Full Text Journal Articles by
Author John O Warner

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Asthma/Rhinitis (The United Airway) and Allergy: Chicken or Egg; Which Comes First?

John O Warner,

While allergy, asthma and rhinitis do not inevitably co-exist, there are strong associations. Not all those with asthma are allergic, rhinitis may exist without asthma, and allergy commonly exists in the absence of asthma and/or rhinitis. This is likely due to the separate gene/environment interactions which influence susceptibility to allergic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(5):]

Cited: 0 times

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Not being heard: barriers to high quality unplanned hospital care during young people's transition to adult services - evidence from 'this sickle cell life' research.

Alicia Renedo, Sam Miles, Subarna Chakravorty, Andrea Leigh, Paul Telfer, John O Warner, Cicely Marston,

BACKGROUND:Young people's experiences of healthcare as they move into adult services can have a major impact on their health, and the transition period for young people with sickle cell disease (SCD) needs improvement. In this study, we explore how young people with SCD experience healthcare during this period of transition. ... Read more >>

BMC Health Serv Res (BMC health services research)
[2019, 19(1):876]

Cited: 0 times

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Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review.

Oleg Blyuss, Ka Yan Cheung, Jessica Chen, Callum Parr, Loukia Petrou, Alina Komarova, Maria Kokina, Polina Luzan, Egor Pasko, Alina Eremeeva, Dmitrii Peshko, Vladimir I Eliseev, Sindre Andre Pedersen, Meghan B Azad, Kirsi M Jarvinen, Diego G Peroni, Valerie Verhasselt, Robert J Boyle, John O Warner, Melanie R Simpson, Daniel Munblit,

A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight pitfalls and unmet needs. A comprehensive literature search in MEDLINE and Embase retrieved 13,607 unique records. Following ... Read more >>

Nutrients (Nutrients)
[2019, 11(10):]

Cited: 0 times

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Paediatric asthma care in the UK: fragmented and fatally fallible.

Mark L Levy, Louise Fleming, John O Warner, Andrew Bush,

Br J Gen Pract (The British journal of general practice : the journal of the Royal College of General Practitioners)
[2019, 69(685):405-406]

Cited: 1 time

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Editorial: Human Milk Composition and Health Outcomes in Children.

Daniel Munblit, Valerie Verhasselt, John O Warner,

Front Pediatr (Frontiers in pediatrics)
[2019, 7:319]

Cited: 0 times

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Transforming growth factor beta in human milk and allergic outcomes in children: A systematic review.

Ekaterina Khaleva, Zoya Gridneva, Donna T Geddes, Wendy H Oddy, Silvia Colicino, Oleg Blyuss, Robert J Boyle, John O Warner, Daniel Munblit,

BACKGROUND:Human milk (HM) transforming growth factor beta (TGF-β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF-β levels are associated with allergic outcomes. OBJECTIVE:We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF-β and ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2019, 49(9):1201-1213]

Cited: 4 times

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Reviewing the evidence on breast milk composition and immunological outcomes.

Alba Boix-Amorós, Maria Carmen Collado, Belinda Van't Land, Anna Calvert, Kirsty Le Doare, Johan Garssen, Heather Hanna, Ekaterina Khaleva, Diego G Peroni, Donna T Geddes, Anita L Kozyrskyj, John O Warner, Daniel Munblit,

A large number of biologically active components have been found in human milk (HM), and in both human and animal models, studies have provided some evidence suggesting that HM composition can be altered by maternal exposures, subsequently influencing health outcomes for the breastfed child. Evidence varies from the research studies ... Read more >>

Nutr. Rev. (Nutrition reviews)
[2019, :]

Cited: 4 times

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Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, , Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw,

In the version of this article initially published, a source of funding was not included in the Acknowledgements section. That section should include the following: P.J.M.O. was supported by EU FP7 PREPARE project 602525. The error has been corrected in the HTML and PDF version of the article. ... Read more >>

Nat. Immunol. (Nature immunology)
[2019, 20(3):373]

Cited: 0 times

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Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy.

Daniel Munblit, Priya Abrol, Shreya Sheth, Li Yan Chow, Ekaterina Khaleva, Alan Asmanov, Silvana Lauriola, Ezio M Padovani, Pasquale Comberiati, Attilio L Boner, John O Warner, Robert J Boyle, Diego G Peroni,

Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, ... Read more >>

Nutrients (Nutrients)
[2018, 10(9):]

Cited: 3 times

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Patient-reported experience measure in sickle cell disease.

