Full Text Journal Articles by
Author Joel Singer

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A whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis severity score, based on cartilage, osteophytes and meniscus (OA-COM).

Eric C Sayre, Ali Guermazi, Savvas Nicolaou, John M Esdaile, Jacek A Kopec, Joel Singer, Hubert Wong, Anona Thorne, Jolanda Cibere,

<h4>Objective</h4>To develop a whole-joint, unidimensional, irreversible, and fine-grained MRI knee osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM), and to predict progression across different severity states using OA-COM as outcome and clinical variables as predictors.<h4>Methods</h4>Population-based knee pain cohort aged 40-79 was assessed at baseline and 7-year follow-up. ... Read more >>

PLoS One (PloS one)
[2021, 16(10):e0258451]

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A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes.

Cody Durrer, Sean McKelvey, Joel Singer, Alan M Batterham, James D Johnson, Kelsey Gudmundson, Jay Wortman, Jonathan P Little,

Type 2 diabetes can be treated, and sometimes reversed, with dietary interventions; however, strategies to implement these interventions while addressing medication changes are lacking. We conducted a 12-week pragmatic, community-based parallel-group randomized controlled trial (ClinicalTrials.gov: NCT03181165) evaluating the effect of a low-carbohydrate (<50 g), energy-restricted diet (~850-1100 kcal/day; Pharm-TCR; n = 98) compared to ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):5367]

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Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections-A Systematic Review and Meta-Analysis.

Matthew P Cheng, Alessandro Cau, Todd C Lee, Daniel Brodie, Arthur Slutsky, John Marshall, Srin Murthy, Terry Lee, Joel Singer, Koray K Demir, John Boyd, Hyejee Ohm, David Maslove, Alberto Goffi, Isaac I Bogoch, David D Sweet, Keith R Walley, James A Russell, ,

<h4>Objectives</h4>Severe acute respiratory syndrome-related coronavirus-2 binds and inhibits angiotensin-converting enzyme-2. The frequency of acute cardiac injury in patients with coronavirus disease 2019 is unknown. The objective was to compare the rates of cardiac injury by angiotensin-converting enzyme-2-binding viruses from viruses that do not bind to angiotensin-converting enzyme-2.<h4>Data sources</h4>We performed a ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(9):1558-1566]

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A pragmatic parallel group implementation study of a prehospital-activated ECPR protocol for refractory out-of-hospital cardiac arrest.

Brian Grunau, Jamil Bashir, Anson Cheung, Robert Boone, Ken McDonald, Frank Scheuermeyer, Joel Singer, Sandra Jenneson, Ron Straight, Brian Twaites, Luke Harris, Scott Haig, Devin Harris, Richard Vandegriend, Hussein Kanji, Jim Christenson,

<h4>Objectives</h4>Extracorporeal membrane oxygenation within CPR (ECPR) may improve survival among patients with refractory out-of-hospital cardiac arrest (OHCA). We evaluated outcomes after incorporating ECPR into a conventional resuscitation system.<h4>Methods</h4>We introduced a prehospital-activated ECPR protocol for select refractory OHCAs into one of four metropolitan regions in British Columbia. We prospectively identified ECPR-eligible ... Read more >>

Resuscitation (Resuscitation)
[2021, 167:22-28]

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Predictors of the Use of Mineralocorticoid Receptor Antagonists in Patients With Left Ventricular Dysfunction Post-ST-Segment-Elevation Myocardial Infarction.

Eric C Wong, Christopher B Fordyce, Graham Wong, Terry Lee, Michele Perry-Arnesen, Martha Mackay, Joel Singer, John A Cairns, Ricky D Turgeon,

Background Guidelines recommend mineralocorticoid receptor antagonist (MRA) use in patients with left ventricular ejection fraction ≤40% following a myocardial infarction plus heart failure or diabetes mellitus, based on mortality benefit in the EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) trial. The objective of this study was ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2021, 10(14):e019167]

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Causes and circumstances of maternal death: a secondary analysis of the Community-Level Interventions for Pre-eclampsia (CLIP) trials cohort.

