Full Text Journal Articles by
Author John F Thompson

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The role of regional chemotherapy for advanced limb melanoma in the era of potentially effective systemic therapies.

Rebecca L Read, John F Thompson,

To review the current role of regional chemotherapy in the management of advanced limb melanoma. Articles reporting the results of isolated limb infusion (ILI) were identified by performing a comprehensive literature search using the PubMed database. Keywords included isolated limb infusion, in-transit melanoma and melphalan. No publication date restrictions were ... Read more >>

Melanoma Res (Melanoma research)
[2021, 31(4):290-297]

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Contemporary management of locoregionally advanced melanoma in Australia and New Zealand and the role of adjuvant systemic therapy.

B Mark Smithers, Robyn P M Saw, David E Gyorki, Richard C W Martin, Victoria Atkinson, Andrew Haydon, Rachel Roberts-Thomson, John F Thompson,

Australia and New Zealand have the highest incidence and mortality rates for melanoma in the world. Local surgery is still the standard treatment of primary cutaneous melanoma, and it is therefore important that surgeons understand the optimal care pathways for patients with melanoma. Accurate staging is critical to ensure a ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, 91 Suppl 2:3-13]

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Histological regression in melanoma: impact on sentinel lymph node status and survival.

Karina Aivazian, Tasnia Ahmed, Mary-Ann El Sharouni, Jonathan R Stretch, Robyn P M Saw, Andrew J Spillane, Kerwin F Shannon, Sydney Ch'ng, Omgo E Nieweg, John F Thompson, Serigne N Lo, Richard A Scolyer,

Regression in melanoma is an immunological phenomenon that results in partial or complete replacement of the tumor with variably vascular fibrous tissue, often accompanied by pigment-laden macrophages and chronic inflammation. In some cases, tumor-infiltrating lymphocytes (TILs) may represent the earliest phase of this process. The prognostic significance of regression has ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Response to the Comment on "Preoperative Ultrasound Assessment of Regional Lymph Nodes in Melanoma Patients Does Not Provide Reliable Staging: Results From a Large Multicenter Trial".

John F Thompson, Roger F Uren, Omgo E Nieweg, Mark B Faries,

Ann Surg (Annals of surgery)
[2021, 274(1):e104-e105]

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Characterizing the Clinical Implications of Histologic Regression in Melanoma Requires Clear Diagnostic Criteria That Are Consistently Applied-Reply.

Richard A Scolyer, Mary-Ann El Sharouni, John F Thompson,

JAMA Dermatol (JAMA dermatology)
[2021, :]

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Clinical and Molecular Heterogeneity in Patients with Innate Resistance to Anti-PD-1 +/- Anti-CTLA-4 Immunotherapy in Metastatic Melanoma Reveals Distinct Therapeutic Targets.

Tuba N Gide, Inês Pires da Silva, Camelia Quek, Peter M Ferguson, Marcel Batten, Ping Shang, Tasnia Ahmed, Alexander M Menzies, Matteo S Carlino, Robyn P M Saw, John F Thompson, Richard A Scolyer, Georgina V Long, James S Wilmott,

While immune checkpoint inhibitors targeting the CTLA-4 and PD-1 receptors have significantly improved outcomes of many patients with metastatic melanoma, there remains a group of patients who demonstrate no benefit. In this study, we sought to characterise patients who do not respond to anti-PD-1-based therapies based on their clinical, genetic ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies.

Sydney Ch'ng, Semra Uyulmaz, Matteo S Carlino, Thomas E Pennington, Kerwin F Shannon, Michael Rtshiladze, Jonathan R Stretch, Omgo E Nieweg, Alexander H R Varey, Edward Hsiao, Rony Kapoor, Ines Pires da Silva, Serigne N Lo, Andrew J Spillane, Richard A Scolyer, Georgina V Long, Angela M Hong, Robyn P M Saw, John F Thompson, Alexander M Menzies,

Although previously the mainstay of treatment, the role of surgery in the management of patients with oligometastatic stage IV melanoma has changed with the advent of effective systemic therapies (most notably immunotherapy). Contemporary treatment options for patients with asymptomatic solitary or oligo-metastases include upfront surgery followed by adjuvant immunotherapy or ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 153:8-15]

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Current Challenges in Access to Melanoma Care: A Multidisciplinary Perspective.

