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Author Jinping Song

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

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Qualitative and quantitative bioanalytical methods validation of aristolochic acid DNA adducts and application in human formalin-fixed paraffin-embedded hepatocellular carcinoma tissues

Wang xin, Song jinping, Dong yapping, Hu linghua, Chen xiaoying, Yang fangfang, Qi haiyang, Qi xinming, Wen wen, Chen shuzhen, Xing guozhen, Ren jin,

Mutation signature of aristolochic acid (AA) found in urothelial or hepatocellular carcinoma causes public concern about the cancer risk of AA. In contrast, direct evidence based on the reliable bioanalytical method for the exposure of AA is still lacking and not universal. Here, we strictly complied with the qualitative and ... Read more >>

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Alteration of calcium signalling in cardiomyocyte induced by simulated microgravity and hypergravity.

Caizhi Liu, Guohui Zhong, Yuezhang Zhou, Yuchen Yang, Yingjun Tan, Yuheng Li, Xingcheng Gao, Weijia Sun, Jianwei Li, Xiaoyan Jin, Dengchao Cao, Xinxin Yuan, Zizhong Liu, Shuai Liang, Youyou Li, Ruikai Du, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Jinping Song, Shukuan Ling, Yingxian Li,

<h4>Objectives</h4>Cardiac Ca<sup>2+</sup> signalling plays an essential role in regulating excitation-contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to simulated microgravity and hypergravity and the effects on Ca<sup>2+</sup> signalling remain unknown. Here, we elucidate the mechanisms underlying the proliferation and remodelling of HL-1 cardiomyocytes subjected to rotation-simulated microgravity and ... Read more >>

Cell Prolif (Cell proliferation)
[2020, 53(3):e12783]

Cited: 3 times

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Clustering of cardiovascular disease biological risk factors among older adults in Shenzhen City, China: a cross-sectional study.

Wenqing Ni, Rongxing Weng, Xueli Yuan, Deliang Lv, Jinping Song, Hongshan Chi, Hailong Liu, Jian Xu,

<h4>Objectives</h4>Few studies reported the clustering of cardiovascular disease (CVD) biological risk factors among older adults. The objective of this study was to characterise the clustering of CVD biological risk factors among adults aged 65 or older in Shenzhen city, China.<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>General communities in Shenzhen, Guangdong, China.<h4>Participants</h4>A representative sample of 5635 ... Read more >>

BMJ Open (BMJ open)
[2019, 9(3):e024336]

Cited: 3 times

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TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling.

Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li,

Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca<sup>2+</sup> leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of TMCO1 in osteogenesis mediated by local Ca<sup>2+</sup>/CaMKII signaling in osteoblasts. ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1589]

Cited: 7 times

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Fluorescent boron and nitrogen co-doped carbon dots with high quantum yield for the detection of nimesulide and fluorescence staining.

Jinping Song, Xiaomin Liang, Qi Ma, Jinhui An, Feng Feng,

In this work, we firstly developed a new rapid detection method of nimesulide (Nim) based on the boron and nitrogen co-doped carbon dots (B,N-CDs) as the fluorescence probe. The B,N-CDs were prepared by a facile hydrothermal treatment using ammonium citrate and bis(pinacolato)diboron as precursors. The as-prepared B,N-CDs were mono-dispersed with ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2019, 216:296-302]

Cited: 1 time

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Hematopoietic stem cells and lineage cells undergo dynamic alterations under microgravity and recovery conditions.

