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Author John F Ward

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Long-Term Outcomes of Whole Gland Salvage Cryotherapy for Locally Recurrent Prostate Cancer following Radiation Therapy: A Combined Analysis of Two Centers.

Joseph L Chin, Arnon Lavi, Michael J Metcalfe, Khuram Siddiqui, Malcolm Dewar, Firas G Petros, Roger Li, Graciela M Nogueras González, Xuemei Wang, Shiva M Nair, John F Ward, Louis Pisters,

<h4>Purpose</h4>Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose of this study is to determine long-term outcomes following salvage cryotherapy for RRPca.<h4>Materials and methods</h4>Patients undergoing salvage cryotherapy for biopsy-proven, ... Read more >>

J Urol (The Journal of urology)
[2021, 206(3):646-654]

Cited: 0 times

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Incidental 18F-Fluciclovine Uptake in a Desmoid Tumor Detected in a Patient Undergoing PET/CT Imaging for Prostate Cancer.

Ali Baiomy, Corey T Jensen, John F Ward, Beth A Chasen, Gregory C Ravizzini,

<h4>Abstract</h4>A 74-year-old man with biochemical recurrent prostate cancer underwent 18F-fluciclovine PET/CT for restaging to determine subsequent treatment strategy. 18F-fluciclovine PET/CT imaging demonstrated incidental focal heterogeneous increased 18F-fluciclovine uptake corresponding to a soft tissue nodule within the musculature of the left anterior abdominal wall. Subsequent ultrasound-guided biopsy of the lesion revealed ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(4):355-357]

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Accuracy of Prostate Magnetic Resonance Imaging: Reader Experience Matters.

Hyunseon C Kang, Nahyun Jo, Anas Saeed Bamashmos, Mona Ahmed, Jia Sun, John F Ward, Haesun Choi,

<h4>Background</h4>Prostate magnetic resonance imaging (MRI) is increasingly used in the detection, image-guided biopsy, and active surveillance of prostate cancer. The accuracy of prostate MRI may differ based on factors including imaging technique, patient population, and reader experience.<h4>Objective</h4>To determine whether the accuracy of prostate MRI varies with reader experience.<h4>Design setting and ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, 27:53-60]

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Utilization of focal therapy for patients discontinuing active surveillance of prostate cancer: Recommendations of an international Delphi consensus.

Wei Phin Tan, Ardeshir R Rastinehad, Laurence Klotz, Peter R Carroll, Mark Emberton, John F Feller, Arvin K George, Inderbir S Gill, Rajan T Gupta, Aaron E Katz, Amir H Lebastchi, Leonard S Marks, Giancarlo Marra, Peter A Pinto, Daniel Y Song, Abhinav Sidana, John F Ward, Rafael Sanchez-Salas, Jean de la Rosette, Thomas J Polascik, ,

<h4>Background</h4>With the advancement of imaging technology, focal therapy (FT) has been gaining acceptance for the treatment of select patients with localized prostate cancer (CaP). We aim to provide details of a formal physician consensus on the utilization of FT for patients with CaP who are discontinuing active surveillance (AS).<h4>Methods</h4>A 3-stage ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

Cited: 1 time

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Prospective trial of regional (hockey-stick) prostate cryoablation: oncologic and quality of life outcomes.

Justin R Gregg, Leonardo D Borregales, Haesun Choi, Marisa Lozano, Stephen E McRae, Aradhana M Venkatesan, John W Davis, Graciela M Nogueras-Gonzalez, Louis L Pisters, John F Ward,

<h4>Purpose</h4>To report long-term follow-up of the efficacy of subtotal prostate ablation using a "hockey-stick" template, including oncologic control and quality of life (QoL) impact.<h4>Methods</h4>We performed a prospective controlled trial to evaluate the efficacy of subtotal prostate ablation in selected men with baseline and confirmatory biopsy showing grade group (GG) 1-2 ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Temporal learning curve of a multidisciplinary team for magnetic resonance imaging/transrectal ultrasonography fusion prostate biopsy.

