Full Text Journal Articles by
Author Joan Robinson

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Association of outcomes in acute flaccid myelitis with identification of enterovirus at presentation: a Canadian, nationwide, longitudinal study.

Carmen Yea, Ari Bitnun, Helen M Branson, Beyza Ciftci-Kavaklioglu, Mubeen F Rafay, Olivier Fortin, Paola Moresoli, Guillaume Sébire, Myriam Srour, Hélène Decaluwe, Louis Marois, Félixe Pelletier, Michelle Barton, Maryam Nabavi Nouri, Jason Brophy, Sunita Venkateswaran, Daniela Pohl, Kathryn Selby, Kevin Jones, Joan Robinson, Aleksandra Mineyko, Christoph Licht, Birgit Ertl-Wagner, E Ann Yeh,

BACKGROUND:Acute flaccid myelitis (AFM) is characterised by rapid onset of limb weakness with spinal cord grey-matter abnormalities on MRI scan. We aimed to assess whether detection of enterovirus in respiratory or other specimens can help predict prognosis in children with AFM. METHODS:In this nationwide, longitudinal study, we evaluated the significance ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):828-836]

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Predictive value of repeated cerebrospinal fluid parameters in the outcomes of bacterial meningitis in infants <90 days of age.

Joseph Y Ting, Ashley Roberts, Sarah Khan, Ari Bitnun, Michael Hawkes, Michelle Barton, Jennifer Bowes, Jason Brophy, Lynda Ouchenir, Christian Renaud, Andrée-Anne Boisvert, Jane McDonald, Joan L Robinson,

BACKGROUND:There are variations in recommendations from different guidelines regarding the indications for repeat lumbar puncture (LP) in young infants with the diagnosis of bacterial meningitis. OBJECTIVE:To evaluate the frequency of repeat LPs and the characteristics of cerebrospinal fluid (CSF) parameters in repeated sampling and their predictive values for adverse outcomes ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0238056]

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Intravenous immunoglobulin for presumed viral myocarditis in children and adults.

Joan Robinson, Lisa Hartling, Ben Vandermeer, Meghan Sebastianski, Terry P Klassen,

BACKGROUND:This is an update of a previous review. Case reports and case series have described dramatic responses to intravenous immunoglobulin (IVIG) in people with presumed viral myocarditis, and its administration has become commonplace. OBJECTIVES:The primary objective of this review was to compare event-free (death, requirement for a cardiac transplant, or placement ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 8:CD004370]

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Enteroviral and Herpes Simplex Virus  Central Nervous System Infections in Infants <90 Days Old: A Paediatric Investigators’ Collaborative Network on Infections in Canada (PICNIC) Study

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

Abstract Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. Methods: In this cross-sectional retrospective study, seven centers from the Pediatric ... Read more >>

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Risk of Repeated Admissions for Respiratory Syncytial Virus in a Cohort of >10 000 Hospitalized Children.

Kerry Wong, Joan L Robinson, Michael T Hawkes,

BACKGROUND:The objective was to describe respiratory syncytial virus (RSV) hospitalizations in Alberta, Canada over a 13-year period with an emphasis on the incidence and risk factors for repeat hospitalizations attributable to new RSV infections. METHODS:This was a retrospective database analysis. The Alberta Health Services Discharge Abstract Database was searched for ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2020, :]

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What the pregnancy test is testing.

Joan H Robinson,

Is the test result positive or negative? Tests that occur in labs and doctors' offices pose specific questions to try to obtain specific information. But what happens in the social world when these tests never see the inside of a lab or doctor's office, and instead they are used in ... Read more >>

Br J Sociol (The British journal of sociology)
[2020, 71(3):460-473]

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Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan L Robinson,

BACKGROUND:The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome. METHODS:In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):252]

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COVID- 19 Infection in Children: Estimating Pediatric Morbidity and Mortality

Michelle Barton Forbes, Kayur Mehta, Kriti Kumar, Jielin Lu, Nicole Le Saux, Margaret Sampson, Joan Robinson,

BACKGROUND: Estimates of pediatric morbidity and mortality from COVID-19 are vital for planning optimal use of human and material resources throughout this pandemic. METHODS: Government websites from countries with minimum 1000 cases in adults and children on April 13, 2020 were searched to find the number of cases confirmed in ... Read more >>

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Demographic, clinical, and virological characteristics of patients with a laboratory-confirmed diagnosis of influenza during three consecutive seasons, 2015/2016-2017/18, in the Islamic Republic of Iran.

Alireza Nateghian, Mohammad Mehdi Gouya, Mahmood Nabavi, Hanieh Soltani, Seyed Vahid Mousavi, Elmira Agah, Hosein Erfani, Peiman Parchami, Mohammadnasr Dadras, Joan L Robinson,

BACKGROUND:There are minimal data on the differences in demographics, clinical presentations and outcomes for patients with different types and sub-types of influenza in the Middle East. OBJECTIVES:To use population-based data from Iran to investigate factors associated with unfavorable disease outcome. STUDY DESIGN:Clinical data were compiled from the Iranian Ministry of ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2020, 124:104281]

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856. Invasive Haemophilus influenzae Disease in Children: A Canadian MultiCenter Study on Emerging Serotypes.