Annet M Aukes, Kristina Arion, Jeffrey N Bone, Jing Li, Marianne Vidler, Mrutyunjaya B Bellad, Umesh Charantimath, Shivaprasad S Goudar, Zahra Hoodbhoy, Geetanjali Katageri, Salésio Macuacua, Ashalata A Mallapur, Khátia Munguambe, Rahat N Qureshi, Charfudin Sacoor, Esperança Sevene, Sana Sheikh, Anifa Valá, Gwyneth Lewis, Zulfiqar A Bhutta, Peter von Dadelszen, Laura A Magee, ,

<h4>Background</h4>Incomplete vital registration systems mean that causes of death during pregnancy and childbirth are poorly understood in low-income and middle-income countries. To inform global efforts to reduce maternal mortality, we compared physician review and computerised analysis of verbal autopsies (interpreting verbal autopsies [InterVA] software), to understand their agreement on maternal ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, 9(9):e1242-e1251]

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Reduction in Doses to Organs at Risk and Normal Tissue During Breast Radiation Therapy With a Carbon-Fiber Adjustable Reusable Accessory.

Cheryl Duzenli, Theodora Koulis, Tara Menna, Emilie Carpentier, Tania Arora, Robin Coope, Bradford Gill, Peter Lim, Christina Aquino-Parsons, Alan Nichol, Joel Singer, Paris-Anne Ingledew, Sheri Grahame, Elisa K Chan,

<h4>Purpose</h4>This pilot study (ClinicalTrials.gov NCT04543851) investigates a novel breast positioning device using a low density, high tensile carbon-fiber cradle to support the breast, remove the inframammary fold, and reduce dose to organs at risk for whole breast radiation therapy in the supine position.<h4>Methods and materials</h4>Thirty patients with inframammary folds ≥1 ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2021, :]

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Unique Challenges of Randomised Controlled Trials in Pediatric Cardiology.

Kevin C Harris, Andrew S Mackie, Frederic Dallaire, Michael Khoury, Joel Singer, William T Mahle, Terry P Klassen, Brian W McCrindle,

Pediatric cardiology has evolved over time with reductions in childhood mortality due to congenital heart disease. Surgical innovation drove early changes in care. Increasingly, the need for more robust evidence provided by randomised controlled trials (RCTs) has been recognised. Although the number of RCTs has increased, there remains a relative ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, 37(9):1394-1403]

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Blood pressure thresholds in pregnancy for identifying maternal and infant risk: a secondary analysis of Community-Level Interventions for Pre-eclampsia (CLIP) trial data.

Jeffrey N Bone, Laura A Magee, Joel Singer, Hannah Nathan, Rahat N Qureshi, Charfudin Sacoor, Esperança Sevene, Andrew Shennan, Mrutyunjaya B Bellad, Shivaprasad S Goudar, Ashalata A Mallapur, Khátia Munguambe, Marianne Vidler, Zulfiqar A Bhutta, Peter von Dadelszen, ,

<h4>Background</h4>Blood pressure measurement is a marker of antenatal care quality. In well resourced settings, lower blood pressure cutoffs for hypertension are associated with adverse pregnancy outcomes. We aimed to study the associations between blood pressure thresholds and adverse outcomes and the diagnostic test properties of these blood pressure cutoffs in ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, 9(8):e1119-e1128]

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Impact of regionalizing ST-elevation myocardial infarction care on sex differences in reperfusion times and clinical outcomes.

