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Potential combination therapy using twenty phytochemicals from twenty plants to prevent SARS- CoV-2 infection: An in silico Approach.

Dipjyoti Dey, Nirban Dey, Shalini Ghosh, Natrajan Chandrasekaran, Amitava Mukherjee, John Thomas,

Covid 19 caused by novel strain SARS- CoV-2 has become a pandemic due to its contagious nature of infection. It enters by binding with ACE2 receptor present on the outer surface of a cell by cleaving S1/S2 with proteolytic protein Furin. Further viral replication or transcription then takes place with ... Read more >>

Virusdisease (Virusdisease)
[2021, :1-9]

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Potential combination therapy using twenty phytochemicals from twenty plants to prevent SARS- CoV-2 infection: An in silico Approach

Dipjyoti Dey, Nirban Dey, Shalini Ghosh, Natrajan Chandrasekaran, Amitava Mukherjee, John Thomas,

Covid 19 caused by novel strain SARS- CoV-2 has become a pandemic due to its contagious nature of infection. It enters by binding with ACE2 receptor present on the outer surface of a cell by cleaving S1/S2 with proteolytic protein Furin. Further viral replication or transcription then takes place with ... Read more >>

Virusdisease (Virusdisease)
[2021, :1-9]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

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Multi-Center Validation Study of Automated Classification of Pathological Slowing in Adult Scalp Electroencephalograms Via Frequency Features.

Wei Yan Peh, John Thomas, Elham Bagheri, Rima Chaudhari, Sagar Karia, Rahul Rathakrishnan, Vinay Saini, Nilesh Shah, Rohit Srivastava, Yee-Leng Tan, Justin Dauwels,

Pathological slowing in the electroencephalogram (EEG) is widely investigated for the diagnosis of neurological disorders. Currently, the gold standard for slowing detection is the visual inspection of the EEG by experts, which is time-consuming and subjective. To address those issues, we propose three automated approaches to detect slowing in EEG: ... Read more >>

Int J Neural Syst (International journal of neural systems)
[2021, :2150016]

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Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease

Lejla Gul, Dezso Modos, Sonia Fonseca, Matthew Madgwick, John Thomas, Padhmanand Sudhakar, Régis Stentz, Simon Carding, Tamas Korcsmaros,

The gastrointestinal (GI) tract is inhabited by a complex microbial community, which contributes to its homeostasis. Disrupted microbiome can cause GI-related diseases, including inflammatory bowel disease, therefore identifying host-microbe interactions is crucial for better understanding gut health. Bacterial extracellular vesicles (BEVs), released into the gut lumen, can cross the mucus ... Read more >>

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A CFD Digital Twin to Understand Miscible Fluid Blending.

John Thomas, Kushal Sinha, Gayathri Shivkumar, Lei Cao, Marina Funck, Sherwin Shang, Nandkishor K Nere,

The mixing of stratified miscible fluids with widely different material properties is a common step in biopharmaceutical manufacturing processes. Differences between the fluid densities and viscosities, however, can lead to order-of-magnitude increase in blend times relative to the blending of single-fluid systems. Moreover, the mixing performance in two-fluid systems can ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2021, 22(3):91]

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Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling.

Tian Wang, Ezra Wiater, Xinmin Zhang, John B Thomas, Marc Montminy,

Fasting in mammals promotes increases in circulating glucagon and decreases in circulating insulin that stimulate catabolic programs and facilitate a transition from glucose to lipid burning. The second messenger cAMP mediates effects of glucagon on fasting metabolism, in part by promoting the phosphorylation of CREB and the dephosphorylation of the ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(12):]

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Clinical utility of plasma EGFR mutation detection with quantitative PCR in advanced lung cancer: A meta-analysis.

Peey-Sei Kok, Kirsty Lee, Sally Lord, James Chih-Hsin Yang, Rafael Rosell, Koichi Goto, Thomas John, Yi-Long Wu, Tony S K Mok, Chee Khoon Lee,

<h4>Objectives</h4>To assess the clinical utility of quantitative PCR (qPCR) assays, a routinely used test for detection of epidermal growth factor receptor (EGFR) mutation in circulating tumour DNA (ctDNA) in treatment-naive advanced lung cancer patients.<h4>Materials and methods</h4>We performed a meta-analysis of randomized controlled trials (RCTs) with individual patient data. Eligible RCTs ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 154:113-117]

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Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain.

Daniel E Troyetsky, Jeffrey Tithof, John H Thomas, Douglas H Kelley,

Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer's disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow of fluid. We examine the relative contributions of diffusion and advection in the perivascular spaces (PVSs) that surround ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4595]

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Working classification and the quest for an effective, reconstructive management strategy in Y duplication of male urethra.

