstaged patients (pNx regret). Using nomograms, patients with low to intermediate-risk prostate cancer can be selected to omit a pelvic lymph node dissection (PLND) at the time of a radical prostatectomy (RP). However, some patients will experience ... Read more >>

Urology (Urology)
[2021, :]

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Oncologic outcomes among Black and White men with grade group 4 or 5 (Gleason score 8-10) prostate cancer treated primarily by radical prostatectomy.

Lamont J Wilkins, Jeffrey J Tosoian, Chad A Reichard, Debasish Sundi, Weranja Ranasinghe, Ridwan Alam, Zeyad Schwen, Chandana Reddy, Mohammed Allaf, John W Davis, Brian F Chapin, Ashley E Ross, Eric A Klein, Yaw A Nyame,

<h4>Background</h4>The aim of this study was to describe pathologic and short-term oncologic outcomes among Black and White men with grade group 4 or 5 prostate cancer managed primarily by radical prostatectomy.<h4>Methods</h4>This was a multi-institutional, observational study (2005-2015) evaluating radical prostatectomy outcomes by self-identified race. Descriptive analysis was performed via nonparametric ... Read more >>

Cancer (Cancer)
[2021, 127(9):1425-1431]

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Medicine in Mind, Healing at Heart: Big Data and Its Limits in Compassionate Care.

John W Davis,

In 2020, as a 24-year-old MD PhD student studying cardiovascular population health, I suffered a non-ST elevated myocardial infarction while playing basketball. It was confirmed the cause was familial hypercholesterolemia leading to 95%+ occlusions of both the left anterior descending and left circumflex arteries. The following reflective essay describes my ... Read more >>

J Am Board Fam Med (Journal of the American Board of Family Medicine : JABFM)
[2021, 34(2):449-451]

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Stability Assessment of a Polymeric Brominated Flame Retardant in Polystyrene Foams under Application-Relevant Conditions.

Mark W Beach, Kenneth L Kearns, John W Davis, John R Stutzman, Dean Lee, Yuming Lai, Daria Monaenkova, Shari Kram, Jing Hu, Christine Lukas,

The flame retardant (FR) BLUEDGE polymeric flame retardant (PFR) has been in use since 2011 and was developed as a replacement FR for hexabromocyclododecane in polystyrene (PS)-based insulation foams. To better understand the degradation behavior of the PFR used within PS foams, we examined the degradation of PFR under application-relevant ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, 55(5):3050-3058]

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Editorial Comment.

John W Davis,

J Urol (The Journal of urology)
[2021, 205(4):1088]

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Prospective trial of regional (hockey-stick) prostate cryoablation: oncologic and quality of life outcomes.

Justin R Gregg, Leonardo D Borregales, Haesun Choi, Marisa Lozano, Stephen E McRae, Aradhana M Venkatesan, John W Davis, Graciela M Nogueras-Gonzalez, Louis L Pisters, John F Ward,

<h4>Purpose</h4>To report long-term follow-up of the efficacy of subtotal prostate ablation using a "hockey-stick" template, including oncologic control and quality of life (QoL) impact.<h4>Methods</h4>We performed a prospective controlled trial to evaluate the efficacy of subtotal prostate ablation in selected men with baseline and confirmatory biopsy showing grade group (GG) 1-2 ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort.

Justin R Gregg, Xiaotao Zhang, Brian F Chapin, John F Ward, Jeri Kim, John W Davis, Carrie R Daniel,

<h4>Background</h4>The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti-inflammatory, antilipidemic, and chemopreventive properties. This study prospectively investigated adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors.<h4>Methods</h4>Men with ... Read more >>

Cancer (Cancer)
[2021, 127(5):720-728]

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Re: Randomized Comparison of Techniques for Control of the Dorsal Venous Complex During Robot-assisted Laparoscopic Radical Prostatectomy.

John W Davis,

Eur Urol (European urology)
[2021, 79(5):702-703]

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Surgical techniques to improve continence recovery after robot-assisted radical prostatectomy.

Ahmet Urkmez, Weranja Ranasinghe, John W Davis,

Radical prostatectomy directly affects urinary continence dynamics with incontinence being a major factor in patients' quality of life, social and psychological status. In order to help maintain continence after robot-assisted radical prostatectomy (RARP), a number of surgical techniques have been described. In the present narrative review, we summarize the surgical ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):3036-3048]

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Ductal Prostate Cancers Demonstrate Poor Outcomes with Conventional Therapies.

