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Division without Binary Fission: Cell Division in the FtsZ-Less Chlamydia.

Scot P Ouellette, Junghoon Lee, John V Cox,

Chlamydia is an obligate intracellular bacterial pathogen that has significantly reduced its genome size in adapting to its intracellular niche. Among the genes that Chlamydia has eliminated is ftsZ, encoding the central organizer of cell division that directs cell wall synthesis in the division septum. These Gram-negative pathogens have cell ... Read more >>

J. Bacteriol. (Journal of bacteriology)
[2020, :]

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Oncology Care Delivery in the COVID-19 Pandemic: An Opportunity to Study Innovations and Outcomes.

Pelin Cinar, John Cox, Arif Kamal, Kathleen Bickel, Monika Krzyzanowska, James Armitage, Apar Kishor Ganti, Jeffery Ward, Sandra Wong, Sagar Lonial, Linda Bosserman,

JCO Oncol Pract (JCO oncology practice)
[2020, :OP2000326]

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A randomized trial of mail and email recruitment strategies for a physician survey on clinical trial accrual.

Caitlin C Murphy, Simon J Craddock Lee, Ann M Geiger, John V Cox, Chul Ahn, Rasmi Nair, David E Gerber, Ethan A Halm, Katharine McCallister, Celette Sugg Skinner,

BACKGROUND:Patient participation in cancer clinical trials is suboptimal. A challenge to capturing physicians' insights about trials has been low response to surveys. We conducted a study using varying combinations of mail and email to recruit a nationally representative sample of medical, surgical, and radiation oncologists to complete a survey on ... Read more >>

BMC Med Res Methodol (BMC Medical Research Methodology)
[2020, 20(1):123]

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Critical Role for the Extended N Terminus of Chlamydial MreB in Directing Its Membrane Association and Potential Interaction with Divisome Proteins.

Junghoon Lee, John V Cox, Scot P Ouellette,

Chlamydiae lack the conserved central coordinator protein of cell division FtsZ, a tubulin-like homolog. Current evidence indicates that Chlamydia uses the actin-like homolog, MreB, to substitute for the role of FtsZ in a polarized division mechanism. Interestingly, we observed MreB as a ring at the septum in dividing cells of ... Read more >>

J. Bacteriol. (Journal of bacteriology)
[2020, 202(9):]

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A spatial genomic approach identifies time lags and historical barriers to gene flow in a rapidly fragmenting Appalachian landscape.

Thomas A Maigret, John J Cox, David W Weisrock,

The resolution offered by genomic data sets coupled with recently developed spatially informed analyses are allowing researchers to quantify population structure at increasingly fine temporal and spatial scales. However, both empirical research and conservation measures have been limited by questions regarding the impacts of data set size, data quality thresholds ... Read more >>

Mol. Ecol. (Molecular ecology)
[2020, 29(4):673-685]

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A spatial genomic approach identifies time lags and historic barriers to gene flow in a rapidly fragmenting Appalachian landscape

Thomas Maigret, John Cox, David Weisrock,

Abstract The resolution offered by genomic data sets coupled with recently developed spatially informed analyses are allowing researchers to quantify population structure at increasingly fine temporal and spatial scales. However, uncertainties regarding data set size and quality thresholds and the time scale at which barriers to gene flow become detectable ... Read more >>

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Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial.

Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A Harrington, ,

BACKGROUND:Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ... Read more >>

Lancet (Lancet (London, England))
[2019, 394(10204):1169-1180]

Cited: 1 time

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Ticagrelor in Patients with Stable Coronary Disease and Diabetes.

P Gabriel Steg, Deepak L Bhatt, Tabassome Simon, Kim Fox, Shamir R Mehta, Robert A Harrington, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Maria Leonsson-Zachrisson, Yuyin Liu, Grzegorz Opolski, Dmitry Zateyshchikov, Junbo Ge, José C Nicolau, Ramón Corbalán, Jan H Cornel, Petr Widimský, Lawrence A Leiter, ,

BACKGROUND:Patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke are at high risk for cardiovascular events. Whether adding ticagrelor to aspirin improves outcomes in this population is unclear. METHODS:In this randomized, double-blind trial, we assigned patients who were 50 years of ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(14):1309-1320]

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Critical Role for the Unique N-Terminus of Chlamydial MreB in Directing Its Membrane Association and Interaction with Elements of the Divisome

Junghoon Lee, John Cox, Scot Ouellette,

Abstract Chlamydiae lack the conserved central coordinator protein of cell division FtsZ, a tubulin-like homolog. Current evidence indicates Chlamydia uses the actin-like homolog, MreB, to substitute for the role of FtsZ. Interestingly, we observed MreB as a ring at the septum in dividing cells of Chlamydia . We hypothesize that ... Read more >>

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The Centers for Medicare & Medicaid Services Oncology Care Model Halfway Through: Perspectives from Diverse Participants.

