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Author John Fell

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HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

Aleksejs Sazonovs, Nicholas A Kennedy, Loukas Moutsianas, Graham A Heap, Daniel L Rice, Mark Reppell, Claire M Bewshea, Neil Chanchlani, Gareth J Walker, Mandy H Perry, Timothy J McDonald, Charlie W Lees, J R Fraser Cummings, Miles Parkes, John C Mansfield, Peter M Irving, Jeffrey C Barrett, Dermot McGovern, James R Goodhand, Carl A Anderson, Tariq Ahmad, ,

BACKGROUND & AIMS:Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(1):189-199]

Cited: 3 times

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Custom 3-Dimensional Printed Ultrasound-Compatible Vascular Access Models: Training Medical Students for Vascular Access.

Alexander Y Sheu, Grace L Laidlaw, John C Fell, Brian P Triana, Christopher S Goettl, Rajesh P Shah,

PURPOSE:To generate 3-dimensional (3D) printed ultrasound (US)-compatible vascular models (3DPVAM) and test them for noninferiority in training medical students in femoral artery access. MATERIALS AND METHODS:A 3DPVAM of normal femoral artery (FA) anatomy was developed from an anonymized computerized tomography (CT) examination. Students were randomized to a 3DPVAM or a ... Read more >>

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2019, 30(6):922-927]

Cited: 0 times

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Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.

Nicholas A Kennedy, Graham A Heap, Harry D Green, Benjamin Hamilton, Claire Bewshea, Gareth J Walker, Amanda Thomas, Rachel Nice, Mandy H Perry, Sonia Bouri, Neil Chanchlani, Neel M Heerasing, Peter Hendy, Simeng Lin, Daniel R Gaya, J R Fraser Cummings, Christian P Selinger, Charlie W Lees, Ailsa L Hart, Miles Parkes, Shaji Sebastian, John C Mansfield, Peter M Irving, James Lindsay, Richard K Russell, Timothy J McDonald, Dermot McGovern, James R Goodhand, Tariq Ahmad, ,

BACKGROUND:Anti-TNF drugs are effective treatments for the management of Crohn's disease but treatment failure is common. We aimed to identify clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal. METHODS:The personalised anti-TNF therapy in ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2019, 4(5):341-353]

Cited: 18 times

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Use of Infliximab Biosimilar Versus Originator in a Pediatric United Kingdom Inflammatory Bowel Disease Induction Cohort.

Neil Chanchlani, Kajal Mortier, Linda J Williams, Rafeeq Muhammed, Marcus K H Auth, Mike Cosgrove, Andrew Fagbemi, John Fell, Sonny Chong, Veena Zamvar, Warren Hyer, W Michael Bisset, Mary-Anne Morris, Astor Rodrigues, Sally G Mitton, Su Bunn, R Mark Beattie, Anne Willmott, David C Wilson, Richard K Russell,

OBJECTIVES:The aim of the study was to summarize short-term effectiveness, safety, and cost of using infliximab biosimilar (IFX-B) drugs, (Inflectra [Hospira] and Remsima [NAAP]) compared to originator infliximab (IFX-O) (Remicade [MSD]) in biologic naive pediatric inflammatory bowel disease in the United Kingdom. METHODS:Prospective audit of patients starting anti-tumour necrosis factor ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2018, 67(4):513-519]

Cited: 5 times

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Improved Medical Treatment and Surgical Surveillance of Children and Adolescents with Ulcerative Colitis in the United Kingdom.

Marcus Karl-Keinz Auth, Su K Bunn, Aimee Leanne Protheroe, Linda Jane Williams, John M Fell, Rafeeq Muhammed, Nicholas Michael Croft, R Mark Beattie, Anne Willmott, Christine Spray, Babu Vadamalayan, Astor Rodrigues, John Puntis, Anna Jane Pigott, David C Wilson, Sally Mitton, Mark Furman, Charlie Charlton, Sonny K F Chong, , , Richard K Russell,

Background:Pediatric ulcerative colitis (UC) presents at an earlier age and increasing prevalence. Our aim was to examine morbidity, steroid sparing strategies, and surgical outcome in children with active UC. Methods:A national prospective audit was conducted for the inpatient period of all children with UC for medical or surgical treatment in ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2018, 24(7):1520-1530]

Cited: 0 times

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Real-life Anti-tumor Necrosis Factor Experience in More Than 500 Patients: High Co-immunosuppression Rates But Low Rates of Quantifying Treatment Response.

