Full Text Journal Articles by
Author Joel Meyer

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Direct comparisons of bisulfite pyrosequencing versus targeted bisulfite sequencing.

Dillon E King, A Clare Sparling, Rashmi Joglekar, Joel N Meyer, Susan K Murphy,

DNA methylation is an important epigenetic mechanism involved in proper genome function. Bisulfite pyrosequencing (PSQ) is a commonly used technique to quantify DNA methylation. Although very accurate, bisulfite pyrosequencing can be expensive and time consuming for large-scale quantitative DNA methylation analysis at the single nucleotide level. High throughput DNA methylation ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Caenorhabditis elegans strain sensitivity to sodium arsenite exposure is varied based on age and outcome measured.

Kathleen Hershberger, Tess Leuthner, Tanner Waters, Joel Meyer,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Transitions of Care After Critical Illness-Challenges to Recovery and Adaptive Problem Solving.

Kimberley J Haines, Elizabeth Hibbert, Nina Leggett, Leanne M Boehm, Tarli Hall, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Pamela Mactavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Theodore J Iwashyna, Mark E Mikkelsen, Joanne McPeake, Carla M Sevin, ,

<h4>Objectives</h4>Investigate the challenges experienced by survivors of critical illness and their caregivers across the transitions of care from intensive care to community, and the potential problem-solving strategies used to navigate these challenges.<h4>Design</h4>Qualitative design-data generation via interviews and data analysis via the framework analysis method.<h4>Setting</h4>Patients and caregivers from three continents, identified ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1923-1931]

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Recovery, rehabilitation and follow-up services following critical illness: an updated UK national cross-sectional survey and progress report.

Bronwen Connolly, Rhian Milton-Cole, Claire Adams, Ceri Battle, Joanne McPeake, Tara Quasim, Jon Silversides, Andrew Slack, Carl Waldmann, Elizabeth Wilson, Joel Meyer, ,

<h4>Objective</h4>To comprehensively update and survey the current provision of recovery, rehabilitation and follow-up services for adult critical care patients across the UK.<h4>Design</h4>Cross-sectional, self-administered, predominantly closed-question, electronic, online survey.<h4>Setting</h4>Institutions providing adult critical care services identified from national databases.<h4>Participants</h4>Multiprofessional critical care clinicians delivering services at each site.<h4>Results</h4>Responses from 176 UK hospital sites ... Read more >>

BMJ Open (BMJ open)
[2021, 11(10):e052214]

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Discharge Documentation and Follow-Up of Critically Ill Patients With Acute Kidney Injury Treated With Kidney Replacement Therapy: A Retrospective Cohort Study.

Xin Yi Choon, Nuttha Lumlertgul, Lynda Cameron, Andrew Jones, Joel Meyer, Andrew Slack, Helen Vollmer, Nicholas A Barrett, Richard Leach, Marlies Ostermann,

Leading organisations recommend follow-up of acute kidney injury (AKI) survivors, as these patients are at risk of long-term complications and increased mortality. Information transfer between specialties and from tertiary to primary care is essential to ensure timely and appropriate follow-up. Our aim was to examine the association between completeness of ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:710228]

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Communication and Virtual Visiting for Families of Patients in Intensive Care during the COVID-19 Pandemic: A UK National Survey.

Louise Rose, Lisa Yu, Joseph Casey, Amelia Cook, Victoria Metaxa, Natalie Pattison, Anne Marie Rafferty, Pam Ramsay, Sian Saha, Andreas Xyrichis, Joel Meyer,

<b>Rationale:</b> Restriction or prohibition of family visiting intensive care units (ICUs) during the coronavirus disease (COVID-19) pandemic poses substantial barriers to communication and family- and patient-centered care. <b>Objectives:</b> To understand how communication among families, patients, and the ICU team was enabled during the pandemic. The secondary objectives were to understand ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(10):1685-1692]

Cited: 4 times

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Lack of Detectable Direct Effects of Silver and Silver Nanoparticles on Mitochondria in Mouse Hepatocytes.

