Full Text Journal Articles by
Author Jintanat Ananworanich

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Brief Report: Syphilis Incidence and Effect on Viral Load, CD4, and CD4/CD8 Ratio in a Thai Cohort of Predominantly Men Who Have Sex With Men Living With HIV.

Camilla Muccini, Trevor A Crowell, Suteeraporn Pinyakorn, Eugène Kroon, Carlo Sacdalan, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby, ,

<h4>Background</h4>Syphilis has been increasing in the past years, especially among men who have sex with men (MSM). The aim of the study was to assess syphilis prevalence and incidence and changes in CD4 count and viremia in the RV254 cohort of persons living with HIV who initiated antiretroviral therapy during ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2021, 86(2):219-223]

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Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes.

Tatiana M Garcia-Bates, Mariana L Palma, Renee R Anderko, Denise C Hsu, Jintanat Ananworanich, Bette T Korber, Gaurav D Gaiha, Nittaya Phanuphak, Rasmi Thomas, Sodsai Tovanabutra, Bruce D Walker, John W Mellors, Paolo A Piazza, Eugene Kroon, Sharon A Riddler, Nelson L Michael, Charles R Rinaldo, Robbie B Mailliard, ,

<h4>Background</h4>During early HIV-1 infection, immunodominant T cell responses to highly variable epitopes lead to the establishment of immune escape virus variants. Here we assessed a type 1-polarized monocyte-derived dendritic cell (MDC1)-based approach to selectively elicit cytotoxic T lymphocyte (CTL) responses against highly conserved and topologically important HIV-1 epitopes in HIV-1-infected ... Read more >>

EBioMedicine (EBioMedicine)
[2021, 63:103175]

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Association of Immunosuppression and Viral Load With Subcortical Brain Volume in an International Sample of People Living With HIV.

Talia M Nir, Jean-Paul Fouche, Jintanat Ananworanich, Beau M Ances, Jasmina Boban, Bruce J Brew, Joga R Chaganti, Linda Chang, Christopher R K Ching, Lucette A Cysique, Thomas Ernst, Joshua Faskowitz, Vikash Gupta, Jaroslaw Harezlak, Jodi M Heaps-Woodruff, Charles H Hinkin, Jacqueline Hoare, John A Joska, Kalpana J Kallianpur, Taylor Kuhn, Hei Y Lam, Meng Law, Christine Lebrun-Frénay, Andrew J Levine, Lydiane Mondot, Beau K Nakamoto, Bradford A Navia, Xavier Pennec, Eric C Porges, Lauren E Salminen, Cecilia M Shikuma, Wesley Surento, April D Thames, Victor Valcour, Matteo Vassallo, Adam J Woods, Paul M Thompson, Ronald A Cohen, Robert Paul, Dan J Stein, Neda Jahanshad,

<h4>Importance</h4>Despite more widely accessible combination antiretroviral therapy (cART), HIV-1 infection remains a global public health challenge. Even in treated patients with chronic HIV infection, neurocognitive impairment often persists, affecting quality of life. Identifying the neuroanatomical pathways associated with infection in vivo may delineate the neuropathologic processes underlying these deficits. However, ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(1):e2031190]

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Novel Criteria for Diagnosing Acute and Early HIV Infection in a Multi-National Study of Early Antiretroviral Therapy Initiation.

Trevor A Crowell, Justin Ritz, Robert W Coombs, Lu Zheng, Joseph J Eron, John W Mellors, Joan Dragavon, Gert U van Zyl, Javier R Lama, Kiat Ruxrungtham, Beatriz Grinsztejn, Roberto C Arduino, Lawrence Fox, Jintanat Ananworanich, Eric S Daar, ,

<h4>Background</h4>Antiretroviral therapy (ART) initiation during acute and early HIV infection (AEHI) limits HIV reservoir formation and may facilitate post-ART control but is logistically challenging. We evaluated the performance of new AEHI diagnostic criteria from a multi-national prospective study of ART initiation during AEHI.<h4>Methods</h4>ACTG 5354 enrolled adults at 30 sites in ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Longitudinal Analysis of Peripheral and Colonic CD161+ CD4+ T Cell Dysfunction in Acute HIV-1 Infection and Effects of Early Treatment Initiation.