Jujju Jacob Kurian, John K Thomas, Srinivasan Kuppusamy, Sundeep Kisku, Pavai Arunachalam, Sudipta Sen,

<h4>Introduction</h4>Y-duplication is a rare subtype of urethral duplication whose surgical correction has traditionally yielded less than satisfactory results. Herein we report 18 patients, 17 of whom have completed successful urethral reconstruction.<h4>Materials and methods</h4>A retrospective analysis was done on 18 children who have undergone repair of Y-duplication urethra in two tertiary ... Read more >>

J Pediatr Urol (Journal of pediatric urology)
[2021, :]

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Loss of Factor H family proteins associates with meningococcal disease severity

Anna van Beek, Richard Pouw, Victoria Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin Fink, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco Kuijpers,

<h4>ABSTRACT</h4> Neisseria meningitidis , the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH). The FH protein family also comprises the homologous FH-related (FHR) proteins, hypothesized to act as antagonists of FH, and FHR-3 has recently been implicated to ... Read more >>

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A validated method for the quantification of IOX-2, a potent prolyl hydroxylase inhibitor in equine urine and plasma using liquid chromatography-high-resolution mass spectrometry.

Ezra Mikhail, Erik Siccardi, Ali Bawazir, Ambika Rajesh, Seetharani Prathyush, Duaa Mohammad Kamal Al Wazani, Muhammed Sabeek, Thomas John,

IOX-2 is a potent inhibitor of enzyme prolyl hydroxylases-2 (PHD) that plays a critical role in regulating hypoxia inducible factor (HIF) abundance and oxygen homeostasis. Federation for Equestrian Sports has listed HIF activators as prohibited substances to prevent their usage in doping. Consequently, it became essential to develop adequate knowledge ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2021, :]

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Genetic diversity and recombination between turnip yellows virus strains in Australia.

Fiona Filardo, Narelle Nancarrow, Monica Kehoe, Alistair R McTaggart, Benjamin Congdon, Safaa Kumari, Mohammad Aftab, Piotr Trębicki, Brendan Rodoni, John Thomas, Murray Sharman,

Disease outbreaks caused by turnip yellows virus (TuYV), a member of the genus Polerovirus, family Luteoviridae, regularly occur in canola and pulse crops throughout Australia. To understand the genetic diversity of TuYV for resistance breeding and management, genome sequences of 28 TuYV isolates from different hosts and locations were determined ... Read more >>

Arch Virol (Archives of virology)
[2021, 166(3):813-829]

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The impact of high dose oral cotrimoxazole in patients with COVID-19 with hypoxic respiratory failure requiring non-invasive ventilation: A Case Control Study

Saurabh Singh, Thomas John, Prashant Kumar, Syed Rehan Quadery,

<h4>ABSTRACT</h4> <h4>Background</h4> COVID-19 can be fatal in a significant proportion of people who develop critical illness, resulting in hypoxic respiratory failure secondary to Acute Respiratory Distress Syndrome (ARDS) which is thought to be mediated by a cytokine storm syndrome. Steroids have been shown to be of some benefit, but the ... Read more >>

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First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial.

Luis Paz-Ares, Tudor-Eliade Ciuleanu, Manuel Cobo, Michael Schenker, Bogdan Zurawski, Juliana Menezes, Eduardo Richardet, Jaafar Bennouna, Enriqueta Felip, Oscar Juan-Vidal, Aurelia Alexandru, Hiroshi Sakai, Alejo Lingua, Pamela Salman, Pierre-Jean Souquet, Pedro De Marchi, Claudio Martin, Maurice Pérol, Arnaud Scherpereel, Shun Lu, Thomas John, David P Carbone, Stephanie Meadows-Shropshire, Shruti Agrawal, Abderrahim Oukessou, Jinchun Yan, Martin Reck,

<h4>Background</h4>First-line nivolumab plus ipilimumab has shown improved overall survival in patients with advanced non-small-cell lung cancer (NSCLC). We aimed to investigate whether the addition of a limited course (two cycles) of chemotherapy to this combination would further enhance the clinical benefit.<h4>Methods</h4>This randomised, open-label, phase 3 trial was done at 103 ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(2):198-211]

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Lingering Dynamics in Microvascular Blood Flow.

Alexander Kihm, Stephan Quint, Matthias W Laschke, Michael D Menger, Thomas John, Lars Kaestner, Christian Wagner,

The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of red blood cells (RBCs) through these networks ensures the gas exchange in as well as the transport of nutrients to the tissues. Any alterations in this blood flow ... Read more >>

Biophys J (Biophysical journal)
[2021, 120(3):432-439]

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Automated Adult Epilepsy Diagnostic Tool Based on Interictal Scalp Electroencephalogram Characteristics: A Six-Center Study.

