Full Text Journal Articles by
Author John M Hoffman

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18F-Fluciclovine Positron Emission Tomography in Men With Biochemical Recurrence of Prostate Cancer After Radical Prostatectomy and Planning to Undergo Salvage Radiation Therapy: Results from LOCATE.

Abhishek A Solanki, Bital Savir-Baruch, Stanley L Liauw, Jeff Michalski, Jonathan D Tward, Neha Vapiwala, Eugene J Teoh, ,

PURPOSE:Conventional imaging rarely localizes the site(s) of prostate cancer recurrence in patients undergoing evaluation for salvage radiation therapy (sRT) after radical prostatectomy (RP). LOCATE (NCT02680041) was a prospective, multicenter study investigating the impact of 18F-fluciclovine positron emission tomography and computed tomography (PET/CT) on the management of patients with biochemical recurrence ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2020, 10(5):354-362]

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Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.

Nicole L Mihalopoulos, Jeffrey T Yap, Britney Beardmore, Richard Holubkov, M Nazeem Nanjee, John M Hoffman,

OBJECTIVE:This study aimed to test the hypothesis that young adults with obesity and cold-activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold-activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2020, 28(5):916-923]

Cited: 2 times

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Examining the Relationship between a Verbal Incidental Learning Measure from the WAIS-IV and Neuroimaging Biomarkers for Alzheimer's Pathology.

Dustin B Hammers, Amanda Kucera, Robert J Spencer, Tracy J Abildskov, Zane G Archibald, John M Hoffman, Elizabeth A Wilde,

Convergent validation of a verbal incidental learning (IL) task from the WAIS-IV using neuroimaging biomarkers is warranted to understand its sensitivity to Alzheimer's disease (AD) pathology. Fifty-five memory clinic patients aged 59 to 87 years received neuropsychological assessment, and measures of IL and quantitative brain imaging. Worse IL-Total Score and IL-Similarities ... Read more >>

Dev Neuropsychol (Developmental neuropsychology)
[2020, 45(3):95-109]

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Oral Administration of 99mTechnetium-Labeled Heparin in Eosinophilic Esophagitis.

Hedieh Saffari, Kathryn A Peterson, Kristin M Leiferman, Michael G Stabin, Jeffrey J Krstyen, Frederic C Clayton, Leonard F Pease, Jeffrey T Yap, John M Hoffman, Gerald J Gleich,

OBJECTIVE:To determine if heparin labeled with 99mTechnetium (99mTc) could be an imaging probe to detect eosinophil-related inflammation in eosinophilic esophagitis and to determine the biodistribution and radiation dosimetry of 99mTc-heparin oral administration using image-based dosimetry models with esophageal modeling. METHODS:Freshly prepared 99mTc-heparin was administered orally to 5 research subjects. Radioactivity ... Read more >>

Mayo Clin. Proc. (Mayo Clinic proceedings)
[2020, 95(3):449-458]

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Accelerating iterative coordinate descent using a stored system matrix.

Scott S Hsieh, John M Hoffman, Frederic Noo,

PURPOSE:The computational burden associated with model-based iterative reconstruction (MBIR) is still a practical limitation. Iterative coordinate descent (ICD) is an optimization approach for MBIR that has sometimes been thought to be incompatible with modern computing architectures, especially graphics processing units (GPUs). The purpose of this work is to accelerate the ... Read more >>

Med Phys (Medical physics)
[2019, 46(12):e801-e809]

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Prospective Evaluation of Bone Metabolic Markers as Surrogate Markers of Response to Radium-223 Therapy in Metastatic Castration-resistant Prostate Cancer.

Neeraj Agarwal, Roberto Nussenzveig, Andrew W Hahn, John M Hoffman, Kathryn Morton, Sumati Gupta, Julia Batten, Jared Thorley, Josiah Hawks, Victor Sacristan Santos, Gayatri Nachaegari, Xuechen Wang, Kenneth Boucher, Benjamin Haaland, Benjamin L Maughan,

PURPOSE:Radium-223 is approved for metastatic castration-resistant prostate cancer (mCRPC) based on improved overall survival, and delay in skeletal related events. However, it is not associated with PSA or radiographic response, which poses a challenge in real-time assessment of its efficacy. Surrogate markers of treatment outcomes may facilitate tailoring treatment duration ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(9):2104-2110]

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Analysis of retention of gadolinium by brain, bone, and blood following linear gadolinium-based contrast agent administration in rats with experimental sepsis.

