Full Text Journal Articles by
Author John Germiller

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Audiologic Phenotype and Progression in Pediatric STRC-Related Autosomal Recessive Hearing Loss.

Andrea Simi, Julia Perry, Emma Schindler, Andrea Oza, Minjie Luo, Tiffiney Hartman, Ian D Krantz, John A Germiller, Kosuke Kawai, Margaret Kenna,

<h4>Objectives</h4>Sensorineural hearing loss (SNHL) is a common sensory deficit affecting pediatric populations. The majority of pediatric SNHL is genetic in etiology, with over 123 identified nonsyndromic causative genes. One such gene is STRC, which has been identified as the second most frequent autosomal recessive nonsyndromic gene associated with SNHL in ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, :]

Cited: 0 times

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Drug delivery to the pediatric upper airway.

Soheila Ali Akbari Ghavimi, Paul M Gehret, Matthew R Aronson, Rossana Schipani, Kyra W Y Smith, Ryan C Borek, John A Germiller, Ian N Jacobs, Karen B Zur, Riccardo Gottardi,

Pediatric upper airway disorders are frequently life-threatening and require precise assessment and intervention. Targeting these pathologies remains a challenge for clinicians due to the high complexity of pediatric upper airway anatomy and numerous potential etiologies; the most common treatments include systemic delivery of high dose steroids and antibiotics or complex ... Read more >>

Adv Drug Deliv Rev (Advanced drug delivery reviews)
[2021, 174:168-189]

Cited: 0 times

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Validation of a Parent Proxy Quality-of-Life Measure for Young Children With Hearing Loss.

Cathy Y Yu, Donna B Jeffe, Margaret A Kenna, John A Germiller, Judith E C Lieu,

<h4>Objectives</h4>No hearing-related quality of life (QL) questionnaire currently exists for children < 7 years. This study aimed to develop and evaluate the construct validity and reliability of a new parent-proxy Preschool Hearing Environments and Reflection on Quality of Life (HEAR-QL) questionnaire.<h4>Methods</h4>Parents of children 2 to 6 years old with any hearing loss (HL) ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, 131(3):663-670]

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Perspective on the Development of a Large-Scale Clinical Data Repository for Pediatric Hearing Research.

Jeffrey W Pennington, Byron Ruth, Jeffrey M Miller, Joy Peterson, Baichen Xu, Aaron J Masino, Ian Krantz, Juliana Manganella, Tamar Gomes, Derek Stiles, Margaret Kenna, Linda J Hood, John Germiller, E Bryan Crenshaw,

The use of "big data" for pediatric hearing research requires new approaches to both data collection and research methods. The widespread deployment of electronic health record systems creates new opportunities and corresponding challenges in the secondary use of large volumes of audiological and medical data. Opportunities include cost-effective hypothesis generation, ... Read more >>

Ear Hear (Ear and hearing)
[2020, 41(2):231-238]

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ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.

Alex M Rohacek, Thomas W Bebee, Richard K Tilton, Caleb M Radens, Chris McDermott-Roe, Natoya Peart, Maninder Kaur, Michael Zaykaner, Benjamin Cieply, Kiran Musunuru, Yoseph Barash, John A Germiller, Ian D Krantz, Russ P Carstens, Douglas J Epstein,

Alternative splicing contributes to gene expression dynamics in many tissues, yet its role in auditory development remains unclear. We performed whole-exome sequencing in individuals with sensorineural hearing loss (SNHL) and identified pathogenic mutations in Epithelial Splicing-Regulatory Protein 1 (ESRP1). Patient-derived induced pluripotent stem cells showed alternative splicing defects that were restored upon ... Read more >>

Dev Cell (Developmental cell)
[2017, 43(3):318-331.e5]

Cited: 12 times

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International Pediatric Otolaryngology Group (IPOG) consensus recommendations: Hearing loss in the pediatric patient.

Bryan J Liming, John Carter, Alan Cheng, Daniel Choo, John Curotta, Daniela Carvalho, John A Germiller, Stephen Hone, Margaret A Kenna, Natalie Loundon, Diego Preciado, Anne Schilder, Brian J Reilly, Stephane Roman, Julie Strychowsky, Jean-Michel Triglia, Nancy Young, Richard J H Smith,

<h4>Objective</h4>To provide recommendations for the workup of hearing loss in the pediatric patient.<h4>Methods</h4>Expert opinion by the members of the International Pediatric Otolaryngology Group.<h4>Results</h4>Consensus recommendations include initial screening and diagnosis as well as the workup of sensorineural, conductive and mixed hearing loss in children. The consensus statement discusses the role of ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2016, 90:251-258]

Cited: 16 times

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Temporal bone radiology report classification using open source machine learning and natural langue processing libraries.