Victoria M Merrick, Kajal Mortier, Linda J Williams, Rafeeq Muhammed, Marcus K H Auth, Mamoun Elawad, John M E Fell, R Mark Beattie, Sabarinathan Loganathan, Franco Torrente, Mary-Anne Morris, Charles Charlton, Nick M Croft, Astor Rodrigues, Mark Furman, Babu Vadamalayan, Huw Jenkins, Veena Zamvar, Sally G Mitton, Sonny Chong, Mike Cosgrove, Anthony Akobeng, David C Wilson, Richard K Russell,

OBJECTIVE:The aim of this study was to measure the effectiveness, safety, and use of anti-tumor necrosis Factor (TNF) therapy in pediatric inflammatory bowel disease in the United Kingdom (UK). METHODS:Prospective UK audit of patients newly starting anti-TNF therapy. Disease severity was assessed using Physician Global Assessment +/or the Paediatric Crohn ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2018, 66(2):274-280]

Cited: 2 times

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Safety and efficacy of parenteral iron in children with inflammatory bowel disease.

Michael Papadopoulos, Deepa Patel, Roxanna Korologou-Linden, Eunice Goto, Krishna Soondrum, John M E Fell, Jenny Epstein,

AIMS:Iron deficiency anaemia frequently complicates inflammatory bowel disease (IBD) in children and adults. Oral iron may exacerbate gastrointestinal symptoms and absorption may be insufficient in intestinal inflammation. Even where oral iron is successful, repletion of iron stores can be unacceptably slow. Intravenous iron compounds were in the past associated with ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2018, 84(4):694-699]

Cited: 2 times

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Oral Iron Treatment Response and Predictors in Anaemic Adolescents and Adults with IBD: A Prospective Controlled Open-Label Trial.

David S Rampton, James R Goodhand, Neerav M Joshi, Abu-Bakarr Karim, Yasmine Koodun, Farah M Barakat, Lucia Macken, Douglas G Ward, Tariq H Iqbal, Jenny Epstein, John M Fell, Ian R Sanderson,

Because of previous concerns about the efficacy and safety of oral iron for treating iron deficiency anaemia in inflammatory bowel disease [IBD], particularly in young people, we compared the effects of ferrous sulphate on haemoglobin response, disease activity and psychometric scores in adolescents and adults with IBD. We also assessed ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2017, 11(6):706-715]

Cited: 6 times

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Surgical Management of Crohn Disease in Children: Guidelines From the Paediatric IBD Porto Group of ESPGHAN.

Jorge Amil-Dias, Sanja Kolacek, Dan Turner, Anders Pærregaard, Risto Rintala, Nadeem A Afzal, Katarzyna Karolewska-Bochenek, Jiri Bronsky, Sonny Chong, John Fell, Iva Hojsak, Jean-Pierre Hugot, Sibylle Koletzko, Devinder Kumar, Izabella Lazowska-Przeorek, Craig Lillehei, Paolo Lionetti, Javier Martin-de-Carpi, Mikko Pakarinen, Frank M Ruemmele, Ron Shaoul, Christine Spray, Annamaria Staiano, Ian Sugarman, David C Wilson, Harland Winter, Kaija-Leena Kolho, ,

The incidence of Crohn disease (CD) has been increasing and surgery needs to be contemplated in a substantial number of cases. The relevant advent of biological treatment has changed but not eliminated the need for surgery in many patients. Despite previous publications on the indications for surgery in CD, there ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2017, 64(5):818-835]

Cited: 5 times

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Infliximab Is Not Associated With Increased Risk of Malignancy or Hemophagocytic Lymphohistiocytosis in Pediatric Patients With Inflammatory Bowel Disease.

Jeffrey S Hyams, Marla C Dubinsky, Robert N Baldassano, Richard B Colletti, Salvatore Cucchiara, Johanna Escher, William Faubion, John Fell, Benjamin D Gold, Anne Griffiths, Sibylle Koletzko, Subra Kugathasan, James Markowitz, Frank M Ruemmele, Gigi Veereman, Harland Winter, Nicholas Masel, Chu Ri Shin, Kezhen L Tang, Meena Thayu,

Immunosuppressive therapy for inflammatory bowel disease (IBD) in pediatric patients is thought to increase the risk of malignancy and lymphoproliferative disorders, including hemophagocytic lymphohistiocytosis (HLH). We compared unadjusted incidence rates of malignancy and HLH in pediatric patients with IBD exposed to infliximab (IFX) with patients not exposed to biologics and ... Read more >>

Gastroenterology (Gastroenterology)
[2017, 152(8):1901-1914.e3]

Cited: 39 times

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Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test.