Nikhil I Khushalani, Thach-Giao Truong, John F Thompson,

A diagnosis of melanoma requires multidisciplinary specialized care across all stages of disease. Although many important advances have been made for the treatment of melanoma for local and advanced disease, barriers to optimal care remain for many patients who live in areas without ready access to the expertise of a ... Read more >>

Am Soc Clin Oncol Educ Book (American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting)
[2021, 41:e295-e303]

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Treatment of in-transit melanoma metastases using intralesional PV-10.

John F Thompson, Robyn P M Saw, Johanna M Dalton, Jonathan R Stretch, Andrew J Spillane, Natalie S Osborne, Gabrielle J Williams, Serigne N Lo,

Melanoma in-transit metastases (ITMs) can sometimes be difficult to manage by surgical excision due to their number, size or location. Treatment by intralesional injection of PV-10, a 10% solution of rose bengal, has been reported to be a simple, safe and effective alternative, but more outcome data are required to ... Read more >>

Melanoma Res (Melanoma research)
[2021, 31(3):232-241]

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Melanoma In Situ: A Critical Review and Re-Evaluation of Current Excision Margin Recommendations.

Erica B Friedman, Richard A Scolyer, Gabrielle J Williams, John F Thompson,

Most international clinical guidelines recommend 5-10 mm clinical margins for excision of melanoma in situ (MIS). While the evidence supporting this is weak, these guidelines are generally consistent. However, as a result of the high incidence of subclinical extension of MIS, especially of the lentigo maligna (LM) subtype, wider margins will ... Read more >>

Adv Ther (Advances in therapy)
[2021, 38(7):3506-3530]

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Melanoma with osseous or chondroid differentiation: a report of eight cases including SATB2 expression and mutation analysis.

Stuart J Gallagher, Teresa Bailey, Robert V Rawson, Annabelle M Mahar, John F Thompson, Georgina V Long, James S Wilmott, Richard A Scolyer,

Melanoma can present with osteocartilaginous differentiation, however few reports exist on this rare subtype. We present eight cases of melanoma with osteocartilaginous differentiation to highlight its clinical, pathological and molecular features. The cases showed no association with gender (5 males and 3 females) or age (range 23-84 years). Cases included ... Read more >>

Pathology (Pathology)
[2021, :]

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Can patient-led surveillance detect subsequent new primary or recurrent melanomas and reduce the need for routinely scheduled follow-up? A protocol for the MEL-SELF randomised controlled trial.

Deonna M Ackermann, Amelia K Smit, Monika Janda, Cathelijne H van Kemenade, Mbathio Dieng, Rachael L Morton, Robin M Turner, Anne E Cust, Les Irwig, Jolyn K Hersch, Pascale Guitera, H Peter Soyer, Victoria Mar, Robyn P M Saw, Donald Low, Cynthia Low, Dorothy Drabarek, David Espinoza, Jon Emery, Peter Murchie, John F Thompson, Richard A Scolyer, Anthony Azzi, Alister Lilleyman, Katy J L Bell,

<h4>Background</h4>Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). Routinely scheduled clinic visits (clinician-led surveillance) is resource-intensive and has not been shown to improve health outcomes; fewer visits may be possible ... Read more >>

Trials (Trials)
[2021, 22(1):324]

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Reply to: CT and PET/CT Surveillance in Stage IIIA-D Melanoma Results in More False-Positive Than True-Positive Findings and Should Not be Routinely Recommended, by Nicholas Taylor et al.

