Full Text Journal Articles by
Author John Kinuthia

Advertisement

Find full text journal articles






Antiretroviral therapy reduces but does not normalize immune and vascular inflammatory markers in adults with chronic HIV infection in Kenya.

Tecla M Temu, Jerry S Zifodya, Stephen J Polyak, Jessica Wagoner, Celestine N Wanjalla, Sarah Masyuko, Jerusha Nyabiage, John Kinuthia, Gerald S Bloomfield, Stephanie T Page, Carey Farquhar,

<h4>Introduction</h4>Markers of monocyte/macrophage activation and vascular inflammation are associated with HIV-related cardiovascular diseases (CVD) and mortality. We compared these markers among African people living with HIV (PLWH) and HIV-negative adults, and examined risk factors associated with elevated biomarkers (>75th percentile) in PLWH on antiretroviral therapy (ART).<h4>Design</h4>Cross-sectional study.<h4>Methods</h4>We measured serum concentrations ... Read more >>

AIDS (AIDS (London, England))
[2021, 35(1):45-51]

Cited: 0 times

View full text PDF listing >>



Association between obstetric and medical risk factors and stillbirths in a low-income urban setting.

George N Gwako, Moses M Obimbo, Peter B Gichangi, John Kinuthia, Onesmus W Gachuno, Fredrick Were,

<h4>Objective</h4>To evaluate the association between obstetric and medical risk factors and stillbirths in a Kenyan set-up.<h4>Methods</h4>A case-control study was conducted in four hospitals between August 2018 and April 2019. Two hundred and fourteen women with stillbirths and 428 with live births at more than >28 weeks of gestation were enrolled. Data ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis.

Sylvia M LaCourse, Daniel Leon, Nuttada Panpradist, Barbra A Richardson, Elizabeth Maleche-Obimbo, Jerphason Mecha, Daniel Matemo, Jaclyn N Escudero, John Kinuthia, Barry Lutz, Grace John-Stewart,

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e43-e45]

Cited: 0 times

View full text PDF listing >>



Human Immunodeficiency Virus Is Associated With Higher Levels of Systemic Inflammation Among Kenyan Adults Despite Viral Suppression.

Sarah J Masyuko, Stephanie T Page, Stephen J Polyak, John Kinuthia, Alfred O Osoti, Fredrick C Otieno, Joseph M Kibachio, Jerusha N Mogaka, Paul M Macharia, Bhavna H Chohan, Jessica Wogner, Aidan O'Connor, Tecla M Temu, Jerry S Zifodya, Amos Otedo, Damalie Nakanjako, James P Hughes, Carey Farquhar,

<h4>Background</h4>Systemic inflammation independently predicts future cardiovascular events and is associated with a 2-fold increase in cardiovascular disease (CVD) risk among persons living with human immunodeficiency virus (PLHIV). We examined the association between inflammatory markers, HIV status, and traditional CVD risk factors.<h4>Methods</h4>We conducted a cross-sectional study of Kenyan adults with and ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Psychosocial Factors, Condomless Sex, and Detectable Viral Load in HIV-Positive Women in Serodiscordant Couples in Nairobi, Kenya.

Michela Blain, Barbra A Richardson, John Kinuthia, Danielle N Poole, Walter Jaoko, Kate S Wilson, Anne Kaggiah, Jane M Simoni, Carey Farquhar, R Scott McClelland,

This prospective study of HIV-positive Kenyan women in serodiscordant couples examined relationships between psychosocial factors, viral suppression, and condomless sex. Participants were screened for alcohol use disorders and intimate partner violence (IPV) annually and depressive symptoms every 6 months. Prostate specific antigen (PSA) detection was used as a marker for condomless sex. ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(12):3346-3358]

Cited: 0 times

View full text PDF listing >>



Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration.

