Full Text Journal Articles by
Author Joanna Turkowska

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Strain release - an old tool for new transformations.

Joanna Turkowska, Jakub Durka, Dorota Gryko,

Strain-release driven transformations give access to attractive bioisosteric motifs highly prized by medicinal chemists and they are characteristic of molecules possessing distorted bond lengths and angles. By broadening the chemical space in drug discovery, recently, these compounds have attracted a lot of interest. Their reactivity stems mainly from an increased ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(43):5718-5734]

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Polarity-Reversal Strategy for the Functionalization of Electrophilic Strained Molecules via Light-Driven Cobalt Catalysis.

Michał Ociepa, Aleksandra J Wierzba, Joanna Turkowska, Dorota Gryko,

Strain-release-driven methodology is a powerful tool for accessing structural motifs, highly desirable by the pharmaceutical industry. The reactivity of spring-loaded cyclic reagents is dominated by transformations relying on their inherent electrophilic reactivity. Herein, we present a polarity-reversal strategy based on light-driven cobalt catalysis, which enables the generation of nucleophilic radicals ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(11):5355-5361]

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From Amines to Alkynes – Lighting the Way

Dorota Gryko, Michał Ociepa, Joanna Turkowska,

We present a metal-free photoredox strategy for the formation of Csp3-Csp bonds from redox-activated primary amine derivatives. The developed reaction of 2,4,6-triphenylpyridiniu salts with alkynyl tosylates, leading to functionalized alkynes , is easily scalable, offers broad substrate scope, high chemoselectivity, and mild conditions. Its potentials also highlighted by diversification of ... Read more >>

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Photoinduced Vitamin B12-Catalysis for Deprotection of (Allyloxy)arenes.

Maciej Giedyk, Joanna Turkowska, Sandra Lepak, Marcin Marculewicz, Keith Ó Proinsias, Dorota Gryko,

Vitamin B<sub>12</sub> is a natural cobalt complex that, while reduced to the "supernucleophilic" Co(I) form, can easily react with electrophiles via an S<sub>N</sub>2 mechanism. It is also shown to react via an S<sub>N</sub>2' mechanism with allylic compounds allowing for photochemical deprotection of (allyloxy)arenes. A sustainable alternative to commonly used noble ... Read more >>

Org Lett (Organic letters)
[2017, 19(10):2670-2673]

Cited: 1 time

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Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.

Mikołaj Ogrodnik, Hanna Salmonowicz, Rachel Brown, Joanna Turkowska, Władysław Średniawa, Sundararaghavan Pattabiraman, Triana Amen, Ayelet-chen Abraham, Noam Eichler, Roman Lyakhovetsky, Daniel Kaganovich,

Aging is associated with the accumulation of several types of damage: in particular, damage to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that works by preventing the inheritance of damaged and misfolded proteins by specific cells during division. Asymmetric inheritance of misfolded and aggregated proteins has ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(22):8049-8054]

Cited: 57 times

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