Ahmet Urkmez, John F Ward, Haesun Choi, Patricia Troncoso, Irene Inguillo, Justin R Gregg, Muammer Altok, Huseyin C Demirel, Wei Qiao, Hyunseon C Kang,

BJU Int (BJU international)
[2021, 127(5):524-527]

Cited: 1 time

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Origin of Subsequent Malignant Neoplasms in Patients with History of Testicular Germ Cell Tumor.

Eric C Umbreit, Bilal A Siddiqui, Michael J Hwang, Aron Y Joon, Tapati Maity, Mary E Westerman, Kelly W Merriman, Hussam Alhasson, Joma Uthup, Tao Guo, Joseph A Moore, John F Ward, Jose A Karam, Christopher G Wood, Louis L Pisters, Miao Zhang, Shi-Ming Tu,

Although genetic changes may be pivotal in the origin of cancer, cellular context is paramount. This is particularly relevant in a progenitor germ cell tumor and its differentiated mature teratoma counterpart when it concerns tumor heterogeneity and cancer dormancy in subsequent second malignancies (subsequent malignant neoplasms (SMNs)). From our tumor ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(12):]

Cited: 3 times

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Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort.

Justin R Gregg, Xiaotao Zhang, Brian F Chapin, John F Ward, Jeri Kim, John W Davis, Carrie R Daniel,

<h4>Background</h4>The Mediterranean diet (MD) may be beneficial for men with localized prostate cancer (PCa) on active surveillance (AS) because of its anti-inflammatory, antilipidemic, and chemopreventive properties. This study prospectively investigated adherence to the MD with Gleason score progression and explored associations by diabetes status, statin use, and other factors.<h4>Methods</h4>Men with ... Read more >>

Cancer (Cancer)
[2021, 127(5):720-728]

Cited: 2 times

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Making a case "for" focal therapy of the prostate in intermediate risk prostate cancer: current perspective and ongoing trials.

Alex Z Wang, Amir H Lebastchi, Luke P O'Connor, Michael Ahdoot, Sherif Mehralivand, Nitin Yerram, Samir S Taneja, Arvin K George, Rafael Sanchez-Salas, John F Ward, Pilar Laguna, Jean de la Rosette, Peter A Pinto,

Focal therapy is growing as an alternative management options for men with clinically localized prostate cancer. Parallel to the increasing popularity of active surveillance (AS) as a treatment for low-risk disease, there has been an increased interest towards providing focal therapy for patients with intermediate-risk disease. Focal therapy can act ... Read more >>

World J Urol (World journal of urology)
[2021, 39(3):729-739]

Cited: 1 time

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Intraoperative and early postoperative complications in postchemotherapy retroperitoneal lymphadenectomy among patients with germ cell tumors using validated grading classifications.

Eric C Umbreit, Andrew G McIntosh, Chalairat Suk-Ouichai, Luis A Segarra, Levi C Holland, Bryan M Fellman, Stephen B Williams, Arun Z Thomas, Shi-Ming Tu, Curtis A Pettaway, Louis L Pisters, John F Ward, Christopher G Wood, Jose A Karam,

<h4>Background</h4>Postchemotherapy retroperitoneal lymphadenectomy (PC-RPLND) is an essential, yet potentially morbid, therapy for the management of patients with advanced germ cell tumors. In the current study, the authors sought to define the complication profile of PC-RPLND using validated grading systems for intraoperative adverse events (iAEs) and early postoperative complications.<h4>Methods</h4>Between 2000 and ... Read more >>

Cancer (Cancer)
[2020, 126(22):4878-4885]

Cited: 1 time

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The Association of Periprostatic Fat and Grade Group Progression in Men with Localized Prostate Cancer on Active Surveillance.

Justin R Gregg, Devaki Shilpa Surasi, Alexandria Childs, Nicholas Moll, John F Ward, Jeri Kim, Carrie R Daniel, Christopher Logothetis, Tharakeswara Bathala, John W Davis,

<h4>Purpose</h4>Evidence suggests that visceral fat quantity may be associated with post-prostatectomy outcomes and risk of prostate cancer related death. We evaluated whether increased fat volume, normalized to prostate size, is associated with decreased risk of disease progression.<h4>Materials and methods</h4>Patients enrolled on a prospective active surveillance trial for at least 6 ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):122-128]

Cited: 1 time

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Comparing confirmatory biopsy outcomes between MRI-targeted biopsy and standard systematic biopsy among men being enrolled in prostate cancer active surveillance.