Eleanor Minshall, Harsita Patel, Nicholas Francis, Trevor T Hansel, John O Warner, Robert J Boyle, John Fell, Jenny Epstein,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(1):100-102]

Cited: 0 times

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Treatment Options and Outcomes of Pediatric IBDU Compared with Other IBD Subtypes: A Retrospective Multicenter Study from the IBD Porto Group of ESPGHAN.

Marina Aloi, Liron Birimberg-Schwartz, Stephan Buderus, Iva Hojsak, John M Fell, Jiri Bronsky, Gigi Veereman, Sibylle Koletzko, Ron Shaoul, Erasmo Miele, Dan Turner, Richard K Russell,

Inflammatory bowel disease unclassified (IBDU) is the rarest IBD subtype with treatment based on extrapolation from ulcerative colitis (UC) and Crohn's disease (CD) studies. We compared IBDU treatment choices with other colonic IBDs and explored long-term outcomes.This was a multicenter retrospective longitudinal study of 23 centers of pediatric IBD with ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2016, 22(6):1378-1383]

Cited: 4 times

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Age-related alterations in blood and colonic dendritic cell properties.

Rakesh Vora, David Bernardo, Lydia Durant, Durga Reddi, Ailsa L Hart, John M E Fell, Hafid O Al-Hassi, Stella C Knight,

Dendritic cells (DC) determine initiation, type and location of immune responses and, in adults, show decreased Toll-like receptors and some increased cytokine levels on ageing. Few studies in children have characterised DC or explored DC-related mechanisms producing age-related immune changes.The pDC marker BDCA2 (but not CD123) was absent in pre-pubertal ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(11):11913-11922]

Cited: 1 time

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Management of ulcerative colitis.

John M Fell, Rafeeq Muhammed, Chris Spray, Kay Crook, Richard K Russell, ,

Ulcerative colitis (UC) in children is increasing. The range of treatments available has also increased too but around 1 in 4 children still require surgery to control their disease. An up-to-date understanding of treatments is essential for all clinicians involved in the care of UC patients to ensure appropriate and ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2016, 101(5):469-474]

Cited: 6 times

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Management of Crohn's disease.

Jochen Kammermeier, Mary-Anne Morris, Vikki Garrick, Mark Furman, Astor Rodrigues, Richard K Russell, ,

Crohn's disease (CD) is rapidly increasing in children so an up to date knowledge of diagnosis, investigation and management is essential. Exclusive enteral nutrition is the first line treatment for active disease. The vast majority of children will need immunosuppressant treatment and around 20% will need treatment with biologics. Recent ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2016, 101(5):475-480]

Cited: 8 times

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Disease phenotype at diagnosis in pediatric Crohn's disease: 5-year analyses of the EUROKIDS Registry.

Charlotte I de Bie, Anders Paerregaard, Sanja Kolacek, Frank M Ruemmele, Sibylle Koletzko, John M E Fell, Johanna C Escher, ,

It has been speculated that pediatric Crohn's disease (CD) is a distinct disease entity, with probably different disease subtypes. We therefore aimed to accurately phenotype newly diagnosed pediatric CD by using the pediatric modification of the Montreal classification, the Paris classification.Information was collected from the EUROKIDS registry, a prospective, web-based ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2013, 19(2):378-385]

Cited: 71 times

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Evolution of in vitro cow's milk protein-specific inflammatory and regulatory cytokine responses in preterm infants with necrotising enterocolitis.

Adel E Abdelhamid, Shu-Ling Chuang, Peter Hayes, John M E Fell,

BACKGROUND: We have previously reported evidence of in vitro sensitisation to cow's milk protein in peripheral blood mononuclear cells (PBMCs) in preterm infants with necrotising enterocolitis (NEC). In the present study, we document the changes in the PBMC responses to stimulation with mitogen (phytohaemagglutinin) and cow's milk proteins β-lactoglobulin (β-lg) ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2013, 56(1):5-11]

Cited: 8 times

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Risk of infection and prevention in pediatric patients with IBD: ESPGHAN IBD Porto Group commentary.

