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Thermal decomposition of cyclohexane by flash pyrolysis vacuum ultraviolet photoionization time-of-flight mass spectrometry: a study on the initial unimolecular decomposition mechanism.

Kuanliang Shao, Xinghua Liu, Paul J Jones, Ge Sun, Mariah Gomez, Blake P Riser, Jingsong Zhang,

Thermal decomposition of cyclohexane at temperatures up to 1310 K was performed using flash pyrolysis coupled with vacuum ultraviolet (118.2 nm) photoionization time-of-flight mass spectrometry. The experimental results revealed that the major initiation reaction of cyclohexane decomposition was C-C bond fission leading to the formation of 1,6-hexyl diradical. The 1,6-hexyl ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2021, 23(16):9804-9813]

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Integrative Analysis of Selected Metabolites and the Fungal Transcriptome during the Developmental Cycle of Ganoderma lucidum Strain G0119 Correlates Lignocellulose Degradation with Carbohydrate and Triterpenoid Metabolism.

Shuai Zhou, Xiaoyu Zhang, Fuying Ma, Shangxian Xie, Chuanhong Tang, Qingjiu Tang, Jingsong Zhang,

To systemically understand the biosynthetic pathways of bioactive substances, including triterpenoids and polysaccharides, in Ganoderma lucidum, the correlation between substrate degradation and carbohydrate and triterpenoid metabolism during growth was analyzed by combining changes in metabolite content and changes in related enzyme expression in <i>G. lucidum</i> over 5 growth phases. Changes ... Read more >>

Appl Environ Microbiol (Applied and environmental microbiology)
[2021, 87(13):e0053321]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit Jain, Jad Chahoud, Michael Poch, Brandon J Manley, Roger Li, Wade Sexton, Scott M Gilbert,

<h4>Purpose</h4>Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or improved overall survival (OS) for patients with variant histology. Our objective was to assess for associations between receipt of neoadjuvant ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001855]

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Tumor Induced Osteomalacia in Patients With Metastatic Prostate Cancer: Case Report and Literature Review

Arjun Khadilkar, Valentina Tarasova, Jingsong Zhang, Julie E Hallanger-Johnson,

Abstract Background:Tumor induced osteomalacia (TIO), driven by elevated levels of fibroblast growth factor (FGF23), has been associated with progressive aggressive prostate cancer. FGF23, expressed by osteocytes, plays an important role in tumorigenesis through cell proliferation, chemotaxis, and angiogenesis. FGF23 regulates phosphate homeostasis through feedback loops between the kidney and bone. ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A229-A230]

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Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit K Jain, Jad Chahoud, Philippe E Spiess, Wade Sexton, Scott M Gilbert, Brandon J Manley,

<h4>Importance</h4>Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a real-world cohort outside of a clinical trial setting is ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2111329]

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Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2

Jingsong Zhang, Yang Zhang, Junyan Kang, Shuiye Chen, Yongqun He, Benhao Han, Mofang Liu, Lina Lu, Li Li, Zhigang Yi, Luonan Chen,

The presence of SARS-CoV-2 mutants, including the emerging variant B.1.1.7, has raised great concerns in terms of pathogenesis, transmission, and immune escape. Characterizing SARS-CoV-2 mutations, evolution, and effects on infectivity and pathogenicity is crucial to the design of antibody therapies and surveillance strategies. Here we analyzed 454,443 SARS-CoV-2 spike genes/proteins ... Read more >>

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Universal scaling of the critical temperature and the strange-metal scattering rate in unconventional superconductors

Kui Jin, Jie Yuan, Qihong Chen, Kun Jiang, Zhongpei Feng, Zefeng Lin, Heshan Yu, Ge He, Jingsong Zhang, Xingyu Jiang, Xu Zhang, Yujun Shi, Yanmin Zhang, Mingyang Qin, Zhi Gang Cheng, Nobumichi Tamura, Yi-feng Yang, Tao Xiang, Jiangping Hu, Ichiro Takeuchi, Zhongxian Zhao,

Dramatic evolution of properties with minute change in the doping level is a hallmark of the complex chemistry which governs copper oxide superconductivity as manifested in the celebrated superconducting domes as well as quantum criticality taking place at precise compositions. The strange metal state, where the resistivity varies linearly with ... Read more >>

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Budget Impact of Adaptive Abiraterone Therapy for Castration-Resistant Prostate Cancer.

Neil T Mason, Jason M Burkett, Ryan S Nelson, Julio M Pow-Sang, Robert A Gatenby, Timothy Kubal, John W Peabody, G Douglas Letson, Howard L McLeod, Jingsong Zhang,

<h4>Background</h4>The use of a novel strategy known as adaptive abiraterone therapy based on mathematical modeling of evolutionary dynamics of tumor subpopulations was shown in a clinical trial to extend the time to disease progression in patients with metastatic castration-resistant prostate cancer (CRPC) and reduced the use of abiraterone therapy. Although ... Read more >>

Am Health Drug Benefits (American health & drug benefits)
[2021, 14(1):15-20]

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Structure and chain conformation of bioactive β-D-glucan purified from water extracts of Ganoderma lucidum unbroken spores.

Yanfang Liu, Yatao Wang, Shuai Zhou, Mengqiu Yan, Qingjiu Tang, Jingsong Zhang,

Two polysaccharide fractions (GLSB50 and GLSB70) with total sugar content of 82.07 wt% and 53.79 wt%, respectively, were obtained from the water extracts of unbroken Ganoderma lucidum spores by sequential ethanol precipitation treatment. Compared with GLSB70, GLSB50 exhibited better activity on stimulation of humoral immune responses in immunosuppressed mice. A novel β-D-glucan ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2021, 180:484-493]

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Response to Mistry.

Jingsong Zhang, Jessica J Cunningham, Joel S Brown, Robert A Gatenby,

Nat Commun (Nature communications)
[2021, 12(1):329]

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Development and Optimization of the Triterpenoid and Sterol Production Process with Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum Strain G0017 (Agaricomycetes), in Liquid Submerged Fermentation at Large Scale.

Jie Feng, Na Feng, Qingjiu Tang, Yanfang Liu, Chuanhong Tang, Shuai Zhou, Jinyan Wang, Yi Tan, Jingsong Zhang, Chi-Chung Lin,

Ganoderma lucidum mycelia are rich in active substances such as triterpenoids and sterols. However, reports on the development of effective submerged fermentation processes are lacking and the resulting total triterpene and sterol yield is still quite low. In this study, a new G. lucidum strain G0017 mycelium isolated by screening ... Read more >>

Int J Med Mushrooms (International journal of medicinal mushrooms)
[2021, 23(3):43-53]

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Volatile profiles of two genotype Agaricus bisporus species at different growth stages.