Aaron J Masino, Robert W Grundmeier, Jeffrey W Pennington, John A Germiller, E Bryan Crenshaw,

<h4>Background</h4>Radiology reports are a rich resource for biomedical research. Prior to utilization, trained experts must manually review reports to identify discrete outcomes. The Audiological and Genetic Database (AudGenDB) is a public, de-identified research database that contains over 16,000 radiology reports. Because the reports are unlabeled, it is difficult to select ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2016, 16:65]

Cited: 6 times

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Infectious complications and ventilation tubes in pediatric cochlear implant recipients.

Luv Javia, Jason Brant, Jessica Guidi, Anaïs Rameau, Seth Pross, Samuel Cohn, Ken Kazahaya, Brian Dunham, John Germiller,

At many centers, ventilating tubes (VTs) are placed routinely in otitis-prone pediatric cochlear implant recipients. However, this practice is controversial, as many otologists believe VTs represent a possible route for contamination of the device. Toward better understanding of the safety of VTs, we reviewed our center's infectious complications and their ... Read more >>

Laryngoscope (The Laryngoscope)
[2016, 126(7):1671-1676]

Cited: 1 time

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Children With Sensorineural Hearing Loss And Referral To Early Intervention.

Terri Giordano, Amanda M Marchegiani, John A Germiller,

<h4>Objective</h4>Sensorineural hearing loss (SNHL) is identified at a rate of 1-3 per 1,000 newborns in the United States. Timely referral to Early Intervention (EI) services is critical, as early EI referral has been shown to improve outcomes, including speech and language development, social and emotional development, and academic performance. The ... Read more >>

ORL Head Neck Nurs (ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses)
[2015, 33(3):10-14]

Cited: 0 times

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Unilateral cochlear nerve deficiency in children.

Clarice S Clemmens, Jessica Guidi, Aviva Caroff, Samuel J Cohn, Jason A Brant, Adrienne M Laury, Larissa T Bilaniuk, John A Germiller,

<h4>Objective</h4>Cochlear nerve deficiency (CND) is increasingly diagnosed in children with sensorineural hearing loss (SNHL). We sought to determine the prevalence of CND, its imaging characteristics, and correlations with audiologic phenotype in children with unilateral SNHL.<h4>Design</h4>Case series with chart review.<h4>Setting</h4>Tertiary pediatric hospital.<h4>Subjects/methods</h4>In 128 consecutive children with unilateral SNHL who underwent high-resolution ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2013, 149(2):318-325]

Cited: 26 times

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Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear

Lisa M. Bank, Lynne M. Bianchi, Fumi Ebisu, Dov Lerman-Sinkoff, Elizabeth C. Smiley, Yu-chi Shen, Poornapriya Ramamurthy, Deborah L. Thompson, Therese M. Roth, Christine R. Beck, Matthew Flynn, Ryan S. Teller, Luming Feng, G. Nicholas Llewellyn, Brandon Holmes, Cyrrene Sharples, Jaeda Coutinho-Budd, Stephanie A. Linn, Andrew P. Chervenak, David F. Dolan, Jennifer Benson, Ariane Kanicki, Catherine A. Martin, Richard Altschuler, Alisa E. Koch, Ethan M. Jewett, John A. Germiller, Kate F. Barald,

Development (Development (Cambridge, England))
[2013, 140(2):479-479]

Cited: 0 times

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Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear.

Lisa M Bank, Lynne M Bianchi, Fumi Ebisu, Dov Lerman-Sinkoff, Elizabeth C Smiley, Yu-chi Shen, Poornapriya Ramamurthy, Deborah L Thompson, Therese M Roth, Christine R Beck, Matthew Flynn, Ryan S Teller, Luming Feng, G Nicholas Llewellyn, Brandon Holmes, Cyrrene Sharples, Jaeda Coutinho-Budd, Stephanie A Linn, Andrew P Chervenak, David F Dolan, Jennifer Benson, Ariane Kanicki, Catherine A Martin, Richard Altschuler, Alisa E Koch, Ethan M Jewett, John A Germiller, Kate F Barald,

This study is the first to demonstrate that macrophage migration inhibitory factor (MIF), an immune system 'inflammatory' cytokine that is released by the developing otocyst, plays a role in regulating early innervation of the mouse and chick inner ear. We demonstrate that MIF is a major bioactive component of the ... Read more >>

Development (Development (Cambridge, England))
[2012, 139(24):4666-4674]

Cited: 22 times

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Venous malformations of the temporal bone are a common feature in CHARGE syndrome.