Gigi Veereman-Wauters, Lissy de Ridder, Gábor Veres, Sanja Kolacek, John Fell, Petter Malmborg, Sibylle Koletzko, Jorge Amil Dias, Zrinjka Misak, Jean-François Rahier, Johanna C Escher, ,

Combined immunosuppression by immunomodulators and biological therapy has become standard in the medical management of moderate-to-severe inflammatory bowel disease (IBD) because of clearly demonstrated efficacy. Clinical studies, registries, and case reports warn of the increased risk of infections, particularly opportunistic infections; however, already in the steroid monotherapy era, patients are ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2012, 54(6):830-837]

Cited: 27 times

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Microvillus inclusion disease: antenatal ultrasound and phenotypic severity.

Rakesh Vora, John Fell,

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2012, 55(3):237]

Cited: 0 times

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Surgery in children with Crohn disease refractory to medical therapy.

Maurizio Pacilli, Simon Eaton, John M Fell, David Rawat, Simon Clarke, Munther J Haddad,

OBJECTIVE: The aim of this study was to evaluate the results of surgery in children with Crohn disease (CD) not responding to medical therapy and establish whether surgery improves growth and nutrition. PATIENTS AND METHODS: Children with CD diagnosed between 1998 and 2008 were reviewed. Relapse was defined by Harvey-Bradshaw ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2011, 52(3):286-290]

Cited: 14 times

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In vitro cow's milk protein-specific inflammatory and regulatory cytokine responses in preterm infants with necrotizing enterocolitis and sepsis.

Adel E Abdelhamid, Shu-Ling Chuang, Peter Hayes, John M E Fell,

Enteral feeding with cow's milk formula is associated with neonatal necrotizing enterocolitis (NEC) and sepsis. Dietary antigen sensitization may play a role in promoting and/or sustaining inflammation in both conditions. Aiming at investigating cow's milk protein (CMP)-specific cytokine responses in preterm infants with NEC and sepsis, 14 babies with NEC, ... Read more >>

Pediatr. Res. (Pediatric research)
[2011, 69(2):165-169]

Cited: 18 times

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A randomized, double-blind, controlled trial of the effect of prebiotic oligosaccharides on enteral tolerance in preterm infants (ISRCTN77444690).

Neena Modi, Sabita Uthaya, John Fell, Elena Kulinskaya,

Breast milk prebiotic oligosaccharides are believed to promote enteral tolerance. Many mothers delivering preterm are unable to provide sufficient milk. We conducted a multicenter, randomized, controlled trial comparing preterm formula containing 0.8 g/100 mL short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides in a 9:1 ratio and an otherwise identical formula, using formula only to ... Read more >>

Pediatr. Res. (Pediatric research)
[2010, 68(5):440-445]

Cited: 20 times

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Health-related quality of life in children with achalasia.

Matko Marlais, Julia R Fishman, John Me Fell, David J Rawat, Munther J Haddad,

AIMS: To assess self-reported QoL in children with achalasia aged 5-18 and compare this with both disease and healthy control children in a prospective study. METHODS: All children diagnosed with achalasia at one hospital were asked to participate in this study by completing the self-report module of the validated PedsQL™ ... Read more >>

J Paediatr Child Health (Journal of paediatrics and child health)
[2011, 47(1-2):18-21]

Cited: 7 times

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Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification.

Arie Levine, Anne Griffiths, James Markowitz, David C Wilson, Dan Turner, Richard K Russell, John Fell, Frank M Ruemmele, Thomas Walters, Mary Sherlock, Marla Dubinsky, Jeffrey S Hyams,

Crohn's disease and ulcerative colitis are complex disorders with some shared and many unique predisposing genes. Accurate phenotype classification is essential in determining the utility of genotype-phenotype correlation. The Montreal Classification of IBD has several weaknesses with respect to classification of children. The dynamic features of pediatric disease phenotype (change ... Read more >>

Inflamm. Bowel Dis. (Inflammatory bowel diseases)
[2011, 17(6):1314-1321]

Cited: 482 times

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Guidelines for the management of inflammatory bowel disease in children in the United Kingdom.

Bhupinder K Sandhu, John M E Fell, R Mark Beattie, Sally G Mitton, David C Wilson, Huw Jenkins, ,

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2010, 50 Suppl 1:S1-13]

Cited: 54 times

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