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Author Jodi A Flaws

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Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice.

Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A Flaws, Humphrey Hung-Chang Yao,

Steroid hormones regulate various aspects of physiology, from reproductive functions to metabolic homeostasis. Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Inactivation of Nr5a1 in the mouse results in a complete gonadal and adrenal agenesis, absence of gonadotropes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21770]

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Maternal phthalate and phthalate alternative metabolites and urinary biomarkers of estrogens and testosterones across pregnancy.

Diana C Pacyga, Joseph C Gardiner, Jodi A Flaws, Zhong Li, Antonia M Calafat, Susan A Korrick, Susan L Schantz, Rita S Strakovsky,

<h4>Background/objectives</h4>Pregnant women are ubiquitously exposed to phthalates from food packaging materials and personal care products. Phthalates alter estrogen and testosterone concentrations in experimental models, but their ability to impact these hormones in human pregnancy is not well characterized.<h4>Methods</h4>We recruited women ages 18-40 into the Illinois Kids Development Study (I-KIDS) in ... Read more >>

Environ Int (Environment international)
[2021, 155:106676]

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Iodoacetic acid affects Estrous Cyclicity, ovarian gene expression, and hormone levels in mice.

Andressa Gonsioroski, Daryl D Meling, Liying Gao, Michael J Plewa, Jodi A Flaws,

Iodoacetic acid (IAA) is a water disinfection byproduct that is an ovarian toxicant in vitro. However, information on the effects of IAA on ovarian function in vivo was limited. Thus, we determined whether IAA exposure affects estrous cyclicity, steroidogenesis, and ovarian gene expression in mice. Adult CD-1 mice were dosed ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, :]

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Placental outcomes of phthalate exposure.

Genoa R Warner, Raquel S Dettogni, Indrani C Bagchi, Jodi A Flaws, Jones B Graceli,

Proper placental development and function relies on hormone receptors and signaling pathways that make the placenta susceptible to disruption by endocrine disrupting chemicals, such as phthalates. Here, we review relevant research on the associations between phthalate exposures and dysfunctions of the development and function of the placenta, including morphology, physiology, ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2021, 103:1-17]

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Urinary phthalate metabolite concentrations and serum hormone levels in pre- and perimenopausal women from the Midlife Women's Health Study.

Catheryne Chiang, Diana C Pacyga, Rita S Strakovsky, Rebecca L Smith, Tamarra James-Todd, Paige L Williams, Russ Hauser, Daryl D Meling, Zhong Li, Jodi A Flaws,

<h4>Background</h4>Phthalate exposure is associated with altered reproductive function, but little is known about associations between phthalate and hormone levels in midlife women.<h4>Methods</h4>This cross-sectional analysis includes 45-54-year-old pre- and perimenopausal women from Baltimore, MD and its surrounding counties enrolled in the Midlife Women's Health Study (n = 718). Serum and urine samples were ... Read more >>

Environ Int (Environment international)
[2021, 156:106633]

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Exposure to Iodoacetic Acid, a Water Disinfection Byproduct, Leads to Abnormal Expression of Key Reproductive Axis Genes in the Hypothalamus and Pituitary

Rachel V L Gonzalez, Karen E Weis, Andressa V Gonsioroski, Jodi A Flaws, Lori T Raetzman,

Abstract Iodoacetic acid (IAA) – a water disinfection byproduct (DBP) formed from the reaction between an oxidizing disinfectant, i.e. chlorine, and iodide – is an understudied, yet potentially dangerous environmental toxicant. DBPs have been epidemiologically associated with reproductive dysfunction. In vitro studies have indicated that IAA is one of the ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A487-A487]

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Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries†.

Genoa R Warner, Daryl D Meling, Kathy M De La Torre, Karen Wang, Jodi A Flaws,

Phthalates are a group of chemicals used as additives in various consumer products, medical equipment, and personal care products. Phthalates and their metabolites are consistently detected in humans, indicating widespread and continuous exposure to multiple phthalates. Thus, environmentally relevant mixtures of phthalates and phthalate metabolites were investigated to determine the ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, 104(4):806-817]

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Urinary phthalate metabolite concentrations and hot flashes in women from an urban convenience sample of midlife women.

Genoa R Warner, Diana C Pacyga, Rita S Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L Williams, Russ Hauser, Daryl D Meling, Zhong Li, Jodi A Flaws,

<h4>Context</h4>Phthalate exposure is associated with altered reproductive function, but little is known about associations of phthalate exposure with risk of hot flashes.<h4>Objective</h4>To investigate associations of urinary phthalate metabolite levels with four hot flash outcomes in midlife women.<h4>Design</h4>A cross-sectional study of the first year of a prospective cohort of midlife women, ... Read more >>

Environ Res (Environmental research)
[2021, 197:110891]

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Effects of Chronic Dietary Exposure to Phytoestrogen Genistein on Uterine Morphology in Mice.