Tao Feng, Moyao Yang, Bowen Ma, Yu Zhao, Haining Zhuang, Jingsong Zhang, Da Chen,

The compositions of volatile compounds in fresh mushrooms varied with their genotype species, maturity and growth conditions. This study aimed to identify volatile compounds in five growth stages of two genotype (A15 and W192) Agaricus bisporus species and used mathematical analysis to explain result. A total of 67 different compounds ... Read more >>

Food Res Int (Food research international (Ottawa, Ont.))
[2021, 140:109761]

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Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer.

Maha Hussain, Joaquin Mateo, Karim Fizazi, Fred Saad, Neal Shore, Shahneen Sandhu, Kim N Chi, Oliver Sartor, Neeraj Agarwal, David Olmos, Antoine Thiery-Vuillemin, Przemyslaw Twardowski, Guilhem Roubaud, Mustafa Özgüroğlu, Jinyu Kang, Joseph Burgents, Christopher Gresty, Claire Corcoran, Carrie A Adelman, Johann de Bono, ,

<h4>Background</h4>We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician's choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying alterations in homologous recombination repair genes and whose disease had progressed during previous treatment with a next-generation hormonal agent. The ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(24):2345-2357]

Cited: 17 times

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Emerging Treatment Options for the Treatment of Metastatic Urothelial Cancer: Therapeutic Potential of Enfortumab Vedotin.

Rohit K Jain, William Paul Skelton, Jingsong Zhang,

Enfortumab vedotin (EV) is an antibody-drug conjugate with humanized anti-Nectin-4 antibody linked with a microtubule-disrupting agent called monomethyl auristatin E. Nectin-4 is a cellular adhesion protein that is overexpressed in urothelial cancer. EV was approved in December 2019 for patients with locally advanced or metastatic urothelial cancer who previously received ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:8379-8386]

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Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial.

Thomas Powles, Michiel S van der Heijden, Daniel Castellano, Matthew D Galsky, Yohann Loriot, Daniel P Petrylak, Osamu Ogawa, Se Hoon Park, Jae-Lyun Lee, Ugo De Giorgi, Martin Bögemann, Aristotelis Bamias, Bernhard J Eigl, Howard Gurney, Som D Mukherjee, Yves Fradet, Iwona Skoneczna, Marinos Tsiatas, Andrey Novikov, Cristina Suárez, André P Fay, Ignacio Duran, Andrea Necchi, Sophie Wildsmith, Philip He, Natasha Angra, Ashok K Gupta, Wendy Levin, Joaquim Bellmunt, ,

<h4>Background</h4>Survival outcomes are poor for patients with metastatic urothelial carcinoma who receive standard, first-line, platinum-based chemotherapy. We assessed the overall survival of patients who received durvalumab (a PD-L1 inhibitor), with or without tremelimumab (a CTLA-4 inhibitor), as a first-line treatment for metastatic urothelial carcinoma.<h4>Methods</h4>DANUBE is an open-label, randomised, controlled, phase ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2020, 21(12):1574-1588]

Cited: 5 times

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Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration.

Wassim Abida, Akash Patnaik, David Campbell, Jeremy Shapiro, Alan H Bryce, Ray McDermott, Brieuc Sautois, Nicholas J Vogelzang, Richard M Bambury, Eric Voog, Jingsong Zhang, Josep M Piulats, Charles J Ryan, Axel S Merseburger, Gedske Daugaard, Axel Heidenreich, Karim Fizazi, Celestia S Higano, Laurence E Krieger, Cora N Sternberg, Simon P Watkins, Darrin Despain, Andrew D Simmons, Andrea Loehr, Melanie Dowson, Tony Golsorkhi, Simon Chowdhury, ,

<h4>Purpose</h4><i>BRCA1</i> or <i>BRCA2</i> (<i>BRCA</i>) alterations are common in men with metastatic castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly(ADP-ribose) polymerase inhibitors. We present results from patients with mCRPC associated with a <i>BRCA</i> alteration treated with rucaparib 600 mg twice daily in the phase II TRITON2 study.<h4>Methods</h4>We enrolled patients ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2020, 38(32):3763-3772]

Cited: 16 times

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Proof-of-principle Phase I results of combining nivolumab with brachytherapy and external beam radiation therapy for Grade Group 5 prostate cancer: safety, feasibility, and exploratory analysis.

Zhigang Yuan, Daniel Fernandez, Jasreman Dhillon, Julieta Abraham-Miranda, Shivanshu Awasthi, Youngchul Kim, Jingsong Zhang, Rohit Jain, Amparo Serna, Julio M Pow-Sang, Michael Poch, Roger Li, Brandon Manley, Angelina Fink, Arash Naghavi, Javier F Torres-Roca, G Daniel Grass, Sungjune Kim, Kujtim Latifi, Dylan Hunt, Peter A S Johnstone, Kosj Yamoah,

<h4>Background</h4>To determine whether combining brachytherapy with immunotherapy is safe in prostate cancer (PCa) and provides synergistic effects, we performed a Phase I/II trial on the feasibility, safety, and benefit of concurrent delivery of anti-PD-1 (nivolumab) with high-dose-rate (HDR) brachytherapy and androgen deprivation therapy (ADT) in patients with Grade Group 5 ... Read more >>

Prostate Cancer Prostatic Dis (Prostate cancer and prostatic diseases)
[2021, 24(1):140-149]

Cited: 1 time

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Protective effect of bromfenac sodium on femtosecond laser‑assisted cataract surgery via modulating cyclooxygenase‑2 expression.

