Full Text Journal Articles by
Author John C LaMattina

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The Impact of Treatment Delay on Hepatitis C Liver Transplant Outcomes.

Ian A Booth, Jacqueline E Clark, John C LaMattina, Rolf N Barth, Abdolreza Haririan, Bharath R Ravichandran,

<b>Background:</b> Direct-acting antivirals for the treatment of hepatitis C virus (HCV) have improved outcomes in liver transplant recipients (LTRs). However, the timing of HCV treatment and approach to treating rejection have not been well described. Additionally, pharmacists' roles in these comprehensive areas have not been investigated. <b>Methods:</b> This single-center, retrospective, ... Read more >>

J Pharm Pract (Journal of pharmacy practice)
[2021, :8971900211034261]

Cited: 0 times

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Reno-appendiceal fistula in autosomal dominant polycystic kidney disease.

Madison S Hill, Natalia Arias Villela, John C LaMattina, Yvonne M Rasko, Michael W Phelan,

We present a very rare Case of a 53-year-old female with autosomal dominant polycystic kidney disease (ADPKD) who was incidentally found to have a reno-appendiceal fistula while undergoing open bilateral nephrectomy. The mid-portion of the appendix was fistulized to a cyst in the lower pole of the right kidney. The ... Read more >>

Urol Case Rep (Urology case reports)
[2021, 38:101701]

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Transplant Hepatectomy With Portacaval Shunt and MARS Therapy for Perioperative Catastrophe: A Series of Four Liver Transplant Cases.

Arielle Cimeno, Samuel Sultan, Josue Alvarez-Casas, Steven I Hanish, David A Bruno, William R Hutson, Deborah M Stein, Thomas M Scalea, Rolf N Barth, John C LaMattina,

Increased worldwide focus on maximal donor utilization and transplantation of patients once considered too ill to survive liver transplantation may increase the otherwise rare frequency of catastrophic graft failure. Although the deleterious effects of an acutely failing allograft have been established for decades, the optimal strategy in this patient population ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(3):e674]

Cited: 0 times

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Small bowel obstruction post-living liver transplantation.

Naeem Goussous, Wen Xie, Rolf N Barth, John C LaMattina,

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(2):898-900]

Cited: 0 times

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Treatment of Renin-Angiotensin-Aldosterone System Dysfunction With Angiotensin II in High-Renin Septic Shock.

Jonathan H Chow, Marianne Wallis, Allison S Lankford, Zackary Chancer, Rolf N Barth, Joseph R Scalea, John C LaMattina, Michael A Mazzeffi, Michael T McCurdy,

Endothelial dysfunction is common in septic shock and has been shown to impair angiotensin converting enzyme and the renin-angiotensin-aldosterone system (RAAS). Dysregulation of this pathway, which can be measured with plasma renin activity (PRA), is important not only because RAAS dysfunction is associated with increased mortality but also because treatment ... Read more >>

Semin Cardiothorac Vasc Anesth (Seminars in cardiothoracic and vascular anesthesia)
[2021, 25(1):67-73]

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Hepatic Artery Pseudoaneurysm in the Liver Transplant Recipient: A Case Series.

David P St Michel, Naeem Goussous, Nathalie L Orr, Rolf N Barth, Stephen H Gray, John C LaMattina, David A Bruno,

Introduction:Hepatic artery pseudoaneurysm is a rare and potentially fatal complication of liver transplantation with a reported incidence of 0.3-2.6% and associated mortality approaching 75%. Clinical presentation typically includes sudden hypotension, gastrointestinal bleed or abnormal liver function tests within two months of transplantation. We report a series of four cases of ... Read more >>

Case Rep Transplant (Case reports in transplantation)
[2019, 2019:9108903]

Cited: 1 time

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Extracorporeal membrane oxygenation support following liver transplantation-A case series.

Naeem Goussous, Hashem Akbar, John C LaMattina, Steven I Hanish, Rolf N Barth, David A Bruno,

<h4>Background</h4>Postoperative severe cardiopulmonary failure carries a high rate of mortality. Extracorporeal membrane oxygenation (ECMO) can be used as a salvage therapy when conventional therapies fail.<h4>Methods</h4>We retrospectively reviewed our experience with ECMO support in the early postoperative period after liver transplant between September 2011 and May 2016.<h4>Results</h4>Out of 537 liver transplants ... Read more >>

Clin Transplant (Clinical transplantation)
[2019, 33(7):e13628]

Cited: 1 time

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Advances in liver xenotransplantation.