Jean B Nachega, Nadia A Sam-Agudu, Samantha Budhram, Taha E Taha, Valerie Vannevel, Priya Somapillay, Daniel Katuashi Ishoso, Michel Tshiasuma Pipo, Christian Bongo-Pasi Nswe, John Ditekemena, Birhanu T Ayele, Rhoderick N Machekano, Onesmus W Gachuno, John Kinuthia, Nancy Mwongeli, Musa Sekikubo, Philippa Musoke, Evans Kofi Agbeno, Lawal W Umar, Mukanire Ntakwinja, Denis M Mukwege, Emily R Smith, Eduard J Mills, John Otokoye Otshudiema, Placide Mbala-Kingebeni, Jean-Marie N Kayembe, Don Jethro Mavungu Landu, Jean-Jacques Muyembe Tamfum, Alimuddin Zumla, Eduard J Langenegger, Lynne M Mofenson, For The AFREhealth Covid-Research Collaboration Working Group,

In the African context, there is a paucity of data on SARS-CoV-2 infection and associated COVID-19 in pregnancy. Given the endemicity of infections such as malaria, HIV, and tuberculosis (TB) in sub-Saharan Africa (SSA), it is important to evaluate coinfections with SARS-CoV-2 and their impact on maternal/infant outcomes. Robust research ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Influences on early discontinuation and persistence of daily oral PrEP use among Kenyan adolescent girls and young women: a qualitative evaluation from a PrEP implementation program.

Jillian Pintye, Gabrielle O'Malley, John Kinuthia, Felix Abuna, Jaclyn N Escudero, Melissa Mugambi, Mercy Awuor, Annabell Dollah, Julia C Dettinger, Pamela Kohler, Grace John-Stewart, Kristin Beima-Sofie,

<h4>Background</h4>Discontinuation of daily oral PrEP is frequent among adolescent girls and young women (AGYW) in African settings. We explored factors influencing early PrEP discontinuation and persistence among Kenyan AGYW who accepted PrEP within a programmatic setting.<h4>Methods</h4>We conducted in-depth interviews (IDI) with AGYW (aged 15-24 years) who accepted PrEP from 4 ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, :]

Cited: 0 times

View full text PDF listing >>



Frequency and Predictors of Tenofovir-diphosphate Detection Among Young Kenyan Women in a Real-world Pre-exposure Prophylaxis Implementation Program.

Jillian Pintye, John Kinuthia, Felix Abuna, Kenneth Mugwanya, Harison Lagat, Julia C Dettinger, Daniel Odinga, Joseph Sila, Peter L Anderson, Grace John-Stewart, Jared M Baeten,

In a pre-exposure prophylaxis program for Kenyan women, we detected tenofovir-diphosphate in 61% (125/201) of randomly selected dried blood spots collected at the first follow-up visit. Tenofovir-diphosphate was detected more frequently among women who had partners living with human immunodeficiency virus, who were not pregnant, and who were ≥24 years. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(9):e509-e512]

Cited: 0 times

View full text PDF listing >>



Alcohol use and viral suppression in HIV-positive Kenyan female sex workers on antiretroviral therapy.

Jessica E Long, Barbra A Richardson, George Wanje, Kate S Wilson, Juma Shafi, Kishorchandra Mandaliya, Jane M Simoni, John Kinuthia, Walter Jaoko, R Scott McClelland,

<h4>Background</h4>Excessive alcohol intake has been associated with poor adherence to antiretroviral therapy (ART). The impact of alcohol on viral suppression is particularly important among groups at high risk of HIV transmission, such as female sex workers (FSWs). Few studies have directly evaluated the association between alcohol use and HIV viral ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242817]

Cited: 0 times

View full text PDF listing >>



A risk scoring tool for predicting Kenyan women at high risk of contraceptive discontinuation.

Claire W Rothschild, Barbra A Richardson, Brandon L Guthrie, Peninah Kithao, Tom Omurwa, James Mukabi, Erica M Lokken, Grace John-Stewart, Jennifer A Unger, John Kinuthia, Alison L Drake,

<h4>Objective</h4>We developed and validated a pragmatic risk assessment tool for identifying contraceptive discontinuation among Kenyan women who do not desire pregnancy.<h4>Study design</h4>Within a prospective cohort of contraceptive users, participants were randomly allocated to derivation (<i>n</i> = 558) and validation (<i>n</i> = 186) cohorts. Risk scores were developed by selecting the Cox proportional hazards model ... Read more >>

Contracept X (Contraception: X)
[2020, 2:100045]

Cited: 0 times

View full text PDF listing >>



Recent Diagnosis, Lower Rates of HIV Disclosure, and High Technology Access in Pregnant Adolescent Girls and Young Women Living With HIV: A Descriptive Study.

Wenwen Jiang, Lusi Osborn, Alison L Drake, Jennifer A Unger, Daniel Matemo, John Kinuthia, Grace John-Stewart, Keshet Ronen,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries.