Ronald M Kline, Michelle Brown, Nikolas Buescher, John Cox, Elizabeth Horenkamp, Russell Hoverman, Marcus Neubauer, Randall Oyer, Anne Marie Fraley Rainey, Larisa Strawbridge,

The Oncology Care Model (OCM) is a 5-year model developed and tested by the Centers for Medicare & Medicaid Services that uses an episode-based payment model triggered by the receipt of chemotherapy to test if changing payment mechanisms, in conjunction with a requirement for enhanced patient services, can generate clinical ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, 111(8):764-771]

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Patient and provider perspectives on delivery of oral cancer therapies.

Caitlin C Murphy, Simon J Craddock Lee, David E Gerber, John V Cox, Hannah M Fullington, Robin T Higashi,

OBJECTIVE:The introduction of oral cancer therapies presents new challenges to delivery of quality cancer care. Little is known about how patients and providers address and overcome these challenges. We conducted a qualitative study exploring the range of patient and provider perspectives on oral cancer therapies. METHODS:We conducted semi-structured interviews with ... Read more >>

Patient Educ Couns (Patient education and counseling)
[2019, 102(11):2102-2109]

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Conceptual Model for Accrual to Cancer Clinical Trials.

Simon J Craddock Lee, Caitlin C Murphy, Ann M Geiger, David E Gerber, John V Cox, Rasmi Nair, Celette Sugg Skinner,

J. Clin. Oncol. (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2019, 37(23):1993-1996]

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Thirty years with the Edinburgh Postnatal Depression Scale: voices from the past and recommendations for the future.

John Cox,

The Edinburgh Postnatal Depression Scale (EPDS) was published over 30 years ago as a ten-item self-report questionnaire to facilitate the detection of perinatal depression - and for use in research. It is widely used at the present time in many regions of the world and has been translated into over ... Read more >>

Br J Psychiatry (The British journal of psychiatry : the journal of mental science)
[2019, 214(3):127-129]

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Characteristics of women with different perinatal depression trajectories.

Anna Wikman, Cathrine Axfors, Stavros I Iliadis, John Cox, Emma Fransson, Alkistis Skalkidou,

Maternal perinatal depression (PND), a common mental disorder with a prevalence of over 10%, is associated with long-term health risks for both mothers and offspring. This study aimed at describing characteristics related to background and lifestyle, pregnancy, delivery, and postpartum of different PND trajectories defined according to the onset of ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2020, 98(7):1268-1282]

Cited: 1 time

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Care coordination for complex cancer survivors in an integrated safety-net system: a study protocol.

Simon J Craddock Lee, Katelyn K Jetelina, Emily Marks, Eric Shaw, Kevin Oeffinger, Deborah Cohen, Noel O Santini, John V Cox, Bijal A Balasubramanian,

BACKGROUND:The growing numbers of cancer survivors challenge delivery of high-quality survivorship care by healthcare systems. Innovative ways to improve care coordination for patients with cancer and multiple chronic conditions ("complex cancer survivors") are needed to achieve better care outcomes, improve patient experience of care, and lower cost. Our study, Project ... Read more >>

BMC Cancer (BMC cancer)
[2018, 18(1):1204]

Cited: 2 times

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Impact on Oncology Practices of Including Drug Costs in Bundled Payments.

Jeffery C Ward, Laura A Levit, Ray D Page, John E Hennessy, John V Cox, Deborah Y Kamin, Suanna S Bruinooge, Ya-Chen Tina Shih, Blase N Polite,

INTRODUCTION:This analysis evaluates the impact of bundling drug costs into a hypothetic bundled payment. METHODS:An economic model was created for patient vignettes from: advanced-stage III colon cancer and metastatic non-small-cell lung cancer. First quarter 2016 Medicare reimbursement rates were used to calculate the average fee-for-service (FFS) reimbursement for these vignettes. ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2018, 14(5):e259-e268]

Cited: 3 times

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Functional liver image guided hepatic therapy (FLIGHT) with hepatobiliary iminodiacetic acid (HIDA) scans.