Erin Rayner-Hartley, Graham C Wong, Cassandra Fayowski, John A Cairns, Joel Singer, Terry Lee, Tara Sedlak, Karin H Humphries, Michele Perry-Arnesen, Martha Mackay, Christopher B Fordyce,

<h4>Background</h4>Women with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention historically experience worse in-hospital outcomes compared to men.<h4>Hypothesis</h4>Implementation of a regional STEMI system will reduce care gaps in reperfusion times and in-hospital outcomes between women and men.<h4>Methods</h4>1928 patients (413 women, 21.4%) presented with an acute STEMI between June ... Read more >>

Clin Cardiol (Clinical cardiology)
[2021, 44(8):1113-1119]

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E-mental health in child psychiatry during COVID-19: an initial attitudinal study.

Valsamma Eapen, Ann Dadich, Srilaxmi Balachandran, Anitha Dani, Rasha Howari, Anupama Zeena Sequeria, Joel D Singer,

<h4>Objective</h4>COVID-19 propelled e-mental health within the Australian health system. It is important to learn from this to inform mental healthcare during future crises.<h4>Method</h4>A lexical analysis was conducted of clinician reflections during COVID-19 as they delivered psychiatry services to children and families in New South Wales (<i>n</i> = 6) and transitioned ... Read more >>

Australas Psychiatry (Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists)
[2021, :10398562211022748]

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The Use of SMS Text Messaging to Improve the Hospital-to-Community Transition in Patients With Acute Coronary Syndrome (Txt2Prevent): Results From a Pilot Randomized Controlled Trial.

Emily S Ross, Brodie M Sakakibara, Martha H Mackay, David G T Whitehurst, Joel Singer, Mustafa Toma, Kitty K Corbett, Harriette G C Van Spall, Kimberly Rutherford, Bobby Gheorghiu, Jillianne Code, Scott A Lear,

<h4>Background</h4>Acute coronary syndrome (ACS) is a leading cause of hospital admission in North America. Many patients with ACS experience challenges after discharge that impact their clinical outcomes and psychosocial well-being. SMS text messaging has the potential to provide support to patients during this postdischarge period.<h4>Objective</h4>This study pilot tested a 60-day ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2021, 9(5):e24530]

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Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in COVID-19: Meta-analysis/Meta-regression Adjusted for Confounding Factors.

Terry Lee, Alessandro Cau, Matthew Pellan Cheng, Adeera Levin, Todd C Lee, Donald C Vinh, Francois Lamontagne, Joel Singer, Keith R Walley, Srinivas Murthy, David Patrick, Oleksa G Rewa, Brent W Winston, John Marshall, John Boyd, Karen Tran, Andre C Kalil, Russell Mcculoh, Robert Fowler, James M Luther, James A Russell, ,

<h4>Background</h4>Angiotensin receptor blockers (ARBs) and/or angiotensin-converting enzyme (ACE) inhibitors could alter mortality from coronavirus disease 2019 (COVID-19), but existing meta-analyses that combined crude and adjusted results may be confounded by the fact that comorbidities are more common in ARB/ACE inhibitor users.<h4>Methods</h4>We searched PubMed/MEDLINE/Embase for cohort studies and meta-analyses reporting mortality ... Read more >>

CJC Open (CJC open)
[2021, 3(7):965-975]

Cited: 1 time

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Cardiac Risk Score to Predict Small for Gestational Age Infants in Pregnant Women With Heart Disease.

Jasmine Grewal, Samuel C Siu, Rohan d'Souza, Terry Lee, Joel Singer, Valerie Rychel, Marla Kiess, Mathew Sermer, Candice K Silversides,

<h4>Background</h4>One of the most common fetal complications in pregnant women with cardiovascular disease is a small for gestational age (SGA) neonate, which is associated with a higher risk of perinatal morbidity/mortality and poor long-term health outcomes. The objective of this study was to identify cardiac determinants and derive a risk ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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Effect of alternative income assistance schedules on drug use and drug-related harm: a randomised controlled trial.