Dengchao Cao, Jinping Song, Shukuan Ling, Shuaishuai Niu, Liang Lu, Zhengzhi Cui, Yuheng Li, Shanshan Hao, Guohui Zhong, Zhihong Qi, Weijia Sun, Xinxin Yuan, Hongxing Li, Dingsheng Zhao, Xiaoyan Jin, Caizhi Liu, Xiaorui Wu, Guanghan Kan, Hongqing Cao, Youmin Kang, Shuyang Yu, Yingxian Li,

Spaceflight leads to health risks including bone demineralization, skeletal muscle atrophy, cardiovascular dysfunction, and disorders of almost all physiologic systems. However, the impacts of microgravity on blood lineage cells and hematopoietic stem cells (HSCs) in vivo are largely unknown. In this study, we analyzed peripheral blood samples from 6 astronauts ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(6):6904-6918]

Cited: 6 times

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The GC2 haplotype of the vitamin D binding protein is a risk factor for a low plasma 25-hydroxyvitamin D concentration in a Han Chinese population.

Ji-Chang Zhou, Yumei Zhu, Chunmei Gong, Xiongshun Liang, Xiaoying Zhou, Yuanfei Xu, Deliang Lyu, Junluan Mo, Jian Xu, Jinping Song, Xiaoling Che, Shiqiang Sun, Changhua Huang, Xiao-Li Liu,

<h4>Background</h4>The <i>GC</i> haplotype of the vitamin D binding protein (encoded by the <i>GC</i> gene) might be a risk factor to the vitamin D (VD) nutritional status for many populations, while evidences from the Chinese Han population are sparse. We test the association between vitamin D binding protein genotypes and VD ... Read more >>

Nutr Metab (Lond) (Nutrition & metabolism)
[2019, 16:5]

Cited: 6 times

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Correlation analysis between depression and family fitness in chronic obstructive pulmonary disease inpatients: A cross-sectional study.

Xuexue Deng, Jinping Song,

To explore the relationship between depression and family fitness in chronic obstructive pulmonary disease (COPD) inpatients.COPD inpatients (280) in our hospital from Jan to June 2016 were included. Depression level and family fitness were quantified with self-rating depression scale (SDS) and Adaptability, Partnership, Growth, Affection, and Resolve (APGAR) test. The ... Read more >>

Medicine (Baltimore) (Medicine)
[2018, 97(52):e13946]

Cited: 1 time

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Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity.

Huiyuan Sun, Shukuan Ling, Dingsheng Zhao, Yang Li, Guohui Zhong, Ming Guo, Yuheng Li, Lin Yang, Jianpeng Du, Yuezhang Zhou, Jianwei Li, Shuai Liang, Yanqing Wang, Xingcheng Gao, Yating Zhang, Dengchao Cao, Caizhi Liu, Xiaoyan Jin, Zizhong Liu, Weijia Sun, Xiaorui Wu, Jinping Song, Yingxian Li, Dazhuo Shi,

<h4>Background</h4>Cardiac atrophy and reduced cardiac distensibility have been reported following space flight. Cardiac function is correspondingly regulated in response to changes in loading conditions. Panax quinquefolium saponin (PQS) improves ventricular remodeling after acute myocardial infarction by alleviating endoplasmic reticulum stress and Ca<sup>2+</sup>overload. However, whether PQS can ameliorate cardiac atrophy following ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2019, 56:83-93]

Cited: 2 times

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Myocardial CKIP-1 Overexpression Protects from Simulated Microgravity-Induced Cardiac Remodeling.

Shukuan Ling, Yuheng Li, Guohui Zhong, Yongjun Zheng, Qing Xu, Dingsheng Zhao, Weijia Sun, Xiaoyan Jin, Hongxing Li, Jianwei Li, Huiyuan Sun, Dengchao Cao, Jinping Song, Caizhi Liu, Xinxin Yuan, Xiaorui Wu, Yinlong Zhao, Zizhong Liu, Qi Li, Yingxian Li,

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced ... Read more >>

Front Physiol (Frontiers in physiology)
[2018, 9:40]

Cited: 5 times

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Circulating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest.