Nikolas M Damme, Diego P Fernandez, Li-Ming Wang, Qi Wu, Ryan A Kirk, Rheal A Towner, J Scott McNally, John M Hoffman, Kathryn A Morton,

PURPOSE:It is important to identify populations that may be vulnerable to the brain deposition of gadolinium (Gd) from MRI contrast agents. At intervals from 24 hours to 6 weeks following injection of a linear Gd contrast agent, the brain, blood and bone content of Gd were compared between control rats ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2020, 83(6):1930-1939]

Cited: 1 time

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Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits.

Ryan A Kirk, Raymond P Kesner, Li-Ming Wang, Qi Wu, Rheal A Towner, John M Hoffman, Kathryn A Morton,

Sepsis is a severe systemic inflammatory response to infection associated with acute and chronic neurocognitive consequences, including an increased risk of later-life dementia. In a lipopolysaccharide-induced rat sepsis model, we have demonstrated neuroinflammation, cortical amyloid-beta plaque deposition, and increased whole brain levels of phosphorylated tau. Hippocampal abnormalities, particularly those of ... Read more >>

Geroscience (GeroScience)
[2019, 41(4):467-481]

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Optimization of 89Zr PET Imaging for Improved Multisite Quantification and Lesion Detection Using an Anthropomorphic Phantom.

Paul E Christian, Simon-Peter Williams, Lance Burrell, Paulo Castaneda, Justin Albiani, Nicholas Sandella, Andrei Iagaru, John M Hoffman, Alex de Crespigny, Sandra Sanabria Bohorquez,

Our objective was to harmonize multicenter 89Zr PET imaging for oncology trials and to evaluate lesion detection. Methods: Seven PET scanners were evaluated using a custom chest oncology phantom with 9 spheric lesions 7-20 mm in diameter. A 4:1 signal-to-background ratio simulated a patient dose of 92.5 MBq. Various image ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2020, 48(1):54-57]

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Long-term Changes in 18F-Flutemetamol Uptake in Nondemented Older Adults.

Kevin Duff, Kevin P Horn, John M Hoffman,

PURPOSE:Longitudinal studies into the variability of F-Flutemetamol uptake are lacking. METHODS/PATIENTS:Therefore, the current study examined change in F-Flutemetamol uptake in 19 nondemented older adults (65 to 82 y old) who were either cognitively intact or had Mild Cognitive Impairment (MCI) who were scanned twice across 3.6 years. RESULTS:Baseline and follow-up composite ... Read more >>

Alzheimer Dis Assoc Disord (Alzheimer disease and associated disorders)
[2019, 33(2):113-117]

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Hypoxia imaging in upper gastrointestinal tumors and application to radiation therapy.

Randa Tao, Bryan Ager, Shane Lloyd, Anna Torgeson, Michelle Denney, David Gaffney, Jordan Kharofa, Steven H Lin, Albert C Koong, Yoshimi Anzai, John M Hoffman,

Survival for upper gastrointestinal tumors remains poor, likely in part due to treatment resistance associated with intratumoral hypoxia. In this review, we highlight advances in nuclear medicine imaging that allow for characterization of in vivo tumor hypoxia in esophageal, pancreatic, and liver cancers. Strategies for adaptive radiotherapy in upper gastrointestinal ... Read more >>

(Journal of gastrointestinal oncology)
[2018, 9(6):1044-1053]

Cited: 1 time

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Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults.

Kevin Duff, Jeffrey S Anderson, Atul K Mallik, Kayla R Suhrie, Taylor J Atkinson, Bonnie C A Dalley, Sarah Shizuko Morimoto, John M Hoffman,

BACKGROUND:Practice effects are improvements in cognitive test scores due to repeated exposure to testing materials. If practice effects provide information about Alzheimer's disease pathology, then they could be useful for clinical trials enrichment. The current study sought to add to the limited literature on short-term practice effects on cognitive tests ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2018, 57:121-125]

Cited: 2 times

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Technical Note: FreeCT_ICD: An open-source implementation of a model-based iterative reconstruction method using coordinate descent optimization for CT imaging investigations.

