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Author Jingmeng Sun


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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

Cited: 0 times

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Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu,

The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an active component extracted from ginseng, is reported to protect against CP-induced nephrotoxicity. However, the mechanisms ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(11):e22896]

Cited: 1 time

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li, Xiaoyu Qu,

Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb Astragalus membranaceus, alleviated CDDP-induced AKI. To explore the mechanism, we performed a metabolomics study to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 183:114299]

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Quercetin attenuates NLRP3 inflammasome activation and apoptosis to protect INH-induced liver injury via regulating SIRT1 pathway.

Yueming Zhang, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song, Jie Zhang,

Severe hepatotoxicity greatly limits the clinical application of the first-line anti-tuberculosis drug isoniazid(INH). Quercetin(Que) has multiple pharmacological properties, and is regarded as a potential protective agent against a variety of organ injuries. However, the exact effect of quercetin on INH-induced hepatotoxicity and the underlying mechanisms are not yet completely understood. ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2020, 85:106634]

Cited: 3 times

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Jingmeng Sun, Zhuoming Wang, Weiyu Zhang,

<h4>ABSTRACT</h4> Rana chensinensis ( R. chensinensis ) is an important wild animal found in China, and a precious animal in Chinese herbal medicine. R. chensinensis is rich in polyunsaturated fatty acids (PUFAS). However, information regarding the genes of R. chensinensis related to the synthesis of PUFAs is limited. To identify ... Read more >>

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Astragaloside IV enhances cisplatin chemosensitivity in hepatocellular carcinoma by suppressing MRP2.

Xiaoyu Qu, Huan Gao, Jinghui Zhai, Jingmeng Sun, Lina Tao, Yueming Zhang, Yanqing Song, Tingting Hu,

Decreased chemosensitivity among tumor cells is often an obstacle in cisplatin (Cis) chemotherapy. Overexpression of multidrug resistance-associated protein 2 (MRP2) is a key mechanism underlying decreased Cis chemosensitivity and resistance. Astragaloside IV (AS IV) is an important component derived from the well-known traditional Chinese herb Astragalus membranaceus. The aim of ... Read more >>

Eur J Pharm Sci (European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences)
[2020, 148:105325]

Cited: 3 times

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Calycosin ameliorates doxorubicin-induced cardiotoxicity by suppressing oxidative stress and inflammation via the sirtuin 1-NOD-like receptor protein 3 pathway.

Jinghui Zhai, Lina Tao, Sixi Zhang, Huan Gao, Yueming Zhang, Jingmeng Sun, Yanqing Song, Xiaoyu Qu,

The limitation of doxorubicin (DOX), which is widely used for the treatment of solid tumors and hematologic malignancies, is a vital problem in clinical application. The most serious of limit factors is cardiotoxicity. Calycosin (CA), an isoflavonoid that is the major active component in Radix astragali, has been reported in ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, 34(3):649-659]

Cited: 10 times

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Identification of key metabolites during cisplatin-induced acute kidney injury using an HPLC-TOF/MS-based non-targeted urine and kidney metabolomics approach in rats.

Xiaoyu Qu, Huan Gao, Jingmeng Sun, Lina Tao, Yueming Zhang, Jinghui Zhai, Yanqing Song, Tingting Hu, Zhiyuan Li,

Kidney injury is a major adverse effect of cisplatin use. Metabolomics has been used to characterize physiological or pathological conditions through identification of metabolites and characterization of the metabolic pathway. Metabolomics profiling could allow for identification of nephrotoxic mechanisms of cisplatin and identification of biomarkers of cisplatin-induced injury. In this ... Read more >>

Toxicology (Toxicology)
[2020, 431:152366]

Cited: 3 times

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Astragaloside IV protects against cisplatin-induced liver and kidney injury via autophagy-mediated inhibition of NLRP3 in rats.

Xiaoyu Qu, Huan Gao, Lina Tao, Yueming Zhang, Jinghui Zhai, Jingmeng Sun, Yanqing Song, Sixi Zhang,

The aim of this study was to explore the role of the NOD-like receptor family, pyrin domain containing (NLRP3) inflammasome and autophagy in Astragaloside IV (AS IV)-mediated protection against cisplatin-induced liver and kidney injury in rats. Rats were intraperitoneally administered cisplatin at a dose of 15 mg/kg and orally administered ... Read more >>

J Toxicol Sci (The Journal of toxicological sciences)
[2019, 44(3):167-175]

Cited: 9 times

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Rapid diagnosis of Propionibacterium acnes infection in patient with hyperpyrexia after hematopoietic stem cell transplantation by next-generation sequencing: a case report.

Mingzhi Ye, Wei Wei, Zhikai Yang, Yingzhen Li, Shaomin Cheng, Kang Wang, Tianliangwen Zhou, Jingmeng Sun, Sha Liu, Na Ni, Hui Jiang, Hua Jiang,

<h4>Background</h4>The rapid determination of pathogenic agent is very important to clinician for guiding their clinical medication. However, current diagnostic methods are of limitation in many aspects, such as detecting range, time-consuming, specificity and sensitivity. In this report, we apply our new-developing pathogen detection method to clarify that Propionibacterium acnes is ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2016, 16:5]

Cited: 6 times

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