Kerri G Lal, Yuwadee Phuang-Ngern, Suchada Suhkumvittaya, Edwin Leeansyah, Aljawharah Alrubayyi, Joana Dias, Adam Waickman, Dohoon Kim, Eugène Kroon, Suteeraporn Pinyakorn, Leigh Anne Eller, Milton Maciel, Rungsun Rerknimitr, Nitiya Chomchey, Nittaya Phanuphak, Mark S S de Souza, Sorachai Nitayaphan, Julie A Ake, Sandhya Vasan, Merlin L Robb, Jintanat Ananworanich, Johan K Sandberg, Alexandra Schuetz, Michael A Eller, Dominic Paquin-Proulx,

CD161 expression on CD4<sup>+</sup> T cells is associated with a Th17 functional phenotype, as well as with an innate capacity to respond to interleukin (IL)-12 and IL-18 without T cell receptor (TCR) stimulation. Chronic HIV-1 infection is associated with loss of the CD161<sup>+</sup> CD4 T cell population, and non-human primate ... Read more >>

Viruses (Viruses)
[2020, 12(12):]

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HIV-related enacted stigma and increase frequency of depressive symptoms among Thai and Cambodian adolescents and young adults with perinatal HIV.

Linda Aurpibul, Jiratchaya Sophonphan, Kathleen Malee, Stephen J Kerr, Ly Penh Sun, Pradthana Ounchanum, Pope Kosalaraksa, Chaiwat Ngampiyaskul, Suparat Kanjanavanit, Kea Chettra, Tulathip Suwanlerk, Claude A Mellins, Robert Paul, Reuben N Robbins, Jintanat Ananworanich, Thanyawee Puthanakit, ,

HIV-related enacted stigma and social problems may increase risk for depression and/or behavioral problems among adolescents and young adults with perinatal HIV(AYA-PHIV), yet few studies have explored stigma in AYA-PHIV residing in low-to-middle income regions, including Southeast Asia. We assessed HIV-related enacted stigma and social problems in AYA-PHIV who participated ... Read more >>

Int J STD AIDS (International journal of STD & AIDS)
[2020, :956462420960602]

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Minimal detection of cerebrospinal fluid escape after initiation of antiretroviral therapy in acute HIV-1 infection.

Ryan Handoko, Phillip Chan, Linda Jagodzinski, Suteeraporn Pinyakorn, Sasiwimol Ubolyam, Nittaya Phanuphak, Carlo Sacdalan, Eugene Kroon, Netsiri Dumrongpisutikul, Robert Paul, Victor Valcour, Jintanat Ananworanich, Sandhya Vasan, Serena Spudich, ,

<h4>Objective</h4>Despite suppression of HIV-1 replication in the periphery by antiretroviral therapy (ART), up to 10% of treated individuals have quantifiable HIV-1 in the CSF, termed CSF escape. CSF escape may be asymptomatic but has also been linked to progressive neurological disease, and may indicate persistence of HIV in the central ... Read more >>

AIDS (AIDS (London, England))
[2020, :]

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Performance of a simple flow cytometric assay in diagnosing active tuberculosis.

Sasiwimol Ubolyam, Thatri Iampornsin, Jiratchaya Sophonphan, Anchalee Avihingsanon, Gompol Suwanpimolkul, Kamon Kawkitinarong, Weerawat Manosuthi, Sivaporn Gatechompol, Jintanat Ananworanich, Kiat Ruxrungtham, Praphan Phanuphak, Anthony D Kelleher,

A flow cytometric assay measuring Mycobacterium tuberculosis-specific CD4 T-cell responses using co-expression of CD25/CD134 (OX40 assay) was explored as a diagnostic tool for active tuberculosis (TB) in a Thai population with and without HIV infection. Peripheral blood mononuclear cells (PBMC) obtained from 133 participants at TB diagnosis were cryopreserved. Seventy-six ... Read more >>

Tuberculosis (Edinb) (Tuberculosis (Edinburgh, Scotland))
[2020, 126:102017]

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Increased burden of concordant and sequential anogenital human papillomavirus infections among Asian young adult females with perinatally acquired HIV compared to HIV-negative peers.

