Full Text Journal Articles by
Author John C Reed

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Correction: Regulation of ATG4B Stability by RNF5 Limits Basal Levels of Autophagy and Influences Susceptibility to Bacterial Infection.

Ersheng Kuang, Cheryl Y M Okumura, Sharon Sheffy-Levin, Tal Varsano, Vincent Chih-Wen Shu, Jianfei Qi, Ingrid R Niesman, Huei-Jiun Yang, Carlos López-Otín, Wei Yuan Yang, John C Reed, Limor Broday, Victor Nizet, Ze'ev A Ronai,

[This corrects the article DOI: 10.1371/journal.pgen.1003007.]. ... Read more >>

PLoS Genet. (PLoS genetics)
[2020, 16(5):e1008795]

Cited: 0 times

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Chinese scientists and US leadership in the life sciences.

Steven H Holtzman, Ron Cohen, Jeremy M Levin, John Maraganore, ,

Nat. Biotechnol. (Nature biotechnology)
[2019, 37(11):1261-1263]

Cited: 0 times

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Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.

Marisa Sanchez, Zebin Xia, Elizabeth Rico-Bautista, Xihua Cao, Michael Cuddy, David J Castro, Ricardo G Correa, Liqun Chen, Jinghua Yu, Andrey Bobkov, Vivian Ruvolo, Michael Andreeff, Robert G Oshima, Shu-Ichi Matsuzawa, John C Reed, Xiao-Kun Zhang, Donna Hansel, Dieter A Wolf, Marcia I Dawson,

Di(1H-indol-3-yl)(4-trifluoromethylphenyl)methane (DIM-Ph-4-CF3) is an analog of orphan nuclear receptor 4A1 (NR4A1) ligand cytosporone B. We have synthesized several oxidation products of DIM-Ph-4-CF3, focusing on analogs with electron-withdrawing or donating groups at their phenyl ring 4-positions, and examined their anti-cancer activity and mechanism-of-action. Mesylates (DIM-Ph-4-X+ OMs-s) having CF3, CO2Me and Cl ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(38):25057-25074]

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Tissue-Specific Immunoregulation: A Call for Better Understanding of the "Immunostat" in the Context of Cancer.

William Pao, Chia-Huey Ooi, Fabian Birzele, Astrid Ruefli-Brasse, Michael A Cannarile, Bernhard Reis, Sebastian H Scharf, David A Schubert, Klas Hatje, Nadege Pelletier, Olivia Spleiss, John C Reed,

Checkpoint inhibitor therapy has been a breakthrough in cancer research, but only some patients with cancer derive substantial benefit. Although mechanisms underlying sensitivity and resistance to checkpoint inhibitors are being elucidated, the importance of organ-specific regulation of immunity is currently underappreciated. Here, we call for a greater understanding of tissue-specific ... Read more >>

Cancer Discov (Cancer discovery)
[2018, 8(4):395-402]

Cited: 10 times

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Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy.

Pei-Feng Liu, Kun-Lin Tsai, Chien-Jen Hsu, Wei-Lun Tsai, Jin-Shiung Cheng, Hsueh-Wei Chang, Chung-Wai Shiau, Yih-Gang Goan, Ho-Hsing Tseng, Chih-Hsuan Wu, John C Reed, Lee-Wei Yang, Chih-Wen Shu,

Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that specifically inhibit autophagy-related (ATG) proteins. ... Read more >>

Theranostics (Theranostics)
[2018, 8(3):830-845]

Cited: 20 times

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Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.

Gema Perez-Chacon, Magdalena Adrados, Maria T Vallejo-Cremades, Sophie Lefebvre, John C Reed, Juan M Zapata,

TNF-Receptor Associated Factor (TRAF)-3 is a master regulator of B cell homeostasis and function. TRAF3 has been shown to bind and regulate various proteins involved in the control of innate and adaptive immune responses. Previous studies showed that TRAF3 overexpression renders B cells hyper-reactive to antigens and Toll-like receptor (TLR) ... Read more >>

Front Immunol (Frontiers in immunology)
[2018, 9:3114]

Cited: 2 times

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Bcl-2 on the brink of breakthroughs in cancer treatment.

John C Reed,

Cell Death Differ. (Cell death and differentiation)
[2018, 25(1):3-6]

Cited: 12 times

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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.

Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D Leverson, Gwen Nichols, John C Reed, Marina Konopleva, Michael Andreeff,

Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition overcome apoptosis resistance and markedly prolong survival in three mouse models of resistant acute myeloid leukemia (AML). Mechanistically, p53 activation negatively regulates ... Read more >>

Cancer Cell (Cancer cell)
[2017, 32(6):748-760.e6]

Cited: 32 times

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Therapeutics targeting Bcl-2 in hematological malignancies.

Astrid Ruefli-Brasse, John C Reed,

Members of the B-cell lymphoma 2 (BCL-2) gene family are attractive targets for cancer therapy as they play a key role in promoting cell survival, a long-since established hallmark of cancer. Clinical utility for selective inhibition of specific anti-apoptotic Bcl-2 family proteins has recently been realized with the Food and ... Read more >>

Biochem. J. (The Biochemical journal)
[2017, 474(21):3643-3657]

Cited: 22 times

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Peter C. Nowell (1928-2016).

