Full Text Journal Articles by
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Hypoglossal Nerve Stimulator Twiddler's Syndrome.

Amar Miglani, Jeffrey C Mecham, John Peyton Hines, Michael L Hinni, Bernie W Miller, Stephen F Bansberg,

Laryngoscope (The Laryngoscope)
[2020, :]

Cited: 0 times

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Mutant-selective Degradation by BRAF-targeting PROTACs

Shanique Alabi, Saul Jaime-Figueroa, Zhan Yao, Yijun Gao, John Hines, Kusal T.G. Samarasinghe, Lea Vogt, Neal Rosen, Craig Crews,

Abstract Over 300 BRAF missense mutations have been identified in patients, yet currently approved drugs target V600 mutants alone. Moreover, acquired resistance inevitably emerges, primarily due to RAF lesions that prevent inhibition of BRAF V600 with current treatments. Therefore, there is a need for new therapies that target other mechanisms ... Read more >>

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Evaluation of 30-day mortality for 500 patients undergoing non-emergency surgery in a COVID-19 cold site within a multicentre regional surgical network during the COVID-19 pandemic

Veeru Kasivisvanathan, Jamie Lindsay, Sara Rakhshani-moghadam, Ahmed Elhamshary, Konstantinos Kapriniotis, Georgios Kazantzis, Bilal Syed, John Hines, Axel Bex, Daniel Heffernan Ho, Martin Hayward, Chetan Bhan, Nicola MacDonald, Simon Clarke, David Walker, Geoff Bellingan, James Moore, Jennifer Rohn, Asif Muneer, Lois Roberts, Fares Haddad, John Kelly,

Background Two million non-emergency surgeries are being cancelled globally every week due to the COVID-19 pandemic, which will have a major impact on patients and healthcare systems. Objective To determine whether it is feasible and safe to continue non-emergency surgery in the COVID-19 pandemic Design, setting and participants ... Read more >>

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Implementing major system change in specialist cancer surgery: The role of provider networks.

Cecilia Vindrola-Padros, Angus Ig Ramsay, Catherine Perry, Sarah Darley, Victoria J Wood, Caroline S Clarke, John Hines, Claire Levermore, Mariya Melnychuk, Caroline M Moore, Stephen Morris, Muntzer M Mughal, Kathy Pritchard-Jones, David Shackley, Naomi J Fulop,

OBJECTIVE:Major system change (MSC) has multiple, sometimes conflicting, goals and involves implementing change across a number of organizations. This study sought to develop new understanding of how the role that networks can play in implementing MSC, using the case of centralization of specialist cancer surgery in London, UK. METHODS:The study ... Read more >>

J Health Serv Res Policy (Journal of health services research & policy)
[2020, :1355819620926553]

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Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties.

Saul Jaime-Figueroa, Alexandru D Buhimschi, Momar Toure, John Hines, Craig M Crews,

A new series of Proteolysis Targeting Chimeras (PROTACs) targeting Bruton's Tyrosine Kinase (BTK) was synthesized, with the goal of improving the pharmacokinetic properties of our previously reported PROTAC, MT802. We recently described the ability of MT802 to induce degradation of both wild-type and C481S mutant BTK in immortalized cells and ... Read more >>

Bioorg. Med. Chem. Lett. (Bioorganic & medicinal chemistry letters)
[2020, 30(3):126877]

Cited: 3 times

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How to Read, Write, and Review the Imaging Literature.

Arielle Sasson, Oseogie Okojie, Ryan Verano, Mariam Moshiri, Michael N Patlas, Jason C Hoffmann, John J Hines, Douglas S Katz,

Everyone at all levels in academic radiology is supposed to know how to read an original research article or a review article and to evaluate it critically, to participate in writing such manuscripts, and, as one becomes more senior, to participate in the peer review process, yet there is little ... Read more >>

Curr Probl Diagn Radiol (Current problems in diagnostic radiology)
[2020, :]

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Reply by Authors.