Lu Wang, Danielle F Mello, Robert M Zucker, Nelson A Rivera, Nicholas M K Rogers, Nicholas K Geitner, William K Boyes, Mark R Wiesner, Heileen Hsu-Kim, Joel N Meyer,

Silver nanoparticles (AgNPs) are well-proven antimicrobial nanomaterials, yet little is elucidated regarding the mechanism underlying cytotoxicity induced by these nanoparticles. Here, we tested the hypothesis that mitochondria are primary intracellular targets of two AgNPs and silver ions in mouse hepatocytes (AML12) cultured in glucose- and galactose-based media. AML12 cells were ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2021, :]

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Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-induced Myeloid-Derived Suppressor Cells

Wei Huang, Yaping Liu, Anthony Luz, Mark Berrong, Joel Meyer, Yujing Zou, Excel Swann, Pasupathi Sundaramoorthy, Yubin Kang, Shekeab Jauhari, William Lento, Nelson Chao, Luigi Racioppi,

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells, which can suppress the immune response, promote tumor progression and impair the efficacy of immunotherapies. Consequently, the pharmacological targeting of MDSC is emerging as a new immunotherapeutic strategy to stimulate the natural anti-tumor immune response and potentiate the efficacy of ... Read more >>

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Proning related bilateral anterior ischaemic optic neuropathy in a patient with COVID-19 related acute respiratory distress syndrome.

Kirsty Michelle Clarke, Vivi Riga, Amy-Lee Shirodkar, Joel Meyer,

<h4>Background</h4>Non-arteritic ischaemic optic neuropathy (NAION) is a rare but harmful complication of prone positioning. Prone mechanical ventilation is a therapeutic strategy which has been used extensively during the COVID-19 pandemic to treat acutely hypoxemic patients with COVID-19 related acute respiratory distress syndrome (ARDS). Though a small number of cases of ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2021, 21(1):276]

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Optimizing Critical Illness Recovery: Perspectives and Solutions From the Caregivers of ICU Survivors.

Carla M Sevin, Leanne M Boehm, Elizabeth Hibbert, Anthony J Bastin, James C Jackson, Joel Meyer, Tara Quasim, Rita N Bakhru, Ashley Montgomery-Yates, Andrew Slack, Mary Still, Giora Netzer, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Joanne McPeake,

<h4>Objectives</h4>To understand the unmet needs of caregivers of ICU survivors, how they accessed support post ICU, and the key components of beneficial ICU recovery support systems as identified from a caregiver perspective.<h4>Design</h4>International, qualitative study.<h4>Subjects</h4>We conducted 20 semistructured interviews with a diverse group of caregivers in the United States, the United ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(5):e0420]

Cited: 1 time

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Benefits of Peer Support for Intensive Care Unit Survivors: Sharing Experiences, Care Debriefing, and Altruism.

Joanne McPeake, Theodore J Iwashyna, Leanne M Boehm, Elizabeth Hibbert, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Joel Meyer, Ashley Montgomery-Yates, Mark E Mikkelsen, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Tara Quasim, Carla M Sevin, Kimberley J Haines,

<h4>Background</h4>After critical illness, patients are often left with impairments in physical, social, emotional, and cognitive functioning. Peer support interventions have been implemented internationally to ameliorate these issues.<h4>Objective</h4>To explore what patients believed to be the key mechanisms of effectiveness of peer support programs implemented during critical care recovery.<h4>Methods</h4>In a secondary analysis ... Read more >>

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, 30(2):145-149]

Cited: 2 times

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Xenobiotic metabolism and transport in Caenorhabditis elegans.

Jessica H Hartman, Samuel J Widmayer, Christina M Bergemann, Dillon E King, Katherine S Morton, Riccardo F Romersi, Laura E Jameson, Maxwell C K Leung, Erik C Andersen, Stefan Taubert, Joel N Meyer,

<i>Caenorhabditis elegans</i> has emerged as a major model in biomedical and environmental toxicology. Numerous papers on toxicology and pharmacology in <i>C. elegans</i> have been published, and this species has now been adopted by investigators in academic toxicology, pharmacology, and drug discovery labs. <i>C. elegans</i> has also attracted the interest of ... Read more >>

J Toxicol Environ Health B Crit Rev (Journal of toxicology and environmental health. Part B, Critical reviews)
[2021, 24(2):51-94]

Cited: 3 times

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Establishing a Peer Support Program for Survivors of COVID-19: A Report From the Critical and Acute Illness Recovery Organization.