Annette H Sohn, Amphan Chalermchockcharoenkit, Sirinya Teeraananchai, Rawiwan Hansudewechakul, Sivaporn Gatechompol, Kulkanya Chokephaibulkit, Hanh Le Dung Dang, Dan Ngoc Hanh Tran, Jullapong Achalapong, Nipat Teeratakulpisarn, Manopchai Thamkhantho, Nittaya Phanuphak, Jintanat Ananworanich, Peter Reiss, Stephen J Kerr,

<h4>Background</h4>Youth with perinatally acquired HIV (YPHIV) are at higher risk of anogenital human papillomavirus (HPV) infection.<h4>Methods</h4>We enrolled a cohort of YPHIV and HIV-negative youth in Thailand and Vietnam, matched by age and lifetime sex partners, and followed them over 144 weeks (to 2017). Participants had annual pelvic examinations with samples ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, :]

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Corrigendum to: Impact of Acute HIV Infection and Early Antiretroviral Therapy on the Human Gut Microbiome.

Ornella Sortino, Nittaya Phanuphak, Alexandra Schuetz, Alexandra M Ortiz, Nitiya Chomchey, Yasmine Belkaid, Jacquice Davis, Harry A Mystakelis, Mariam Quiñones, Claire Deleage, Brian Ingram, Rungsun Rerknimitr, Suteeraporn Pinyakorn, Adam Rupert, Merlin L Robb, Jintanat Ananworanich, Jason Brenchley, Irini Sereti,

[This corrects the article DOI: 10.1093/ofid/ofz367.]. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):ofaa381]

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Central nervous system safety during brief analytic treatment interruption of antiretroviral therapy within four HIV remission trials: an observational study in acutely treated people living with HIV.

Joanna Hellmuth, Camilla Muccini, Donn J Colby, Eugène Kroon, Mark de Souza, Trevor A Crowell, Phillip Chan, Carlo Sacdalan, Jintana Intasan, Khunthalee Benjapornpong, Somporn Tipsuk, Suwanna Puttamaswin, Nitiya Chomchey, Victor Valcour, Michal Sarnecki, Frank Tomaka, Shelly J Krebs, Bonnie M Slike, Linda L Jagodzinski, Netsiri Dumrongpisutikul, Napapon Sailasuta, Vishal Samboju, Nelson L Michael, Merlin L Robb, Sandhya Vasan, Jintanat Ananworanich, Praphan Phanuphak, Nittaya Phanuphak, Robert Paul, Serena Spudich,

<h4>Background</h4>The central nervous system (CNS) is a likely reservoir of HIV, vulnerable to viral rebound, inflammation, and clinical changes upon stopping antiretroviral therapy (ART). It is critical to evaluate the CNS safety of studies using analytic treatment interruption (ATI) to assess HIV remission.<h4>Methods</h4>Thirty participants who started ART during acute HIV ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection.

Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,

Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):ofaa383]

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Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

Catherine W Cai, Suteeraporn Pinyakorn, Eugène Kroon, Mark de Souza, Donn J Colby, Tippawan Pankam, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Adam Rupert, Perrine Lallemand, Robin Dewar, Helene C Highbarger, Jintanat Ananworanich, Sandhya Vasan, Irini Sereti,

Abstract Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(9):]

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Brief Report: Group Sex and Methamphetamine Use Fuel an Explosive Epidemic of Hepatitis C Among HIV-Infected Men Who Have Sex With Men in Bangkok, Thailand.