Lei Xu, Xueying Mao, Alistair Grey, Glenda Scandura, Tianyu Guo, Edwina Burke, Jacek Marzec, Semah Abdu, Elzbieta Stankiewicz, Caitlin R Davies, Prabhakar Rajan, Karen Tipples, John Hines, Pui Ying Chan, Diane Campbell, Karen Wilkinson, Sakunthala Kudahetti, Jonathan Shamash, Tim Oliver, Daniel Berney, Greg Shaw, Yong-Jie Lu,

J. Urol. (The Journal of urology)
[2020, 203(1):81-82]

Cited: 0 times

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Noninvasive Detection of Clinically Significant Prostate Cancer Using Circulating Tumor Cells.

Lei Xu, Xueying Mao, Alistair Grey, Glenda Scandura, Tianyu Guo, Edwina Burke, Jacek Marzec, Semah Abdu, Elzbieta Stankiewicz, Caitlin R Davies, Prabhakar Rajan, Karen Tipples, John Hines, Pui Ying Chan, Diane Campbell, Karen Wilkinson, Sakunthala Kudahetti, Jonathan Shamash, Tim Oliver, Daniel Berney, Greg Shaw, Yong-Jie Lu,

PURPOSE:Prostate specific antigen testing results in unnecessary biopsy and over diagnosis with consequent overtreatment. Tissue biopsy is an invasive procedure associated with significant morbidity. More accurate noninvasive or minimally invasive diagnostic approaches should be developed to avoid unnecessary prostate biopsy and over diagnosis. We investigated the potential of using circulating ... Read more >>

J. Urol. (The Journal of urology)
[2020, 203(1):73-82]

Cited: 2 times

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Multimodality Imaging of the Pancreatic Neuroendocrine Tumors.

Amandeep Singh, John J Hines, Barak Friedman,

Pancreatic neuroendocrine tumors (PNETs) are uncommon pancreatic masses which arise from amine precursor and uptake decarboxylation cells. They are classified as functional or nonfunctional based on the associated clinical symptoms. Insulinomas and gastrinomas are the most common functional tumors. PNETs are also classified based on their biologic behavior as benign ... Read more >>

Semin. Ultrasound CT MR (Seminars in ultrasound, CT, and MR)
[2019, 40(6):469-482]

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Mixed adenoneuroendocrine carcinoma of the urethra.

Nicholas Raison, Ursula McGovern, John Hines, Dimitrios Volanis,

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour found predominantly in the gastrointestinal tract. Comprising adenocarcinomatous and neuroendocrine components, MANEC have been reported in the bladder. We report the first case to our knowledge of a MANEC arising in the urethra. A 62-year-old woman presented with a suburethral mass. Initial ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(3):]

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Subpectoral implantation of the hypoglossal nerve stimulator: An effective technical modification.

Nicholas L Deep, John Peyton Hines, James M Parish, Michael L Hinni, Stephen F Bansberg,

Upper airway stimulation is now a well-established treatment option for selected patients with obstructive sleep apnea. The implanted pulse generator of this system activates the hypoglossal nerve and is routinely placed in a subcutaneous pocket overlying the pectoralis muscle. This case report describes a patient with a history of bilateral ... Read more >>

Laryngoscope (The Laryngoscope)
[2019, 129(10):2420-2423]

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Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation.

Philipp M Cromm, Kusal T G Samarasinghe, John Hines, Craig M Crews,

Enzymatic inhibition has proven to be a successful modality for the development of many small-molecule drugs. In recent years, small-molecule-induced protein degradation has emerged as an orthogonal therapeutic strategy that has the potential to expand the druggable target space. Focal adhesion kinase (Fak) is a key player in tumor invasion ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2018, 140(49):17019-17026]

Cited: 17 times

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Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion.