Lindsey Richardson, Allison Laing, JinCheol Choi, Ekaterina Nosova, M-J Milloy, Brandon Dl Marshall, Joel Singer, Evan Wood, Thomas Kerr,

<h4>Background</h4>The synchronised monthly disbursement of income assistance, whereby all recipients are paid on the same day, has been associated with increases in illicit drug use and serious associated harms. This phenomenon is often referred to as the cheque effect. Because payment variability can affect consumption patterns, this study aimed to ... Read more >>

Lancet Public Health (The Lancet. Public health)
[2021, 6(5):e324-e334]

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Pregnancy Outcomes and Blood Pressure Visit-to-Visit Variability and Level in Three Less-Developed Countries.

Laura A Magee, Jeffrey Bone, Salwa Banoo Owasil, Joel Singer, Terry Lee, Mrutunjaya B Bellad, Shivaprasad S Goudar, Alexander G Logan, Salésio E Macuacua, Ashalata A Mallapur, Hannah L Nathan, Rahat N Qureshi, Esperança Sevene, Andrew H Shennan, Anifa Valá, Marianne Vidler, Zulfiqar A Bhutta, Peter von Dadelszen, ,

[Figure: see text]. ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, 77(5):1714-1722]

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Access-Site vs Non-Access-Site Major Bleeding and In-Hospital Outcomes Among STEMI Patients Receiving Primary PCI.

Michael J Thibert, Christopher B Fordyce, John A Cairns, Ricky D Turgeon, Martha Mackay, Terry Lee, Wendy Tocher, Joel Singer, Michele Perry-Arnesen, Graham C Wong,

<h4>Background</h4>Major bleeding (MB) is an independent predictor of mortality among ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI). Prevention of access-site MB has received significant attention. However, limited data have been obtained on the influence of access-site MB vs non-access-site MB and association with subsequent adverse in-hospital ... Read more >>

CJC Open (CJC open)
[2021, 3(7):864-871]

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Elevated Blood Mitochondrial DNA in Early Life Among Uninfected Children Exposed to Human Immunodeficiency Virus and Combination Antiretroviral Therapy in utero.

Abhinav Ajaykumar, Mayanne Zhu, Fatima Kakkar, Jason Brophy, Ari Bitnun, Ariane Alimenti, Hugo Soudeyns, Sara Saberi, Arianne Y K Albert, Deborah M Money, Hélène C F Côté, ,

<h4>Background</h4>Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure to maternal human immunodeficiency virus (HIV) and/or cART could have long-term effects on children who are HIV exposed and uninfected (CHEU). Our objective was to compare blood mitochondrial DNA ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 223(4):621-631]

Cited: 1 time

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The association of pH values during the first 24 h with neurological status at hospital discharge and futility among patients with out-of-hospital cardiac arrest.

Rahaf Al Assil, Joel Singer, Matthieu Heidet, Christopher B Fordyce, Frank Scheuermeyer, Sean van Diepen, Mypinder Sekhon, K H Benjamin Leung, Rob Stenstrom, Jim Christenson, Brian Grunau,

<h4>Study objective</h4>Post-resuscitation prognostic biomarkers for out-of-hospital cardiac arrest (OHCA) outcomes have not been fully elucidated. We examined the association of acid-base blood values (pH) with patient outcomes and calculated the pH test performance to predict prognosis.<h4>Methods</h4>This was a post-hoc analysis of data from the continuous chest compression trial, which enrolled ... Read more >>

Resuscitation (Resuscitation)
[2021, 159:105-114]

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Sustained Dysregulation of the Plasma Renin-angiotensin System in Acute COVID-19

Kevin Burns, Matthew Cheng, Todd Lee, Allison McGeer, David Sweet, Karen Tran, Terry Lee, Srinivas Murthy, John Boyd, Joel Singer, Keith Walley, David Patrick, Francois Lamontagne, John Marshall, Greg Haljan, Robert Fowler, Brent Winston, James Russell,

SARS-CoV-2 enters cells by binding to angiotensin-converting enzyme 2 (ACE2), and COVID-19 infection may therefore induce changes in the renin-angiotensin system (RAS). To determine the effects of COVID-19 on plasma RAS components, we measured plasma ACE, ACE2, and angiotensins I, (1-7), and II in 46 adults with COVID-19 at hospital ... Read more >>

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Impact of extended-release niacin on immune activation in HIV-infected immunological non-responders on effective antiretroviral therapy.

