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Author Joan Santamaria

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Insights into the Use of Peripherally Acting μ-Opioid Receptor Antagonists (PAMORAs) in Oncologic Patients: from Scientific Evidence to Real Clinical Practice.

Ana Fernández-Montes, Guillermo de Velasco, Santiago Aguín, Cristina Farriols, María Guirado-Risueño, Vanessa G Jerviz-Guía, María Victoria Baeza-Nadal, Rodolfo Chicas-Sett, José Luis Fírvida, Francisco García-Navalón, Patricia Martín, Carmen Perezagua-Marín, Dulce Rodríguez, Joan Santamaría, Tamara Saurí, Manuel Cobo,

<h4>Opinion statement</h4>Management of chronic pain is crucial to improve the quality of life of cancer and palliative care patients. Opioid-based treatments used to control pain can be prolonged over time. Unfortunately, constipation is one of the most disturbing adverse effects of long-term use of opioids. Opioid-induced constipation (OIC) occurs when ... Read more >>

Curr Treat Options Oncol (Current treatment options in oncology)
[2021, 22(3):26]

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Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study.

Alex Iranzo, Graham Fairfoul, Anutra Chumbala Na Ayudhaya, Monica Serradell, Ellen Gelpi, Isabel Vilaseca, Raquel Sanchez-Valle, Carles Gaig, Joan Santamaria, Eduard Tolosa, Renata L Riha, Alison J E Green,

<h4>Background</h4>Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion (RT-QuIC) analysis of CSF has high sensitivity and specificity for the detection of misfolded α-synuclein in patients with Parkinson's disease and dementia with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):203-212]

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New 2013 incidence peak in childhood narcolepsy: more than vaccination?

Zhongxing Zhang, Jari K Gool, Rolf Fronczek, Yves Dauvilliers, Claudio L A Bassetti, Geert Mayer, Giuseppe Plazzi, Fabio Pizza, Joan Santamaria, Markku Partinen, Sebastiaan Overeem, Rosa Peraita-Adrados, Antonio Martins da Silva, Karel Sonka, Rafael Del Rio-Villegas, Raphael Heinzer, Aleksandra Wierzbicka, Peter Young, Birgit Högl, Mauro Manconi, Eva Feketeova, Johannes Mathis, Teresa Paiva, Francesca Canellas, Michel Lecendreux, Christian R Baumann, Gert Jan Lammers, Ramin Khatami,

Increased incidence rates of narcolepsy type-1 (NT1) have been reported worldwide after the 2009-2010 H1N1 influenza pandemic (pH1N1). While some European countries found an association between the NT1 incidence increase and the H1N1 vaccination Pandemrix, reports from Asian countries suggested the H1N1 virus itself to be linked to the increased ... Read more >>

Sleep (Sleep)
[2021, 44(2):]

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Magnetic resonance imaging abnormalities as a marker of multiple system atrophy in isolated rapid eye movement sleep behavior disorder.

Amaia Muñoz-Lopetegi, Joan Berenguer, Alex Iranzo, Monica Serradell, Teresa Pujol, Carles Gaig, Esteban Muñoz, Eduard Tolosa, Joan Santamaría,

<h4>Study objectives</h4>Patients with isolated rapid eye movement (REM) sleep behavior disorder (IRBD) develop Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA). Magnetic resonance imaging (MRI) is abnormal in MSA showing abnormalities in the putamen, cerebellum, and brainstem. Our objective was to evaluate the usefulness of ... Read more >>

Sleep (Sleep)
[2021, 44(1):]

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Sleep disorders in autoimmune encephalitis.

Amaia Muñoz-Lopetegi, Francesc Graus, Josep Dalmau, Joan Santamaria,

Sleep disorders in people with autoimmune encephalitis have received little attention, probably overshadowed by the presence of other neurological and psychiatric symptoms in this group of conditions. However, sleep disorders are frequent, often severe, and usually persist beyond the acute disease stage, interfering with patients' recovery and quality of life. ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(12):1010-1022]

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Did inspector Kurt Wallander develop dementia with Lewy bodies?

Alex Iranzo, Joan Santamaría,

Sleep Med (Sleep medicine)
[2021, 78:36-37]

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Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder.

Kristian Stær, Alex Iranzo, Morten G Stokholm, Karen Østergaard, Mónica Serradell, Marit Otto, Kristina B Svendsen, Alicia Garrido, Dolores Vilas, Joan Santamaria, Arne Møller, Carles Gaig, David J Brooks, Per Borghammer, Eduardo Tolosa, Nicola Pavese,

<h4>Introduction</h4>In vivo PET studies in patients with isolated REM sleep behavior disorder (iRBD) have shown presence of neuroinflammation (microglial activation) in the substantia nigra, and reduced cortical acetylcholinesterase activity, suggestive of cholinergic dysfunction, that was more widespread in patients with poorer cognitive performances. This study aimed to explore whether reduced ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2020, 81:89-93]

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Stridor during sleep: description of 81 consecutive cases diagnosed in a tertiary sleep disorders center.