Rachel B Arcanjo, Kadeem A Richardson, Shuhong Yang, Shreya Patel, Jodi A Flaws, Romana A Nowak,

Genistein is naturally occurring in plants and binds to estrogen receptors. Humans are mainly exposed through diet, but the use of supplements is increasing as genistein is claimed to promote health and alleviate menopausal symptoms. We analyzed diverse uterine features in adult mice chronically fed genistein for different times. The ... Read more >>

J Agric Food Chem (Journal of agricultural and food chemistry)
[2021, 69(5):1693-1704]

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Effects of Chemical Mixtures on the Ovary.

Vasiliki E Mourikes, Jodi A Flaws,

The ovaries play a critical role in female reproductive health because they are the site of oocyte maturation and sex steroid hormone production. The unique cellular processes that take place within the ovary make it a susceptible target for chemical mixtures. Herein, we review the available data regarding the effects ... Read more >>

Reproduction (Reproduction (Cambridge, England))
[2021, :]

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The effects of plasticizers on the ovary.

Alison M Neff, Jodi A Flaws,

Endocrine disrupting chemicals pose a threat to health and reproduction. Plasticizers such as phthalates and bisphenols are particularly problematic because they are present in many consumer products and exposure can begin in utero and continue throughout the lifetime of the individual. Evidence suggests that these chemicals can have ancestral and ... Read more >>

Curr Opin Endocr Metab Res (Current opinion in endocrine and metabolic research)
[2021, 18:35-47]

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Racial differences in lifestyle, demographic, and health factors associated with quality of life (QoL) in midlife women.

Brandi Patrice Smith, Esmeralda Cardoso-Mendoza, Jodi A Flaws, Zeynep Madak-Erdogan, Rebecca L Smith,

Previously, quality of life (Qol) has been defined as an individual's evaluation of a satisfactory life as a whole (i.e. physically, mentally, psychologically, and socially). Only a few studies have examined the racial differences between QoL and risk factors associated with health, demographics, and lifestyle in midlife women. Thus, the ... Read more >>

Womens Midlife Health (Women's midlife health)
[2021, 7(1):2]

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Phthalate exposures and one-year change in body mass index across the menopausal transition.

Diana K Haggerty, Jodi A Flaws, Zhong Li, Rita S Strakovsky,

<h4>Background</h4>The menopausal transition is a hormonally sensitive period associated with changes in body weight. Phthalates are ubiquitous endocrine disrupting chemicals that could disrupt weight homeostasis, but it is unknown whether this occurs during the menopausal transition.<h4>Objectives</h4>Our objectives were to (1) determine if phthalate exposure in pre- and perimenopausal women was ... Read more >>

Environ Res (Environmental research)
[2021, 194:110598]

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Subacute exposure to di-isononyl phthalate alters the morphology, endocrine function, and immune system in the colon of adult female mice.

Karen Chiu, Shah Tauseef Bashir, Romana A Nowak, Wenyan Mei, Jodi A Flaws,

Di-isononyl phthalate (DiNP), a common plasticizer used in polyvinyl chloride products, exhibits endocrine-disrupting capabilities. It is also toxic to the brain, reproductive system, liver, and kidney. However, little is known about how DiNP impacts the gastrointestinal tract (GIT). It is crucial to understand how DiNP exposure affects the GIT because ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18788]

Cited: 1 time

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Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice.

Emily Brehm, Changqing Zhou, Liying Gao, Jodi A Flaws,

Phthalates are known endocrine-disrupting chemicals that are found in many consumer products. Our laboratory previously developed a relevant phthalate mixture consisting of six phthalates and found that it disrupted female fertility in mice. However, it is unknown if prenatal exposure to phthalate mixtures can accelerate reproductive aging and if this ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 98:260-268]

Cited: 1 time

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Association of phthalate exposure and endogenous hormones with self-reported sleep disruptions: results from the Midlife Women's Health Study.

Katherine M Hatcher, Rebecca L Smith, Catheryne Chiang, Zhong Li, Jodi A Flaws, Megan M Mahoney,

<h4>Objective</h4>Follicle-stimulating hormone and estradiol (E2) have been associated with sleep in midlife women, however, few studies have examined the association of other hormones or environmental chemical exposure such as phthalates, with self-reported sleep quality. We assessed the relationship of self-reported sleep with hormones and phthalates.<h4>Methods</h4>In total, 762 women (aged 45-54 ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2020, 27(11):1251-1264]

Cited: 1 time

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Iodoacetic acid disrupts mouse oocyte maturation by inducing oxidative stress and spindle abnormalities.