Bertrand Lebouché, Alexis Yero, Tao Shi, Omar Farnos, Joel Singer, Ido Kema, Cecilia T Costiniuk, Réjean Thomas, Marie-Josée Brouillette, Kim Engler, Jean-Pierre Routy, Mohammad-Ali Jenabian, ,

<h4>Background</h4><b>Background:</b> Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) is involved in immune dysregulation during HIV infection. Niacin (vitamin B3) could control the excess of tryptophan depletion and represents a potential strategy to improve immune functions and CD4 count recovery in immunological non-responder HIV-infected individuals on antiretroviral therapy (ART).<h4>Methods</h4><b>Methods:</b> In the ... Read more >>

HIV Res Clin Pract (HIV research & clinical practice)
[2020, 21(6):182-190]

Cited: 1 time

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A Framework to Ensure Patient Partners Have Equal and Contributing Voices Throughout the Research Program Evaluation Process.

David R Hillier, Mila Tang, William Clark, Cynthia MacDonald, Carol Connolly, Chantel Large, Malcolm King, Joel Singer, Adeera Levin, Braden Manns, Ana Konvalinka, James Scholey, Norman D Rosenblum,

<h4>Purpose of program</h4>Traditionally, peer review was a closed process conducted only by individuals working in the research field. To establish a more integrated and patient-centered approach, one of Canada's largest kidney research networks (Can-SOLVE CKD) has created a Research Operations Committee (ROC) that includes patients as key members. The ROC ... Read more >>

Can J Kidney Health Dis (Canadian journal of kidney health and disease)
[2020, 7:2054358120970093]

Cited: 1 time

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Study protocol for a multicentre, prospective cohort study of the association of angiotensin II type 1 receptor blockers on outcomes of coronavirus infection.

James A Russell, John C Marshall, Arthur Slutsky, Srinivas Murthy, Dave Sweet, Terry Lee, Joel Singer, David M Patrick, Bin Du, Zhiyong Peng, Matthew Cheng, Kevin D Burns, Michael O Harhay,

<h4>Introduction</h4>The COVID-19 epidemic grows and there are clinical trials of antivirals. There is an opportunity to complement these trials with investigation of angiotensin II type 1 receptor blockers (ARBs) because an ARB (losartan) was effective in murine influenza pneumonia.<h4>Methods and analysis</h4>Our innovative design includes: ARBs; alignment with the WHO Ordinal ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e040768]

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Interventions to improve linear growth during complementary feeding period for children aged 6-24 months living in low- and middle-income countries: a systematic review and network meta-analysis

Jay Park, Ofir Harari, Ellie Siden, Louis Dron, Noor-E Zannat, Joel Singer, Richard Lester, Kristian Thorlund, Edward Mills,

Background: Optimizing linear growth in children during complementary feeding period (CFP) (6-24 months) is critical for their development. Several interventions, such as micronutrient and food supplements, deworming, maternal education, and water, sanitation and hygiene (WASH), could potentially be provided to prevent stunting, but their comparative effectiveness are currently unclear. In ... Read more >>

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Correction: A pragmatic randomized controlled trial testing the effects of the international scientific SCI exercise guidelines on SCI chronic pain: protocol for the EPIC-SCI trial.

Kathleen A Martin Ginis, Jan W van der Scheer, Kendra R Todd, Jennifer C Davis, Sonja Gaudet, Femke Hoekstra, Mohammad Ehsanul Karim, John L K Kramer, Jonathan Peter Little, Joel Singer, Andrea Townson, Christopher R West,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Spinal Cord (Spinal cord)
[2020, 58(9):1046]

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