Subarna Chakravorty, Amy Tallett, Cara Witwicki, Harriet Hay, Catherine Mkandawire, Avanelle Ogundipe, Patrick Ojeer, Antonia Whitaker, Jessica Thompson, Stephen Sizmur, Ganesh Sathyamoorthy, John O Warner,

OBJECTIVES:To develop patient-reported experience measure surveys for patients with sickle cell disease (SCD) to understand their healthcare and lived experience in the UK and for their use in future to inform healthcare service development. DESIGN:Picker methodology was used as follows: (1) qualitative scoping by focus group discussions; (2) questionnaire development ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2018, 103(12):1104-1109]

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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

Jake Dunning, Simon Blankley, Long T Hoang, Mike Cox, Christine M Graham, Philip L James, Chloe I Bloom, Damien Chaussabel, Jacques Banchereau, Stephen J Brett, Miriam F Moffatt, Anne O'Garra, Peter J M Openshaw, ,

Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures ... Read more >>

Nat. Immunol. (Nature immunology)
[2018, 19(6):625-635]

Cited: 9 times

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Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

Laurien H Ulfman, Jeanette H W Leusen, Huub F J Savelkoul, John O Warner, R J Joost van Neerven,

This review aims to provide an in depth overview of the current knowledge of the effects of bovine immunoglobulins on the human immune system. The stability and functional effects of orally ingested bovine immunoglobulins in milk products are described and potential mechanisms of action are discussed. Orally ingested bovine IgG ... Read more >>

Front Nutr (Frontiers in nutrition)
[2018, 5:52]

Cited: 4 times

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Human Milk and Allergic Diseases: An Unsolved Puzzle.

Daniel Munblit, Diego G Peroni, Alba Boix-Amorós, Peter S Hsu, Belinda Van't Land, Melvin C L Gay, Anastasia Kolotilina, Chrysanthi Skevaki, Robert J Boyle, Maria Carmen Collado, Johan Garssen, Donna T Geddes, Ralph Nanan, Carolyn Slupsky, Ganesa Wegienka, Anita L Kozyrskyj, John O Warner,

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It ... Read more >>

Nutrients (Nutrients)
[2017, 9(8):]

Cited: 27 times

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A national survey of Russian physicians' knowledge of diagnosis and management of food-induced anaphylaxis.

Daniel Munblit, Marina Treneva, Ilya Korsunskiy, Alan Asmanov, Alexander Pampura, John O Warner,

OBJECTIVES:Food allergy is an increasing burden worldwide and is a common problem within paediatric populations, affecting 5%-8% of children. Anaphylaxis caused by food proteins is a potentially life-threatening condition and all healthcare practitioners should be aware of its recognition and management. Russia is the largest country in Europe but it ... Read more >>

BMJ Open (BMJ open)
[2017, 7(7):e015901]

Cited: 1 time

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Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development.

Harm Wopereis, Kathleen Sim, Alexander Shaw, John O Warner, Jan Knol, J Simon Kroll,

BACKGROUND:Development of the gut microbiota in infancy is important in maturation of the immune system. Deviations in colonization patterns have been associated with allergic manifestations such as eczema, but exact microbiome dysfunctions underlying allergies remain unclear. We studied the gut microbiota of 138 infants at increased risk of allergy, participating ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2018, 141(4):1334-1342.e5]

Cited: 16 times

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Colostrum and Mature Human Milk of Women from London, Moscow, and Verona: Determinants of Immune Composition.

Daniel Munblit, Marina Treneva, Diego G Peroni, Silvia Colicino, LiYan Chow, Shobana Dissanayeke, Priya Abrol, Shreya Sheth, Alexander Pampura, Attilio L Boner, Donna T Geddes, Robert J Boyle, John O Warner,

Cytokines and growth factors in colostrum and mature milk may play an important role in infant immune maturation, and may vary significantly between populations. We aimed to examine associations between environmental and maternal factors, and human milk (HM) cytokine and growth factor levels. We recruited 398 pregnant/lactating women in the ... Read more >>

Nutrients (Nutrients)
[2016, 8(11):]

Cited: 12 times

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Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis.

Daniel Munblit, Marina Treneva, Diego G Peroni, Silvia Colicino, Li Yan Chow, Shobana Dissanayeke, Alexander Pampura, Attilio L Boner, Donna T Geddes, Robert J Boyle, John O Warner,

The role of breastfeeding in improving allergy outcomes in early childhood is still unclear. Evidence suggests that immune mediators in human milk (HM) play a critical role in infant immune maturation as well as protection against atopy/allergy development. We investigated relationships between levels of immune mediators in colostrum and mature ... Read more >>

Nutrients (Nutrients)
[2017, 9(6):]

Cited: 14 times

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Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test.

Eleanor Minshall, Harsita Patel, Nicholas Francis, Trevor T Hansel, John O Warner, Robert J Boyle, John Fell, Jenny Epstein,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(1):100-102]

Cited: 0 times

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Validation study of the pediatric allergic rhinitis quality of life questionnaire.

