Full Text Journal Articles by
Author John M Dennis

Advertisement

Find full text journal articles








Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021.

John M Dennis, Andrew P McGovern, Nicholas J Thomas, Harrison Wilde, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>All English hospital trusts (i.e., groups of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1895-1900]

Cited: 1 time

View full text PDF listing >>



Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study.

Jonathan M Locke, Petra Dusatkova, Kevin Colclough, Alice E Hughes, John M Dennis, Beverley Shields, Sarah E Flanagan, Maggie H Shepherd, Emma L Dempster, Andrew T Hattersley, Michael N Weedon, Stepanka Pruhova, Kashyap A Patel,

Diabetologia (Diabetologia)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study.

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, Sebastian J Vollmer,

<h4>Background</h4>The literature paints a complex picture of the association between mortality risk and ICU strain. In this study, we sought to determine if there is an association between mortality risk in intensive care units (ICU) and occupancy of beds compatible with mechanical ventilation, as a proxy for strain.<h4>Methods</h4>A national retrospective ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):213]

Cited: 0 times

View full text PDF listing >>



Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study.

Lauren R Rodgers, Anita V Hill, John M Dennis, Zoe Craig, Benedict May, Andrew T Hattersley, Timothy J McDonald, Rob C Andrews, Angus Jones, Beverley M Shields,

<h4>Background</h4>Type 2 diabetes (T2D) is common and increasing in prevalence. It is possible to prevent or delay T2D using lifestyle intervention programmes. Entry to these programmes is usually determined by a measure of glycaemia in the 'intermediate' range. This paper investigated the relationship between HbA1c and future diabetes risk and ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):184]

Cited: 0 times

View full text PDF listing >>



A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk.

Harrison Wilde, John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs).<h4>Design</h4>English national retrospective cohort study.<h4>Setting</h4>89 English hospital trusts (i.e. small groups of hospitals functioning as single operational units).<h4>Patients</h4>All adults with COVID-19 admitted to ICU between 2nd April and 1st ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0255377]

Cited: 1 time

View full text PDF listing >>



DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

Nicholas J Thomas, John M Dennis, Seth A Sharp, Akaal Kaur, Shivani Misra, Helen C Walkey, Desmond G Johnston, Nick S Oliver, William A Hagopian, Michael N Weedon, Kashyap A Patel, Richard A Oram,

<h4>Aims/hypothesis</h4>Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(10):2258-2265]

Cited: 0 times

View full text PDF listing >>



The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation.

Andrew P McGovern, Nick J Thomas, Sebastian J Vollmer, Andrew T Hattersley, Bilal A Mateen, John M Dennis,

Diabetologia (Diabetologia)
[2021, 64(5):1184-1186]

Cited: 3 times

View full text PDF listing >>



Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020.

John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time.<h4>Design</h4>Retrospective observational cohort; based on data reported ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):209-214]

Cited: 46 times

View full text PDF listing >>



Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis.

Bilal Akhter Mateen, Harrison Wilde, John M Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Objective</h4>In this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.<h4>Design</h4>Descriptive survey.<h4>Setting</h4>All non-specialist secondary care providers in England from 27 March27to 5 June 2020.<h4>Participants</h4>Acute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e042945]

Cited: 7 times

View full text PDF listing >>



Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020.

John M Dennis, Bilal A Mateen, Raphael Sonabend, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer,

<h4>Objective</h4>To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.<h4>Research design and methods</h4>This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):50-57]

Cited: 26 times

View full text PDF listing >>



Precision Medicine in Type 2 Diabetes: Using Individualized Prediction Models to Optimize Selection of Treatment.

John M Dennis,

Despite the known heterogeneity of type 2 diabetes and variable response to glucose lowering medications, current evidence on optimal treatment is predominantly based on average effects in clinical trials rather than individual-level characteristics. A precision medicine approach based on treatment response would aim to improve on this by identifying predictors ... Read more >>

Diabetes (Diabetes)
[2020, 69(10):2075-2085]

Cited: 4 times

View full text PDF listing >>



Risk of Anemia With Metformin Use in Type 2 Diabetes: A MASTERMIND Study.