Arielle Cimeno, Rolf N Barth, John C LaMattina,

<h4>Purpose of review</h4>This review highlights advances in liver xenotransplantation, focusing on immunologic barriers and mechanisms underlying graft failure and recipient demise, and discussion of recent in-vivo results.<h4>Recent findings</h4>Pig to primate models of liver xenotransplantation have been plagued by thrombocytopenia, anemia, and coagulopathy. It is now known that platelet sequestration is ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2018, 23(6):615-620]

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Minimally invasive donor nephrectomy: current state of the art.

Nicole M Shockcor, Sam Sultan, Josue Alvarez-Casas, Philip S Brazio, Michael Phelan, John C LaMattina, Rolf N Barth,

BACKGROUND:The concept of a minimally invasive live donor nephrectomy developed over 20 years ago. Surgeons gained expertise with the laparoscopic technique and utilized multiple variations that are now utilized in transplant centers throughout the world. Recent modifications include laparoendoscopic single-site and robotic approaches that have been adopted by an additional smaller ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2018, 403(6):681-691]

Cited: 4 times

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Synthetic liver function is detectable in transgenic porcine livers perfused with human blood.

Arielle Cimeno, Beth M French, Jessica M Powell, Carol Phelps, David Ayares, Natalie A O'Neill, Christopher T Laird, Richard N Pierson, Agnes M Azimzadeh, Rolf N Barth, John C LaMattina,

In addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. Assessment and measurement of synthetic function of genetically modified porcine livers after ex vivo perfusion with human blood have not previously been described. Eight porcine livers from α1,3-galactosyl transferase knockout ... Read more >>

Xenotransplantation (Xenotransplantation)
[2018, 25(1):]

Cited: 2 times

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Previous living donor hemihepatectomy as cadaveric donor of remnant liver.

John C LaMattina, Samuel Sultan, Steven I Hanish, David A Bruno, Paul J Thuluvath, Anurag Maheshwari, Rolf N Barth,

Liver Transpl (Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society)
[2017, 23(10):1348-1350]

Cited: 0 times

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Liver Scaffolds Support Survival and Metabolic Function of Multilineage Neonatal Allogenic Cells.

Wessam Hassanein, Arielle Cimeno, Avraham Werdesheim, Bryan Buckingham, Joshua Harrison, Mehmet C Uluer, Ali Khalifeh, Carlos Rivera-Pratt, Stephen Klepfer, Jhade D Woodall, Urmil Dhru, Elliot Bromberg, Dawn Parsell, Cinthia Drachenberg, Rolf N Barth, John C LaMattina,

Organ scaffold bioengineering is currently limited by the inability to effectively repopulate the scaffold with appropriately distributed functional cells. We examined the feasibility of a decellularized liver scaffold to support the growth and function of multilineage allogenic cells derived from either adult or neonatal liver cells. Cell slurries from neonatal ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2018, 24(9-10):786-793]

Cited: 0 times

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Robotic-assisted single-port donor nephrectomy using the da Vinci single-site platform.

John C LaMattina, Josue Alvarez-Casas, Irene Lu, Jessica M Powell, Samuel Sultan, Michael W Phelan, Rolf N Barth,

BACKGROUND:Although single-port donor nephrectomy offers improved cosmetic outcomes, technical challenges have limited its application to selected centers. Our center has performed over 400 single-port donor nephrectomies. The da Vinci single-site robotic platform was utilized in an effort to overcome the steric, visualization, ergonomic, and other technical limitations associated with the ... Read more >>

J Surg Res (The Journal of surgical research)
[2018, 222:34-38]

Cited: 5 times

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N-glycolylneuraminic acid knockout reduces erythrocyte sequestration and thromboxane elaboration in an ex vivo pig-to-human xenoperfusion model.

Arielle Cimeno, Wessam Hassanein, Beth M French, Jessica M Powell, Lars Burdorf, Olga Goloubeva, Xiangfei Cheng, Dawn M Parsell, Jagdeece Ramsoondar, Kasinath Kuravi, Todd Vaught, Mehmet C Uluer, Emily Redding, Natalie O'Neill, Christopher Laird, Alena Hershfeld, Ivan Tatarov, Kathryn Thomas, David Ayares, Agnes M Azimzadeh, Richard N Pierson, Rolf N Barth, John C LaMattina,

<h4>Background</h4>Wild-type pigs express several carbohydrate moieties on their cell surfaces that differ from those expressed by humans. This difference in profile leads to pig tissue cell recognition of human blood cells causing sequestration, in addition to antibody-mediated xenograft injury. One such carbohydrate is N-glycolylneuraminic acid (Neu5Gc), a sialic acid molecule ... Read more >>

Xenotransplantation (Xenotransplantation)
[2017, 24(6):]

Cited: 3 times

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Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation.