John Thomas, Prasanth Thangavel, Wei Yan Peh, Jin Jing, Rajamanickam Yuvaraj, Sydney S Cash, Rima Chaudhari, Sagar Karia, Rahul Rathakrishnan, Vinay Saini, Nilesh Shah, Rohit Srivastava, Yee-Leng Tan, Brandon Westover, Justin Dauwels,

The diagnosis of epilepsy often relies on a reading of routine scalp electroencephalograms (EEGs). Since seizures are highly unlikely to be detected in a routine scalp EEG, the primary diagnosis depends heavily on the visual evaluation of Interictal Epileptiform Discharges (IEDs). This process is tedious, expert-centered, and delays the treatment ... Read more >>

Int J Neural Syst (International journal of neural systems)
[2021, 31(5):2050074]

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ICTV Virus Taxonomy Profile: Nanoviridae.

John E Thomas, Bruno Gronenborn, Robert M Harding, Bikash Mandal, Ioana Grigoras, John W Randles, Yoshitaka Sano, Tania Timchenko, H Josef Vetten, Hsin-Hung Yeh, Heiko Ziebell, Ictv Report Consortium,

<i>Nanoviridae</i> is a family of plant viruses (nanovirids) whose members have small isometric virions and multipartite, circular, single-stranded (css) DNA genomes. Each of the six (genus <i>Babuvirus</i>) or eight (genus <i>Nanovirus</i>) genomic DNAs is 0.9-1.1 kb and is separately encapsidated. Many isolates are associated with satellite-like cssDNAs (alphasatellites) of 1.0-1.1 kb. Hosts ... Read more >>

J Gen Virol (The Journal of general virology)
[2021, 102(3):]

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Building eConsult (Electronic Consults) Capability at an Academic Medical Center to Improve Efficiencies in Delivering Specialty Care.

Matthew A Thompson, Anne L Fuhlbrigge, Duane W Pearson, David R Saxon, Linda A Oberst-Walsh, John F Thomas,

As the COVID-19 health crisis continues to reshape healthcare, systems across the country face increasing pressure to adapt their models of care to expand access to care, while also improving efficiency and quality in the face of limited resources. Consequently, many have shown a growing interest and receptivity to the ... Read more >>

J Prim Care Community Health (Journal of primary care & community health)
[2021, 12:21501327211005303]

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Prognosis as Health Trajectory: Educating Patients and Informing the Plan of Care.

John M Thomas, Leo M Cooney, Terri R Fried,

J Gen Intern Med (Journal of general internal medicine)
[2021, :]

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Expression of EGFR and conformational forms of EGFR in malignant pleural mesothelioma and its impact on survival.

Puey Ling Chia, Sagun Parakh, Prudence Russell, Hui K Gan, Khashayer Asadi, Val Gebski, Carmel Murone, Marzena Walkiewicz, Zhanqi Liu, Bibhusal Thapa, Fiona E Scott, Andrew M Scott, Thomas John,

<h4>Aim</h4>Conformational forms of the epidermal growth factor receptor (EGFR) are pro-tumorigenic. The prevalence and impact of conformational forms of EGFR in malignant mesothelioma (MM) is unknown. We investigated expression of EGFR and conformational forms of EGFR by immunohistochemistry using EGFR-targeting monoclonal antibodies (mAb). In addition, EGFR gene amplification was investigated ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2021, 153:35-41]

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Resting-State functional networks of different topographic representations in the somatosensory cortex of macaque monkeys and humans.

John Thomas, Dixit Sharma, Sounak Mohanta, Neeraj Jain,

Information processing in the brain is mediated through a complex functional network architecture whose comprising nodes integrate and segregate themselves on different timescales. To gain an understanding of the network function it is imperative to identify and understand the network structure with respect to the underlying anatomical connectivity and the ... Read more >>

Neuroimage (NeuroImage)
[2021, 228:117694]

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The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma.

Surein Arulananda, Erinna F Lee, W Douglas Fairlie, Thomas John,

<b>Introduction:</b> With limited recent therapeutic changes, malignant pleural mesothelioma (MPM) is associated with poor survival and death within 12 months, making it one of the most lethal malignancies. Due to unregulated asbestos use in developing countries and home renovation exposures, cases of MPM are likely to present for decades. As MPM ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2021, 21(4):413-424]

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Lung Cancer in Australia.

Thomas John, Wendy A Cooper, Gavin Wright, Shankar Siva, Benjamin Solomon, Henry M Marshall, Kwun M Fong,

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2020, 15(12):1809-1814]

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Socioeconomic inequalities in hypertension in Kenya: a decomposition analysis of 2015 Kenya STEPwise survey on non-communicable diseases risk factors.

Samwel Maina Gatimu, Thomas Wiswa John,

<h4>Background</h4>One in four Kenyans aged 18-69 years have raised blood pressure. Despite this high prevalence of hypertension and known association between socioeconomic status and hypertension, there is limited understanding of factors explaining inequalities in raised blood pressure in Kenya. Hence, we quantified the socioeconomic inequality in hypertension in Kenya and decomposed ... Read more >>

Int J Equity Health (International journal for equity in health)
[2020, 19(1):213]

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