Lu Lu, Jiangyue Zhao, Jing Wang, Yu Qin, Jingsong Zhang,

Cataract is a blinding‑caused disease and affects millions of individuals worldwide. Although conventional phacoemulsification (CPCS) has been widely used for treatment of cataract, the incidence of cataract‑caused blindness still increased year by year. Recently, femtosecond laser technology has been expanded to variety of clinical applications, including cataract surgery. The present ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2020, 22(3):2433-2441]

Cited: 1 time

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Multi-site co-mutations and 5’UTR CpG immunity escape drive the evolution of SARS-CoV-2

Jingsong Zhang, Junyan Kang, Mofang Liu, Benhao Han, Li Li, Yongqun He, Zhigang Yi, Luonan Chen,

The SARS-CoV-2 infected cases and the caused mortalities have been surging since the COVID-19 pandemic. Viral mutations emerge during the virus circulating in the population, which is shaping the viral infectivity and pathogenicity. Here we extensively analyzed 6698 SARS-CoV-2 whole genome sequences with specific sample collection dates in NCBI database. ... Read more >>

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Positive Ki-67 and PD-L1 expression in post-neoadjuvant chemotherapy muscle-invasive bladder cancer is associated with shorter overall survival: a retrospective study.

Selene Rubino, Youngchul Kim, Junmin Zhou, Jasreman Dhilon, Roger Li, Philippe Spiess, Michael Poch, Brandon J Manley, Julio Pow-Sang, Scott Gilbert, Wade Sexton, Jingsong Zhang,

<h4>Purpose</h4>There is an unmet need to develop prognostic biomarkers in post-neoadjuvant chemotherapy (NAC) muscle-invasive bladder cancer (MIBC) patients. We examine whether Ki-67 and PD-L1 expression can be used to guide adjuvant therapy.<h4>Methods</h4>Tissue microarrays were constructed from 130 post-NAC radical cystectomy samples. Up to 5 cores per sample were included. Expressions ... Read more >>

World J Urol (World journal of urology)
[2021, 39(5):1539-1547]