David K C Cooper, Martin Wijkstrom, Sundaram Hariharan, Joshua L Chan, Avneesh Singh, Keith Horvath, Muhammad Mohiuddin, Arielle Cimeno, Rolf N Barth, John C LaMattina, Richard N Pierson,

Several groups have reported extended survival of genetically engineered pig organs in nonhuman primates, varying from almost 10 months for life-supporting kidney grafts and more than 2 years for non-life-supporting heart grafts to less than 1 month for life-supporting liver and lung grafts. We have attempted to define groups of ... Read more >>

Transplantation (Transplantation)
[2017, 101(7):1551-1558]

Cited: 19 times

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Resolution of donor non-alcoholic fatty liver disease following liver transplantation.

Andrew D Posner, Samuel T Sultan, Norann A Zaghloul, William S Twaddell, David A Bruno, Steven I Hanish, William R Hutson, Laci Hebert, Rolf N Barth, John C LaMattina,

<h4>Introduction</h4>Transplant surgeons conventionally select against livers displaying high degrees (>30%) of macrosteatosis (MaS), out of concern for primary non-function or severe graft dysfunction. As such, there is relatively limited experience with such livers, and the natural history remains incompletely characterized. We present our experience of transplanted livers with high degrees ... Read more >>

Clin Transplant (Clinical transplantation)
[2017, 31(9):]

Cited: 2 times

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Surgical complications of laparoendoscopic single-site donor nephrectomy: a retrospective study.

John C LaMattina, Jessica M Powell, Nadiesda A Costa, David B Leeser, Silke V Niederhaus, Jonathan S Bromberg, Josue Alvarez-Casas, Michael S Phelan, Rolf N Barth,

The single-port approach has been associated with an unacceptably high rate of umbilical port hernias in large series of patients undergoing single-port cholecystectomy and colectomy and with additional surgical risks thought secondary to technical and ergonomic limitations. A retrospective review of 378 consecutive laparoendoscopic single-site(LESS) donor nephrectomies performed between 04/15/2009 ... Read more >>

Transpl Int (Transplant international : official journal of the European Society for Organ Transplantation)
[2017, 30(11):1132-1139]

Cited: 3 times

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Postoperative Elevated Resistive Indices Do Not Predict Hepatic Artery Thrombosis in Extended Criteria Donor Livers.

Eric J Siskind, Fauzia Vandermeer, Tamar R Siskind, David A Bruno, Samuel Sultan, Josue Alvarez-Casas, Arielle Stafford, Barton Lane, John C Lamattina, Rolf N Barth, Steven I Hanish,

Postoperative transplant liver ultrasounds were analyzed in standard criteria donor (SCD), extended criteria donor (ECD), and donation after cardiac death (DCD) liver allografts to determine if elevated resistive indices (RIs) are consistently present and if they are pathological. Postoperative transplant liver ultrasounds were reviewed from 115 consecutive patients. Hepatic arterial ... Read more >>

Int J Angiol (The International journal of angiology : official publication of the International College of Angiology, Inc)
[2017, 26(4):238-240]

Cited: 1 time

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Recellularization via the bile duct supports functional allogenic and xenogenic cell growth on a decellularized rat liver scaffold.

Wessam Hassanein, Mehmet C Uluer, John Langford, Jhade D Woodall, Arielle Cimeno, Urmil Dhru, Avraham Werdesheim, Joshua Harrison, Carlos Rivera-Pratt, Stephen Klepfer, Ali Khalifeh, Bryan Buckingham, Philip S Brazio, Dawn Parsell, Charlie Klassen, Cinthia Drachenberg, Rolf N Barth, John C LaMattina,

Recent years have seen a proliferation of methods leading to successful organ decellularization. In this experiment we examine the feasibility of a decellularized liver construct to support growth of functional multilineage cells. Bio-chamber systems were used to perfuse adult rat livers with 0.1% SDS for 24 hours yielding decellularized liver scaffolds. ... Read more >>

Organogenesis (Organogenesis)
[2017, 13(1):16-27]

Cited: 9 times

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Sequential kidney-liver transplantation from the same living donor for lecithin cholesterol acyl transferase deficiency.