Cristiana Silva, Alex Iranzo, Gerard Maya, Mónica Serradell, Amaia Muñoz-Lopetegi, Paula Marrero-González, Carles Gaig, Joan Santamaría, Isabel Vilaseca,

<h4>Objective</h4>To describe the characteristics of stridor during sleep (SDS) in a series of adults identified by video-polysomnography (V-PSG).<h4>Methods</h4>Retrospective clinical, V-PSG, laryngoscopic and therapeutic data of patients diagnosed with SDS in a tertiary referral sleep disorders center between 1997 and 2017.<h4>Results</h4>Eighty-one patients were identified (56.8% males, age 61.8 ± 11.2 years). ... Read more >>

Sleep (Sleep)
[2020, :]

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Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: A European Academy of Neurology, European Sleep Research Society and International League against Epilepsy-Europe consensus review.

Lino Nobili, Al de Weerd, Guido Rubboli, Sándor Beniczky, Christopher Derry, Sofia Eriksson, Peter Halasz, Birgit Högl, Joan Santamaria, Ramin Khatami, Philippe Ryvlin, Jan Rémi, Paolo Tinuper, Claudio Bassetti, Raffaele Manni, Michalis Koutroumanidis, Luca Vignatelli,

<h4>Background</h4>Some epilepsy syndromes (sleep-related epilepsies [SRE]) have a strong link with sleep. Comorbid sleep disorders are common in patients with SRE and can exert a negative impact on seizure control and quality of life.<h4>Purposes</h4>To define the standard procedures for the diagnostic pathway of patients with possible SRE (scenario 1) and ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, 29(6):e13184]

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Significance of hyposmia in isolated REM sleep behavior disorder.

Alex Iranzo, Paula Marrero-González, Mónica Serradell, Carles Gaig, Joan Santamaria, Isabel Vilaseca,

<h4>Objective</h4>To determine if hyposmia in isolated REM sleep behavior disorder (IRBD) predicts short-term conversion to any α-synucleinopathy and declines with time.<h4>Methods</h4>Olfaction was tested using the University of Pennsylvania Smell Identification Test (UPSIT-40) in 140 consecutive patients with polysomnography-confirmed IRBD and in 77 matched controls. Patients were followed-up during 5.6 ± 3.9 (range ... Read more >>

J Neurol (Journal of neurology)
[2021, 268(3):963-966]

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Alpha-synuclein seeds in olfactory mucosa of patients with isolated rapid-eye-movement sleep behaviour disorder

Ambra Stefani, Alex Iranzo, Evi Holzknecht, Daniela Perra, Matilde Bongianni, Carles Gaig, Beatrice Heim, Monica Serradell, Luca Sacchetto, Alicia Garrido, Stefano Capaldi, Almudena Sánchez-Gómez, Michele Fiorini, Joachim Schmutzhard, Pietro Cocchiara, Isabel Vilaseca, Lorenzo Brozzetti, Salvatore Monaco, Jose Marti, Klaus Seppi, Eduardo Tolosa, Joan Santamaria, Birgit Högl, Werner Poewe, Gianluigi Zanusso, ,

<h4>ABSTRACT</h4> Isolated REM sleep behaviour disorder is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological alpha-synuclein in peripheral tissues of isolated REM sleep behaviour disorder patients may identify those progressing to Parkinson’s disease, dementia with Lewy bodies or multiple system atrophy, with the ultimate goal ... Read more >>

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Take Care.

Joan Santamaria, Myrna R Rosenfeld,

Curr Treat Options Neurol (Current treatment options in neurology)
[2020, 22(10):32]

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Sleep disorders in anti-NMDAR encephalitis.

Helena Ariño, Amaia Muñoz-Lopetegi, Eugenia Martinez-Hernandez, Thaís Armangue, Mireia Rosa-Justicia, Domingo Escudero, Nuria Matos, Francesc Graus, Gisela Sugranyes, Josefina Castro-Fornieles, Albert Compte, Josep Dalmau, Joan Santamaria,

<h4>Objective</h4>To describe the sleep disorders in anti-NMDA receptor encephalitis (anti-NMDARe).<h4>Methods</h4>Patients recovering from anti-NMDARe were invited to participate in a prospective observational single-center study including comprehensive clinical, video-polysomnography (V-PSG) sleep assessment, and neuropsychological evaluation. Age- and sex-matched healthy participants served as controls.<h4>Results</h4>Eighteen patients (89% female, median age 26 years, interquartile range ... Read more >>

Neurology (Neurology)
[2020, 95(6):e671-e684]

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Prodromal Parkinson disease in patients with idiopathic hyposmia.