David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth,

PURPOSE:Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2018, 8(6):429-436]

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Spatial Capture-Recapture for Categorically Marked Populations with An Application to Genetic Capture-Recapture

Ben Augustine, Andrew Royle, Sean Murphy, Richard Chandler, John Cox, Marcella Kelly,

Abstract Recently introduced unmarked spatial capture-recapture (SCR), spatial mark-resight (SMR), and 2-flank spatial partial identity models (SPIM) extend the domain of SCR to populations or observation systems that do not always allow for individual identity to be determined with certainty. For example, some species do not have natural marks that ... Read more >>

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Use and misuse of the Edinburgh Postnatal Depression Scale (EPDS): a ten point 'survival analysis'.

John Cox,

Arch Womens Ment Health (Archives of women's mental health)
[2017, 20(6):789-790]

Cited: 4 times

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Spatial genetic structure in American black bears (Ursus americanus): female philopatry is variable and related to population history.

Thea V Kristensen, Emily E Puckett, Erin L Landguth, Jerrold L Belant, John T Hast, Colin Carpenter, Jaime L Sajecki, Jeff Beringer, Myron Means, John J Cox, Lori S Eggert, Don White, Kimberly G Smith,

Previously, American black bears (Ursus americanus) were thought to follow the pattern of female philopatry and male-biased dispersal. However, recent studies have identified deviations from this pattern. Such flexibility in dispersal patterns can allow individuals greater ability to acclimate to changing environments. We explored dispersal and spatial genetic relatedness patterns ... Read more >>

Heredity (Edinb) (Heredity)
[2018, 120(4):329-341]

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Consequences of severe habitat fragmentation on density, genetics, and spatial capture-recapture analysis of a small bear population.

Sean M Murphy, Ben C Augustine, Wade A Ulrey, Joseph M Guthrie, Brian K Scheick, J Walter McCown, John J Cox,

Loss and fragmentation of natural habitats caused by human land uses have subdivided several formerly contiguous large carnivore populations into multiple small and often isolated subpopulations, which can reduce genetic variation and lead to precipitous population declines. Substantial habitat loss and fragmentation from urban development and agriculture expansion relegated the ... Read more >>

PLoS ONE (PloS one)
[2017, 12(7):e0181849]

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CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model.

Ruisong Ye, Min Pi, John V Cox, Satoru K Nishimoto, L Darryl Quarles,

GPRC6A is implicated in the pathogenesis of prostate cancer, but its role remains uncertain because of a purported tolerant gene variant created by substitution of a K..Y polymorphism in the 3rd intracellular loop (IL) that evolved in the majority of humans and replaces the ancestral RKLP present in 40% of ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2017, 36(1):90]

Cited: 5 times

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Cross-circulation thrombectomy with use of a stent retriever: A case report.

Ali Sultan-Qurraie, Gregory Rozansky, John Andrew Cox, Marc Lazzaro,

Introduction The efficacy of the endovascular treatment of acute ischemic stroke has been substantiated by several recent randomized clinical trials. While intra-arterial therapy has significantly evolved in recent years, anatomic cerebrovascular variants and disease burden can present challenges to timely recanalization. We present the first reported case of anterior-to-posterior mechanical ... Read more >>

Interv Neuroradiol (Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences)
[2017, 23(4):422-426]

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The association of nonaccidental trauma with historical factors, examination findings, and diagnostic testing during the initial trauma evaluation.

Mauricio A Escobar, Katherine T Flynn-OʼBrien, Marc Auerbach, Gunjan Tiyyagura, Matthew A Borgman, Susan J Duffy, Kelly S Falcone, Rita V Burke, John M Cox, Sabine A Maguire,

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2017, 82(6):1147-1157]

Cited: 1 time

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Retained Surgical Drains in Orthopedics: Two Case Reports and a Review of the Literature.

John S Cox, Darin Friess,

Though a relatively rare event, retained surgical drains are preventable and can lead to significant consequences. Two case reports from our institution are discussed as examples for the challenging management of this problem as well as an overview of techniques for the prevention and removal of retained drains based on ... Read more >>

Case Rep Orthop (Case reports in orthopedics)
[2017, 2017:8194571]

Cited: 2 times

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