John C Reed, Brian J Druker,

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2017, 114(18):4569-4570]

Cited: 0 times

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Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity.

Erina Joo, Toru Fukushima, Norio Harada, John C Reed, Shu-Ichi Matsuzawa, Nobuya Inagaki,

Obesity is associated with low-grade inflammation that leads to insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine receptor (TNFR) signaling pathways. Ubc13 is an ubiquitin-conjugating enzyme responsible for non-canonical K63-linked polyubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in TLR and TNFR pathways. However, ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:35983]

Cited: 2 times

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Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosford,

Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously by the second mitochondrial activator of caspases (SMAC), which binds to selected baculovirus IAP repeat ... Read more >>

PLoS ONE (PloS one)
[2016, 11(9):e0161952]

Cited: 7 times

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Finally, An Apoptosis-Targeting Therapeutic for Cancer.

Carlo M Croce, John C Reed,

Resistance to cell death represents one of the hallmarks of cancer. Various genetic and epigenetic changes in malignant cells afford cytoprotection in the face of genomic instability, oncogene activation, microenvironment stress, chemotherapy, targeted anticancer drugs, and even immunotherapy. Central among the regulators of cell life and death are Bcl-2 family ... Read more >>

Cancer Res. (Cancer research)
[2016, 76(20):5914-5920]

Cited: 38 times

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Orphan Nuclear Receptor NR4A1 Binds a Novel Protein Interaction Site on Anti-apoptotic B Cell Lymphoma Gene 2 Family Proteins.

Paulo H C Godoi, Rachel P Wilkie-Grantham, Asami Hishiki, Renata Sano, Yasuko Matsuzawa, Hiroko Yanagi, Claudia E Munte, Ya Chen, Yong Yao, Francesca M Marassi, Hans R Kalbitzer, Shu-Ichi Matsuzawa, John C Reed,

B cell lymphoma gene 2 (Bcl-2) family proteins are key regulators of programmed cell death and important targets for drug discovery. Pro-apoptotic and anti-apoptotic Bcl-2 family proteins reciprocally modulate their activities in large part through protein interactions involving a motif known as BH3 (Bcl-2 homology 3). Nur77 is an orphan ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2016, 291(27):14072-14084]

Cited: 6 times

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Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation.

Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnick,

PLoS ONE (PloS one)
[2015, 10(12):e0146210]

Cited: 1 time

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Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death.

Snezana Milutinovic, Arun K Kashyap, Teruki Yanagi, Carina Wimer, Sihong Zhou, Ryann O'Neil, Aaron L Kurtzman, Alexsandr Faynboym, Li Xu, Charles H Hannum, Paul W Diaz, Shu-ichi Matsuzawa, Michael Horowitz, Lawrence Horowitz, Ramesh R Bhatt, John C Reed,

Death receptors of the TNF family are found on the surface of most cancer cells and their activation typically kills cancer cells through the stimulation of the extrinsic apoptotic pathway. The endogenous ligand for death receptors 4 and 5 (DR4 and DR5) is TNF-related apoptosis-inducing ligand, TRAIL (Apo2L). As most ... Read more >>

Mol. Cancer Ther. (Molecular cancer therapeutics)
[2016, 15(1):114-124]

Cited: 6 times

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Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

Juan Rong, Ian Pass, Paul W Diaz, Tram A Ngo, Michelle Sauer, Gavin Magnuson, Fu-Yue Zeng, Christian A Hassig, Michael R Jackson, Nicholas D P Cosford, Shu-Ichi Matsuzawa, John C Reed,

Endoplasmic reticulum (ER) stress activates three distinct signal transducers on the ER membrane. Inositol-requiring protein 1 (IRE1), the most conserved signal transducer, plays a key role in ER stress-mediated signaling. During ER stress, IRE1 initiates two discrete signaling cascades: the "adaptive" signaling cascade mediated by the XBP1 pathway and the ... Read more >>

J Biomol Screen (Journal of biomolecular screening)
[2015, 20(10):1232-1245]

Cited: 3 times

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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Stuart L Schreiber, Joanne D Kotz, Min Li, Jeffrey Aubé, Christopher P Austin, John C Reed, Hugh Rosen, E Lucile White, Larry A Sklar, Craig W Lindsley, Benjamin R Alexander, Joshua A Bittker, Paul A Clemons, Andrea de Souza, Michael A Foley, Michelle Palmer, Alykhan F Shamji, Mathias J Wawer, Owen McManus, Meng Wu, Beiyan Zou, Haibo Yu, Jennifer E Golden, Frank J Schoenen, Anton Simeonov, Ajit Jadhav, Michael R Jackson, Anthony B Pinkerton, Thomas D Y Chung, Patrick R Griffin, Benjamin F Cravatt, Peter S Hodder, William R Roush, Edward Roberts, Dong-Hoon Chung, Colleen B Jonsson, James W Noah, William E Severson, Subramaniam Ananthan, Bruce Edwards, Tudor I Oprea, P Jeffrey Conn, Corey R Hopkins, Michael R Wood, Shaun R Stauffer, Kyle A Emmitte, ,

Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a manner distinct from other experimental approaches. Despite the tremendous promise of chemical tools for investigating biology and disease, small-molecule probes were unavailable for most targets and pathways as recently ... Read more >>

Cell (Cell)
[2015, 161(6):1252-1265]

Cited: 55 times

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Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

Andrea D'Osualdo, Veronica G Anania, Kebing Yu, Jennie R Lill, Randal J Kaufman, Shu-ichi Matsuzawa, John C Reed,

Perturbation of endoplasmic reticulum (ER) homeostasis triggers the ER stress response (also known as Unfolded Protein Response), a hallmark of many pathological disorders. However the connection between ER stress and inflammation remains largely unexplored. Recent data suggest that ER stress controls the activity of inflammasomes, key signaling platforms that mediate ... Read more >>

PLoS ONE (PloS one)
[2015, 10(6):e0130635]

Cited: 14 times

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Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.

Rongqing Pan, Vivian R Ruvolo, Jun Wei, Marina Konopleva, John C Reed, Maurizio Pellecchia, Michael Andreeff, Peter P Ruvolo,

Overexpression of antiapoptotic Bcl-2 proteins such as Bcl-2, Bcl-xL, and Mcl-1 is widely associated with tumor initiation, progression, and chemoresistance. Furthermore, it has been demonstrated that Mcl-1 upregulation renders several types of cancers resistant to the Bcl-2/Bcl-xL inhibitors ABT-737 and ABT-263. The emerging importance of Mcl-1 in pathogenesis and drug ... Read more >>

Blood (Blood)
[2015, 126(3):363-372]

Cited: 49 times

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Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies.

Jane Huang, Wayne Fairbrother, John C Reed,

The BCL2 gene was discovered nearly 30 years ago, launching a field of scientific inquiry and medical research with the potential for delivering transformational therapeutics. Revealed by its involvement in chromosomal translocations of B-cell lymphomas, BCL2 is the founding member of a family of cell survival genes that endow cells ... Read more >>

Expert Rev Hematol (Expert review of hematology)
[2015, 8(3):283-297]

Cited: 10 times

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PCTAIRE1-knockdown sensitizes cancer cells to TNF family cytokines.

Teruki Yanagi, Ranxin Shi, Pedro Aza-Blanc, John C Reed, Shu-ichi Matsuzawa,

While PCTAIRE1/PCTK1/Cdk16 is overexpressed in malignant cells and is crucial in tumorigenesis, its function in apoptosis remains unclear. Here we investigated the role of PCTAIRE1 in apoptosis, especially in the extrinsic cell death pathway. Gene-knockdown of PCTAIRE1 sensitized prostate cancer PPC1 and Du145 cells, and breast cancer MDA-MB-468 cells to ... Read more >>

PLoS ONE (PloS one)
[2015, 10(3):e0119404]

Cited: 12 times

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Benzodiazepinone derivatives protect against endoplasmic reticulum stress-mediated cell death in human neuronal cell lines.

Haixia Zou, Allison S Limpert, Jiwen Zou, Anna Dembo, Pooi-San Lee, Daniel Grant, Robert Ardecky, Anthony B Pinkerton, Gavin K Magnuson, Mark E Goldman, Juan Rong, Peter Teriete, Douglas J Sheffler, John C Reed, Nicholas D P Cosford,

Endoplasmic reticulum (ER) stress causes neuronal dysfunction followed by cell death and is recognized as a feature of many neurodegenerative diseases. Using a phenotypic screen, we recently identified benzodiazepinone derivatives that reduce ER stress-mediated apoptosis in a rat neuronal progenitor cell line (CSM14.1). Herein we describe how structure-activity relationship (SAR) ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2015, 6(3):464-475]

Cited: 3 times

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PCTAIRE1 regulates p27 stability, apoptosis and tumor growth in malignant melanoma.

Teruki Yanagi, John C Reed, Shu-Ichi Matsuzawa,

PCTAIRE1 is a cyclin-dependent kinase family protein that has been implicated in spermatogenesis. Although we recently revealed the function of PCTAIRE1 in tumorigenesis of epithelial carcinoma cells, its tumorigenic function in melanoma remains unclear. Interrogation of the Oncomine database revealed that malignant melanoma showed up-regulation of PCTAIRE1 mRNA compared to ... Read more >>

Oncoscience (Oncoscience)
[2014, 1(10):624-633]

Cited: 13 times

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Dissecting the in vivo leukemogenic potency of BCLxl.

Kumar Saurabh, Michael T Scherzer, Amy Song, Kenneth W Yip, John C Reed, Chi Li, Levi J Beverly,

Overexpression of anti-apoptotic members of the BCL2 family has been found in all types of cancer. A member of the family, BCLxl (B-cell lymphoma extra-large), is known to be associated with the progression of leukemogenesis. In the present study, we focused on understanding the domains of BCLxl responsible for in ... Read more >>

J Leuk (Los Angel) (Journal of leukemia (Los Angeles, Calif.))
[2014, 2(5):158]

Cited: 2 times

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