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Message from our President

Kevin C. Zorn, Naeem Bhojani, Dean S. Elterman, S. Larry Goldenberg, Alan I. So, Ryan F. Paterson, Mihir Desai, Roehrborn Roehrborn, Steven Kaplan, Peter Gilling, Fernanda Gabrigna Berto, Zhan Tao (Peter) Wang, Jennifer Bjazevic, Guido Filler, Blayne K. Welk, Hassan Razvi, Sumit Dave, Gregory Hosier, Thomas McGregor, Darren T. Beiko, Gregory E. Tasian, Michael A. Di Lena, Christopher M. Booth, Marlo Whitehead, D. Robert Siemens, Jonathan Lim, Kymora Scotland, Seth K. Bechis, Roger L. Sur, Stephen Y. Nakada, Sri Sivalingam, Timothy D. Averch, Jaime Landman, Thomas Chi, Sero Andonian, Naeem Bhojani, Noah E. Canvasser, Jonathan D. Harper, Kristina L. Penniston, Ben H. Chew, David-Dan Nguyen, Jack W. Luo, Jonathan R.Z Lim, Kymora Scotland, Seth K. Bechis, Roger L. Sur, Stephen Y. Nakada, Jody A. Antonelli, Necole M. Streepe, Sri Sivalingam, Davis P. Viprakasit, Timothy D. Averch, Jaime Landman, Thomas Chi, Vernon M. Pais, Vincent G. Bird, Sero Andonian, Noah E. Canvasser, Jonathan D. Harper, Ben H. Chew, Kristina L Penniston, Naeem Bhojani, Jennifer Bjazevic, Kaitlin Al, Hassan Razvi, Jeremy Burton, Pui Long Wilson Hung, Stacia Chun, Chiu Fung Tsang, Brian Ho, Ada Ng, Hok Leung Tsu, Wayne Lam, Frédéric Pouliot, Peter Carroll, Stephan Probst, Kenneth J. Pienta, Stephen P. Rowe, Lawrence Saperstein, Barry Siegel, Akash Patnaik, Mark A. Preston, Ajjai Shivaram Alva, Michael A. Gorin, Michael J. Morris, L.K. Joseph Chin, Ur Metser, Antonio Finelli, Laurence H. Klotz, Anil Kapoor, Katherine Zukotynski, Luke T. Lavallée, Marlon Hagerty, Wei Liu, Glenn Bauman, Adam Bobrowski, Ur Metser, Antonio Finelli, Neil E. Fleshner, Alejandro Berlin, Nathan Perlis, Girish S. Kulkarni, Peter Chung, Kopika Kuhathaas, Robert J. Hamilton, Russell Schwartz, Ahmed S. Zakaria, Amr Hodhod, Hanna Shahine, Felix Couture, David-Dan Nguyen, Côme Tholomier, Cristina Negrean, Kyle Law, Pierre Karakiewicz, Assaad El-Hakim, Kevin C. Zorn, Christopher J.D. Wallis, Zachary W. Klaassen, Amy Luckenbaugh, Aaron Laviana, Bimal Bhindi, Jennifer A. Locke, Yu Zheng, Goran Rac, Nicholas Major, Jennifer Rolef, Lauren Rittenberg, Arthur Mourtzinos, Matthew Moynihan, O. Lenaine Westney, Mike Metro, Sender Herschorn, Sarah R. Ferrara, Caitlin Lim, Brittani Barrett-Harlow, Ross Rames, Lindsey Cox, Eric Rovner, Elaine Redmond, Geneviève Nadeau, Le Mai Tu, R. Christopher Doiron, Stephen S. Steele, Dean S. Elterman, Jennifer A. Locke, Sender Herschorn, Conrad Maciejewski, Neil T. Dwyer, Lysanne Campeau, Kevin V. Carlson, Keith F. Rourke, Roselyne Choiniere, Philippe D. Violette, Melanie Morin, Le Mai Tu, Christine Reed, Philie Camille-Ariane, Benjamin Legault, Marie-Michele Beaudry, Gordon H Guyatt, Patrick Richard, Rutuja Kadam, Bridget Wiafe, Peter D. Metcalfe, Sender Herschorn, Kevin T. McVary, Javier Cambronero Santos, Steve Foley, Rita M. Kristy, Nurul Choudhury, John Hairston, Steven A. Kaplan, David K. Charles, Ross G. Everett, Zachary J. Prebay, Truman P. Landowski, R. Corey O’Connor, Michael L. Guralnick, Taeweon Lee, Miles Mannas, Peter C. Black, Mark Assmus, Tim Wollin, Sinan Khadhouri, Kevin Gallagher, Kenneth MacKenzie, Taimur Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Matthew Nielsen, John McGrath, Veeru Kasivisvananthan, Taeweon Lee, Miles Mannas, Peter C. Black, Mark Assmus, Tim Wollin, Sinan Khadhouri, Kevin Gallagher, Kenneth MacKenzie, Taimur Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Matthew Nielsen, John McGrath, Veeru Kasivisvananthan, Logan Zemp, Anders Berglund, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit K. Jain, G. Daniel Grass, Jingsong Zhang, Michael A. Poch, Julio Pow-Sang, Wade J. Sexton, Scott M. Gilbert, Shari Pilon-Thomas, José Conejo-Garcia, Colin P.N. Dinney, James J. Mulé, Roger Li, Ameeta Nayak, Luke T. Lavallée, Ranjeeta Mallick, Simon Tanguay, Antonio Finelli, Anil Kapoor, Alan I. So, Bimal Bhindi, Ricardo A. Rendon, Adrian Fairey, Frédéric Pouliot, Lori A. Wood, Rodney H. Breau, Marian S. Wettstein, Alejandro Berlin, Song Pham, Srikala S. Sridhar, Peter Chung, Shabbir M.H. Alibhai, Theodorus van der Kwast, Syed R. Qadri, Kathy Li, Ning Liu, Thomas Hermanns, Girish S. Kulkarni, Robert J. Hamilton, Lauren Landoni, Kopika Kuhathaas, Peter W. M. Chung, Philippe L. Bedard, Padraig R. Warde, Aaron R. Hansen, Tran Truong, Ezra Hahn, Michael A.S. Jewett, Jordan Bekkema, Keith F. Rourke, R. Christopher Doiron, Keith F. Rourke, Sarah R. Ferrara, Humberto R. Vigil, Jennifer A. Locke, Sender Herschorn, Karan Gandhi, Jacob Davidson, Zhan Tao (Peter) Wang, Sumit Dave, Yuding Wang, Jen Hoogenes, Hark Randhawa, Catherine Anne Lovatt, Kevin Kim, Roderick Clark, Courtney Moore, Bobby Shayegan, Edward D. Matsumoto, David M. Mikhail, Aaron Tabibzadeh, Zachary Kozel, Arun Rai, Joseph Sarcona, Patrick Samson, Christopher Hartman, Jessica Kreshover, Michael Schwartz, Louis Kavoussi, Domenico Veneziano, Lee Richstone, Dean S. Elterman, Kevin C. Zorn, Naeem Bhojani, Rhea Coriaty, Iman Sadri, Côme Tholomier, Félix Couture, David-Dan Nguyen, Kyle Law, Ahmed S. Zakaria, Naeem Bhojani, Dean S. Elterman, Esteban Rijo, V. Misrai, Kevin C. Zorn, Emily Whelan, Amanda Hird, Diana E. Magee, Sidney B. Radomski, Amanda Eng, M. Eric Saltel, Premal Patel, Morgan MacDonald, Stewart Whalen, Robyn Parker, Ross Mason, Andrea G. Lantz Powers, Courtney Moore, Jen Hoogenes, Jaskirat Saini, Adel Moalwi, Bobby Shayegan, Edward D. Matsumoto, Alexandra Bain, Blair A. St Martin, Michael G. Hobart, Nick Dean, Gillian Shiau, Shubhadip (Shubha) K. De, Tim Wollin, Samantha McGirr, Luke Wang, Jinfeng Jiang, Bryant Van Leeuwen, Chad A. LaGrange, Shawna L. Boyle, Kashif Visram, D. Robert Siemens, Craig Rodrigues, Kevin Martell, Hans Chung, Gerard Morton, Danny Vesprini, Eric Tseng, Ewa