Antigoni Mavroudi, Elisavet-Anna Chrysochoou, Robert J Boyle, Antonis Papastergiopulos, Nikolaos Karantaglis, Agathi Karagiannidou, Ioannis Xinias, Evangelia Farmaki, Elpis Hatziagorou, Fotios Kirvassilis, Grigorios Kourentas, John Tsanakas, John O Warner,

The Paediatric Allergic Rhinitis Quality of Life Questionnaire (Ped-AR-QoL) is the first tool developed for the assessment of health-related quality of life (QoL) in Greek children with allergic rhinitis (AR).The aim of the current study was to validate the child and parent forms of the Ped-AR-QoL in children aged 6-14 ... Read more >>

Asian Pac. J. Allergy Immunol. (Asian Pacific journal of allergy and immunology)
[2016, 34(2):159-165]

Cited: 0 times

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Effects of Pre-Natal Vitamin D Supplementation with Partial Correction of Vitamin D Deficiency on Early Life Healthcare Utilisation: A Randomised Controlled Trial.

Megan Griffiths, Stephen Goldring, Chris Griffiths, Seif O Shaheen, Adrian Martineau, Louise Cross, Stephen Robinson, John O Warner, Angela Devine, Robert J Boyle,

Some observational studies have suggested that higher prenatal Vitamin D intake may be associated with improved health outcomes in childhood. However there have been mixed results in this area with some negative studies, especially for effects on atopic and respiratory outcomes. We examined the effect of prenatal Vitamin D on ... Read more >>

PLoS ONE (PloS one)
[2015, 10(12):e0145303]

Cited: 1 time

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Ready-to-use therapeutic food with elevated n-3 polyunsaturated fatty acid content, with or without fish oil, to treat severe acute malnutrition: a randomized controlled trial.

Kelsey D J Jones, Rehema Ali, Maureen A Khasira, Dennis Odera, Annette L West, Grielof Koster, Peter Akomo, Alison W A Talbert, Victoria M Goss, Moses Ngari, Johnstone Thitiri, Said Ndoro, Miguel A Garcia Knight, Kenneth Omollo, Anne Ndungu, Musa M Mulongo, Paluku Bahwere, Greg Fegan, John O Warner, Anthony D Postle, Steve Collins, Philip C Calder, James A Berkley,

Ready-to-use therapeutic foods (RUTF) are lipid-based pastes widely used in the treatment of acute malnutrition. Current specifications for RUTF permit a high n-6 polyunsaturated fatty acid (PUFA) content and low n-3 PUFA, with no stipulated requirements for preformed long-chain n-3 PUFA. The objective of this study was to develop an ... Read more >>

BMC Med (BMC medicine)
[2015, 13:93]

Cited: 10 times

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Factors predicting future ACS episodes in children with sickle cell anemia.

Michael R DeBaun, Mark Rodeghier, Robyn Cohen, Fenella J Kirkham, Carol L Rosen, Irene Roberts, Ben Cooper, Janet Stocks, Olu Wilkey, Baba Inusa, John O Warner, Robert C Strunk,

While a doctor-diagnosis of asthma is associated with an increased risk of pain and acute chest syndrome (ACS) in children with sickle cell anemia (SCA), little is known about the relationship between specific asthma characteristics and clinical factors and future morbidity in children with SCA. We evaluated the relationship between ... Read more >>

Am. J. Hematol. (American journal of hematology)
[2014, 89(11):E212-7]

Cited: 24 times

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Mesalazine in the initial management of severely acutely malnourished children with environmental enteric dysfunction: a pilot randomized controlled trial.

Kelsey D J Jones, Barbara Hünten-Kirsch, Ahmed M R Laving, Caroline W Munyi, Moses Ngari, Jenifer Mikusa, Musa M Mulongo, Dennis Odera, H Samira Nassir, Molline Timbwa, Moses Owino, Greg Fegan, Simon H Murch, Peter B Sullivan, John O Warner, James A Berkley,

Environmental enteric dysfunction (EED) is an acquired syndrome of impaired gastrointestinal mucosal barrier function that is thought to play a key role in the pathogenesis of stunting in early life. It has been conceptualized as an adaptive response to excess environmental pathogen exposure. However, it is clinically similar to other ... Read more >>

BMC Med (BMC medicine)
[2014, 12:133]

Cited: 30 times

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Anxiety and stress in mothers of food-allergic children.

Gar-Yen Lau, Nisha Patel, Thisanayagam Umasunthar, Claudia Gore, John O Warner, Heather Hanna, Katherine Phillips, Amirah Mohd Zaki, Matthew Hodes, Robert J Boyle,

Previous reports suggest that parents especially mothers of food-allergic children may have increased anxiety. Studies with an appropriate control group have not been undertaken, and the determinants of such anxiety are not known. We compared measures of anxiety and stress in mothers of food-allergic children and atopic non-food-allergic children, with ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2014, 25(3):236-242]

Cited: 15 times

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O06 - The Chelsea, asthma and fresh fruit intake in children (CHAFFINCH) trial – pilot study.

Vanessa Garcia-Larsen, Andrew Bush, Robert J Boyle, Seif O Shaheen, John O Warner, Toby Athersuch, Ian Mudway, Peter GJ Burney,

Clin Transl Allergy (Clinical and translational allergy)
[2014, 4(Suppl 1):O6-O6]

Cited: 1 time

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