Tanyaporn Wansom, Suteeraporn Pinyakorn, Christy J Kolsteeg, Eugene Kroon, Carlo P Sacdalan, Nitiya Chomchey, Jintanat Ananworanich, Sandhya Vasan, Nittaya Phanuphak, Donn J Colby,

BACKGROUND:Increased rates of hepatitis C virus (HCV) infection among HIV-infected men who have sex with men (MSM) and who deny injecting drugs have been reported in resource-rich settings. SETTING:We measured HCV prevalence and incidence in a predominantly MSM cohort with acute HIV infection in Bangkok, Thailand. METHODS:In 2009-2018, participants with ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 84(4):331-335]

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An inflammatory composite score predicts mycobacterial IRIS in people with HIV and severe lymphopenia: A prospective international cohort study.

Caian L Vinhaes, Virginia Sheikh, Deivide Oliveira de-Souza, Jing Wang, Adam Rupert, Gregg Roby, María B Arriaga, Kiyoshi F Fukutani, Fred Sawe, Doug Shaffer, Jintanat Ananworanich, Nittaya Phanuphak, Bruno B Andrade, Irini Sereti,

<h4>Background</h4>Immune reconstitution inflammatory syndrome (IRIS) is a common cause of morbidity among people with HIV (PWH) who initiate ART with severe lymphopenia. Easily accessible tools that reliably predict emergence and elucidate pathogenesis of IRIS are needed to facilitate improved clinical management.<h4>Methods</h4>Plasma levels of biomarkers were measured before ART initiation in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, :]

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A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection.

Eugène D M B Kroon, Jintanat Ananworanich, Amélie Pagliuzza, Ajantha Rhodes, Nittaya Phanuphak, Lydie Trautmann, Julie L Mitchell, Michelle Chintanaphol, Jintana Intasan, Suteeraporn Pinyakorn, Khuntalee Benjapornpong, J Judy Chang, Donn J Colby, Nitiya Chomchey, James L K Fletcher, Keith Eubanks, Hua Yang, John Kapson, Ashanti Dantanarayana, Surekha Tennakoon, Robert J Gorelick, Frank Maldarelli, Merlin L Robb, Jerome H Kim, Serena Spudich, Nicolas Chomont, Praphan Phanuphak, Sharon R Lewin, Mark S de Souza, ,

<h4>Objective and design</h4>A randomized, open-label pilot study in individuals treated with antiretroviral therapy (ART) since acute HIV infection (AHI) with a regimen including a histone deacetylase inhibitor to induce HIV from latency and control HIV replication during subsequent treatment interruption (TI).<h4>Methods</h4>Fifteen participants who initiated ART at AHI were randomized to ... Read more >>

J Virus Erad (Journal of virus eradication)
[2020, 6(3):100004]

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Dendritic cells focus CTL responses toward highly conserved and topologically important HIV epitopes

Tatiana Garcia-Bates, Mariana Palma, Denise Hsu, Jintanat Ananworanich, Bette Korber, Gaurav Gaiha, Nittaya Phanuphak, Rasmi Thomas, Sodsai Tovanabutra, Bruce Walker, John Mellors, Paolo Piazza, Eugene Kroon, Sharon Riddler, Nelson Michael, Charles Rinaldo, Robbie Mailliard, ,

During early HIV Infection, immunodominant T cell responses to highly variable epitopes lead to the selection and expansion of immune escape variants. As a potential therapeutic strategy, we assessed a specialized type 1-polarized monocyte-derived DC dendritic cell (MDC1)-based approach to selectively elicit functional CD8 + cytotoxic T lymphocyte (CTL) responses ... Read more >>

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Parallel but connected: Nuances of conducting behavioral and social science research alongside ethically challenging HIV remission trials.

Gail E Henderson, Stuart Rennie, Amy Corneli, Karen Meagher, R Jean Cadigan, Eugène Kroon, Jintanat Ananworanich, Holly L Peay,

Collaborations between clinical investigators and behavioral and social science researchers (BSSR) produce many benefits, but also may generate challenges and complexities. Ongoing relationships between teams may affect the research carried out by the BSSR team and the way they interpret their findings. Here we describe our experiences conducting the HIV ... Read more >>

Contemp Clin Trials Commun (Contemporary clinical trials communications)
[2020, 19:100594]

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Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption.