Szumacher, Patrick Cheung, Will Chu, Stanley Liu, Andrew Loblaw, Kevin Hanna, Amber McMahon, Richard L Sleightholm, Bryant VanLeeuwen, Shawna L. Boyle, Paulo H Werlang, Michael Horrigan, Luke T. Lavallée, Ilias Cagiannos, Christopher G. Morash, Rodney H. Breau, Connor Hoge, Matt Kasson, Tianyuan Guan, Rand Naffouje, Timothy Struve, Sadhna Verma, Abhinav Sidana, Kevin Hanna, Amber McMahon, Bryant VanLeeuwen, Shawna L. Boyle, Jin Kyu (Justin) Kim, Antonio Finelli, Eshetu Atenafu, Neil E. Fleshner, Nathan Perlis, Greg Nason, Girish S. Kulkarni, Robert J. Hamilton, Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Molière Nguile-Makao, Hélène Hovington, Caroline Léger, Yves Fradet, Arnaud Marien, Frédéric Pouliot, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Michele Lodde, Etienne Racine, Dominique Trudel, Martine Périgny, Thierry Duschesne, Josée Savard, Pierre Julien, Isabelle Bairati, Vincent Fradet, Jethro C.C. Kwong, Simona Minotti, Adrian Cozma, Ashkan Javidan, Amna Ali, Munir A. Jamal, Thomas Short, Frank F. Papanikolaou, John R. Srigley, Andrew H. Feifer, Anna Parackal, Jean-Eric Tarride, Feng Xie, Gord Blackhouse, Jen Hoogenes, Paul Cheon, Daniell Hylton, Edward D. Matsumoto, Wael Hanna, Anthony Adili, Bobby Shayegan, Samuel Fradet, Karine Robitaille, Jean-François Pelletier, Louis Lacombe, Frédéric Pouliot, Paul Toren, Yves Fradet, Michele Lodde, Rabi Tiguert, Thierry Dujardin, Josée Savard, Isabelle Bairati, Narcisse Singbo, Vincent Fradet, Abir El-Haouly, Anaïs Lacasse, Hares El-Rami, Frédéric Liandier, Alice Dragomir, L.K. Joseph Chin, Shiva Nair, Gencay Hatiboglu, James Relle, Jason Hafron, Matthias Roethke, Maya Mueller-Wolf, David Bonekamp, Zahra Kassam, Robert Staruch, Mathieu Burtnyk, Heinz-Peter Schlemmer, Sascha Pahernik, Jeffrey R. Talarek, Sean Maynor, Juliana Tobler, Sadhna Verma, Abhinav Sidana, Arnon Lavi, Shiva M Nair, L.K. Joseph Chin, Mustafa Andkhoie, Michael Szafron, Ellen O’Connor, Samantha S. Koschel, Niranjan N. Sathianathen, Isaac I. Thangasamy, Daniel D. Moon, Declan D. Murphy, Rebecca Power, Jason A. Hearn, Charles J. Gillis, David R. Harvey, Christopher G. French, Michael K. Organ, Jason Hearn, Rebecca J. Power, Charles Gillis, Jennifer Young, Michael K. Organ, Walid Shahrour, Ahmed Kotb, Owen Prowse, Hazem Elmansy, Sarah R. Ferrara, Taylor Remondini, Amanda Hird, Jennifer A. Locke, Sender Herschorn, Ronald T. Kodama, Ross Everett, David Charles, Halle Foss, Michael Avallone, R. Corey O’Connor, Michael Guralnick, Dean S. Elterman, Richard W. Casey, Thomas J. De los Reyes, Michael Holloway, Louisa Ho, Lynn Stothers, Thomas J. De los Reyes, Sidney B. Radomski, Rachel Wong, Uday Mann, Amanda Eng, Ruben Blachman-Bruan, Premal Patel, Joshua White, Jenna Coles, Ross Mason, Karthik Tennankore, Ashley R. Cox, Brennan Timm, Peter Liodakis, Tristan Juvet, Malek Meskawi, Laureano J Rangel, Paige Nichols, Matthew T. Gettman, Louise Moodie, Gabriela Ilie, Susan Kirkland, Rob Rutledge, Gabriela Ilie, Rob Rutledge, Ellen Sweeney, Joshua White, Gabriela Ilie, David G. Bell, Gregory G. Bailly, Ricardo A. Rendon, Ross Mason, Joseph Lawen, Rob Rutledge, Tarek Lawen, Gabriela Ilie, David Bell, Ross Mason, Gregory G. Bailly, Ricardo A. Rendon, Joseph Lawen, Rob Rutledge, Lauren M. Walker, Erik Wibowo, Carly S. Sears, John W. Robinson, Andrew G. Matthew, Deborah McLeod, Richard J. Wassersug, Ameeta Nayak, Ana Flaman, Ranjeeta Mallick, Luke T. Lavallée, Dean Fergusson, Rodney H. Breau, Douglas C. Cheung, Lisa Martin, Maria Komisarenko, Christopher Dharma, Girish S. Kulkarni, Shabbir M. Alibhai, Antonio Finelli, Douglas C. Cheung, Ayesha Syeda, Diana E. Magee, Amanda Hird, Lisa Martin, Maria Komisarenko, Karen Bremner, Shabbir M. Alibhai, Girish S. Kulkarni, Antonio Finelli, Murray Krahn, Paulo Werlang, Tom Ying, Christopher Knee, Igal Kushnir, Christopher G. Morash, Rodney H. Breau, Luke T. Lavallée, Ilias Cagiannos, Jason Hu, Armen-G. Aprikian, Marie Vanhuyse, Alice Dragomir, Jason Hu, Armen G. Aprikian, Marie Vanhuyse, Soukaina Ouizzane, Alice Dragomir, Zoe Glase, Mohamad Baker Berjaou, Karen Hersey, Heidi Wagner, Miran Kenk, Yazan Qaoud, Saranya Kulendran, Susan Nguyen, Alisha Bhimani, Neil E. Fleshner, Gabriel Lachance, Karine Robitaille, Hélène Hovington, Alain Bergeron, Yves Fradet, Vincent Fradet, Ming-Hsien Wang, Kathy Luong, Alaina Dozar, O. Emmanuel Abara, Valerie Lamontagne, Ogechi Abara, Nickolas Syvestre, Nick Dean, Jan K. Rudzinski, Graham Follett, Derrick Tilley, Niels-E. B. Jacobsen, Adrian Fairey, Gagan Fervaha, Jaime Herrera-Caceres, Khaled Ajib, Aravinth Jebanesan, Alexandre Zlotta, Neil E. Fleshner, Girish S. Kulkarni, Julie G Trudel, Conrad Maciejewski, Douglas C. Cheung, Lisa Martin, Maria Komisarenko, Naheed Jivraj, Christina Diong, Olli Saarela, Madhur Nayan, Hance Clarke, Duminda Wijeysundera, Tara Gomes, Girish S. Kulkarni, Shabbir M. Alibhai, Antonio Finelli, Arnon Lavi, Rodney H. Breau, Ranjeeta Mallick, Anil Kapoor, Antonio Finelli, Alan I. So, Frédéric Pouliot, Simon Tanguay, Luke T. Lavallée, Ricardo A. Rendon, Adrian Fairey, Darrel E. Drachenberg, Jean-Baptiste Lattouf, Ranjena Maloni, Nicholas E. Power, Ellen O’Connor, Brennan Timm, Joseph Ischia, Amy Baker, Damien Bolton, Nathan L. Lawrentschuk, Felix Couture, Rodney H. Breau, Adrian Fairey, Antonio Finelli, Daniel YC Heng, Luke T. Lavallée, Ricardo A. Rendon, Simon Tanguay, Patrick Richard, Ryan Sun, Benjamin Shiff, Oksana Harasemiw, Navdeep Tangri, Lourens Jacobs, Jeffery W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir (Jay) G. Nayak, Kaitlin Marshall, Nicholas E. Power, Shiva Nair, Katherine E Willmore, Tyler S Beveridge, Adam Bobrowski, Robert J. Hamilton, Lauren Landoni, Kopika Kuhathaas, Peter Chung, Philippe L. Bedard, Padraig Warde, Aaron Hansen, Tran Truong, Ezra Hahn, Michael A. Jewett, Jackie Bender, Benjamin Beech, David W. Chapman, Keith F. Rourke, David W. Chapman, Steven Tong, Peter D. Metcalfe, Philippe Sarlieve, Nathan Hoy, Darcie A. Kiddoo, Amr Hodhod, Francis Petrella, Mohamed El-Sherbiny, Iman Sadri, Roman Jednak, J.