Sarwat B Ahmad, Michael Miller, Steven Hanish, Stephen T Bartlett, William Hutson, Rolf N Barth, John C LaMattina,

<h4>Background</h4>Lecithin cholesterol acyl transferase (LCAT) deficiency is a rare autosomal recessive disorder of lipoprotein metabolism that results in end-stage renal disease (ESRD) necessitating transplantation. As LCAT is produced in the liver, combined kidney and liver transplantation was proposed to cure the clinical syndrome of LCAT deficiency.<h4>Methods</h4>A 29-year-old male with ESRD ... Read more >>

Clin Transplant (Clinical transplantation)
[2016, 30(10):1370-1374]

Cited: 2 times

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Live Donor Renal Transplant With Simultaneous Bilateral Nephrectomy for Autosomal Dominant Polycystic Kidney Disease Is Feasible and Satisfactory at Long-term Follow-up.

Sarwat B Ahmad, Brian Inouye, Michael S Phelan, Andrew C Kramer, Jay Sulek, Matthew R Weir, Rolf N Barth, John C LaMattina, Eugene J Schweitzer, David B Leeser, Silke V Niederhaus, Stephen T Bartlett, Jonathan S Bromberg,

<h4>Background</h4>Timing of bilateral nephrectomy (BN) is controversial in patients with refractory symptoms of autosomal dominant polycystic kidney disease (APKD) in need of a renal transplant.<h4>Methods</h4>Adults who underwent live donor renal transplant (LRT) + simultaneous BN (SBN) from August 2003 to 2013 at a single transplant center (n = 66) were ... Read more >>

Transplantation (Transplantation)
[2016, 100(2):407-415]

Cited: 8 times

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Pharmacokinetics and Tolerability of Intravenous Sildenafil in Two Subjects with Child-Turcotte-Pugh Class C Cirrhosis and Renal Dysfunction.

Ayse L Mindikoglu, Thomas C Dowling, David J Schaub, William R Hutson, Darryn R Potosky, Robert H Christenson, Rolf N Barth, John C LaMattina, Steven I Hanish, Matthew R Weir, Jean-Pierre Raufman,

Dig Dis Sci (Digestive diseases and sciences)
[2015, 60(11):3491-3494]

Cited: 0 times

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Shorter waitlist times and improved graft survivals are observed in patients who accept hepatitis C virus+ renal allografts.

Joseph R Scalea, Rolf N Barth, Raghava Munivenkatappa, Benjamin Philosophe, Matthew Cooper, Victoria Whitlow, John C LaMattina,

There is a paucity of data regarding long-term renal graft survival in hepatitis C virus positive (HCV+) patients. We analyzed our institution's experience with HCV+ renal transplantation and factors contributing to subsequent renal graft failure.We analyzed 1,679 adult, deceased donor, single-organ renal transplants occurring between 2000 and 2012. Recipient and ... Read more >>

Transplantation (Transplantation)
[2015, 99(6):1192-1196]

Cited: 33 times

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Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade.

John C LaMattina, Lars Burdorf, Tianshu Zhang, Elana Rybak, Xiangfei Cheng, Raghava Munivenkatappa, Isabelle I Salles, Katleen Broos, Evelyn Sievert, Brian McCormick, Marc Decarlo, David Ayares, Hans Deckmyn, Agnes M Azimzadeh, Richard N Pierson, Rolf N Barth,

<h4>Background</h4>Although transplantation of genetically modified porcine livers into baboons has yielded recipient survival for up to 7 days, survival is limited by profound thrombocytopenia, which becomes manifest almost immediately after revascularization, and by subsequent coagulopathy. Porcine von Willebrand's factor (VWF), a glycoprotein that adheres to activated platelets to initiate thrombus formation, ... Read more >>

Xenotransplantation (Xenotransplantation)
[2014, 21(3):274-286]

Cited: 6 times

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Safety of belatacept bridging immunosuppression in hepatitis C-positive liver transplant recipients with renal dysfunction.

John C LaMattina, Mihaela P Jason, Steven I Hanish, Shane E Ottmann, David K Klassen, Darryn Potosky, William R Hutson, Rolf N Barth,

<h4>Background</h4>Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperative risks. The authors' experience with seven liver transplant patients who received belatacept and mycophenolic acid maintenance immunosuppression ... Read more >>

Transplantation (Transplantation)
[2014, 97(2):133-137]

Cited: 12 times

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