Paula Marrero-González, Alex Iranzo, David Bedoya, Mònica Serradell, Aida Niñerola-Baizán, Andrés Perissinotti, Carles Gaig, Isabel Vilaseca, Isam Alobid, Joan Santamaría, Joaquim Mullol,

<h4>Background</h4>Idiopathic hyposmia (IH) is a prodromal marker of Parkinson disease (PD). However, IH is common in the general population and only a minority will develop PD. Identification of individuals with IH at prodromal stage of PD would serve to select them to implement neuroprotective agents, when available.<h4>Objective</h4>To identify prodromal PD ... Read more >>

J Neurol (Journal of neurology)
[2020, 267(12):3673-3682]

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Transcriptomic differences in MSA clinical variants.

Alexandra Pérez-Soriano, Magdalena Arnal Segura, Teresa Botta-Orfila, Darly Giraldo, Manel Fernández, Yaroslau Compta, Rubén Fernández-Santiago, Mario Ezquerra, Gian G Tartaglia, M J Martí, ,

<h4>Background</h4>Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C).<h4>Objective</h4>To identify novel disease mechanisms we performed a blood transcriptomic study investigating differential gene expression changes and biological process alterations in MSA and its clinical subtypes.<h4>Methods</h4>We ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):10310]

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Left-hemispheric predominance of nigrostriatal deficit in isolated REM sleep behavior disorder.

Alex Iranzo, Ambra Stefani, Aida Niñerola-Baizan, Heike Stokner, Monica Serradell, Dolores Vilas, Evi Holzknecht, Carles Gaig, Javier Pavia, Francesc Lomeña, David Reyes, Klaus Seppi, Joan Santamaria, Birgit Högl, Eduard Tolosa, Werner Poewe, ,

OBJECTIVE:Unilateral onset of parkinsonism due to nigrostriatal damage of the contralateral hemisphere is frequent in Parkinson disease (PD). There is evidence for a left-hemispheric bias of motor asymmetry in right-handed patients with PD indicating a hemispheric dominance. Isolated REM sleep behavior disorder (IRBD) constitutes the prodromal stage of PD and ... Read more >>

Neurology (Neurology)
[2020, 94(15):e1605-e1613]

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Diagnosis of central disorders of hypersomnolence: A reappraisal by European experts.

Gert Jan Lammers, Claudio L A Bassetti, Leja Dolenc-Groselj, Poul J Jennum, Ulf Kallweit, Ramin Khatami, Michel Lecendreux, Mauro Manconi, Geert Mayer, Markku Partinen, Giuseppe Plazzi, Paul J Reading, Joan Santamaria, Karel Sonka, Yves Dauvilliers,

The aim of this European initiative is to facilitate a structured discussion to improve the next edition of the International Classification of Sleep Disorders (ICSD), particularly the chapter on central disorders of hypersomnolence. The ultimate goal for a sleep disorders classification is to be based on the underlying neurobiological causes ... Read more >>

Sleep Med Rev (Sleep medicine reviews)
[2020, 52:101306]

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Lack of Asymmetry of Nigrostriatal Dopaminergic Function in Healthy Subjects.

Alicia Garrido, Alex Iranzo, Ambra Stefani, Mònica Serradell, Amaia Muñoz-Lopetegi, Paula Marrero, Birgit Högl, Carles Gaig, Joan Santamaria, Eduard Tolosa, Werner Poewe, ,

OBJECTIVE:In right-handed patients with Parkinson's disease (PD) or isolated rapid eye movement sleep behavior disorder, dopamine transporter (DAT) [(123)I]β-carboxymethyoxy-3-β-(4-iodophenyl) tropane single photon emission computed tomography (SPECT) shows predominant nigrostriatal deficit in the left striatum. This suggests that in PD patients, the nigrostriatal system of the dominant hemisphere is more susceptible ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2020, 35(6):1072-1076]

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A new incidence peak of childhood narcolepsy type 1 in 2013: a new perspective on the role of influenza virus?