, Olufemi T Oladapo, Joshua P Vogel, Gilda Piaggio, My-Huong Nguyen, Fernando Althabe, A Metin Gülmezoglu, Rajiv Bahl, Suman P N Rao, Ayesha De Costa, Shuchita Gupta, Abdullah H Baqui, Rasheda Khanam, Mohammod Shahidullah, Saleha B Chowdhury, Salahuddin Ahmed, Nazma Begum, Arunangshu D Roy, M A Shahed, Iffat A Jaben, Farida Yasmin, M Mozibur Rahman, Anjuman Ara, Soofia Khatoon, Gulshan Ara, Shaheen Akter, Nasreen Akhter, Probhat R Dey, M Abdus Sabur, Mohammad T Azad, Shahana F Choudhury, M A Matin, Shivaprasad S Goudar, Sangappa M Dhaded, Mrityunjay C Metgud, Yeshita V Pujar, Manjunath S Somannavar, Sunil S Vernekar, Veena R Herekar, Shailaja R Bidri, Sangamesh S Mathapati, Preeti G Patil, Mallanagouda M Patil, Muttappa R Gudadinni, Hidaytullah R Bijapure, Ashalata A Mallapur, Geetanjali M Katageri, Sumangala B Chikkamath, Bhuvaneshwari C Yelamali, Ramesh R Pol, Sujata S Misra, Leena Das, Saumya Nanda, Rashmita B Nayak, Bipsa Singh, Zahida Qureshi, Fredrick Were, Alfred Osoti, George Gwako, Ahmed Laving, John Kinuthia, Hafsa Mohamed, Nawal Aliyan, Adelaide Barassa, Elizabeth Kibaru, Margaret Mbuga, Lydia Thuranira, Njoroge J Githua, Bernadine Lusweti, Adejumoke I Ayede, Adegoke G Falade, Olubukola A Adesina, Atinuke M Agunloye, Oluwatosin O Iyiola, Wilfred Sanni, Ifeyinwa K Ejinkeonye, Hadiza A Idris, Chinyere V Okoli, Theresa A Irinyenikan, Omolayo A Olubosede, Olaseinde Bello, Olufemi M Omololu, Olanike A Olutekunbi, Adesina L Akintan, Olorunfemi O Owa, Rosena O Oluwafemi, Ireti P Eniowo, Adetokunbo O Fabamwo, Elizabeth A Disu, Joy O Agbara, Ebunoluwa A Adejuyigbe, Oluwafemi Kuti, Henry C Anyabolu, Ibraheem O Awowole, Akintunde O Fehintola, Bankole P Kuti, Anthony D Isah, Eyinade K Olateju, Olusanya Abiodun, Olabisi F Dedeke, Francis B Akinkunmi, Lawal Oyeneyin, Omotayo Adesiyun, Hadijat O Raji, Adedapo B A Ande, Ikechukwu Okonkwo, Shabina Ariff, Sajid B Soofi, Lumaan Sheikh, Saima Zulfiqar, Sadia Omer, Raheel Sikandar, Salma Sheikh, Daniel Giordano, Hugo Gamerro, Guillermo Carroli, Jose Carvalho, James Neilson, Elizabeth Molyneux, Khalid Yunis, Kidza Mugerwa, Harish K Chellani,

<h4>Background</h4>The safety and efficacy of antenatal glucocorticoids in women in low-resource countries who are at risk for preterm birth are uncertain.<h4>Methods</h4>We conducted a multicountry, randomized trial involving pregnant women between 26 weeks 0 days and 33 weeks 6 days of gestation who were at risk for preterm birth. The participants ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(26):2514-2525]

Cited: 0 times

View full text PDF listing >>



Community Perceptions About Use of Pre-exposure Prophylaxis Among Adolescent Girls and Young Women in Kenya.

Jaclyn N Escudero, Julia C Dettinger, Jillian Pintye, John Kinuthia, Harison Lagat, Felix Abuna, Pamela Kohler, Jared M Baeten, Gabrielle OʼMalley, Grace C John-Stewart, Kristin M Beima-Sofie,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, 31(6):669-677]

Cited: 0 times

View full text PDF listing >>



An Interactive Text Messaging Intervention to Improve Adherence to Option B+ Prevention of Mother-to-Child HIV Transmission in Kenya: Cost Analysis.