Aluko A Hope, Andrea Annie Johnson, Joanne McPeake, Hali Felt, Carla M Sevin, Mark E Mikkelsen, Theodore J Iwashyna, Caroline Lassen-Greene, Kimberley J Haines, Sachin Agarwal, Rita N Bakhru, Leanne M Boehm, Brad W Butcher, Kelly Drumright, Tammy L Eaton, Elizabeth Hibbert, Karen Sara Hoehn, David Hornstein, Heather Imperato-Shedden, James C Jackson, Janet A Kloos, Anna Lewis, Joel Meyer, Ashley Montgomery-Yates, Veronica Rojas, Christa Schorr, Dorothy Wade, Cydni Williams,

Am J Crit Care (American journal of critical care : an official publication, American Association of Critical-Care Nurses)
[2021, :e1-e5]

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Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling inCaenorhabditis elegans

John Rooney, Kathleen Hershberger, Elena Turner, Lauren Donoghue, Laura Maurer, Ian Ryde, Jina Kim, Rashmi Joglekar, Jonathan Hibshman, Latasha Smith, Dhaval Bhatt, Olga Ilkayeva, Matthew Hirschey, Joel Meyer,

The consequences of damage to the mitochondrial genome (mtDNA) are poorly understood, although mtDNA is more susceptible to damage than nuclear DNA (nucDNA), and many environmental toxicants target the mitochondria. Reports from the toxicological literature suggest that exposure to early-life mitochondrial damage could lead to deleterious consequences later in life ... Read more >>

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PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species.

Tess C Leuthner, Jessica H Hartman, Ian T Ryde, Joel N Meyer,

Mitochondrial DNA (mtDNA) copy number is a critical component of overall mitochondrial health. In this chapter, we describe methods for simultaneous isolation of mtDNA and nuclear DNA (nucDNA), and measurement of their respective copy numbers using quantitative PCR. Methods differ depending on the species and cell type of the starting ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2310:91-111]

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An International Study Exploring the Experience of Survivors of Critical Illness as Volunteers Within ICU Recovery Services.

Carly Robinson, Elizabeth Hibbert, Anthony J Bastin, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Carla M Sevin, Joanne McPeake, Leanne M Boehm,

Many clinicians have implemented follow-up and aftercare to support patients following ICU. Some of this care is supported and facilitated by peer volunteers. There is limited contemporary work that has explicitly explored volunteer roles within ICU recovery services or the experience of volunteers undertaking these roles. We sought to explore ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(11):e0273]

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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.

Claudia P Gonzalez-Hunt, Anthony L Luz, Ian T Ryde, Elena A Turner, Olga R Ilkayeva, Dhaval P Bhatt, Matthew D Hirschey, Joel N Meyer,

Rotenone, a mitochondrial complex I inhibitor, has been widely used to study the effects of mitochondrial dysfunction on dopaminergic neurons in the context of Parkinson's disease. Although the deleterious effects of rotenone are well documented, we found that young adult Caenorhabditis elegans showed resistance to 24 and 48 h rotenone ... Read more >>

Toxicology (Toxicology)
[2021, 447:152630]

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Driving Resumption After Critical Illness: A Survey and Thematic Analysis of Patient Experience and Process

Joel Meyer, Natalie Pattison, Chloe Apps, Melanie Gager, Carl Waldmann,

<h4>Background: </h4> Critical care sequelae are common in survivors of critical illness. Physical, psychological and cognitive impairments can affect quality of life for years after the original insult. Driving is an advanced task reliant on complex physical and cognitive functioning. Driving represents a positive recovery milestone. Little is currently known ... Read more >>

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Evaluation of Peruvian Government Interventions to Reduce Childhood Anemia.

Axel J Berky, Emily Robie, Ernesto J Ortiz, Joel N Meyer, Heileen Hsu-Kim, William K Pan,

<h4>Background</h4>In Peru, anemia has been a persistent health problem that is known to lead to irreversible cognitive and developmental deficits in children. The Peruvian government has recently made anemia a primary health concern by passing legislation in 2017 that makes anemia an intersectoral priority. This new legislation fortifies previous programs ... Read more >>

Ann Glob Health (Annals of global health)
[2020, 86(1):98]

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N-Methyl-3,4-methylendioxymethamphetamine (MDMA)-related coagulopathy and rhabdomyolysis: A case series and literature review.