-P. Capolicchio, Bruce Gao, Keara Decotiis, Adam Bobrowski, Martin A. Koyle, Fardod O’Kelly, O. Emmanuel Abara, Natasha Samarasinghe, Maurice Levy, Colin Cavey, Katie Lyman, Rohit Singla, David I. Harriman, Christopher Y. Nguan, Jesse Ory, Russell G Saltzman, Ruben Blachman-Braun, Simon Dadoun, Darcy L DiFede, Courtney Premer, Barry Hurwitz, Gavin Langille, Joshua M Hare, Ranjith Ramasamy, Benjamin Shiff, Premal Patel, Jasmine DeZeeuw, Michael K. Organ, Christine Goudie, Adam Dubrowski, Colin Lundeen, Victor KF Wong, Kymora Scotland, Ben H. Chew, Zachary Valley, John W. Dushinski, Richard E. Barr, Patricia A. Dere, Derek Bley, Charles B. Metcalfe, Kamaljot S. Kaler, Fabiola Oquendo, Amr Hodhod, Loay Abbas, Brianna Beaudry, Amer Alaref, Yasser Labib, Scott Bonneville, Ahmed Kotb, Owen Prowse, Walid Shahrour, Hazem Elmansy, Fabiola Oquendo, Amr Hodhod, Loay Abbas, Brianna Beaudry, Yasser Labib, Scott Bonneville, Ahmed Kotb, Owen Prowse, Walid Shahrour, Hazem Elmansy, Brennan Timm, Greg Jack, Damien Bolton, Khatereh Aminoltejari, Ben H. Chew, Dirk Lange, David W. Chapman, Devin Demitor, Shubhadip (Shubha) K. De, Jennifer Bjazevic, Noah Stern, Hassan Razvi, Justin Y.H. Chan, Victor K.F. Wong, Julie Wong, Kymora Scotland, Ben H. Chew, Uday Mann, Zack Li, Amanda Eng, Rachel Wong, Ruben Blachman-Braun, Premal Patel, David M. Mikhail, Joseph Sarcona, Aaron Tabibzadeh, Daniel Nassau, Zachary Kozel, Michael Feuerstein, Louis Kavoussi, Lee Richstone, Jennifer A. Locke, Roshan Navaratnam, Sarah R. Ferrara, Andrea Phillips, Avery Nathens, Sender Herschorn, Ronald T. Kodama, Jordana Fersovich, Alvaro Saavedra, Keith F. Rourke, Elaine Redmond, Dylan Hoare, Nathan Hoy, Keith F. Rourke, Dylan Hoare, Jordan Bekkema, Keith F. Rourke, David W. Chapman, Jordan Bekkema, Keith F. Rourke, Sean Elliott, Ramón Virasoro, Jessica DeLong, Rafael Estrella, Merycarla Pichardo, Ramón Rodriguez Lay, Gustavo Espino, George Suarez, George Webster, Gerald Jordan, Mélanie Aube-Peterkin, Sender Herschorn, Geneviève Nadeau, Sarah R. Ferrara, Jennifer A. Locke, Sender Herschorn, Samer Shamout, Richard J. Baverstock, Kevin V. Carlson, Jennifer A. Locke, Roshan Navaratnam, Sarah R. Ferrara, Sender Herschorn, Kate Anderson, Danielle Jenkins, Mary E. Lynch, Ashley R. Cox, Sarah R. Ferrara, Jennifer A. Locke, Lesley Carr, Sender Herschorn, R. Christopher Doiron, Kerri-Lynn Kelly, Brad Dean, J. Curtis Nickel, Quang Loc Bui, Ahmed Khalil, Hong Son Trinh, Carolina Saldana, Aurelien Gobert, Maya Nourieh, Eva Comperat, Olivier Cussenot, Shreyas Gandhi, Alex Koziarz, Jason Y. Lee, Shiva M. Nair, Tina Luu Ly, Arnon Lavi, Michael Haan, Yujiro Sano, Nicholas E. Power, Golmehr Sistani, Jennifer Bjazevic, Zahra Kassam, Jonathan Romsa, Stephen E. Pautler, Kashif Visram, Adam Gabara, Francisco Vera Badillo, Naji J. Touma, Jan K. Rudzinski, Natasha Govindasamy, Konstantin Stoletov, Arun Raturi, John D Lewis, Kenichiro Ikeda, Kohei Kobatake, Tetsutaro Hayashi, Jun Teishima, Akio Matsubara, Jiefei Yao, Luke Witherspoon, Eric Belanger, Neal E. Rowe, Adam Bobrowski, Lauren Landoni, Lynn Anson-Cartwight, Aaron Hansen, Peter Chung, Phillippe Bedard, Padraig Warde, Michael A. Jewett, Martin O’Malley, Joan Sweet, Robert J. Hamilton, Roderick Clark, Arnon Lavi, Tina Luu Ly, Shiva M. Nair, Khalil Hetou, Michael Haan, Nicholas E. Power, Gregory Nason, Kopika Kuhathaas, Lynn Anson-Cartwright, Michael A. Jewett, Martin O’Malley, Joan Sweet, Aaron Hansen, Philippe Bedard, Peter Chung, Ezra Hahn, Padraig Warde, Robert J. Hamilton, Hanane Moussa, Lamoussa Diabaté, Karine Robitaille, Laurence Bettan, Molière Nguile-Makao, Hélène Hovington, Fred Saad, Michel Carmel, Armen-G. Aprikian, BIOCaPPE Network, Benoit Lamarche, Pierre Julien, Yves Fradet, Vincent Fradet, Jesse Spooner, Manjot Birk, Victor Espinosa, Nathan Hoag, Veselina Stefanova, Roger J. Buckley, Rupayan Mukherjee, Abirami Kirubarajan, Nicole Golda, Andrew Loblaw, Stanley Flax, Les Spevack, Veselina Stefanova, Roger J. Buckley, Rupayan Mukherjee, Abirami Kirubarajan, Stanley Flax, Nicole Golda, Les Spevack, David Hajek, Andrew Loblaw, Enoch Lai, Adam Tunis, Joseph Peltz, Thomas Southall, Charlie Gillis, Michelle Anderson, Jennifer Young, Richard Hewitt, J. Matthew Andrews, Charlie Gillis, Thomas M. Southall, Michelle Anderson, Jennifer Young, Richard J. Hewitt, J. Matthew Andrews, Amber McMahon, Kevin Hanna, Richard Sleightholm, Bryant VanLeeuwen, Shawna L. Boyle, Frédéric Pouliot, Cassandra Ringuette Goulet, Hélène Hovington, Hervé Brisson, Bertrand Neveu, François-Alexandre Buteau, Justin Oake, Oksana Harasemiw, Navdeep Tangri, Thomas W. Ferguson, Jeffery W. Saranchuk, Rahul K. Bansal, Darrel E. Drachenberg, Jasmir G. Nayak, Connor Hoge, Sean Maynor, Tianyuan Guan, Rand Naffouje, Monzer Haj-Hamed, Nilesh Patil, James Donovan, Krishnanath Gaitonde, Sadhna Verma, Abhinav Sidana, Jethro C.C. Kwong, Simona Minotti, Adrian Cozma, Ashkan Javidan, Amna Ali, Munir A. Jamal, Thomas Short, Frank F. Papanikolaou, John R. Srigley, Andrew H. Feifer, Kush M. Joshi, Arnon Lavi, Ray S. Jia, David Z. Guy, Danielle A. Starcevic, Sophia Moralis Frost, Natan Veinberg, Shiva M. Nair, L.K. Joseph Chin, Ahmed S. Zakaria Ahmed, Félix Couture, David-Dan Nguyen, Hanna Shahine, Côme Tholomier, Cristina Negrean, Kyle Law, Pierre Karakiewicz, Assaad El-Hakim, Kevin C. 