Full Text Journal Articles by
Author John Dennis

Advertisement

Find full text journal articles






Derivation and validation of a type 2 diabetes treatment selection algorithm for SGLT2-inhibitor and DPP4-inhibitor therapies based on glucose-lowering efficacy: cohort study using trial and routine clinical data

John Dennis, Katherine Young, Andrew McGovern, Bilal Mateen, Sebastian Vollmer, Michael Simpson, William Henley, Rury Holman, Naveed Sattar, Ewan Pearson, Andrew Hattersley, Angus Jones, Beverley Shields,

<h4>Objective</h4> To establish whether clinical patient characteristics routinely measured in primary care can identify people with differing short-term benefits and risks for SGLT2-inhibitor and DPP4-inhibitor therapies, and to derive and validate a treatment selection algorithm to identify the likely optimal therapy for individual patients. <h4>Design</h4> Prospective cohort study. <h4>Setting</h4> Routine ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Correction to: DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

Nicholas J Thomas, John M Dennis, Seth A Sharp, Akaal Kaur, Shivani Misra, Helen C Walkey, Desmond G Johnston, Nick S Oliver, William A Hagopian, Michael N Weedon, Kashyap A Patel, Richard A Oram,

Diabetologia (Diabetologia)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021.

John M Dennis, Andrew P McGovern, Nicholas J Thomas, Harrison Wilde, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>All English hospital trusts (i.e., groups of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1895-1900]

Cited: 1 time

View full text PDF listing >>



Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study.

Jonathan M Locke, Petra Dusatkova, Kevin Colclough, Alice E Hughes, John M Dennis, Beverley Shields, Sarah E Flanagan, Maggie H Shepherd, Emma L Dempster, Andrew T Hattersley, Michael N Weedon, Stepanka Pruhova, Kashyap A Patel,

Diabetologia (Diabetologia)
[2021, :]

Cited: 0 times

View full text PDF listing >>



The association between mechanical ventilator compatible bed occupancy and mortality risk in intensive care patients with COVID-19: a national retrospective cohort study.

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John M Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal A Mateen, Sebastian J Vollmer,

<h4>Background</h4>The literature paints a complex picture of the association between mortality risk and ICU strain. In this study, we sought to determine if there is an association between mortality risk in intensive care units (ICU) and occupancy of beds compatible with mechanical ventilation, as a proxy for strain.<h4>Methods</h4>A national retrospective ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):213]

Cited: 1 time

View full text PDF listing >>



Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study.

Lauren R Rodgers, Anita V Hill, John M Dennis, Zoe Craig, Benedict May, Andrew T Hattersley, Timothy J McDonald, Rob C Andrews, Angus Jones, Beverley M Shields,

<h4>Background</h4>Type 2 diabetes (T2D) is common and increasing in prevalence. It is possible to prevent or delay T2D using lifestyle intervention programmes. Entry to these programmes is usually determined by a measure of glycaemia in the 'intermediate' range. This paper investigated the relationship between HbA1c and future diabetes risk and ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):184]

Cited: 0 times

View full text PDF listing >>



A national retrospective study of the association between serious operational problems and COVID-19 specific intensive care mortality risk.

Harrison Wilde, John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To describe the relationship between reported serious operational problems (SOPs), and mortality for patients with COVID-19 admitted to intensive care units (ICUs).<h4>Design</h4>English national retrospective cohort study.<h4>Setting</h4>89 English hospital trusts (i.e. small groups of hospitals functioning as single operational units).<h4>Patients</h4>All adults with COVID-19 admitted to ICU between 2nd April and 1st ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0255377]

Cited: 1 time

View full text PDF listing >>



Corona Health-A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic.

Felix Beierle, Johannes Schobel, Carsten Vogel, Johannes Allgaier, Lena Mulansky, Fabian Haug, Julian Haug, Winfried Schlee, Marc Holfelder, Michael Stach, Marc Schickler, Harald Baumeister, Caroline Cohrdes, Jürgen Deckert, Lorenz Deserno, Johanna-Sophie Edler, Felizitas A Eichner, Helmut Greger, Grit Hein, Peter Heuschmann, Dennis John, Hans A Kestler, Dagmar Krefting, Berthold Langguth, Patrick Meybohm, Thomas Probst, Manfred Reichert, Marcel Romanos, Stefan Störk, Yannik Terhorst, Martin Weiß, Rüdiger Pryss,

Physical and mental well-being during the COVID-19 pandemic is typically assessed via surveys, which might make it difficult to conduct longitudinal studies and might lead to data suffering from recall bias. Ecological momentary assessment (EMA) driven smartphone apps can help alleviate such issues, allowing for in situ recordings. Implementing such ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(14):]

Cited: 1 time

View full text PDF listing >>



Corona Health -- A Study- and Sensor-based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic

Felix Beierle, Johannes Schobel, Carsten Vogel, Johannes Allgaier, Lena Mulansky, Fabian Haug, Julian Haug, Winfried Schlee, Marc Holfelder, Michael Stach, Marc Schickler, Harald Baumeister, Caroline Cohrdes, Jürgen Deckert, Lorenz Deserno, Johanna-Sophie Edler, Felizitas Eichner, Helmut Greger, Grit Hein, Peter Heuschmann, Dennis John, Hans Kestler, Dagmar Krefting, Berthold Langguth, Patrick Meybohm, Thomas Probst, Manfred Reichert, Marcel Romanos, Stefan Störk, Yannik Terhorst, Martin Weiß, Rüdiger Pryss,

Physical and mental well-being during the COVID-19 pandemic is typically assessed via surveys, which might make it difficult to conduct longitudinal studies and might lead to data suffering from recall bias. Ecological momentary assessment (EMA) driven smartphone apps can help alleviate such issues, allowing for in situ recordings. Implementing such ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

Nicholas J Thomas, John M Dennis, Seth A Sharp, Akaal Kaur, Shivani Misra, Helen C Walkey, Desmond G Johnston, Nick S Oliver, William A Hagopian, Michael N Weedon, Kashyap A Patel, Richard A Oram,

<h4>Aims/hypothesis</h4>Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(10):2258-2265]

Cited: 0 times

View full text PDF listing >>



Using joint models to adjust for informative drop-out when modelling a longitudinal biomarker: an application to type 2 diabetes disease progression

Harry Green, Katie Young, Angus Jones, Michael Weedon, John Dennis,

Linear mixed effects models are frequently used in biomedical statistics to model the trajectory of a repeatedly measured longitudinal variable, such as a biomarker, over time. However, population-level estimates may be biased by censoring bias resulting from exit criteria that depend on the variable in question. A joint longitudinal-survival model, ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



When Love Just Ends: An Investigation of the Relationship Between Dysfunctional Behaviors, Attachment Styles, Gender, and Education Shortly After a Relationship Dissolution.

Cristina Civilotti, John Lawrence Dennis, Daniela Acquadro Maran, Davide Margola,

Much information is known about the long-term consequences of separation and divorce, whereas there is a paucity of studies about the short-term consequences of such experiences. This study investigates the adoption of dysfunctional behaviors (e.g., insistent telephone calls and text messages, verbal threats, and sending unwanted objects) shortly after a ... Read more >>

Front Psychol (Frontiers in psychology)
[2021, 12:662237]

Cited: 0 times

View full text PDF listing >>



Priming the self as an agent influences causal, spatial, and temporal events: implications for animacy, cultural differences, and clinical settings.

John L Dennis, Davide Margola,

People intentionally engage in goal-directed actions-i.e., set goals, create plans, and execute volitional control, which are fundamental for our understanding of ourselves, others, and events. In three experiments we created a novel sentence unscrambling task that was used to prime the self-as-agent (i.e., sentences that contain the pronoun "I"), the ... Read more >>

Psychol Res (Psychological research)
[2021, :]

Cited: 0 times

View full text PDF listing >>



[Community-Based Nutrition Health Promotion Interventions - Evaluation of the Project "Gesunde Südstadt" in Nuremberg].

Dennis John, Christina Röhrich, Verena Walter, Gabi Pfeifer, Niko Kohls,

<h4>Hintergrund</h4>Das Projekt "Gesunde Südstadt" hat den Schwerpunkt Gesundheitsförderung in der Lebenswelt Kommune. Es wurde im Rahmen des "Präventionsgesetzes" (SGB V §20a) initiiert und zielt ab auf die Verringerung der gesundheitlichen Ungleichheit in der Stadt Nürnberg. Die Maßnahmen der kommunalen Gesundheitsförderung im Handlungsfeld Ernährung wurden durch eine externe multiperspektivische, multimethodische Prozess- ... Read more >>

Gesundheitswesen (Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)))
[2021, :]

Cited: 0 times

View full text PDF listing >>



Linked electronic health records for research on a nationwide cohort of more than 54 million people in England: data resource.

Angela Wood, Rachel Denholm, Sam Hollings, Jennifer Cooper, Samantha Ip, Venexia Walker, Spiros Denaxas, Ashley Akbari, Amitava Banerjee, William Whiteley, Alvina Lai, Jonathan Sterne, Cathie Sudlow, ,

<h4>Objective</h4>To describe a novel England-wide electronic health record (EHR) resource enabling whole population research on covid-19 and cardiovascular disease while ensuring data security and privacy and maintaining public trust.<h4>Design</h4>Data resource comprising linked person level records from national healthcare settings for the English population, accessible within NHS Digital's new trusted research ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 373:n826]

Cited: 4 times

View full text PDF listing >>



The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation.

Andrew P McGovern, Nick J Thomas, Sebastian J Vollmer, Andrew T Hattersley, Bilal A Mateen, John M Dennis,

Diabetologia (Diabetologia)
[2021, 64(5):1184-1186]

Cited: 5 times

View full text PDF listing >>



SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters.

Prabhuanand Selvaraj, Christopher Z Lien, Shufeng Liu, Charles B Stauft, Ivette A Nunez, Mario Hernandez, Eric Nimako, Mario A Ortega, Matthew F Starost, John U Dennis, Tony T Wang,

A critical question in understanding the immunity to SARS-COV-2 is whether recovered patients are protected against re-challenge and transmission upon second exposure. We developed a Syrian hamster model in which intranasal inoculation of just 100 TCID<sub>50</sub> virus caused viral pneumonia. Aged hamsters developed more severe disease and even succumbed to ... Read more >>

Life Sci Alliance (Life science alliance)
[2021, 4(4):]

Cited: 7 times

View full text PDF listing >>



Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020.