David R Friedmann, Misha Amoils, John A Germiller, Lawrence R Lustig, Christine M Glastonbury, Bidyut K Pramanik, Anil K Lalwani,

<h4>Objectives/hypothesis</h4>CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and/or development, Genital and/or urinary abnormalities, and Ear abnormalities and/or deafness) syndrome is a genetic disorder with prominent otolaryngologic features including choanal atresia and inner ear malformations. Recent experience with venous malformations during cochlear implant surgery ... Read more >>

Laryngoscope (The Laryngoscope)
[2012, 122(4):895-900]

Cited: 10 times

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Early prediction of postmeningitic hearing loss in children using magnetic resonance imaging.

Jonathan C Kopelovich, John A Germiller, Adrienne M Laury, Samir S Shah, Avrum N Pollock,

<h4>Objective</h4>To determine whether early gadolinium-enhanced magnetic resonance imaging (GdMRI) can reliably detect meningitic labyrinthitis and thereby predict which children are at high risk for hearing loss. Permanent sensorineural hearing loss (SNHL) remains a common sequela of bacterial meningitis, and early diagnosis of the associated suppurative labyrinthitis can be difficult, especially ... Read more >>

Arch Otolaryngol Head Neck Surg (Archives of otolaryngology--head & neck surgery)
[2011, 137(5):441-447]

Cited: 10 times

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An improved, practical stent for choanal atresia and pyriform aperture stenosis repair.

Luv R Javia, Udayan K Shah, John A Germiller,

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2009, 140(2):259-261]

Cited: 2 times

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Etiology of unilateral neural hearing loss in children.

Adrienne M Laury, Sarah Casey, Sarah McKay, John A Germiller,

<h4>Objective</h4>Unilateral sensorineural hearing loss (SNHL) can be caused by a variety of lesions of the inner ear and central nervous system. An inner hair cell or neural site of pathology must be suspected when otoacoustic emissions (OAEs) are present, and inconsistent with audiologic data. We reviewed unilateral neural hearing loss ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2009, 73(3):417-427]

Cited: 16 times

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Real-time intraoperative computed tomography to assist cochlear implant placement in the malformed inner ear.

Jason D Bloom, Mark D Rizzi, John A Germiller,

<h4>Objective</h4>Cochlear implantation is increasingly being performed in children with inner ear malformations. In severe cochleovestibular anomalies, such as severe partitioning defects and common cavity dysplasia, positioning of the electrode array can be hazardous, with inadvertent placement into the internal auditory canal (IAC) or carotid canal being well known. We describe ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2009, 30(1):23-26]

Cited: 17 times

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Intracranial complications of sinusitis in children and adolescents and their outcomes.

John A Germiller, Daniel L Monin, Anthony M Sparano, Lawrence W C Tom,

<h4>Objective</h4>To gain insight into patterns of presentation, imaging, microbiological aspects, therapy, disease course, and outcome of intracranial complications of sinusitis (ICS), which are challenging conditions with the potential to cause significant morbidity and mortality. We reviewed our experience with ICS in children and adolescents.<h4>Design</h4>Consecutive case series with a mean follow-up ... Read more >>

Arch Otolaryngol Head Neck Surg (Archives of otolaryngology--head & neck surgery)
[2006, 132(9):969-976]

Cited: 56 times

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Chronic Pseudomonas infections of cochlear implants.

John A Germiller, Hussam K El-Kashlan, Udayan K Shah,

<h4>Objective</h4>To discuss chronic, refractory Pseudomonas infections of cochlear implants and their management.<h4>Design</h4>Retrospective case series.<h4>Setting</h4>Two university-based cochlear implant programs.<h4>Patients</h4>Twenty-eight-year-old (Case 1) and 4-year-old (Case 2), different devices.<h4>Interventions</h4>Medical and surgical management.<h4>Main outcome measures</h4>Clinical course.<h4>Results</h4>Both patients had delayed presentations, 4 months and 3 years postimplantation, respectively, with fluctuating scalp edema and pain resistant ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2005, 26(2):196-201]

Cited: 13 times

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Molecular characterization of conditionally immortalized cell lines derived from mouse early embryonic inner ear.

John A Germiller, Elizabeth C Smiley, Amanda D Ellis, Jessica S Hoff, Ian Deshmukh, Susan J Allen, Kate F Barald,

Inner ear sensory hair cells (HCs), supporting cells (SCs), and sensory neurons (SNs) are hypothesized to develop from common progenitors in the early embryonic otocyst. Because little is known about the molecular signals that control this lineage specification, we derived a model system of early otic development: conditionally immortalized otocyst ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2004, 231(4):815-827]

Cited: 13 times

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