Full Text Journal Articles by
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CSF1R signaling is a regulator of pathogenesis in progressive MS.

Nellwyn Hagan, John L Kane, Deepak Grover, Lisa Woodworth, Charlotte Madore, Jacqueline Saleh, Jose Sancho, Jinyu Liu, Yi Li, Jonathan Proto, Matija Zelic, Amy Mahan, Michael Kothe, Andrew A Scholte, Maria Fitzgerald, Barbara Gisevius, Aiden Haghikia, Oleg Butovsky, Dimitry Ofengeim,

Microglia serve as the innate immune cells of the central nervous system (CNS) by providing continuous surveillance of the CNS microenvironment and initiating defense mechanisms to protect CNS tissue. Upon injury, microglia transition into an activated state altering their transcriptional profile, transforming their morphology, and producing pro-inflammatory cytokines. These activated ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(10):904]

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Reply to the Comments by Doherty et al.

Chiara Gastaldon, Emanuel Raschi, John M Kane, Corrado Barbui, Georgios Schoretsanitis,

Psychother Psychosom (Psychotherapy and psychosomatics)
[2020, :1-2]

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Identifying emerging mental illness utilizing search engine activity: A feasibility study.

Michael L Birnbaum, Hongyi Wen, Anna Van Meter, Sindhu K Ernala, Asra F Rizvi, Elizabeth Arenare, Deborah Estrin, Munmun De Choudhury, John M Kane,

Mental illness often emerges during the formative years of adolescence and young adult development and interferes with the establishment of healthy educational, vocational, and social foundations. Despite the severity of symptoms and decline in functioning, the time between illness onset and receiving appropriate care can be lengthy. A method by ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0240820]

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Edentulousness in severely mentally ill patients: A pilot study of sex-specific patterns for risk factors including the glutathione S-transferase M1 gene.

Georgios Schoretsanitis, John M Kane, Jose de Leon,

Schizophr Res (Schizophrenia research)
[2020, :]

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Patients' perception of colonoscopy and acceptance of colonoscopy based IBD related colorectal cancer surveillance.

Eve Braithwaite, Jenelyn Carbonell, John S Kane, David Gracie, Christian P Selinger,

OBJECTIVES:Patients with Inflammatory Bowel Disease (IBD) are at an increased risk of colorectal cancer (CRC). Current surveillance for CRC involves often uncomfortable colonoscopy. To assess IBD patients' perception of colonoscopy and examine preferences for hypothetical alternatives. METHODS:IBD patients in clinical remission rated acceptable frequency of colonoscopy and hypothetical alternatives to ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2020, :1-6]

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Elevated Clozapine Concentrations in Clozapine-Treated Patients with Hypersalivation.

Georgios Schoretsanitis, Maxim Kuzin, John M Kane, Christoph Hiemke, Michael Paulzen, Ekkehard Haen,

BACKGROUND AND OBJECTIVE:Hypersalivation is a common, clozapine-related adverse drug reaction with a serious impact on quality of life. Pharmacokinetic correlates of clozapine-related hypersalivation have evaded attention. The purpose of this study was to compare pharmacokinetic parameters between clozapine-treated patients with vs. without hypersalivation from a large therapeutic drug monitoring database. ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2020, :]

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Smartphone relapse prediction in serious mental illness: a pathway towards personalized preventive care.

John Torous, Tanzeem Choudhury, Ian Barnett, Matcheri Keshavan, John Kane,

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):308-309]

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Using behavioral rhythms and multi-task learning to predict fine-grained symptoms of schizophrenia.

Vincent W-S Tseng, Akane Sano, Dror Ben-Zeev, Rachel Brian, Andrew T Campbell, Marta Hauser, John M Kane, Emily A Scherer, Rui Wang, Weichen Wang, Hongyi Wen, Tanzeem Choudhury,

Schizophrenia is a severe and complex psychiatric disorder with heterogeneous and dynamic multi-dimensional symptoms. Behavioral rhythms, such as sleep rhythm, are usually disrupted in people with schizophrenia. As such, behavioral rhythm sensing with smartphones and machine learning can help better understand and predict their symptoms. Our goal is to predict ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):15100]

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Utilizing Machine Learning on Internet Search Activity to Support the Diagnostic Process and Relapse Detection in Young Individuals With Early Psychosis: Feasibility Study.

Michael Leo Birnbaum, Prathamesh Param Kulkarni, Anna Van Meter, Victor Chen, Asra F Rizvi, Elizabeth Arenare, Munmun De Choudhury, John M Kane,

BACKGROUND:Psychiatry is nearly entirely reliant on patient self-reporting, and there are few objective and reliable tests or sources of collateral information available to help diagnostic and assessment procedures. Technology offers opportunities to collect objective digital data to complement patient experience and facilitate more informed treatment decisions. OBJECTIVE:We aimed to develop ... Read more >>

JMIR Ment Health (JMIR mental health)
[2020, 7(9):e19348]

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Predicting Early Warning Signs of Psychotic Relapse From Passive Sensing Data: An Approach Using Encoder-Decoder Neural Networks.