John M Dennis, Andrew P McGovern, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time.<h4>Design</h4>Retrospective observational cohort; based on data reported ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(2):209-214]

Cited: 55 times

View full text PDF listing >>



A national retrospective cohort study of mechanical ventilator availability and its association with mortality risk in intensive care patients with COVID-19

Harrison Wilde, Thomas Mellan, Iwona Hawryluk, John Dennis, Spiros Denaxas, Christina Pagel, Andrew Duncan, Samir Bhatt, Seth Flaxman, Bilal Mateen, Sebastian Vollmer,

<h4>Objectives: </h4> To determine if there is an association between survival rates in intensive care units (ICU) and occupancy of the unit on the day of admission. <h4>Design:</h4> National retrospective observational cohort study during the COVID-19 pandemic. <h4>Setting:</h4> 90 English hospital trusts (i.e. groups of hospitals functioning as single operational ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis.

Bilal Akhter Mateen, Harrison Wilde, John M Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Objective</h4>In this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.<h4>Design</h4>Descriptive survey.<h4>Setting</h4>All non-specialist secondary care providers in England from 27 March27to 5 June 2020.<h4>Participants</h4>Acute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e042945]

Cited: 7 times

View full text PDF listing >>



Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion.

Michael D Kim, Nathalie Baumlin, John S Dennis, Makoto Yoshida, Adrian Kis, Carolina Aguiar, Andreas Schmid, Eliana Mendes, Matthias Salathe,

The aim was to determine whether losartan reduces cigarette smoke (CS)-induced airway inflammation and mucus hypersecretion in an <i>in vitro</i> model and a small clinical trial. Primary human bronchial epithelial cells (HBECs) were differentiated at the air-liquid interface (ALI) and exposed to CS. Expression of transforming growth factor (TGF)-β1 and ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(1):]

Cited: 0 times

View full text PDF listing >>



Hyperglycaemia in cystic fibrosis adversely affects BK channel function critical for mucus clearance.

Charles D Bengtson, Michael D Kim, Abeer Anabtawi, Jianghua He, John S Dennis, Sara Miller, Makoto Yoshida, Nathalie Baumlin, Matthias Salathe,

Large-conductance, Ca<sup>2+</sup>-activated, voltage-dependent K<sup>+</sup> (BK) channel function is critical for adequate airway hydration and mucociliary function. In airway epithelia, BK function is regulated by its γ-subunit, leucine-rich repeat-containing protein 26 (LRRC26). Since patients with cystic fibrosis (CF)-related diabetes mellitus (CFRD) have worse lung function outcomes, this study determined the effects ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, 57(1):]

Cited: 0 times

View full text PDF listing >>



The epidemiology of eczema in children and adults in England: A population-based study using primary care data.

Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Claire Feeney, Carsten Flohr,

<h4>Background</h4>Whilst eczema is a common inflammatory skin condition, we lack contemporary estimates of disease incidence and prevalence across the lifespan.<h4>Objective</h4>To estimate the incidence and prevalence of eczema in children and adults in England and variation by sociodemographic factors (sex, socio-economic status, ethnicity, and geography).<h4>Methods</h4>We used the Royal College of General ... Read more >>

Clin Exp Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2021, 51(3):471-482]

Cited: 4 times

View full text PDF listing >>



Patterns and trends in eczema management in UK primary care (2009-2018): A population-based cohort study.

Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Clarie Feeney, Carsten Flohr,

<h4>Background</h4>Despite the high disease burden of eczema, a contemporary overview of the patterns and trends in primary care healthcare utilization and treatment is lacking.<h4>Objective</h4>To quantify primary care consultations, specialist referrals, prescribing, and treatment escalation, in children and adults with eczema in England.<h4>Methods</h4>A large primary care research database was used to ... Read more >>

Clin Exp Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2021, 51(3):483-494]

Cited: 1 time

View full text PDF listing >>



Investigation of Acetone Vapour Sensing Properties of a Ternary Composite of Doped Polyaniline, Reduced Graphene Oxide and Chitosan Using Surface Plasmon Resonance Biosensor.

Fahad Usman, John Ojur Dennis, E M Mkawi, Yas Al-Hadeethi, Fabrice Meriaudeau, Thomas L Ferrell, Osamah Aldaghri, Abdelmoneim Sulieman,

This work reports the use of a ternary composite that integrates p-Toluene sulfonic acid doped polyaniline (PANI), chitosan, and reduced graphene oxide (RGO) as the active sensing layer of a surface plasmon resonance (SPR) sensor. The SPR sensor is intended for application in the non-invasive monitoring and screening of diabetes ... Read more >>

Polymers (Basel) (Polymers)
[2020, 12(11):]

Cited: 0 times

View full text PDF listing >>



Advertisement


Disclaimer

1.1443 s