Mbathio Dieng, Sarah J Lord, Omgo E Nieweg, Robyn P M Saw, Andrew J Einstein, Amanda A G Nijhuis, Robin M Turner, John F Thompson, Rachael L Morton,

Ann Surg Oncol (Annals of surgical oncology)
[2021, :]

Cited: 1 time

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Organ transplantation and outcomes in patients with a past history of melanoma: A systematic review and meta-analysis.

Gabrielle Jean Williams, Angela C Webster, John F Thompson,

<h4>Background</h4>The incidence of melanoma is steadily rising around the world. There is uncertainty about the safety of solid organ transplantation in patients with a prior history of melanoma.<h4>Aim</h4>To review studies reporting patients with a history of melanoma before solid organ transplantation.<h4>Methods</h4>Electronic searches of Medline, Embase, and the Cochrane library up ... Read more >>

Clin Transplant (Clinical transplantation)
[2021, 35(6):e14287]

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Preoperative Ultrasound Assessment of Regional Lymph Nodes in Melanoma Patients Does not Provide Reliable Nodal Staging: Results From a Large Multicenter Trial.

John F Thompson, Lauren E Haydu, Roger F Uren, Robert H Andtbacka, Jonathan S Zager, Peter D Beitsch, Doreen M Agnese, Nicola Mozzillo, Alessandro Testori, Tawnya L Bowles, Harald J Hoekstra, Mark C Kelley, Jeffrey Sussman, Schlomo Schneebaum, B Mark Smithers, Gregory McKinnon, Eddy Hsueh, Lisa Jacobs, Erwin Schultz, Douglas Reintgen, John M Kane, Erica B Friedman, Hejing Wang, Lisa Van Kreuningen, Vicki Schiller, David A Elashoff, Robert Elashoff, Alistair J Cochran, Stacey Stern, Mark B Faries, ,

<h4>Objective</h4>To assess whether preoperative ultrasound (US) assessment of regional lymph nodes in patients who present with primary cutaneous melanoma provides accurate staging.<h4>Background</h4>It has been suggested that preoperative US could avoid the need for sentinel node (SN) biopsy, but in most single-institution reports, the sensitivity of preoperative US has been low.<h4>Methods</h4>Preoperative ... Read more >>

Ann Surg (Annals of surgery)
[2021, 273(4):814-820]

Cited: 1 time

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Active surveillance of patients who have sentinel node positive melanoma: An international, multi-institution evaluation of adoption and early outcomes after the Multicenter Selective Lymphadenectomy Trial II (MSLT-2).

Kristy Kummerow Broman, Tasha Hughes, Lesly Dossett, James Sun, Dennis Kirichenko, Michael J Carr, Avinash Sharma, Edmund K Bartlett, Amanda A G Nijhuis, John F Thompson, Tina J Hieken, Lisa Kottschade, Jennifer Downs, David E Gyorki, Emma Stahlie, Alexander van Akkooi, David W Ollila, Jill Frank, Yun Song, Giorgos Karakousis, Marc Moncrieff, Jenny Nobes, John Vetto, Dale Han, Jeffrey M Farma, Jeremiah L Deneve, Martin D Fleming, Matthew C Perez, Michael C Lowe, Roger Olofsson Bagge, Jan Mattsson, Ann Y Lee, Russell S Berman, Harvey Chai, Hidde M Kroon, Juri Teras, Roland M Teras, Norma E Farrow, Georgia Beasley, Jane Yuet Ching Hui, Lukas Been, Schelto Kruijff, Youngchul Kim, Syeda Mahrukh Hussnain Naqvi, Amod A Sarnaik, Vernon K Sondak, Jonathan S Zager,

<h4>Background</h4>For patients with sentinel lymph node (SLN)-positive cutaneous melanoma, the Second Multicenter Selective Lymphadenectomy trial demonstrated equivalent disease-specific survival (DSS) with active surveillance using nodal ultrasound versus completion lymph node dissection (CLND). Adoption and outcomes of active surveillance in clinical practice and in adjuvant therapy recipients are unknown.<h4>Methods</h4>In a retrospective ... Read more >>

Cancer (Cancer)
[2021, 127(13):2251-2261]

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The worse survival outcomes reported for melanoma patients having sentinel node biopsy after lymphoscintigraphy the previous day do not appear to be due to overnight migration of Tc99m-nanocolloid tracer.