Daniel A Adler, Dror Ben-Zeev, Vincent W-S Tseng, John M Kane, Rachel Brian, Andrew T Campbell, Marta Hauser, Emily A Scherer, Tanzeem Choudhury,

BACKGROUND:Schizophrenia spectrum disorders (SSDs) are chronic conditions, but the severity of symptomatic experiences and functional impairments vacillate over the course of illness. Developing unobtrusive remote monitoring systems to detect early warning signs of impending symptomatic relapses would allow clinicians to intervene before the patient's condition worsens. OBJECTIVE:In this study, we ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(8):e19962]

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Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis.

Jose M Rubio, Georgios Schoretsanitis, Majnu John, Jari Tiihonen, Heidi Taipale, Daniel Guinart, Anil K Malhotra, Christoph U Correll, John M Kane,

BACKGROUND:Most individuals with schizophrenia-spectrum disorders have relapses, which increase the risk of morbidity and mortality. Because non-adherence to antipsychotic maintenance treatment could affect more than half of individuals with schizophrenia-spectrum disorders, psychosis relapse can often be confounded by unnoticed treatment interruption. Research of relapse during confirmed antipsychotic exposure has basic ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(9):749-761]

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Post-Marketing Safety Concerns with Esketamine: A Disproportionality Analysis of Spontaneous Reports Submitted to the FDA Adverse Event Reporting System.

Chiara Gastaldon, Emanuel Raschi, John M Kane, Corrado Barbui, Georgios Schoretsanitis,

INTRODUCTION:Esketamine nasal spray received approval for treatment-resistant depression in March 2019. OBJECTIVE:Using the FDA Adverse Event Reporting System (FAERS) database (March 2019-March 2020), we analysed esketamine-related adverse events (AEs) to detect and characterize relevant safety signals. METHODS:We used the consolidated case/non-case approach to estimate the reporting odds ratio (ROR) and ... Read more >>

Psychother Psychosom (Psychotherapy and psychosomatics)
[2020, :1-8]

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Examining side effect variation of antipsychotic treatment in schizophrenia spectrum disorders

Maria Neumeier, Stephanie Homan, Stefan Vetter, Erich Seifritz, John Kane, Maximilian Huhn, Stefan Leucht, Philipp Homan,

Background: Side effects of antipsychotic drugs play a key role in non-adherence and discontinuation of treatment in schizophrenia spectrum disorders (SSD). Precision medicine aims to minimize such side effects by selecting the right treatment for the right patient. However, to determine the extent of precision medicine that is required, we ... Read more >>

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Early Intervention Services 2.0: Designing Systems for the Next Generation of Work.

Vinod H Srihari, John M Kane,

Biol. Psychiatry (Biological psychiatry)
[2020, 88(4):291-293]

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Sebelipase alfa for lysosomal acid lipase deficiency: 5-year treatment experience from a phase 2 open-label extension study.

Vĕra Malinová, Manisha Balwani, Reena Sharma, Jean-Baptiste Arnoux, John Kane, Chester B Whitley, Sachin Marulkar, Florian Abel,

BACKGROUND AND AIMS:Lysosomal acid lipase deficiency is characterized by hepatomegaly and dyslipidaemia, which can lead to cirrhosis and premature atherosclerosis. Sebelipase alfa is an approved recombinant human lysosomal acid lipase. In an open-label extension study of adults with lysosomal acid lipase deficiency (LAL-CL04), sebelipase alfa treatment for 1 year reduced ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(9):2203-2214]

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The physical health and side-effect monitoring of patients prescribed clozapine: data from a clinical audit conducted in UK mental health services.

Thomas R E Barnes, James H MacCabe, John M Kane, Oriana Delgado, Carol Paton,

Background:In addition to mandatory haematological monitoring, treatment guidelines recommend routine monitoring of adverse effects and physical health in patients prescribed clozapine. Methods:NHS trusts/healthcare organisations participated in a clinical audit in the context of a UK quality improvement programme addressing clozapine-prescribing practice. Results:Data relating to 6948 adult patients prescribed clozapine were ... Read more >>

Ther Adv Psychopharmacol (Therapeutic advances in psychopharmacology)
[2020, 10:2045125320937908]

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Effect of Long-Acting Injectable Antipsychotics vs Usual Care on Time to First Hospitalization in Early-Phase Schizophrenia: A Randomized Clinical Trial.