Daniel D Shapiro, Justin R Gregg, Amy H Lim, Graciela M Nogueras-González, Haesun Choi, Hyunseon C Kang, Irene A Inguillo, Brian F Chapin, John W Davis, John F Ward,

<h4>Objectives</h4>To evaluate the ability of magnetic resonance imaging (MRI)-targeted biopsy combined with systematic biopsy (MRI-biopsy) to reduce negative biopsies and detect clinically significant prostate cancer compared to systematic biopsy (SB) alone in the confirmatory biopsy setting using matched cohorts.<h4>Patients and methods</h4>Patients were identified from an active surveillance database who had ... Read more >>

BJU Int (BJU international)
[2021, 127(3):340-348]

Cited: 0 times

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Standardized Nomenclature and Surveillance Methodologies After Focal Therapy and Partial Gland Ablation for Localized Prostate Cancer: An International Multidisciplinary Consensus.

Amir H Lebastchi, Arvin K George, Thomas J Polascik, Jonathan Coleman, Jean de la Rosette, Baris Turkbey, Bradford J Wood, Michael A Gorin, Abhinav Sidana, Sangeet Ghai, Kae Jack Tay, John F Ward, Rafael Sanchez-Salas, Berrend G Muller, Bernard Malavaud, Pierre Mozer, Sebastien Crouzet, Peter L Choyke, Osamu Ukimura, Ardeshir R Rastinehad, Peter A Pinto,

<h4>Background</h4>Focal therapy (FT) and partial gland ablation (PGA) are quickly adopted by urologists and radiologists as an option for the management of localized prostate cancer.<h4>Objective</h4>To find consensus on a standardized nomenclature and to define a follow-up guideline after FT and PGA for localized prostate cancer in clinical practice.<h4>Design, setting, and ... Read more >>

Eur Urol (European urology)
[2020, 78(3):371-378]

Cited: 6 times

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Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel.

Antonio C Westphalen, Charles E McCulloch, Jordan M Anaokar, Sandeep Arora, Nimrod S Barashi, Jelle O Barentsz, Tharakeswara K Bathala, Leonardo K Bittencourt, Michael T Booker, Vaughn G Braxton, Peter R Carroll, David D Casalino, Silvia D Chang, Fergus V Coakley, Ravjot Dhatt, Steven C Eberhardt, Bryan R Foster, Adam T Froemming, Jurgen J Fütterer, Dhakshina M Ganeshan, Mark R Gertner, Lori Mankowski Gettle, Sangeet Ghai, Rajan T Gupta, Michael E Hahn, Roozbeh Houshyar, Candice Kim, Chan Kyo Kim, Chandana Lall, Daniel J A Margolis, Stephen E McRae, Aytekin Oto, Rosaleen B Parsons, Nayana U Patel, Peter A Pinto, Thomas J Polascik, Benjamin Spilseth, Juliana B Starcevich, Varaha S Tammisetti, Samir S Taneja, Baris Turkbey, Sadhna Verma, John F Ward, Christopher A Warlick, Andrew R Weinberger, Jinxing Yu, Ronald J Zagoria, Andrew B Rosenkrantz,

Background Prostate MRI is used widely in clinical care for guiding tissue sampling, active surveillance, and staging. The Prostate Imaging Reporting and Data System (PI-RADS) helps provide a standardized probabilistic approach for identifying clinically significant prostate cancer. Despite widespread use, the variability in performance of prostate MRI across practices remains ... Read more >>

Radiology (Radiology)
[2020, 296(1):76-84]

Cited: 14 times

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Determining Clinically Based Factors Associated With Reclassification in the Pre-MRI Era using a Large Prospective Active Surveillance Cohort.