Annette H Chakera, Else la Cour Sibbesen, Mette Schoedt, Lisbet R Hölmich, Bo Zerahn, John F Thompson,

<h4>Introduction</h4>It has been reported that the survival of patients having sentinel node (SN) biopsy for melanoma the day after lymphoscintigraphy using Tc99m-nanocolloid is worse than that of patients having lymphoscintigraphy and SN biopsy on the same day [1,2]. A possible explanation suggested is that overnight migration of the tracer from ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2021, :]

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Tumour gene expression signature in primary melanoma predicts long-term outcomes.

Manik Garg, Dominique-Laurent Couturier, Jérémie Nsengimana, Nuno A Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Göran B Jönsson, Julia Newton-Bishop, Christine Parkinson, Mark R Middleton, D Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A Vergara, Serigne Lo, Felicity Newell, James S Wilmott, John F Thompson, Georgina V Long, Richard A Scolyer, Pippa Corrie, David J Adams, Alvis Brazma, Roy Rabbie,

Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1137]

Cited: 1 time

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Development and Validation of Nomograms to Predict Local, Regional, and Distant Recurrence in Patients With Thin (T1) Melanomas.

Mary-Ann El Sharouni, Tasnia Ahmed, Alexander H R Varey, Sjoerd G Elias, Arjen J Witkamp, Vigfús Sigurdsson, Karijn P M Suijkerbuijk, Paul J van Diest, Richard A Scolyer, Carla H van Gils, John F Thompson, Willeke A M Blokx, Serigne N Lo,

<h4>Purpose</h4>Although the prognosis of patients with thin primary cutaneous melanomas (T1, ≤ 1.0 mm) is generally excellent, some develop recurrence. We sought to develop and validate a model predicting recurrences in patients with thin melanomas.<h4>Methods</h4>A Dutch population-based cohort (n = 25,930, development set) and a cohort from an Australian melanoma ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(11):1243-1252]

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Association of Histologic Regression With a Favorable Outcome in Patients With Stage 1 and Stage 2 Cutaneous Melanoma.

Mary-Ann El Sharouni, Karina Aivazian, Arjen J Witkamp, Vigfús Sigurdsson, Carla H van Gils, Richard A Scolyer, John F Thompson, Paul J van Diest, Serigne N Lo,

<h4>Importance</h4>Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis.<h4>Objective</h4>To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma.<h4>Design, setting, and participants</h4>This cohort study analyzed data from 2 large cohorts of adults (one ... Read more >>

JAMA Dermatol (JAMA dermatology)
[2021, 157(2):166-173]

Cited: 1 time

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Germline variants are associated with increased primary melanoma tumor thickness at diagnosis.

Ernest Mangantig, Stuart MacGregor, Mark M Iles, Richard A Scolyer, Anne E Cust, Nicholas K Hayward, Grant W Montgomery, David L Duffy, John F Thompson, Anjali Henders, Lisa Bowdler, Casey Rowe, Gemma Cadby, Graham J Mann, David C Whiteman, Georgina V Long, Sarah V Ward, Kiarash Khosrotehrani, Jennifer H Barrett, Matthew H Law,

Germline genetic variants have been identified, which predispose individuals and families to develop melanoma. Tumor thickness is the strongest predictor of outcome for clinically localized primary melanoma patients. We sought to determine whether there is a heritable genetic contribution to variation in tumor thickness. If confirmed, this will justify the ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2021, 29(21):3578-3587]

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Performance of Long-Term CT and PET/CT Surveillance for Detection of Distant Recurrence in Patients with Resected Stage IIIA-D Melanoma.