Xiaofei Jiao, Andressa Gonsioroski, Jodi A Flaws, Huanyu Qiao,

Disinfection by-products (DBPs) are compounds produced during the water disinfection process. Iodoacetic acid (IAA) is one of the unregulated DBPs in drinking water, with potent cytotoxicity and genotoxicity in animals. However, whether IAA has toxic effects on oocyte maturation remains unclear. Here, we show that IAA exposure resulted in metaphase ... Read more >>

Environ Pollut (Environmental pollution (Barking, Essex : 1987))
[2021, 268(Pt A):115601]

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Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Jerrold J Heindel, Scott Belcher, Jodi A Flaws, Gail S Prins, Shuk-Mei Ho, Jiude Mao, Heather B Patisaul, William Ricke, Cheryl S Rosenfeld, Ana M Soto, Frederick S Vom Saal, R Thomas Zoeller,

"Consortium Linking Academic and Regulatory Insights on BPA Toxicity" (CLARITY-BPA) was a comprehensive "industry-standard" Good Laboratory Practice (GLP)-compliant 2-year chronic exposure study of bisphenol A (BPA) toxicity that was supplemented by hypothesis-driven independent investigator-initiated studies. The investigator-initiated studies were focused on integrating disease-associated, molecular, and physiological endpoints previously found by ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 98:29-60]

Cited: 7 times

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Subchronic and Low Dose of Tributyltin Exposure Leads to Reduced Ovarian Reserve, Reduced Uterine Gland Number, and Other Reproductive Irregularities in Female Mice.

Isabela V Sarmento, Eduardo Merlo, Silvana S Meyrelles, Elisardo C Vasquez, Genoa R Warner, Andressa Gonsioroski, Kathy De La Torre, Daryl D Meling, Jodi A Flaws, Jones B Graceli,

Tributyltin (TBT) chloride is an endocrine disrupting chemical associated with reproductive complications. Studies have shown that TBT targets the reproductive tract, impairing ovarian folliculogenesis, and uterine morphophysiology. In this investigation, we assessed whether subchronic and low dose of TBT exposure results in abnormal ovarian follicular reserve and other irregularities in ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2020, 176(1):74-85]

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Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver.

Yi Wen, Saniya Rattan, Jodi A Flaws, Joseph Irudayaraj,

Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes epigenetic multi- and transgenerational inheritance of adult onset disease in subsequent generations (F1-F3). However, the epigenetic toxicity is less understood in the liver. In this study, CD-1 mice were prenatally ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 402:115123]

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SUN-241 Adult Exposure to Iodoacetic Acid Leads to Abnormal Expression of Key Genes Related to Hypothalamic and Pituitary Control of Reproductive Function

Rachel Gonzalez, Karen E Weis, Andressa V Gonsioroski, Jodi A Flaws, Lori T Raetzman,

Abstract Water disinfection byproducts (DBPs) are formed when chemicals used to decontaminate water come into contact with natural or synthetic organic material. DBPs have been linked to a range of health concerns including reproductive disfunction. One such DBP, the monohalogenated iodoacetic acid (IAA), is formed when iodide reacts with a ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Germline-dependent transmission of male reproductive traits induced by an endocrine disruptor, di-2-ethylhexyl phthalate, in future generations.

Radwa Barakat, Po-Ching Lin, Chan Jin Park, Mohamed Zeineldin, Sherry Zhou, Saniya Rattan, Emily Brehm, Jodi A Flaws, CheMyong J Ko,

In males, defective reproductive traits induced by an exposure to an endocrine disruptor are transmitted to future generations via epigenetic modification of the germ cells. Interestingly, the impacted future generations display a wide range of heterogeneity in their reproductive traits. In this study, the role that the Y chromosome plays ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5705]

Cited: 2 times

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Prenatal exposure to a phthalate mixture leads to multigenerational and transgenerational effects on uterine morphology and function in mice.

Kailiang Li, Monika Liszka, Changqing Zhou, Emily Brehm, Jodi A Flaws, Romana A Nowak,

Phthalates are commonly used plasticizers and additives that are found in plastic containers, children's toys and medical equipment. Phthalates are classified as endocrine-disrupting chemicals and exposure to phthalates has been associated with several human health risks including reproductive defects. Most studies focus on a single phthalate; however, humans are exposed ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 93:178-190]

Cited: 2 times

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Exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood disrupts hormones and ovarian folliculogenesis throughout the prime reproductive life of the mouse.

Catheryne Chiang, Lily R Lewis, Grace Borkowski, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a phthalate commonly used for its plasticizing capabilities. Because of the wide production and use of DEHP, humans are exposed to DEHP on a daily basis. Diisononyl phthalate (DiNP) is often used as a DEHP replacement chemical, and because of the increased use of DiNP, humans ... Read more >>

Toxicol Appl Pharmacol (Toxicology and applied pharmacology)
[2020, 393:114952]

Cited: 6 times

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Late-life consequences of short-term exposure to di(2-ethylhexyl) phthalate and diisononyl phthalate during adulthood in female mice.

Catheryne Chiang, Lily R Lewis, Grace Borkowski, Jodi A Flaws,

Di(2-ethylhexyl) phthalate (DEHP) is a known endocrine disruptor and diisononyl phthalate (DiNP) is a common DEHP replacement chemical. However, little is known about late-life consequences due to DEHP or DiNP exposure during adulthood. Thus, this study tested the hypothesis that adult exposure to DEHP or DiNP affects female reproductive parameters ... Read more >>

Reprod Toxicol (Reproductive toxicology (Elmsford, N.Y.))
[2020, 93:28-42]

Cited: 3 times

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