Andrew J Doyle, Joel Meyer, Karen Breen, Beverley J Hunt,

Coagulation changes, thrombosis, and hemorrhage have been described in patients following N-methyl-3,4-methylenedioxymethylamphetamine (MDMA) intoxication who subsequently developed serotonin syndrome and rhabdomyolysis. The clinical features and mechanism of this remain poorly described. We describe 5 sequential cases admitted to critical care due to severe recreational MDMA toxicity where coagulopathy occurred, and ... Read more >>

Res Pract Thromb Haemost (Research and practice in thrombosis and haemostasis)
[2020, 4(5):829-834]

Cited: 1 time

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Zebrafish CYP1A expression in transgenic Caenorhabditis elegans protects from exposures to benzo[a]pyrene and a complex polycyclic aromatic hydrocarbon mixture.

Jamie B Harris, Jessica H Hartman, Anthony L Luz, Joanna Y Wilson, Audrey Dinyari, Joel N Meyer,

Polycyclic aromatic hydrocarbons (PAHs) are environmental toxicants primarily produced during incomplete combustion; some are carcinogens. PAHs can be safely metabolized or, paradoxically, bioactivated via specific cytochrome P450 (CYP) enzymes to more reactive metabolites, some of which can damage DNA and proteins. Among the CYP isoforms implicated in PAH metabolism, CYP1A ... Read more >>

Toxicology (Toxicology)
[2020, 440:152473]

Cited: 2 times

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Restricted family visiting in intensive care during COVID-19.

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Intensive Crit Care Nurs (Intensive & critical care nursing)
[2020, 60:102896]

Cited: 8 times

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Key Components of ICU Recovery Programs: What Did Patients Report Provided Benefit?

Joanne McPeake, Leanne M Boehm, Elizabeth Hibbert, Rita N Bakhru, Anthony J Bastin, Brad W Butcher, Tammy L Eaton, Wendy Harris, Aluko A Hope, James Jackson, Annie Johnson, Janet A Kloos, Karen A Korzick, Pamela MacTavish, Joel Meyer, Ashley Montgomery-Yates, Tara Quasim, Andrew Slack, Dorothy Wade, Mary Still, Giora Netzer, Ramona O Hopkins, Mark E Mikkelsen, Theodore J Iwashyna, Kimberley J Haines, Carla M Sevin,

To understand from the perspective of patients who did, and did not attend ICU recovery programs, what were the most important components of successful programs and how should they be organized. Design:International, qualitative study. Setting:Fourteen hospitals in the United States, United Kingdom, and Australia. Patients:We conducted 66 semi-structured interviews with ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(4):e0088]

Cited: 7 times

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Resveratrol Protects Against Hydroquinone-Induced Oxidative Threat in Retinal Pigment Epithelial Cells.

Samantha E Neal, Kristen L Buehne, Nicholas A Besley, Ping Yang, Peter Silinski, Jiyong Hong, Ian T Ryde, Joel N Meyer, Glenn J Jaffe,

<h4>Purpose</h4>Oxidative stress in retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD). Resveratrol exerts a range of protective biologic effects, but its mechanism(s) are not well understood. The aim of this study was to investigate how resveratrol could affect biologic pathways in oxidatively stressed RPE cells.<h4>Methods</h4>Cultured human ... Read more >>

Invest Ophthalmol Vis Sci (Investigative ophthalmology & visual science)
[2020, 61(4):32]

Cited: 3 times

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Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans

Silvia Maglioni, Alfonso Schiavi, Marlen Melcher, Vanessa Brinkmann, Zhongrui Luo, Anna Laromaine, Nuno Raimundo, Joel Meyer, Felix Distelmaier, Natascia Ventura,

Complex I deficiency represents the most frequent pathogenetic cause of human mitochondriopathies. Therapeutic options for these neurodevelopmental life-threating disorders do not exist, partly due to the scarcity of appropriate model systems to study them. Caenorhabditis elegans is a genetically tractable model organism widely used to investigate neuronal pathologies. Here, we ... Read more >>

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