Craig Frankel, Mohammad Alghounaim, Jane McDonald, John Gunawan, Joan Robinson, Sarah Khan, Jacqueline K Wong, Alison Lopez, Sergio Fanella, Jeannette L Comeau, Jennifer Bowes, Robert Slinger, Angela Kalia, Ashley Roberts, Kirk Leifso, Michelle Barton,

AbstractBackgroundOur objective was to describe the serotype distribution and clinical spectrum of invasive Haemophilus influenza (Hi) disease in children admitted to participating centers within the Paediatric Investigator’s Collaborative Network on Infections in Canada (PICNIC).MethodsAll cases of Hi bacteremia were identified from the PICNIC Database of Gram-negative bacteremia (2013–2017). Disease was ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S19-S19]

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Live vaccines after pediatric solid organ transplant: Proceedings of a consensus meeting, 2018.

Sneha Suresh, Julia Upton, Michael Green, Anne Pham-Huy, Klara M Posfay-Barbe, Marian G Michaels, Karina A Top, Yaron Avitzur, Catherine Burton, Pearlie P Chong, Lara Danziger-Isakov, Anne I Dipchand, Diane Hébert, Deepali Kumar, Shaun K Morris, Nadya Nalli, Vicky Lee Ng, Sarah Kogan Nicholas, Joan L Robinson, Melinda Solomon, Bruce Tapiero, Anita Verma, Jolan E Walter, Upton D Allen,

Growing evidence suggests receipt of live-attenuated viral vaccines after solid organ transplant (SOT) has occurred and is safe and needed due to lapses in herd immunity. A 2-day consortium of experts in infectious diseases, transplantation, vaccinology, and immunology was held with the objective to review evidence and create expert recommendations ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2019, 23(7):e13571]

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Palivizumab and prevention of childhood respiratory syncytial viral infection: protocol for a systematic review and meta-analysis of breakthrough infections.

Shelly Jun, Meghan Sebastianski, Robin Featherstone, Joan Robinson,

INTRODUCTION:Childhood respiratory syncytial virus (RSV) infection is a global phenomenon that can lead to fatal respiratory illness. Palivizumab is a drug that is routinely used in affluent countries as a prophylaxis against RSV infection; nevertheless, breakthrough infections are often reported. In light of new findings on potential RSV resistance to ... Read more >>

BMJ Open (BMJ open)
[2019, 9(7):e029832]

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The Clinical Utility of Respiratory Viral Testing in Hospitalized Children: A Meta-analysis.

Kim C Noël, Patricia S Fontela, Nicholas Winters, Caroline Quach, Genevieve Gore, Joan Robinson, Nandini Dendukuri, Jesse Papenburg,

CONTEXT:Respiratory virus (RV) detection tests are commonly used in hospitalized children to diagnose viral acute respiratory infection (ARI), but their clinical utility is uncertain. OBJECTIVES:To systematically review and meta-analyze the impact of RV test results on antibiotic consumption, ancillary testing, hospital length of stay, and antiviral use in children hospitalized ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2019, 9(7):483-494]

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44 Viral Central Nervous System Infections in Canadian Infants <90 Days Old: Encephalitis as a Predictor of Neurodevelopmental Morbidity.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundHerpes simplex virus (HSV) and enterovirus (EV) are important causes of central nervous system (CNS) infections in young infants. Though long-term morbidity has been linked to HSV, there is still limited data on outcomes of other viral CNS infections in young infants.Objectives1) Conduct a descriptive analysis of viral CNS infections ... Read more >>

(Paediatrics & child health)
[2019, 24(Suppl 2):e18-e18]

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CMV-specific T-cells and CD27-CD28-CD4+ T-cells for assignment of cytomegalovirus (CMV) status in adults awaiting organ transplant.

Catherine E Burton, Martina Sester, Joan L Robinson, Dean T Eurich, Simon Urschel, Jutta K Preiksaitis,

BACKGROUND/OBJECTIVES:Determination of Cytomegalovirus (CMV) status in solid organ transplant (SOT) candidates is essential to stratify risk of post-transplant CMV disease. Passive transfusion-acquired antibodies can make serologic determination of CMV status unreliable. We evaluated 3 assays, not affected by passive antibodies (PA), in assignment of CMV status: quantification of CMV-specific CD4 + T-cells ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2019, 115:37-42]

Cited: 1 time

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Surveys of parents and clinicians concerning the minimally important difference of probiotic therapy for prevention of paediatric antibiotic-associated diarrhoea.

Samaneh Khanpour Ardestani, Joan L Robinson, Levinus A Dieleman, Hien Q Huynh, Hsing Jou, Sunita Vohra,

OBJECTIVES:To establish the minimally important difference (MID) that would prompt parents and clinicians to use probiotics for prevention of paediatric antibiotic-associated diarrhoea (AAD) and to obtain parent and clinician opinion about the most important outcomes in clinical trials of AAD. METHODS:In this survey, parents of children presenting to the emergency ... Read more >>

BMJ Open (BMJ open)
[2019, 9(4):e024651]

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Les infections à Salmonella chez les enfants canadiens.