Justin R Gregg, John W Davis, Chad Reichard, Xuemei Wang, Mary Achim, Brian F Chapin, Louis Pisters, Curtis Pettaway, John F Ward, Seungtaek Choi, Quynh-Nhu Nguyen, Deborah Kuban, Richard Babaian, Patricia Troncoso, Lydia T Madsen, Christopher Logothetis, Jeri Kim,

<h4>Objective</h4>To report biopsy-related and oncologic outcomes in a large prospective active surveillance cohort that was initiated in the premagnetic resonance imaging era and to additionally identify clinical factors associated with disease reclassification in order to inform future studies designed to improve enrollment and follow-up on active surveillance.<h4>Methods</h4>Patients were prospectively enrolled ... Read more >>

Urology (Urology)
[2020, 138:91-97]

Cited: 0 times

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Robotic Postchemotherapy Retroperitoneal Lymph Node Dissection for Testicular Cancer.

Roger Li, Jonathan J Duplisea, Firas G Petros, Graciela M Nogueras González, Shi-Ming Tu, Jose A Karam, Tam T Huynh, John F Ward,

<h4>Background</h4>Postchemotherapy retroperitoneal lymph node dissection (pcRPLND) is mandated in patients with nonseminomatous germ cell tumor found to have residual masses after chemotherapy. Performed via the open approach, pcRPLND can incur significant perioperative morbidity.<h4>Objective</h4>To demonstrate the feasibility of robotic pcRPLND (r-pcRPLND) and provide evidence for its selection criteria.<h4>Design, setting, and participants</h4>A ... Read more >>

Eur Urol Oncol (European urology oncology)
[2021, 4(4):651-658]

Cited: 5 times

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Detection and Treatment of Primary Prostatic Melanoma.

Roger Li, Miao Zhang, Jonathan J Duplisea, Patricia Troncoso, John F Ward,

<h4>Objective</h4>To describe a case of primary melanoma of the prostate gland, then review the published literature of similar cases.<h4>Methods</h4>Presentation of the clinical course of a 42-year-old man diagnosed with primary melanoma of the prostate after presenting with gross hematuria. Review of published literature.<h4>Results</h4>Primary melanoma of the genitourinary tract is a ... Read more >>

Urology (Urology)
[2019, 123:16-19]

Cited: 1 time

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Cost and efficacy comparison of five prostate biopsy modalities: a platform for integrating cost into novel-platform comparative research.

Muammer Altok, Bumyang Kim, Bina B Patel, Ya-Chen Tina Shih, John F Ward, Stephen E McRae, Brian F Chapin, Louis L Pisters, Curtis A Pettaway, Jeri Kim, Huseyin C Demirel, John W Davis,

<h4>Background</h4>The cornerstone of prostate cancer diagnosis remains the transrectal ultrasound-guided biopsy (TRUS-BX), which most frequently occurs in the office setting under local anesthesia. However, there are now other techniques of prostate biopsy aimed at improving outcomes such as patient comfort, significant cancer detection, and infectious complications. The purpose of the ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2018, 21(4):524-532]

Cited: 8 times

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Radical Prostatectomy in Metastatic Castration-resistant Prostate Cancer: Feasibility, Safety, and Quality of Life Outcomes.

Chad A Reichard, Justin R Gregg, Mary F Achim, Ana M Aparicio, Curtis A Pettaway, Louis L Pisters, John F Ward, John W Davis, Brian F Chapin,

Ongoing prospective studies are evaluating treatment of the primary tumor in men with de novo metastatic prostate cancer (PCa). One potential benefit is prevention of morbidity from local progression. Thus, local therapy may be best applied selectively to men with local progression once resistance to first-line therapies has occurred. Here, ... Read more >>

Eur Urol (European urology)
[2018, 74(2):140-143]

Cited: 3 times

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Quality of life after brachytherapy or bilateral nerve-sparing robot-assisted radical prostatectomy for prostate cancer: a prospective cohort.

Pierre Blanchard, John W Davis, Steven J Frank, Jeri Kim, Curtis A Pettaway, Thomas J Pugh, Louis L Pisters, John F Ward, Seungtaek Choi, Brian F Chapin, Karen Hoffman, Neema Navai, Mary Achim, Sean E McGuire, Surena F Matin, Quynh Nguyen, Usama Mahmood, William J Graber, Hsiang-Chun Chen, Xuemei Wang, Deborah A Kuban,

<h4>Objective</h4>To provide comparative data on quality of life (QoL) after prostate cancer treatment to help patients make an informed decision regarding their choice of treatment.<h4>Methods</h4>Patients with pathologically proven, non-metastatic, T1-T3bN0 prostate cancer were included in this prospective non-randomized study if they were to receive treatment with curative intent. Sample size ... Read more >>

BJU Int (BJU international)
[2018, 121(4):540-548]

Cited: 4 times

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Characterization of Glomus Tumors of the Kidney.