Shukuan Ling, Guohui Zhong, Weijia Sun, Fengji Liang, Feng Wu, Hongxing Li, Yuheng Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Xiaorui Wu, Hailin Song, Qi Li, Yinghui Li, Shanguang Chen, Jianghui Xiong, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down ... Read more >>

Front Physiol (Frontiers in physiology)
[2017, 8:69]

Cited: 5 times

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The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Zi Xu, Weijia Sun, Yuheng Li, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, Linhao You, Guangjun Nie, Yanzhong Chang, Yingxian Li,

Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron ... Read more >>

Bone (Bone)
[2017, 94:152-161]

Cited: 16 times

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Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle.

Guohui Zhong, Yuheng Li, Hongxing Li, Weijia Sun, Dengchao Cao, Jianwei Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Hailin Song, Xinxin Yuan, Xiaorui Wu, Qi Li, Qing Xu, Guanghan Kan, Hongqing Cao, Shukuan Ling, Yingxian Li,

Physiological adaptations to microgravity involve alterations in cardiovascular systems. These adaptations result in cardiac remodeling and orthostatic hypotension. However, the response of the left ventricle (LV) and right ventricle (RV) following hindlimb unloading (HU) and hindlimb reloading (HR) is not clear and the underlying mechanism remains to be understood. In ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:274]

Cited: 3 times

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Colorimetric detection of riboflavin by silver nanoparticles capped with β-cyclodextrin-grafted citrate.

Qi Ma, Jinping Song, Sufang Zhang, Meifang Wang, Yong Guo, Chuan Dong,

β-Cyclodextrin-grafted citrate was used for the first time as a stabilizer and reducer to prepare silver nanoparticles (AgNPs). The as-synthesized AgNPs were further characterized by UV-vis absorption spectroscopy, powder X-ray diffraction spectroscopy, and transmission electron microscopy. The results show that the presence of riboflavin caused severe aggregation of the nanoparticles, ... Read more >>

Colloids Surf B Biointerfaces (Colloids and surfaces. B, Biointerfaces)
[2016, 148:66-72]

Cited: 4 times

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Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients.

Wei Liu, Shukuan Ling, Weijia Sun, Tong Liu, Yuheng Li, Guohui Zhong, Dingsheng Zhao, Pengfei Zhang, Jinping Song, Xiaoyan Jin, Zi Xu, Hailin Song, Qi Li, Shujuan Liu, Meng Chai, Qinyi Dai, Yi He, Zhanming Fan, Yu Jie Zhou, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:16099]

Cited: 29 times

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CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity.

Yuheng Li, Guohui Zhong, Weijia Sun, Chengyang Zhao, Pengfei Zhang, Jinping Song, Dingsheng Zhao, Xiaoyan Jin, Qi Li, Shukuan Ling, Yingxian Li,

The CD44 is cellular surface adhesion molecule that is involved in physiological processes such as hematopoiesis, lymphocyte homing and limb development. It plays an important role in a variety of cellular functions including adhesion, migration, invasion and survival. In bone tissue, CD44 is widely expressed in osteoblasts, osteoclasts and osteocytes. ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:16124]

Cited: 11 times

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Early versus delayed postoperative oral hydration after general anesthesia: a prospective randomized trial.

Xiaorong Yin, Ling Ye, Liang Zhao, Lisha Li, Jinping Song,

The purpose of our study was to determine the safety and tolerability of early oral hydration (EOH) compared with delayed oral hydration (DOH) after general anesthesia. One thousand anesthesiology (ASA) I to III adult patients undergoing non-gastrointestinal surgery with general anesthesia were randomized assigned into two groups: DOH (n=500, patients ... Read more >>

Int J Clin Exp Med (International journal of clinical and experimental medicine)
[2014, 7(10):3491-3496]

Cited: 4 times

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miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway.