George M Burslem, Jayoung Song, Xin Chen, John Hines, Craig M Crews,

The receptor tyrosine kinase FLT-3 is frequently mutated in acute myeloid leukemia; however, current small molecule inhibitors suffer from limited efficacy in the clinic. Conversion of a FLT-3 inhibitor (quizartinib) into a proteolysis targeting chimera (PROTAC) results in a compound that induces degradation of FLT-3 ITD mutant at low nanomolar ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2018, 140(48):16428-16432]

Cited: 12 times

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Evaluating the effect of electronic monitoring and feedback on hand cream use in healthcare workers: Healthy Hands Project.

Maryam Soltanipoor, Thomas Rustemeyer, Judith K Sluiter, John Hines, Federico Frison, Sanja Kezic,

BACKGROUND:Healthcare workers (HCWs) are at high risk of developing hand dermatitis (HD). Current guidelines on HD prevention recommend the use of emollients; however, in practice, adherence is poor. OBJECTIVE:To assess whether the provision of creams, electronic monitoring and feedback on cream consumption can improve skin care in HCWs. METHODS:A cluster ... Read more >>

Contact Derm. (Contact dermatitis)
[2019, 80(1):26-34]

Cited: 1 time

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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53.

John Hines, Schan Lartigue, Hanqing Dong, Yimin Qian, Craig M Crews,

Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number of E3 ligases successfully exploited to accomplish this has been limited to the few for which small-molecule ligands have been discovered. Although the E3 ligase MDM2 is bound by the nutlin class of ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(1):251-262]

Cited: 11 times

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CT Imaging of Emergent Renal Conditions.

Kunal Kothari, John J Hines,

The kidneys are paired intra-abdominal organs which provide essential functions and maintain homeostasis throughout the human body. Numerous disease processes affect the kidneys and cause acute renal dysfunction or other potentially catastrophic complications. These conditions can be broadly categorized into obstructive, infectious, hemorrhagic, traumatic, and vascular diseases. Imaging plays a ... Read more >>

Semin. Ultrasound CT MR (Seminars in ultrasound, CT, and MR)
[2018, 39(2):129-144]

Cited: 0 times

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Letter to the editor regarding "Foam soap is not as effective as liquid soap in eliminating hand microbial flora".

John D Hines, Paul Alper,

Am J Infect Control (American journal of infection control)
[2017, 45(12):1412-1413]

Cited: 0 times

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Clues to vascular disorders at non-contrast CT of the chest, abdomen, and pelvis.

Yonah B Esterson, Jennifer L Berkowitz, Barak Friedman, John J Hines, Priya K Shah, Gregory M Grimaldi,

Non-contrast chest CT scans are commonly performed while CT scans of the abdomen and pelvis are performed in a select subset of patients; those with limited renal function, an allergy to iodinated contrast, in the setting of suspected renal calculus, retroperitoneal hematoma, common duct calculus, abdominal aortic aneurysm with or ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2017, 42(8):2175-2187]

Cited: 0 times

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The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study.

George M Burslem, Blake E Smith, Ashton C Lai, Saul Jaime-Figueroa, Daniel C McQuaid, Daniel P Bondeson, Momar Toure, Hanqing Dong, Yimin Qian, Jing Wang, Andrew P Crew, John Hines, Craig M Crews,

Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the development of PROTACs for receptor tyrosine kinases, a protein family yet to be targeted for induced protein degradation. The use of VHL-recruiting PROTACs against ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2018, 25(1):67-77.e3]

Cited: 44 times

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Nontraumatic large bowel perforation: spectrum of etiologies and CT findings.