Louise A Donnelly, John M Dennis, Ruth L Coleman, Naveed Sattar, Andrew T Hattersley, Rury R Holman, Ewan R Pearson,

<h4>Objective</h4>To evaluate the association between metformin use and anemia risk in type 2 diabetes, and the time-course for this, in a randomized controlled trial (RCT) and real-world population data.<h4>Research design and methods</h4>Anemia was defined as a hemoglobin measure of <11 g/dL. In the RCTs A Diabetes Outcome Progression Trial (ADOPT; ... Read more >>

Diabetes Care (Diabetes care)
[2020, 43(10):2493-2499]

Cited: 2 times

View full text PDF listing >>



Logistic regression has similar performance to optimised machine learning algorithms in a clinical setting: application to the discrimination between type 1 and type 2 diabetes in young adults.

Anita L Lynam, John M Dennis, Katharine R Owen, Richard A Oram, Angus G Jones, Beverley M Shields, Lauric A Ferrat,

<h4>Background</h4>There is much interest in the use of prognostic and diagnostic prediction models in all areas of clinical medicine. The use of machine learning to improve prognostic and diagnostic accuracy in this area has been increasing at the expense of classic statistical models. Previous studies have compared performance between these ... Read more >>

Diagn Progn Res (Diagnostic and prognostic research)
[2020, 4:6]

Cited: 8 times

View full text PDF listing >>



Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation.

Andrew P McGovern, Michael Hogg, Beverley M Shields, Naveed A Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Angus G Jones, John M Dennis, ,

<h4>Introduction</h4>To identify risk factors, absolute risk, and impact on treatment discontinuation of genital infections with sodium-glucose co-transporter-2 inhibitors (SGLT2i).<h4>Research design and methods</h4>We assessed the relationship between baseline characteristics and genital infection in 21 004 people with type 2 diabetes initiating SGLT2i and 55 471 controls initiating dipeptidyl peptidase-4 inhibitors (DPP4i) in a ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

Cited: 4 times

View full text PDF listing >>



Prior event rate ratio adjustment produced estimates consistent with randomized trial: a diabetes case study.

Lauren R Rodgers, John M Dennis, Beverley M Shields, Luke Mounce, Ian Fisher, Andrew T Hattersley, William E Henley, ,

<h4>Objectives</h4>Electronic health records (EHR) provide a valuable resource for assessing drug side-effects, but treatments are not randomly allocated in routine care creating the potential for bias. We conduct a case study using the Prior Event Rate Ratio (PERR) Pairwise method to reduce unmeasured confounding bias in side-effect estimates for two ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2020, 122:78-86]

Cited: 2 times

View full text PDF listing >>



Clusters provide a better holistic view of type 2 diabetes than simple clinical features - Authors' reply.

John M Dennis, Beverley M Shields, William E Henley, Angus G Jones, Andrew T Hattersley,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2019, 7(9):669]

Cited: 0 times

View full text PDF listing >>



Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: A retrospective analysis of primary care data, 2010-2017.

John M Dennis, William E Henley, Andrew P McGovern, Andrew J Farmer, Naveed Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Beverley M Shields, Angus G Jones, ,

<h4>Aim</h4>To describe population-level time trends in prescribing patterns of type 2 diabetes therapy, and in short-term clinical outcomes (glycated haemoglobin [HbA1c], weight, blood pressure, hypoglycaemia and treatment discontinuation) after initiating new therapy.<h4>Materials and methods</h4>We studied 81 532 people with type 2 diabetes initiating a first- to fourth-line drug in primary care ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2019, 21(7):1576-1584]

Cited: 11 times

View full text PDF listing >>



Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data.