John M Hoffman, Frédéric Noo, Stefano Young, Scott S Hsieh, Michael McNitt-Gray,

PURPOSE:To facilitate investigations into the impacts of acquisition and reconstruction parameters on quantitative imaging, radiomics and CAD using CT imaging, we previously released an open-source implementation of a conventional weighted filtered backprojection reconstruction called FreeCT_wFBP. Our purpose was to extend that work by providing an open-source implementation of a model-based iterative ... Read more >>

Med Phys (Medical physics)
[2018, :]

Cited: 0 times

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External validation of change formulae in neuropsychology with neuroimaging biomarkers: A methodological recommendation and preliminary clinical data.

Kevin Duff, Kayla R Suhrie, Bonnie C A Dalley, Jeffrey S Anderson, John M Hoffman,

OBJECTIVE:Within neuropsychology, a number of mathematical formulae (e.g. reliable change index, standardized regression based) have been used to determine if change across time has reliably occurred. When these formulae have been compared, they often produce different results, but 'different' results do not necessarily indicate which formulae are 'best.' The current ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2019, 33(3):478-489]

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Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain.

Li-Ming Wang, Qi Wu, Ryan A Kirk, Kevin P Horn, Ahmed H Ebada Salem, John M Hoffman, Jeffrey T Yap, Joshua A Sonnen, Rheal A Towner, Fernando A Bozza, Rosana S Rodrigues, Kathryn A Morton,

Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective and increases in response to neuroinflammation. Sepsis is associated with neurocognitive compromise. The objective was to determine, in a rat endotoxemia model of sepsis, whether neuroinflammation and ... Read more >>

(American journal of nuclear medicine and molecular imaging)
[2018, 8(2):86-99]

Cited: 6 times

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Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database.

Heidi A Hanson, Kevin P Horn, Kelli M Rasmussen, John M Hoffman, Ken R Smith,

Objective:Several studies have suggested that cancer is associated with a reduced risk of the development of Alzheimer's disease (AD). This study seeks to improve our understanding of the association between cancer and the development of AD by showing how mortality selection alters this relationship. Method:A retrospective cohort study was carried ... Read more >>

J Gerontol B Psychol Sci Soc Sci (The journals of gerontology. Series B, Psychological sciences and social sciences)
[2017, 72(6):1032-1043]

Cited: 7 times

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Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults.

Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Kevin P Horn, Kelli M Rasmussen, Britney E Beardmore, Lance D Burrell, Kevin Duff, John M Hoffman,

Little research exists examining the relationship between beta-amyloid neuritic plaque density via [18F]flutemetamol binding and cognition; consequently, the purpose of the current study was to compare cognitive performances among individuals having either increased amyloid deposition (Flute+) or minimal amyloid deposition (Flute-). Twenty-seven nondemented community-dwelling adults over the age of 65 ... Read more >>

Am J Alzheimers Dis Other Demen (American journal of Alzheimer's disease and other dementias)
[2017, 32(6):320-328]

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Comparison of Performance of Improved Serum Estimators of Glomerular Filtration Rate (GFR) to 99mTc-DTPA GFR Methods in Patients with Hepatic Cirrhosis.

Zaid Haddadin, Vivian Lee, Christopher Conlin, Lei Zhang, Kristi Carlston, Glen Morrell, Daniel Kim, John M Hoffman, Kathryn Morton,

Glomerular filtration rate (GFR) measurements are critical in patients with hepatic cirrhosis but potentially erroneous when based on serum creatinine. New equations for estimated GFR (eGFR) have shown variable performance in cirrhotics, possibly because of inaccuracies in reference methods for measured GFR (mGFR). The primary objective was to compare the ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2017, 45(1):42-49]

Cited: 1 time

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Relationship between 18F-Flutemetamol uptake and RBANS performance in non-demented community-dwelling older adults.