Chenyang Zhao, Weijia Sun, Pengfei Zhang, Shukuan Ling, Yuheng Li, Dingsheng Zhao, Jiang Peng, Aiyuan Wang, Qi Li, Jinping Song, Cheng Wang, Xiaolong Xu, Zi Xu, Guohui Zhong, Bingxing Han, Yan-Zhong Chang, Yingxian Li,

microRNA is necessary for osteoclast differentiation, function and survival. It has been reported that miR-199/214 cluster plays important roles in vertebrate skeletal development and miR-214 inhibits osteoblast function by targeting ATF4. Here, we show that miR-214 is up-regulated during osteoclastogenesis from bone marrow monocytes (BMMs) with macrophage colony stimulating factor ... Read more >>

RNA Biol (RNA biology)
[2015, 12(3):343-353]

Cited: 92 times

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A graphene-based biosensing platform based on the release of DNA probes and rolling circle amplification.

Meng Liu, Jinping Song, Shaomin Shuang, Chuan Dong, John D Brennan, Yingfu Li,

We report a versatile biosensing platform capable of achieving ultrasensitive detection of both small-molecule and macromolecular targets. The system features three components: reduced graphene oxide for its ability to adsorb single-stranded DNA molecules nonspecifically, DNA aptamers for their ability to bind reduced graphene oxide but undergo target-induced conformational changes that ... Read more >>

ACS Nano (ACS nano)
[2014, 8(6):5564-5573]

Cited: 39 times

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A general strategy to create RNA aptamer sensors using "regulated" graphene oxide adsorption.

Jinping Song, Pui Sai Lau, Meng Liu, Shaomin Shuang, Chuan Dong, Yingfu Li,

Aptamers have been used as molecular recognition elements for sensor development in combination with graphene oxide (GO), a nanomaterial with properties including fluorescence quenching, and selective adsorption of single-stranded nucleic acids. However, previous sensor designs based on aptamer-GO adsorption have not demonstrated wide applicability, and few studies have explored the ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2014, 6(24):21806-21812]

Cited: 7 times

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Monitoring of tumor response to cisplatin with simultaneous fluorescence and positron emission tomography: a feasibility study.

Fei Liu, Xu Cao, Shuangquan Liu, Bin Zhang, Wei He, Jinping Song, Zhongquan Dai, Bin Zhang, Jianwen Luo, Yinghui Li, Baoci Shan, Jing Bai,

Dual modality molecular imaging can capture concurrent molecular events and evaluate therapeutic efficacy from uniquely different perspectives based on different molecular targets. In this work, dual modality tomographic imaging, (18) F-fluorodeoxyglucose based positron emission tomography and subsurface fluorescence molecular tomography ([(18) F]FDG-PET/subsurface FMT), is proposed to monitor tumor response to ... Read more >>

J Biophotonics (Journal of biophotonics)
[2014, 7(11-12):889-896]

Cited: 1 time

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CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A.

Shukuan Ling, Qiao Sun, Yuheng Li, Luo Zhang, Pengfei Zhang, Xiaogang Wang, Chunyan Tian, Qi Li, Jinping Song, Hongju Liu, Guanghan Kan, Hongqing Cao, Zengming Huang, Jielin Nie, Yanqiang Bai, Shanguang Chen, Yinghui Li, Fuchu He, Lingqiang Zhang, Yingxian Li,

<h4>Background</h4>Sustained cardiac pressure overload-induced hypertrophy and pathological remodeling frequently leads to heart failure. Casein kinase-2 interacting protein-1 (CKIP-1) has been identified to be an important regulator of cell proliferation, differentiation, and apoptosis. However, the physiological role of CKIP-1 in the heart is unknown.<h4>Methods and results</h4>The results of echocardiography and histology ... Read more >>

Circulation (Circulation)
[2012, 126(25):3028-3040]

Cited: 34 times

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Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography.

Fei Liu, Xu Cao, Wei He, Jinping Song, Zhongquan Dai, Bin Zhang, Jianwen Luo, Yinghui Li, Jing Bai,

Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of ... Read more >>

J Biomed Opt (Journal of biomedical optics)
[2012, 17(4):040504]

Cited: 5 times

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