John M Kane, Nina R Schooler, Patricia Marcy, Christoph U Correll, Eric D Achtyes, Robert D Gibbons, Delbert G Robinson,

Importance:Long-acting injectable antipsychotics (LAIs) can potentially reduce hospitalization risk by enhancing medication adherence but are rarely considered for early-phase schizophrenia treatment. Objective:To determine whether encouraging use of a LAI compared with usual care delays the time to first hospitalization with patients with early-phase illness. Design, Setting, and Participants:The Prevention of ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Striatal functional connectivity in psychosis relapse: A comparison between antipsychotic adherent and non-adherent patients at the time of relapse

Jose Rubio, Todd Lencz, Anita Barber, Franchesica Bassaw, Gabriela Ventura, Nicole Germano, Anil Malhotra, John Kane,

Most individuals with psychotic disorders relapse over their course of illness. Relapse pathophysiology is generally not well captured in studies that do not account for antipsychotic non-adherence, which is common and often unnoticed in schizophrenia. This study was explicitly designed to understand relapse in patients with guaranteed antipsychotic delivery. We ... Read more >>

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Bertiella sp. (Meyner, 1895) infection of Alouatta caraya (Humboldt, 1812) in urban and natural environments in Ñeembucú, southwest Paraguay.

John Kane, Rebecca L Smith,

Bertiella sp., a cestode known to infect a variety of hosts, including nonhuman primates and humans, was identified in Paraguay as early as 1895, but no systematic analysis of wild primates' gastrointestinal parasites has ever been carried out in Paraguay. Increased urbanization in southwest Paraguay has pushed the Paraguayan howler ... Read more >>

Am. J. Primatol. (American journal of primatology)
[2020, :e23166]

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Clozapine-related drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a systematic review.

Renato de Filippis, Pau Soldevila-Matías, Pasquale De Fazio, Daniel Guinart, Inmaculada Fuentes-Durá, Jose M Rubio, John M Kane, Georgios Schoretsanitis,

INTRODUCTION:The Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, multiorganic, and potentially life-threatening drug-induced hypersensitivity reaction, linked to several common drugs, including antiepileptics, antibiotics, and several psychotropic drugs, including clozapine. Due to the importance of clozapine in the management of treatment-resistant schizophrenia, a systematic review and ... Read more >>

Expert Rev Clin Pharmacol (Expert review of clinical pharmacology)
[2020, 13(8):875-883]

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Clozapine and COVID-19: The authors respond.

Dan Siskind, William G Honer, Scott Clark, Christoph U Correll, Alkomiet Hasan, Oliver Howes, John M Kane, Deanna L Kelly, Robert Laitman, Jimmy Lee, James H MacCabe, Nick Myles, Jimmi Nielsen, Peter F Schulte, David Taylor, Helene Verdoux, Amanda Wheeler, Oliver Freudenreich,

J Psychiatry Neurosci (Journal of psychiatry & neuroscience : JPN)
[2020, 45(4):E1-E2]

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Expanding phenomenologic heterogeneity of tardive syndromes: Time for an updated assessment tool.

Roongroj Bhidayasiri, John M Kane, Karen P Frei, Stanley N Caroff, Christoph U Correll, Stanley Fahn, Joseph Jankovic, Robert A Hauser, Daniel D Truong,

Tardive syndromes (TDS) are a group of hyperkinetic and hypokinetic movement disorders that occurs after exposure to dopamine receptor blocking agents such as antipsychotic and antiemetic drugs. The Abnormal Involuntary Movement Scale (AIMS) is a widely used instrument that has become the standard for assessment of tardive dyskinesia (TDD), the ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 77:141-145]

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Loss-of-Function CREB3L3 Variants in Patients With Severe Hypertriglyceridemia.

Jacqueline S Dron, Allison A Dilliott, Arden Lawson, Adam D McIntyre, Brent D Davis, Jian Wang, Henian Cao, Irina Movsesyan, Mary J Malloy, Clive R Pullinger, John P Kane, Robert A Hegele,

OBJECTIVE:Genetic determinants of severe hypertriglyceridemia include both common variants with small effects (assessed using polygenic risk scores) plus heterozygous and homozygous rare variants in canonical genes directly affecting triglyceride metabolism. Here, we broadened our scope to detect associations with rare loss-of-function variants in genes affecting noncanonical pathways, including those known ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2020, 40(8):1935-1941]

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Drs Kane and Correll Reply.

John M Kane, Christoph U Correll,

J Clin Psychiatry (The Journal of clinical psychiatry)
[2020, 81(4):]

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Machine Learning and Statistical Approaches for Classification of Risk of Coronary Artery Disease using Plasma Cytokines.

Seema Singh Saharan, Pankaj Nagar, Kate Townsend Creasy, Eveline Stock, James Feng, Mary Malloy, John Kane,

Abstract Background As per the 2017 WHO fact sheet, Coronary Artery Disease (CAD) is the primary cause of death in the world, and accounts for 31% of total fatalities. The unprecedented 17.6 million deaths caused by CAD in 2016 underscores the urgent need to facilitate proactive and accelerated pre-emptive diagnosis. ... Read more >>

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