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Morash, Luke T. Lavallée, Hayato Takeda, Go Kimura, Shuhei Nozaki, Mikio Shibasaki, Yuya Hasegawa, Naoto Hodotsuka, Ryo Amakawa, Shigehito Minaguchi, Hikaru Mikami, Masato Yanagi, Jun Akatsuka, Yuki Endo, Tatsuro Hayashi, Yukihiro Kondo, Betty Wang, Nathan Hoy, Shubhadip (Shubha) K. De, Trevor D. Schuler, Timothy A. Wollin, Ahmed Ibrahim, Mélanie Aube-Peterkin, Hazem Elmansy, Serge Carrier, Benjamin Beech, Ryan McLarty, Jan K. Rudzinski, Howard J. Evans, Nuley Seo, Bader Alsaikhan, Sylvia Koo, Brian Carillo, Monica Farcas, Sylvia Koo, Bader Alsaikhan, Nuley Seo, Kai Fok, Brian Carrillo, Monica Farcas, Jason Y. Lee, Luke Reynolds, Monica Farcas, Catherine Anne Lovatt, Michael John Uy, Jennifer Hoogenes, Carol Bernacci, Edward D. Matsumoto, Patrice Levasseur-Fortin, Kyle W. Law, David-Dan Nguyen, Ahmed Zakaria, Vincent Misrai, Dean S. Elterman, Naeem Bhojani, Enrique Rijo, Kevin C. Zorn, Ryan Sun, Wendy Wang, Cole Kubay, Sean Fernando, Andrew Fast, Christopher Dutka, Kianna Cadogan, Darrel E. Drachenberg, Ahmed Ibrahim, Anne Yin, Yasser Noureldin, Serge Carrier, Mélanie Aube-Peterkin, Sero Andonian, Uday Mann, Jasmir G. Nayak, Premal Patel, Jeannette Johnstone, Adam Gabara, Naji J. Touma, Thomas Canil, Monica Farcas, Maylynn Ding, Leah Soderberg, Jae H Jung, Philipp Dahm, Avril J. Lusty, D. Robert Siemens, Mina Tohidi, J. Curtis Nickel, Ghizlane Moussaoui, Cristina Negrean, Felix Couture, Côme Tholomier, David-Dan Nguyen, Ahmed S. Zakaria, Kevin C. Zorn, Dean S. Elterman, Kevin C. Zorn, Naeem Bhojani, Kevin C. Zorn, Naeem Bhojani, Dean S. Elterman, S. Larry Goldenberg, Alan I. So, Ryan F. Paterson, Mihir Desai, Steven Kaplan, Roehrborn Roehrborn, Dean S. Elterman, Thorsten Bach, Enrique Rijo, Vincent Misrai, Paul Anderson, Kevin C. Zorn, Naeem Bhojani, Albert El Hajj, Bilal Chughtai, Mihir Desai, David-Dan Nguyen, Dean S. Elterman, Kevin C. Zorn, Naeem Bhojani, Kyle W. Law, Côme Tholomier, Félix Couture, Ahmed S. Zakaria, David-Dan Nguyen, Luca Cindolo, Giovanni Ferrari, Carlos Vasquez-Lastra, Tiago J. Borelli-Bovo, Edgardo F. Becher, Hannes Cash, Maximilian Reimann, Vincent Misrai, Kevin C. Zorn, Fabiola Oquendo, Amr Hodhod, Loay Abbas, Brianna Beaudry, Ahmed Kotb, Owen Prowse, Walid Shahrour, Hazem Elmansy, Amr Hodhod, Fabiola Oquendo, Loay Abbas, Brianna Beaudry, Ahmed Kotb, Owen Prowse, Walid Shahrour, Hazem Elmansy, Ahmed Ibrahim, Ahmed Zakaria, Mélanie Aube-Peterkin, Simon Tanguay, Serge Carrier, Armen-G. Aprikian, Ahmed Ibrahim, Mélanie Aube-Peterkin, Serge Carrier, Amr Hodhod, Fabiola Oquendo, Loay Abbas, Brianna Beaudry, Jill Skogberg, Ahmed Kotb, Owen Prowse, Walid Shahrour, Hazem Elmansy, Jonathan Moore, Raphael V Carrera, Haidar Abdul-Muhsin, Amihay Nevo Pima, Scott Cheney, Donald Neff, Mitchell Humphreys, Iman Sadri, David-Dan Nguyen, Vincent Misraï, Thorsten Bach, Naeem Bhojani, James E. Lingeman, Dean S. 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Nayak, Juanita Crook, Chad Tang, Howard Thames, Pierre Blanchard, Jeremiah Sanders, Jay Ciezki, Mira Keyes, Gregory Merrick, Charles Catton, Hamid Raziee, Richard Stock, Frank J Sullivan, Jeremy Millar, Mitch Anscher, Steven Frank, Shiva M. Nair, Andrew Warner, Arnon Lavi, George B. Rodrigues, L.K. Joseph Chin, Miran Kenk, Virna Cepero, Lorne E. Aaron, Bobby Shayegan, Richard Sioufi, Anil Kapoor, Victor Mak, Zeid Mohamedali, Jeffrey M. Spodek, Paul Jr. Ouellette, Neil T. Dwyer, George Vrabec, Lee M. Jonat, Sergio Dalla Nora, Neil E. Fleshner, Madonna Peter, Misha Bilenky, Ruth Isserlin, Aaron Hansen, Gary Bader, Martin Hirst, Anthony Joshua, Neil E. Fleshner, Bharati Bapat, Graeme Follett, Derek Tilley, Naveen Basappa, Brita Danielson, Michael P. Chetner, Michael Kolinsky, Scott North, Sarah Rayner-Myers, Gerry Todd, Adrian Fairey, Blayne K. Welk, Sean Peterson, Sender Herschorn, Geneviève Nadeau, Michelle Bergeron, Stéphane J. Bolduc, Elaine Redmond, R. Christopher Doiron, Keith F. Rourke, Blayne K. Welk, Eric McArthur, Jennifer A. Locke, Andrew Macnab, Mark K. Nigro, Saurabh Garg, Sepideh Allahdadian, Martin McKeown, Lynn Stothers, Lynn Stothers, Andrew Macnab, Jennifer A. Locke, A Klausner, J Speich, Bonnie Liu, Jennifer Reid, Michael Silverman, Blayne K. Welk, Luke Witherspoon, Ali Dergham, Thomas A. Skinner, Brian D. Blew, Jeffrey Warren, Cyrus Chehroudi, Alexander Danechi, Andrew E. MacNeily, Kourosh Afshar, Keesha Khehra, Caelie Stewart, Angela Cho, Rohit Singla, Christopher Y. Nguan, Yung Lee, Lucshman Raveendran, Olivia Lovrics, Aristithes Doumouras, Martin A. Koyle, Monica Farcas, Yonah Krawkowsky, Dennis Hong, Amjad Alwaal, Mohannad Awad, Nathan Boggs, Jake Kuzbel, Brian Snoad, Zack Li, Jason Scovell, Sarah McGriff, Christopher J.D. Wallis, Yonah Krakowsky, Premal Patel, Ranjith Ramasamy, Benjamin Shiff, Jason Scovell, Sarah McGriff, Premal Patel, Christopher J.D. Wallis, Yonah Krakowsky, Ranjith Ramasamy, Aishwarya Roshan, Andrew E. MacNeily, Jin Kyu Kim, Lucshman Raveendran, Michael E Chua, Armando J. Lorenzo, Walid A. Farhat, Jessica M Ming, Martin A. Koyle, Amr Hodhod, Iman Sadri, Francis Petrella, J.-P. Capolicchio, Roman Jednak, Mohamed El-Sherbiny, Amr Hodhod, Francis Petrella, Mohamed El-Sherbiny, Iman Sadri, Roman Jednak, J.-P. Capolicchio, Karla Rebullar, Fardod O’Kelly, Martin A. Koyle, Andrew J Kirsch, Armando J. Lorenzo, Rusul Al-Kutbi, Fadi Zu’bi, Youshan Ding, Jacob Davidson, Leandra Stringer, Zhan Tao (Peter) Wang, Sumit Dave, Lucshman Raveendran, Robert DiCesare, Kornelia Twardowski, David During, Darius J. Bagli, Myla Moretti, Martin A. Koyle, Youshan Ding, Jacob Davidson, Ernest Chan, Jennifer Bjazevic, Guido Filler, Sumit Dave, Zhan Tao (Peter) Wang, Catherine McMartin, Jonathan Cloutier, Stéphane J. Bolduc, Steven Tong, David W. Chapman, Peter D. Metcalfe, Adam Forster, Zhan Tao (Peter) Wang, Sumit Dave, Melissa Mcgrath, John Kim, Luis H. Braga, Bruce Li, Adib Shamsuddin, Catherine Anne Lovatt, Luis H. Braga, Joshua White, Dawn L. MacLellan, Rodrigo Romao,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2020, 14(6 Suppl 2):S21-S167]