Yilin Chen, Keshet Ronen, Daniel Matemo, Jennifer A Unger, John Kinuthia, Grace John-Stewart, Carol Levin,

<h4>Background</h4>Mobile health (mHealth) approaches offer potentially affordable ways to support the care of HIV-infected patients in overstretched health care systems. However, only few studies have analyzed the costs associated with mHealth solutions for HIV care.<h4>Objective</h4>The aim of this study was to estimate the total incremental costs and incremental cost per ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(10):e18351]

Cited: 0 times

View full text PDF listing >>



Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia.

Alfred O Osoti, Stephanie T Page, Barbra A Richardson, Brandon L Guthrie, John Kinuthia, Stephen J Polyak, Carey Farquhar,

<b>Objective: </b>To evaluate the association between metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hsCRP), a biomarker of chronic inflammation and an independent predictor for cardiovascular disease overall and in subgroups of women with/without pre-eclampsia and gestational hypertension (GHT).<br><br><b>Methods: </b>A prospective cohort study was conducted in Nairobi, Kenya. Women with pre-eclampsia ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, 151(3):443-449]

Cited: 0 times

View full text PDF listing >>



Endothelial Dysfunction Is Related to Monocyte Activation in Antiretroviral-Treated People With HIV and HIV-Negative Adults in Kenya.

Tecla M Temu, Stephen J Polyak, Jerry S Zifodya, Celestine N Wanjalla, John R Koethe, Sarah Masyuko, Jerusha Nyabiage, John Kinuthia, Ana L Gervassi, Julius Oyugi, Stephanie Page, Carey Farquhar,

<h4>Background</h4>Residual monocyte activation may contribute to increased risk for endothelial dysfunction and subsequent atherosclerotic cardiovascular diseases (CVDs) among people with HIV (PWH) on antiretroviral therapy (ART). We examined the relationship between monocyte activation and endothelial activation in PWH in Kenya.<h4>Methods</h4>Serum levels of markers of endothelial activation (soluble/circulating intercellular [sICAM-1] and ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(10):ofaa425]

Cited: 0 times

View full text PDF listing >>



Brief Report: Incidence and Correlates of Pregnancy in HIV-Positive Kenyan Sex Workers.

Erica M Lokken, George Wanje, Barbra A Richardson, Esther Mutunga, Kate S Wilson, Walter Jaoko, John Kinuthia, Raymond Scott McClelland,

INTRODUCTION:The incidence of pregnancy in female sex workers (FSWs) living with HIV is not well characterized. METHODS:Current and former FSWs living with HIV and enrolled in a prospective cohort study in Mombasa, Kenya, were followed monthly to ascertain sexual behavior and underwent quarterly pregnancy testing. Pregnancies were considered planned, mistimed, ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 85(1):11-17]

Cited: 0 times

View full text PDF listing >>



Elevation of cervical C-X-C motif chemokine ligand 10 levels is associated with HIV-1 acquisition in pregnant and postpartum women.

Michelle C Sabo, Dara A Lehman, Jillian C Pintye, Bingjie Wang, Alison L Drake, John Kinuthia, Lusi Osborn, Daniel Matemo, Barbra A Richardson, Julie Overbaugh, Grace John-Stewart, Susan M Graham,

<h4>Objective</h4>To evaluate the relationship between cervical cytokine/chemokine concentrations and HIV-1 acquisition in peripartum Kenyan women.<h4>Design</h4>Nested case-control study.<h4>Methods</h4>Women participating in a prospective study of peripartum HIV acquisition in Kenya (the Mama Salama Study), were tested for HIV-1 at 1-3 month intervals during pregnancy and through 9 months postpartum. Cases positive for ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(12):1725-1733]

Cited: 0 times

View full text PDF listing >>



Prevalence and Correlates of Pregnancy Self-Testing Among Pregnant Women Attending Antenatal Care in Western Kenya

Nina Njeri Nganga, Julia Dettinger, John Kinuthia, Jared Baeten, Grace John-Stewart, Laurén Gómez, Ben Ochieng, Mary Marwa, Kenneth Mugwanya, Melissa Mugambi,

In sub-Saharan Africa little is known about how often women use pregnancy self-tests or characteristics of these women despite evidence that pregnancy self-testing is associated with early antenatal care (ANC) attendance. Understanding the characteristics of women who use pregnancy self-tests may facilitate early access to ANC and preventive interventions in ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Optimizing Pharmacology Studies in Pregnant and Lactating Women Using Lessons from HIV: A Consensus Statement.