Joan L Robinson,

AbstractLes infections à Salmonella non typhiques (SNT) sont surtout transmises par des aliments ou de l’eau contaminés ou par contact avec des animaux porteurs (notamment des reptiles) et se manifestent par de la diarrhée. Les antibiotiques ne limitent ni la gravité ni la durée de la diarrhée et peuvent accroître ... Read more >>

(Paediatrics & child health)
[2019, 24(1):51-51]

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Salmonella infections in Canadian children.

Joan L Robinson,

Nontyphoidal Salmonella (NTS) infections are primarily transmitted by contaminated food or water or contact with carrier animals (particularly reptiles), and present with diarrhea. Antibiotics do not decrease the severity or duration of diarrhea and may increase the incidence of NTS carriage, so they should only be used with suspected or ... Read more >>

(Paediatrics & child health)
[2019, 24(1):50-51]

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Screening for chlamydia and/or gonorrhea in primary health care: protocol for systematic review.

Jennifer Pillay, Ainsley Moore, Prinon Rahman, Gabriel Lewin, Donna Reynolds, John Riva, Guyléne Thériault, Brett Thombs, Brenda Wilson, Joan Robinson, Amanda Ramdyal, Geneviéve Cadieux, Robin Featherstone, Anne N Burchell, Jo-Anne Dillon, Ameeta Singh, Tom Wong, Marion Doull, Greg Traversy, Susan Courage, Tara MacGregor, Cydney Johnson, Ben Vandermeer, Lisa Hartling,

BACKGROUND:Chlamydia trachomatis and Neisseria gonorrhoeae are the most commonly reported sexually transmitted infections in Canada. Existing national guidance on screening for these infections was not based on a systematic review, and recommendations as well as implementation considerations (e.g., population groups, testing and case management) should be explicit and reflect the ... Read more >>

Syst Rev (Systematic reviews)
[2018, 7(1):248]

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Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013.

Jennifer Tam, Jesse Papenburg, Sergio Fanella, Sandra Asner, Michelle Barton, Cybele Bergeron, Shalini Desai, Charles Hui, Cheryl Foo, Joanne M Langley, Kirk Leifso, My-Linh Ma, Jeffrey Pernica, Joan Robinson, Roopi Singh, Bruce Tapiero, Upton Allen,

Background:Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in children. Mortality rates in previously healthy children hospitalized with RSV are <0.5%, but up to 37% in patients with underlying medical conditions. The objective of this study was to characterize factors associated with deaths among children hospitalized ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 68(1):113-119]

Cited: 3 times

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2342. Treatment Implications of Herpes Simplex Virus Central Nervous System Infection in Canadian Infants <90 Days Old: A Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) Study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason C Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane Mcdonald, André-Anne Boisvert, Joseph Ting, Ashley Roberts, Joan Robinson,

AbstractBackgroundIn the pre-acyclovir era, HSV CNS infection was associated with very high morbidity and mortality. Since antiviral drugs recommended for therapy and long-term prophylaxis improve outcomes, clinicians need to be able to clinically detect young infants most likely to have HSV to facilitate early initiation of therapy. Limited data exist ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S696-S696]

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Assigning Cytomegalovirus Status in Children Awaiting Organ Transplant: Viral Shedding, CMV-Specific T Cells, and CD27-CD28-CD4+ T Cells.

Catherine E Burton, Martina Sester, Joan L Robinson, Dean T Eurich, Jutta K Preiksaitis, Simon Urschel,

Passive antibodies, maternal or transfusion-acquired, make serologic determination of pretransplant cytomegalovirus (CMV) status unreliable. We evaluated 3 assays unaffected by passive antibodies, in assignment of CMV infection status in children awaiting solid organ transplant and in controls: (1) CMV nucleic acid amplification testing (NAAT), (2) quantification of CMV-specific CD4+ T ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2018, 218(8):1205-1209]

Cited: 2 times

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Des stratégies potentielles pour améliorer les taux de vaccination infantile au Canada.

Joan L Robinson,

RésuméLes taux de vaccination sont sous-optimaux au Canada. Certains pays utilisent des stratégies comme des preuves de vaccination obligatoires pour entrer à la garderie ou à l’école et des incitations financières. D’autres stratégies pourraient fonctionner dans le contexte canadien, telles que la remise, à l’entrée à l’école, d’un dossier de ... Read more >>

(Paediatrics & child health)
[2018, 23(5):357-361]

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Role of the Father in Human Papillomavirus Transmission to Infants.

Joan L Robinson,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2018, 37(6):617-618]

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Potential strategies to improve childhood immunization rates in Canada.

Joan L Robinson,

Immunization rates in Canada are suboptimal. Strategies such as making immunization mandatory for child care or school entry and financial incentives are used in other countries. Additional strategies that could work in the Canadian context include requiring accurate immunization records at school entry, implementing immunization registries at the provincial/territorial level, ... Read more >>

(Paediatrics & child health)
[2018, 23(5):353-356]

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