Zhongxing Zhang, Jari Gool, Rolf Fronczek, Claudio Bassetti, Yves Dauvilliers, Geert Mayer, Giuseppe Plazzi, Fabio Pizza, Joan Santamaria, Markku Partinen, Sebastiaan Overeem, Rosa Peraita-Adrados, Antonio Martins da Silva, Karel Sonka, Rafael del Rio-Villegas, Raphael Heinzer, Aleksandra Wierzbicka, Peter Young, Birgit Högl, Mauro Manconi, Eva Feketeova, Johannes Mathis, Teresa Paiva, Francesca Canellas, Michel Lecendreux, Christian Baumann, Lucie Barateau, Carole Pesenti, Elena Antelmi, Carles Gaig, Alex Iranzo, Laura Lillo-Triguero, Pablo Medrano-Martínez, José Haba-Rubio, Corina Gorban, Gert-Jan Lammers, Ramin Khatami,

Increased incidence rates of narcolepsy type 1 (NT1) after the 2009-2010 H1N1 influenza pandemic (pH1N1) have been reported world-wide. While some European countries found an association between the NT1 increase and H1N1 vaccination Pandemrix, reports from Asian countries suggested the H1N1 virus rather than Pandemrix to be linked with the ... Read more >>

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Isolated rapid eye movement sleep behavior disorder and cyclic alternating pattern: is sleep microstructure a predictive parameter of neurodegeneration?

Andrea Melpignano, Liborio Parrino, Joan Santamaria, Carles Gaig, Irene Trippi, Monica Serradell, Carlotta Mutti, Matteo Riccò, Alex Iranzo,

<h4>Objective</h4>To evaluate the role of sleep cyclic alternating pattern (CAP) in patients with isolated REM sleep behavior disorder (IRBD) and ascertain whether CAP metrics might represent a marker of phenoconversion to a defined neurodegenerative condition.<h4>Methods</h4>Sixty-seven IRBD patients were included and classified into patients who phenoconverted to a neurodegenerative disease (RBD ... Read more >>

Sleep (Sleep)
[2019, 42(10):]

Cited: 1 time

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HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease.

Carles Gaig, Guadalupe Ercilla, Xavier Daura, Mario Ezquerra, Ruben Fernández-Santiago, Eduard Palou, Lidia Sabater, Romana Höftberger, Anna Heidbreder, Birgit Högl, Alex Iranzo, Joan Santamaria, Josep Dalmau, Francesc Graus,

<h4>Objectives</h4>We investigated the associations with HLA and microtubule-associated protein tau (<i>MAPT</i>) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy.<h4>Methods</h4>We compared the HLA alleles and <i>MAPT</i> ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(6):]

Cited: 4 times

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Characterization of the sleep disorder of anti-IgLON5 disease.

Carles Gaig, Alex Iranzo, Christian Cajochen, Isabel Vilaseca, Cristina Embid, Josep Dalmau, Francesc Graus, Joan Santamaria,

<h4>Study objective</h4>To characterize the sleep disorder of anti-IgLON5 disease.<h4>Methods</h4>We reviewed 27 video-polysomnographies (V-PSG), 6 multiple sleep latency tests (MSLT), 2 videsomnoscopies with dexmedetomidine, and 10 actigraphies recorded during the disease course of five patients. Due to severe sleep architecture abnormalities, we used a novel modified sleep scoring system combining conventional ... Read more >>

Sleep (Sleep)
[2019, 42(9):]

Cited: 2 times

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Precision Medicine in Rapid Eye Movement Sleep Behavior Disorder.

Birgit Högl, Joan Santamaria, Alex Iranzo, Ambra Stefani,

In recent years, the diagnostic approach to rapid eye movement (REM) sleep behavior disorder (RBD) has become more objective and accurate. This was achieved mainly by introduction of methods to exactly quantify electromyographic (EMG) activity in various muscles during REM sleep. The most established muscle combination for RBD diagnosis is ... Read more >>

Sleep Med Clin (Sleep medicine clinics)
[2019, 14(3):351-362]

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Clinical and video-polysomnographic analysis of rapid eye movement sleep behavior disorder and other sleep disturbances in dementia with Lewy bodies.

Ana Fernández-Arcos, Estrella Morenas-Rodríguez, Joan Santamaria, Raquel Sánchez-Valle, Albert Lladó, Carles Gaig, Alberto Lleó, Alex Iranzo,

<h4>Objective</h4>The main objective of this study was to study rapid eye movement (REM) sleep behavior disorder (RBD) and other sleep disorders in dementia with Lewy bodies (DLB).<h4>Methods</h4>Consecutive patients with DLB and mild dementia severity were recruited irrespective of sleep complaints. Patients underwent clinical interview, assessment of sleep scales, and video-polysomnography ... Read more >>

Sleep (Sleep)
[2019, 42(7):]

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Need for a consensus on definitions and on research methods in RBD and its prodromal phases.

Ambra Stefani, Alex Iranzo, Friederike Sixel-Döring, Aleksandar Videnovic, Joan Santamaria, Claudia Trenkwalder, Birgit Högl,

Sleep (Sleep)
[2019, 42(5):]

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