Julie L Mitchell, Hiroshi Takata, Roshell Muir, Donn J Colby, Eugène Kroon, Trevor A Crowell, Carlo Sacdalan, Suteeraporn Pinyakorn, Suwanna Puttamaswin, Khunthalee Benjapornpong, Rapee Trichavaroj, Randall L Tressler, Lawrence Fox, Victoria R Polonis, Diane L Bolton, Frank Maldarelli, Sharon R Lewin, Elias K Haddad, Praphan Phanuphak, Merlin L Robb, Nelson L Michael, Mark de Souza, Nittaya Phanuphak, Jintanat Ananworanich, Lydie Trautmann, ,

Plasmacytoid dendritic cells (pDCs) are robust producers of IFNα and one of the first immune cells to respond to SIV infection. To elucidate responses to early HIV-1 replication, we studied blood pDCs in 29 HIV-infected participants who initiated antiretroviral therapy during acute infection and underwent analytic treatment interruption (ATI). We ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):2845-2858]

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Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound.

Evan M Cale, Hongjun Bai, Meera Bose, Michael A Messina, Donn J Colby, Eric Sanders-Buell, Bethany Dearlove, Yifan Li, Emily Engeman, Daniel Silas, Anne Marie O'Sullivan, Brendan Mann, Suteeraporn Pinyakorn, Jintana Intasan, Khunthalee Benjapornpong, Carlo Sacdalan, Eugène Kroon, Nittaya Phanuphak, Robert Gramzinski, Sandhya Vasan, Merlin L Robb, Nelson L Michael, Rebecca M Lynch, Robert T Bailer, Amélie Pagliuzza, Nicolas Chomont, Amarendra Pegu, Nicole A Doria-Rose, Lydie Trautmann, Trevor A Crowell, John R Mascola, Jintanat Ananworanich, Sodsai Tovanabutra, Morgane Rolland, ,

Infusion of the broadly neutralizing antibody VRC01 has been evaluated in individuals chronically infected with HIV-1. Here, we studied how VRC01 infusions affected viral rebound after cessation of antiretroviral therapy (ART) in 18 acutely treated and durably suppressed individuals. Viral rebound occurred in all individuals, yet VRC01 infusions modestly delayed ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2020, 130(6):3299-3304]

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Continuous prophylactic ARV/ART since birth reduces seeding and persistence of the viral reservoir in vertically HIV-infected children.

Marta Massanella, Thanyawee Puthanakit, Louise Leyre, Thidarat Jupimai, Panadda Sawangsinth, Mark de Souza, Piyarat Suntarattiwong, Pope Kosalarksa, Thitiporn Borkird, Suparat Kanjanavanit, Kulkanya Chokephaibulkit, Rawiwan Hansudewechakul, Witaya Petdachai, Julie L Mitchell, Merlin L Robb, Lydie Trautmann, Jintanat Ananworanich, Nicolas Chomont,

BACKGROUND:Early antiretroviral therapy (ART) restricts the size of the HIV reservoir in infants. However, whether antiretroviral (ARV) prophylaxis given to exposed vertically infected children exerts similar effects remains unknown. METHODS:We measured total and integrated HIV DNA, as well as the frequency of CD4 T-cells producing multiply-spliced RNA (msRNA) after stimulation ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Machine-learning classification of neurocognitive performance in children with perinatal HIV initiating de novo antiretroviral therapy.