Weranja Ranasinghe, Daniel D Shapiro, Hyunsoo Hwang, Xuemei Wang, Chad A Reichard, Mohamed Elsheshtawi, Mary F Achim, Tharakeswara Bathala, Chad Tang, Ana Aparicio, Shi-Ming Tu, Nora Navone, Timothy C Thompson, Louis Pisters, Patricia Troncoso, John W Davis, Brian F Chapin,

<h4>Background</h4>Ductal prostate adenocarcinoma (DAC) is a rare, aggressive, histologic variant of prostate cancer that is treated with conventional therapies, similar to high-risk prostate adenocarcinoma (PAC).<h4>Objective</h4>To assess the outcomes of men undergoing definitive therapy for DAC or high-risk PAC and to explore the effects of androgen deprivation therapy (ADT) in improving ... Read more >>

Eur Urol (European urology)
[2021, 79(2):298-306]

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Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model.

Timothy P LaBranche, Anna K Kopec, Srinivasa R Mantena, Brett D Hollingshead, Andrew W Harrington, Zachary S Stewart, Yutian Zhan, Kyle D Hayes, Laurence O Whiteley, Andrew D Burdick, John W Davis,

Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncratic DILI. Here, we tested the hypothesis that certain features of asymptomatic metabolic ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2020, 48(8):994-1007]

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Acute infective endocarditis masquerading as septic shock with acute respiratory distress syndrome.

John W Davis, Fawad Virk, Masood Ahmad,

Any new pulmonary edema warrants an urgent rule out of acute cardiac dysfunction. Because sepsis protocols emphasize rapid stabilization and treatment over etiologic evaluation, some cases of endocarditis may be missed as sepsis with acute respiratory distress syndrome. ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, 8(12):3149-3153]

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The Association of Periprostatic Fat and Grade Group Progression in Men with Localized Prostate Cancer on Active Surveillance.

Justin R Gregg, Devaki Shilpa Surasi, Alexandria Childs, Nicholas Moll, John F Ward, Jeri Kim, Carrie R Daniel, Christopher Logothetis, Tharakeswara Bathala, John W Davis,

<h4>Purpose</h4>Evidence suggests that visceral fat quantity may be associated with post-prostatectomy outcomes and risk of prostate cancer related death. We evaluated whether increased fat volume, normalized to prostate size, is associated with decreased risk of disease progression.<h4>Materials and methods</h4>Patients enrolled on a prospective active surveillance trial for at least 6 ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):122-128]

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Comparing confirmatory biopsy outcomes between MRI-targeted biopsy and standard systematic biopsy among men being enrolled in prostate cancer active surveillance.

Daniel D Shapiro, Justin R Gregg, Amy H Lim, Graciela M Nogueras-González, Haesun Choi, Hyunseon C Kang, Irene A Inguillo, Brian F Chapin, John W Davis, John F Ward,

<h4>Objectives</h4>To evaluate the ability of magnetic resonance imaging (MRI)-targeted biopsy combined with systematic biopsy (MRI-biopsy) to reduce negative biopsies and detect clinically significant prostate cancer compared to systematic biopsy (SB) alone in the confirmatory biopsy setting using matched cohorts.<h4>Patients and methods</h4>Patients were identified from an active surveillance database who had ... Read more >>

BJU Int (BJU international)
[2021, 127(3):340-348]

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Patterns of metastases of prostatic ductal adenocarcinoma.

Weranja K B Ranasinghe, Nathan A Brooks, Mohamed A Elsheshtawi, John W Davis, Tharakeswara K Bathala, Chad Tang, Patricia Troncoso, Ana Aparicio, Shi-Ming Tu, Louis L Pisters, Brian F Chapin,

<h4>Background</h4>The current study was conducted to investigate the patterns of metastases in men with metastatic prostatic ductal adenocarcinoma (DAC) and recurrence patterns after therapy.<h4>Methods</h4>All patients with a new diagnosis of DAC with de novo metastases and those with localized disease who developed metastases after treatment and were treated at the ... Read more >>

Cancer (Cancer)
[2020, 126(16):3667-3673]

Cited: 2 times

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Mitochondrial DNA copy number in peripheral blood leukocytes is associated with biochemical recurrence in prostate cancer patients in African Americans.