Roger Li, Firas G Petros, Charles J Davis, John F Ward,

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2017, :]

Cited: 0 times

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Baseline and longitudinal plasma caveolin-1 level as a biomarker in active surveillance for early-stage prostate cancer.

Spyridon P Basourakos, John W Davis, Brian F Chapin, John F Ward, Curtis A Pettaway, Louis L Pisters, Neema Navai, Mary F Achim, Xuemei Wang, Hsiang-Chun Chen, Seungtaek Choi, Deborah Kuban, Patricia Troncoso, Sam Hanash, Timothy C Thompson, Jeri Kim,

<h4>Objectives</h4>To evaluate the role of caveolin-1 (Cav-1) as a predictor of disease reclassification (DR) in men with early prostate cancer undergoing active surveillance (AS).<h4>Patients and methods</h4>We analysed archived plasma samples prospectively collected from patients with early prostate cancer in a single-institution AS study. Of 825 patients enrolled, 542 had ≥1 ... Read more >>

BJU Int (BJU international)
[2018, 121(1):69-76]

Cited: 5 times

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Salvage prostatectomy for post-radiation adenocarcinoma with treatment effect: Pathological and oncological outcomes.

Michael J Metcalfe, Patricia Troncoso, Charles C Guo, Hsiang-Chun Chen, Yasar Bozkurt, John F Ward, Louis L Pisters,

<h4>Introduction</h4>Prostate biopsies following localized radiation therapy for prostate cancer often demonstrate residual prostatic carcinoma with treatment effect (CTE). The final oncological outcome of prostatic CTE is currently uncertain. We studied the pathological and oncological outcomes for a large cohort of patients who had CTE on post-radiation therapy biopsy and subsequently ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2017, 11(7):E277-E284]

Cited: 2 times

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Salvage high-intensity focused ultrasound (HIFU) for locally recurrent prostate cancer after failed radiation therapy: Multi-institutional analysis of 418 patients.

Sebastien Crouzet, Andreas Blana, Francois J Murat, Gilles Pasticier, Stephen C W Brown, Giario N Conti, Roman Ganzer, Olivier Chapet, Albert Gelet, Christian G Chaussy, Cary N Robertson, Stefan Thuroff, John F Ward,

<h4>Objective</h4>To report the oncological outcome of salvage high-intensity focused ultrasound (S-HIFU) for locally recurrent prostate cancer after external beam radiotherapy (EBRT) from a multicentre database.<h4>Patients and methods</h4>This retrospective study comprises patients from nine centres with local recurrent disease after EBRT treated with S-HIFU from 1995 to 2009. The biochemical failure-free ... Read more >>

BJU Int (BJU international)
[2017, 119(6):896-904]

Cited: 13 times

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VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer.

Jianjun Gao, John F Ward, Curtis A Pettaway, Lewis Z Shi, Sumit K Subudhi, Luis M Vence, Hao Zhao, Jianfeng Chen, Hong Chen, Eleni Efstathiou, Patricia Troncoso, James P Allison, Christopher J Logothetis, Ignacio I Wistuba, Manuel A Sepulveda, Jingjing Sun, Jennifer Wargo, Jorge Blando, Padmanee Sharma,

To date, anti-CTLA-4 (ipilimumab) or anti-PD-1 (nivolumab) monotherapy has not been demonstrated to be of substantial clinical benefit in patients with prostate cancer. To identify additional immune-inhibitory pathways in the prostate-tumor microenvironment, we evaluated untreated and ipilimumab-treated tumors from patients in a presurgical clinical trial. Levels of the PD-L1 and ... Read more >>

Nat Med (Nature medicine)
[2017, 23(5):551-555]

Cited: 152 times

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