Dustin B Hammers, Taylor J Atkinson, Bonnie C A Dalley, Kayla R Suhrie, Britney E Beardmore, Lance D Burrell, Kevin P Horn, Kelli M Rasmussen, Norman L Foster, Kevin Duff, John M Hoffman,

OBJECTIVE:The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for patients with mild cognitive impairment and Alzheimer's disease (AD); however, relatively few studies have evaluated the relationship between RBANS performance and AD imaging biomarkers. The purpose of the current ... Read more >>

Clin Neuropsychol (The Clinical neuropsychologist)
[2017, 31(3):531-543]

Cited: 1 time

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18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury.

Rosana S Rodrigues, Fernando A Bozza, Christopher J Hanrahan, Li-Ming Wang, Qi Wu, John M Hoffman, Guy A Zimmerman, Kathryn A Morton,

Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F-fluoro-2-deoxyglucose (18F-FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses ... Read more >>

Nucl Med Biol (Nuclear medicine and biology)
[2017, 48:52-62]

Cited: 6 times

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Advances in PET Imaging of Degenerative, Cerebrovascular, and Traumatic Causes of Dementia.

Laura B Eisenmenger, Eugene J Huo, John M Hoffman, Satoshi Minoshima, Manuela C Matesan, David H Lewis, Brian J Lopresti, Chester A Mathis, David O Okonkwo, James M Mountz,

In this review we present the most recent advances in nuclear medicine imaging as a diagnostic and management tool for dementia. The clinical diagnosis of dementia syndromes can be challenging for physicians, particularly in the early stages of disease. Given the growing number of individuals affected by dementia, early and ... Read more >>

Semin Nucl Med (Seminars in nuclear medicine)
[2016, 46(1):57-87]

Cited: 6 times

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Diagnostic Reference Levels of CT Radiation Dose in Whole-Body PET/CT.

Ngoneh Jallow, Paul Christian, John Sunderland, Michael Graham, John M Hoffman, Jonathon A Nye,

The role of CT in PET/CT imaging includes acquisition techniques for diagnostic, anatomic localization, and attenuation correction purposes. Diagnostic reference levels of the volumetric CT dose index (CTDIvol) are available for dedicated CT procedures on selected body regions, but similar reference levels for whole-body CT used in PET/CT examinations are ... Read more >>

J. Nucl. Med. (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2016, 57(2):238-241]

Cited: 7 times

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FDG and FLT-PET for Early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma.

Kevin P Horn, Jeffrey T Yap, Neeraj Agarwal, Kathryn A Morton, Dan J Kadrmas, Britney Beardmore, Regan I Butterfield, Kenneth Boucher, John M Hoffman,

Metastatic renal cell carcinoma has a poor prognosis and an intrinsic resistance to standard treatment. Sunitinib is an oral receptor tyrosine kinase inhibitor that has been used as a first-line targeted therapy in metastatic renal cell carcinoma. While computed tomography (CT) is currently the gold standard for response assessment in ... Read more >>

Cancer Imaging (Cancer imaging : the official publication of the International Cancer Imaging Society)
[2015, 15:15]

Cited: 15 times

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Short-Term Practice Effects and Brain Hypometabolism: Preliminary Data from an FDG PET Study.

Kevin Duff, Kevin P Horn, Norman L Foster, John M Hoffman,

Practice effects are improvements in cognitive test scores due to repeated exposure to the same tests. Typically viewed as error, short-term practice effects have been shown to provide valuable clinical information about diagnosis, prognosis, and treatment outcomes in older patients with mild cognitive impairments. This study examined short-term practice effects ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2015, 30(3):264-270]

Cited: 8 times

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Histamine Receptor 1 and 2 Antagonists Alter Biodistribution of Radioiodine.

Oliver Edwards, Ellen D Yakish, Li-Ming Wang, Qi Wu, John M Hoffman, Kathryn A Morton,

Nuclear medicine technology assumes responsibility for examination-specific patient preparation procedures. This requires a clear understanding of the possible effects of medications on the outcome of examinations. There is evidence that common over-the-counter drugs, histamine 1 (H1) and histamine 2 (H2) receptor blockers and proton pump inhibitors, may directly or indirectly ... Read more >>

J Nucl Med Technol (Journal of nuclear medicine technology)
[2015, 43(3):214-219]

Cited: 0 times

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