Junfeng Xu, Wen-Shin Chang, Chia-Wen Tsai, Da-Tian Bau, John W Davis, Timothy C Thompson, Christopher J Logothetis, Jian Gu,

Mitochondria play multiple important cellular functions. The purpose of this study was to evaluate whether leukocyte mitochondrial DNA copy number (mtDNAcn) is associated with aggressive prostate cancer (PCa) in African American (AA) men. We measured the mtDNAcn in peripheral blood leukocytes from 317 localized AA PCa patients and evaluated its ... Read more >>

Carcinogenesis (Carcinogenesis)
[2020, 41(3):267-273]

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Downgrading from Biopsy Grade Group 4 Prostate Cancer in Patients Undergoing Radical Prostatectomy for High or Very High Risk Prostate Cancer.

Weranja Ranasinghe, Chad A Reichard, Yaw A Nyame, Debasish Sundi, Jeffrey J Tosoian, Lamont Wilkins, Ridwan Alam, Mary F Achim, Xuemei Wang, Andrew J Stephenson, Eric A Klein, Ashley E Ross, Mohamad E Allaf, John W Davis, Brian F Chapin,

<h4>Purpose</h4>We examined rates of Grade Group 4 downgrading at radical prostatectomy among men diagnosed with high and very high risk prostate cancer at biopsy.<h4>Materials and methods</h4>A pooled cohort of 1,776 patients from 3 tertiary referral centers who underwent radical prostatectomy for National Comprehensive Cancer Network® high risk (prostate specific antigen ... Read more >>

J Urol (The Journal of urology)
[2020, 204(4):748-753]

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Correction to: Unintended consequences of decreased PSA-based prostate cancer screening.

Thomas Ahlering, Linda My Huynh, Kamaljot S Kaler, Stephen Williams, Kathryn Osann, Jean Joseph, David Lee, John W Davis, Ronney Abaza, Jihad Kaouk, Vipul Patel, Isaac Yi Kim, James Porter, Jim C Hu,

In the original publication, part of funding information was missed. ... Read more >>

World J Urol (World journal of urology)
[2020, 38(3):807]

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Re: Medium-term Oncologic Outcomes in a Large Cohort of Men Treated with Focal or Hemi-ablation Using High-intensity Focused Ultrasonography for Primary Localized Prostate Cancer.

John W Davis,

Eur Urol (European urology)
[2020, 77(4):558]

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Leukocyte telomere length is associated with aggressive prostate cancer in localized prostate cancer patients.

Junfeng Xu, Wen-Shin Chang, Chia-Wen Tsai, Da-Tian Bau, Yifan Xu, John W Davis, Timothy C Thompson, Christopher J Logothetis, Jian Gu,

<h4>Background</h4>Telomeres play important roles in cancer initiation and progression. The aim of this study is to investigate whether leukocyte telomere length (LTL) is associated with aggressive prostate cancer (PCa).<h4>Methods</h4>We measured relative LTL in a cohort of 1,889 white PCa patients who were treated and followed up at the University of ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 52:102616]

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"TREXIT 2020": why the time to abandon transrectal prostate biopsy starts now.

Jeremy Grummet, Michael A Gorin, Rick Popert, Tim O'Brien, Alastair D Lamb, Boris Hadaschik, Jan Philipp Radtke, Florian Wagenlehner, Eduard Baco, Caroline M Moore, Mark Emberton, Arvin K George, John W Davis, Richard J Szabo, Roger Buckley, Andrew Loblaw, Matthew Allaway, Christof Kastner, Erik Briers, Peter L Royce, Mark Frydenberg, Declan G Murphy, Henry H Woo,

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2020, 23(1):62-65]

Cited: 3 times

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Determining Clinically Based Factors Associated With Reclassification in the Pre-MRI Era using a Large Prospective Active Surveillance Cohort.

Justin R Gregg, John W Davis, Chad Reichard, Xuemei Wang, Mary Achim, Brian F Chapin, Louis Pisters, Curtis Pettaway, John F Ward, Seungtaek Choi, Quynh-Nhu Nguyen, Deborah Kuban, Richard Babaian, Patricia Troncoso, Lydia T Madsen, Christopher Logothetis, Jeri Kim,

<h4>Objective</h4>To report biopsy-related and oncologic outcomes in a large prospective active surveillance cohort that was initiated in the premagnetic resonance imaging era and to additionally identify clinical factors associated with disease reclassification in order to inform future studies designed to improve enrollment and follow-up on active surveillance.<h4>Methods</h4>Patients were prospectively enrolled ... Read more >>

Urology (Urology)
[2020, 138:91-97]

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