Robin M Turner, Mbathio Dieng, Nikita Khanna, Mai Nguyen, Jiaxu Zeng, Amanda A G Nijhuis, Omgo E Nieweg, Andrew J Einstein, Louise Emmett, Sarah J Lord, Alexander M Menzies, John F Thompson, Robyn P M Saw, Rachael L Morton,

<h4>Background</h4>Follow-up for patients with resected stage IIIA-D melanoma may include computed tomography (CT) or positron emission tomography (PET)/CT imaging to identify distant metastases. The aim of this study was to evaluate the test performance over follow-up time, of structured 6- and 12-monthly follow-up imaging schedules in these patients.<h4>Methods</h4>We conducted a ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2021, 28(8):4561-4569]

Cited: 2 times

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Safety Findings in Pediatric Patients During Long-Term Treatment With Teduglutide for Short-Bowel Syndrome-Associated Intestinal Failure: Pooled Analysis of 4 Clinical Studies.

Susan Hill, Beth A Carter, Valeria Cohran, Simon Horslen, Stuart S Kaufman, Samuel A Kocoshis, David F Mercer, Russell J Merritt, Mikko P Pakarinen, Susan Protheroe, John F Thompson, Charles P B Vanderpool, Robert S Venick, Paul W Wales, Sharon E Smith, MinJung Yoon, Andrew A Grimm,

<h4>Background</h4>This analysis assessed combined safety data from 4 clinical studies of teduglutide in pediatric patients with short-bowel syndrome-associated intestinal failure (SBS-IF).<h4>Methods</h4>Safety data from teduglutide-treated patients in 4 clinical trials were pooled. The completed 12-week and 24-week phase 3 core studies (NCT01952080/EudraCT 2013-004588-30 and NCT02682381/EudraCT 2015-002252-27) enrolled children aged 1-17 years ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2020, :]

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Surveillance of Sentinel Node-Positive Melanoma Patients with Reasons for Exclusion from MSLT-II: Multi-Institutional Propensity Score Matched Analysis.

Kristy K Broman, Tasha M Hughes, Lesly A Dossett, James Sun, Michael J Carr, Dennis A Kirichenko, Avinash Sharma, Edmund K Bartlett, Amanda Ag Nijhuis, John F Thompson, Tina J Hieken, Lisa Kottschade, Jennifer Downs, David E Gyorki, Emma Stahlie, Alexander van Akkooi, David W Ollila, Jill Frank, Yun Song, Giorgos Karakousis, Marc Moncrieff, Jenny Nobes, John Vetto, Dale Han, Jeffrey Farma, Jeremiah L Deneve, Martin D Fleming, Matthew Perez, Kirsten Baecher, Michael Lowe, Roger Olofsson Bagge, Jan Mattsson, Ann Y Lee, Russell S Berman, Harvey Chai, Hidde M Kroon, Roland M Teras, Juri Teras, Norma E Farrow, Georgia M Beasley, Jane Yc Hui, Lukas Been, Schelto Kruijff, David Boulware, Amod A Sarnaik, Vernon K Sondak, Jonathan S Zager, ,

<h4>Background</h4>In sentinel lymph node (SLN)-positive melanoma, two randomized trials demonstrated equivalent melanoma-specific survival with nodal surveillance vs completion lymph node dissection (CLND). Patients with microsatellites, extranodal extension (ENE) in the SLN, or >3 positive SLNs constitute a high-risk group largely excluded from the randomized trials, for whom appropriate management remains ... Read more >>

J Am Coll Surg (Journal of the American College of Surgeons)
[2021, 232(4):424-431]

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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Matthew H Bailey, William U Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Yize Li, Sean Kelso, , , Gordon Saksena, Kyle Ellrott, Michael C Wendl, David A Wheeler, Gad Getz, Jared T Simpson, Mark B Gerstein, Li Ding, ,

Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20128-w. ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):6232]

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