Kunal Kothari, Barak Friedman, Gregory M Grimaldi, John J Hines,

Large bowel perforation is an abdominal emergency that results from a wide range of etiologies. Computed tomography is the most reliable modality in detecting the site of large bowel perforation. The diagnosis is made by identifying direct CT findings such as extraluminal gas or contrast and discontinuity along the bowel ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2017, 42(11):2597-2608]

Cited: 3 times

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

Daniel P Bondeson, Blake E Smith, George M Burslem, Alexandru D Buhimschi, John Hines, Saul Jaime-Figueroa, Jing Wang, Brian D Hamman, Alexey Ishchenko, Craig M Crews,

Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we report a previously understudied benefit of small molecule proteolysis-targeting chimeras (PROTACs) that recruit E3 ubiquitin ligases to target proteins for their ubiquitination and subsequent proteasome-mediated degradation. Using promiscuous CRBN- and VHL-recruiting PROTACs that bind >50 kinases, we ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2018, 25(1):78-87.e5]

Cited: 52 times

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The Novel Association of Circulating Tumor Cells and Circulating Megakaryocytes with Prostate Cancer Prognosis.

Lei Xu, Xueying Mao, Tianyu Guo, Pui Ying Chan, Greg Shaw, John Hines, Elzbieta Stankiewicz, Yuqin Wang, R Tim D Oliver, Amar Sabri Ahmad, Daniel Berney, Jonathan Shamash, Yong-Jie Lu,

Purpose: To develop an approach for the investigation of different subtypes of circulating tumor cells (CTC) and other cells to evaluate their potential prognostic value of prostate cancer.Experimental Design: Malignancy of CTCs undergoing epithelial-to-mesenchymal transition (EMT) was confirmed by repeated FISH. Subgroups of CTCs in 81 patients with prostate cancer ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2017, 23(17):5112-5122]

Cited: 15 times

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Blood Transfusion Requirement and Not Preoperative Anemia Are Associated with Perioperative Complications Following Intracorporeal Robot-Assisted Radical Cystectomy.

Wei Shen Tan, Benjamin W Lamb, Pramit Khetrapal, Mae-Yen Tan, Melanie El Tan, Ashwin Sridhar, Elizabeth Cervi, Simon Rodney, Gerald Busuttil, Senthil Nathan, John Hines, Greg Shaw, Anna Mohammed, Hilary Baker, Timothy P Briggs, Andrew Klein, Toby Richards, John D Kelly,

OBJECTIVES:To assess the prevalence of preoperative anemia and the impact of preoperative anemia and blood transfusion requirement on 30- and 90-day complications in a cohort of patients undergoing robot-assisted radical cystectomy with intracorporeal urinary diversion (iRARC). PATIENTS AND METHODS:IRARC was performed on 166 patients between June 2011 and March 2016. ... Read more >>

J. Endourol. (Journal of endourology)
[2017, 31(2):141-148]

Cited: 6 times

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Study protocol for a randomised controlled trial of brief, habit-based, lifestyle advice for cancer survivors: exploring behavioural outcomes for the Advancing Survivorship Cancer Outcomes Trial (ASCOT).

Rebecca J Beeken, Helen Croker, Maggie Heinrich, Lee Smith, Kate Williams, Allan Hackshaw, John Hines, Michael Machesney, Madhavan Krishnaswamy, Sharon Cavanagh, Rebecca Roylance, Alison Hill, Kathy Pritchard-Jones, Jane Wardle, Abigail Fisher,

INTRODUCTION:Positive health behaviours such as regular physical activity and a healthy diet have significant effects on cancer outcomes. There is a need for simple but effective behaviour change interventions with the potential to be implemented within the cancer care pathway. Habit-based advice encourages repetition of a behaviour in a consistent ... Read more >>

BMJ Open (BMJ open)
[2016, 6(11):e011646]

Cited: 6 times

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Grit and burnout in UK doctors: a cross-sectional study across specialties and stages of training.

Laura Halliday, Abigail Walker, Stella Vig, John Hines, John Brecknell,

PURPOSE OF THE STUDY:Grit is characterised by the ability to persevere during difficulties and maintain a sustained effort over an extended period of time. Throughout their careers, doctors will experience many periods of stress and difficulty. This may result in burnout, defined by the presence of exhaustion and disengagement from ... Read more >>

Postgrad Med J (Postgraduate medical journal)
[2017, 93(1101):389-394]

Cited: 16 times

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