John M Dennis, Beverley M Shields, William E Henley, Angus G Jones, Andrew T Hattersley,

<h4>Background</h4>Research using data-driven cluster analysis has proposed five subgroups of diabetes with differences in diabetes progression and risk of complications. We aimed to compare the clinical utility of this subgroup-based approach for predicting patient outcomes with an alternative strategy of developing models for each outcome using simple patient characteristics.<h4>Methods</h4>We identified ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2019, 7(6):442-451]

Cited: 48 times

View full text PDF listing >>



What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study.

Andrew P McGovern, John M Dennis, Beverley M Shields, Andrew T Hattersley, Ewan R Pearson, Angus G Jones, ,

<h4>Background</h4>It is unclear what to do when people with type 2 diabetes have had no or a limited glycemic response to a recently introduced medication. Intra-individual HbA1c variability can obscure true response. Some guidelines suggest stopping apparently ineffective therapy, but no studies have addressed this issue.<h4>Methods</h4>In a retrospective cohort analysis ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):79]

Cited: 1 time

View full text PDF listing >>



Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach.

John M Dennis, Beverley M Shields, Angus G Jones, Ewan R Pearson, Andrew T Hattersley, William E Henley, ,

<h4>Objective</h4>Precision medicine drug therapy seeks to maximize efficacy and minimize harm for individual patients. This will be difficult if drug response and side effects are positively associated, meaning that patients likely to respond best are at increased risk of side effects. We applied joint longitudinal-survival models to evaluate associations between ... Read more >>

Clin Epidemiol (Clinical epidemiology)
[2018, 10:1869-1877]

Cited: 5 times

View full text PDF listing >>



Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data.

John M Dennis, William E Henley, Michael N Weedon, Mike Lonergan, Lauren R Rodgers, Angus G Jones, William T Hamilton, Naveed Sattar, Salim Janmohamed, Rury R Holman, Ewan R Pearson, Beverley M Shields, Andrew T Hattersley, ,

<h4>Objective</h4>The choice of therapy for type 2 diabetes after metformin is guided by overall estimates of glycemic response and side effects seen in large cohorts. A stratified approach to therapy would aim to improve on this by identifying subgroups of patients whose glycemic response or risk of side effects differs ... Read more >>

Diabetes Care (Diabetes care)
[2018, 41(9):1844-1853]

Cited: 19 times

View full text PDF listing >>



Time trends and geographical variation in prescribing of drugs for diabetes in England from 1998 to 2017.

Helen J Curtis, John M Dennis, Beverley M Shields, Alex J Walker, Seb Bacon, Andrew T Hattersley, Angus G Jones, Ben Goldacre,

<h4>Aims</h4>To measure the variation in prescribing of second-line non-insulin diabetes drugs.<h4>Materials and methods</h4>We evaluated time trends for the period 1998 to 2016, using England's publicly available prescribing datasets, and stratified these by the order in which they were prescribed to patients using the Clinical Practice Research Datalink. We calculated the ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2018, 20(9):2159-2168]

Cited: 12 times

View full text PDF listing >>



Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-term Glycemic Response to DPP-4 Inhibitor Therapy.

John M Dennis, Beverley M Shields, Anita V Hill, Bridget A Knight, Timothy J McDonald, Lauren R Rodgers, Michael N Weedon, William E Henley, Naveed Sattar, Rury R Holman, Ewan R Pearson, Andrew T Hattersley, Angus G Jones, ,

<h4>Objective</h4>A precision approach to type 2 diabetes therapy would aim to target treatment according to patient characteristics. We examined if measures of insulin resistance and secretion were associated with glycemic response to dipeptidyl peptidase 4 (DPP-4) inhibitor therapy.<h4>Research design and methods</h4>We evaluated whether markers of insulin resistance and insulin secretion ... Read more >>

Diabetes Care (Diabetes care)
[2018, 41(4):705-712]

Cited: 21 times

View full text PDF listing >>





Advertisement


Disclaimer

1.2358 s