Robert H Paul, Kyu S Cho, Andrew C Belden, Claude A Mellins, Kathleen M Malee, Reuben N Robbins, Lauren E Salminen, Stephen J Kerr, Badri Adhikari, Paola M Garcia-Egan, Jiratchaya Sophonphan, Linda Aurpibul, Kulvadee Thongpibul, Pope Kosalaraksa, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Jurai Wongsawat, Saphonn Vonthanak, Tulathip Suwanlerk, Victor G Valcour, Rebecca N Preston-Campbell, Jacob D Bolzenious, Merlin L Robb, Jintanat Ananworanich, Thanyawee Puthanakit, ,

OBJECTIVE:To develop a predictive model of neurocognitive trajectories in children with perinatal HIV (pHIV). DESIGN:Machine learning analysis of baseline and longitudinal predictors derived from clinical measures utilized in pediatric HIV. METHODS:Two hundred and eighty-five children (ages 2-14 years at baseline; Mage = 6.4 years) with pHIV in Southeast Asia underwent neurocognitive assessment ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(5):737-748]

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Safety and immunogenicity of Ad26 and MVA vaccines in acutely treated HIV and effect on viral rebound after antiretroviral therapy interruption.

Donn J Colby, Michal Sarnecki, Dan H Barouch, Somporn Tipsuk, Daniel J Stieh, Eugène Kroon, Alexandra Schuetz, Jintana Intasan, Carlo Sacdalan, Suteeraporn Pinyakorn, Pornsuk Grandin, Hongshuo Song, Sodsai Tovanabutra, Zhanna Shubin, Dohoon Kim, Dominic Paquin-Proulx, Michael A Eller, Rasmi Thomas, Mark de Souza, Lindsay Wieczorek, Victoria R Polonis, Amélie Pagliuzza, Nicolas Chomont, Lauren Peter, Joseph P Nkolola, Johan Vingerhoets, Carla Truyers, Maria G Pau, Hanneke Schuitemaker, Nittaya Phanuphak, Nelson Michael, Merlin L Robb, Frank L Tomaka, Jintanat Ananworanich,

We administered Ad26, modified vaccinia Ankara vectors containing mosaic HIV-1 antigens or placebo in 26 individuals who initiated antiretroviral therapy during acute human immunodeficiency virus infection as an exploratory study to determine the safety and duration of viremic control after treatment interruption. The vaccine was safe and generated robust immune ... Read more >>

Nat Med (Nature medicine)
[2020, 26(4):498-501]

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Regional brain volumetric changes despite 2 years of treatment initiated during acute HIV infection.

Kalpana J Kallianpur, Neda Jahanshad, Napapon Sailasuta, Khunthalee Benjapornpong, Phillip Chan, Mantana Pothisri, Netsiri Dumrongpisutikul, Elizabeth Laws, Lishomwa C Ndhlovu, Katherine M Clifford, Robert Paul, Linda Jagodzinski, Shelly Krebs, Jintanat Ananworanich, Serena Spudich, Victor Valcour, ,

<h4>Objective</h4>To assess changes in regional brain volumes after 24 months among individuals who initiated combination antiretroviral therapy (cART) within weeks of HIV exposure.<h4>Design</h4>Prospective cohort study of Thai participants in the earliest stages of HIV-1infection.<h4>Methods</h4>Thirty-four acutely HIV-infected individuals (AHI; Fiebig I-V) underwent brain magnetic resonance (MR) imaging and MR spectroscopy at ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(3):415-426]

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Pattern and Frequency of Seroreactivity to Routinely Used Serologic Tests in Early-Treated Infants With HIV.

Thanyawee Puthanakit, Jintanat Ananworanich, Siriwat Akapirat, Supanit Pattanachaiwit, Sasiwimol Ubolyam, Vatcharain Assawadarachai, Panadda Sawangsinth, Thidarat Jupimai, Suvaporn Anugulruengkitt, Monta Tawan, Pope Kosalaraksa, Thitiporn Borkird, Piyarat Suntarattiwong, Suparat Kanjanavanit, Mark S de Souza,

BACKGROUND:Previous studies have shown low frequencies of seroreactivity to HIV diagnostic assays for infected infants treated with antiretroviral therapy (ART) early in infection. METHODS:Fifty-eight HIV-infected infants treated with ART at a median age of 1.9 months (range: 0.2-5.4) for up to 4 years of life were assessed for seroreactivity to ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2020, 83(3):260-266]

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