Ahizechukwu C Eke, Adeniyi Olagunju, Jeremiah Momper, Martina Penazzato, Elaine J Abrams, Brookie M Best, Edmund V Capparelli, Adrie Bekker, Yodit Belew, Jennifer J Kiser, Kimberly Struble, Graham Taylor, Catriona Waitt, Mark Mirochnick, Tim R Cressey, Angela Colbers, ,

Information on the extent of drug exposure to mothers and infants during pregnancy and lactation normally becomes available years after regulatory approval of a drug. Clinicians face knowledge gaps on drug selection and dosing in pregnancy and infant exposure during breastfeeding. Physiological changes during pregnancy often result in lower drug ... Read more >>

Clin Pharmacol Ther (Clinical pharmacology and therapeutics)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Preferred HIV Testing Modalities Among Adolescent Girls and Young Women in Kenya.

Irene Inwani, Nok Chhun, Kawango Agot, Charles M Cleland, Samwel O Rao, Ruth Nduati, John Kinuthia, Ann E Kurth,

PURPOSE:To improve testing coverage, it is imperative to determine adolescent girls and young women (AGYW) preferences about HIV testing modality and where they prefer receiving services. METHODS:Participants were enrolled between May 2017 and April 2018 from three sites in Homa Bay County, Nyanza region, western Kenya. We explored two recruitment ... Read more >>

J Adolesc Health (The Journal of adolescent health : official publication of the Society for Adolescent Medicine)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Postpartum metabolic syndrome after gestational hypertension and preeclampsia, a prospective cohort study.

Alfred O Osoti, Stephanie T Page, Barbra A Richardson, Brandon L Guthrie, John Kinuthia, Stephen J Polyak, Carey Farquhar,

OBJECTIVE:We evaluated the 6-month postpartum risk of metabolic syndrome (MetS), a marker of future cardiovascular disease (CVD) risk, comparing women whose most recent pregnancies were complicated with gestational hypertension (GH) or preeclampsia (PE) versus those who had normotensive pregnancies. STUDY DESIGN:This was a prospective cohort study in which women with ... Read more >>

Pregnancy Hypertens (Pregnancy hypertension)
[2019, 18:35-41]

Cited: 0 times

View full text PDF listing >>



High Awareness, Yet Low Uptake, of Pre-Exposure Prophylaxis Among Adolescent Girls and Young Women Within Family Planning Clinics in Kenya.

Joseph Sila, Anna M Larsen, John Kinuthia, George Owiti, Felix Abuna, Pamela K Kohler, Grace John-Stewart, Jillian Pintye,

Adolescent girls and young women (AGYW) are a priority population for HIV prevention in high-burden settings. We evaluated psychosocial characteristics, behavioral risk factors for HIV, and pre-exposure prophylaxis (PrEP) awareness and uptake among AGYW seeking contraceptive services at four public sector family planning (FP) clinics offering integrated PrEP delivery in ... Read more >>

AIDS Patient Care STDS (AIDS patient care and STDs)
[2020, 34(8):336-343]

Cited: 0 times

View full text PDF listing >>



Zika Virus Circulates at Low Levels in Western and Coastal Kenya.

Theodore A Gobillot, Caroline Kikawa, Dara A Lehman, John Kinuthia, Alison L Drake, Walter Jaoko, Kishorchandra Mandaliya, Grace John-Stewart, R Scott McClelland, Julie Overbaugh,

BACKGROUND:Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there. METHODS:We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(5):847-852]

Cited: 0 times

View full text PDF listing >>



Metabolic syndrome and 10-year cardiovascular risk among HIV-positive and HIV-negative adults: A cross-sectional study.

Sarah J Masyuko, Stephanie T Page, John Kinuthia, Alfred O Osoti, Stephen J Polyak, Fredrick C Otieno, Joseph M Kibachio, Jerusha N Mogaka, Tecla M Temu, Jerry S Zifodya, Amos Otedo, Damalie Nakanjako, James P Hughes, Carey Farquhar,

To determine the prevalence and correlates of metabolic syndrome (MetS) and compare 10-year cardiovascular disease (CVD) risk among Kenyan adults with and without HIV infection.We conducted a cross-sectional study among adults ≥30 years of age with and without HIV infection seeking care at Kisumu County Hospital. Participants completed a health ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(27):e20845]

Cited: 1 time

View full text PDF listing >>



Advertisement

Disclaimer
1.4068 s