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Ultraviolet photodissociation dynamics of the n-butyl, s-butyl, and t-butyl radicals.

Ge Sun, Xianfeng Zheng, Yu Song, Michael Lucas, Jingsong Zhang,

Photodissociation dynamics of the jet-cooled n-butyl radical via the 3s Rydberg state and the s-butyl radical via the 3p Rydberg states in the ultraviolet region of 233 nm-258 nm, as well as the t-butyl radical via the 3d Rydberg states at 226 nm-244 nm, are studied using the high-n Rydberg ... Read more >>

J Chem Phys (The Journal of chemical physics)
[2020, 152(24):244303]

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Ontology-based systematic classification and analysis of coronaviruses, hosts, and host-coronavirus interactions towards deep understanding of COVID-19

Hong Yu, Li Li, Hsin-hui Huang, Yang Wang, Yingtong Liu, Edison Ong, Anthony Huffman, Tao Zeng, Jingsong Zhang, Pengpai Li, Zhiping Liu, Xiangyan Zhang, Xianwei Ye, Samuel Handelman, Gerry Higgins, Gilbert Omenn, Brian Athey, Junguk Hur, Luonan Chen, Yongqun He,

Given the existing COVID-19 pandemic worldwide, it is critical to systematically study the interactions between hosts and coronaviruses including SARS-Cov, MERS-Cov, and SARS-CoV-2 (cause of COVID-19). We first created four host-pathogen interaction (HPI)-Outcome postulates, and generated a HPI-Outcome model as the basis for understanding host-coronavirus interactions (HCI) and their relations ... Read more >>

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Pre-protective effect of polysaccharides purified from Hericium erinaceus against ethanol-induced gastric mucosal injury in rats.

Wanchao Chen, Di Wu, Yueling Jin, Qiaozhen Li, Yanfang Liu, Xuxin Qiao, Jingsong Zhang, Guochao Dong, Zhengpeng Li, Tingting Li, Yan Yang,

The β-glucan H6PC20 (Mw: 2390 kDa) and α-heteropolysaccharide HPB-3 (Mw: 15 kDa) were purified from the fruiting body of Hericium erinaceus according to the previous methods. Their gastroprotective activities and corresponding structure-activity relationship were studied in the ethanol-induced gastric ulcer model of rats. After intragastric administrated with H6PC20 and HPB-3 for 14 days, ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2020, 159:948-956]

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The Coevolution of Promoters and Transcription Factors in Animal and Plant Cells

Jingsong Zhang, Xiangtian Yu, Zhixi Su, Shutao He, Yiwei Zhou, Hao Dai, Xiaohu Hao, Tao Zeng, Wen Wang, Luonan Chen,

Coevolution has been acknowledged to play a significant role in driving the evolution of molecules and species. Promoters and transcription factors (TFs), especially their interactions, are key determinants for the regulation of gene expression. However, the evolutionary processes and mechanisms of promoter and TF interactions are still poorly understood. Here ... Read more >>

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