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Author Jing Zhi Yan

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Neuronal activity-induced SUMOylation of Akt1 by PIAS3 is required for long-term potentiation of synaptic transmission.

Li Meng, Cai-Ping Du, Chun-Yuan Lu, Kun Zhang, Lin Li, Jing-Zhi Yan, Xiao-Yu Hou,

Neuronal activity regulates spatial distribution of the SUMOylation system in cytosolic and dendritic sites, which has been implicated in learning, memory, and underlying synaptic structural and functional remodeling in the hippocampus. However, the functional target proteins for activated small ubiquitin-like modifiers (SUMOs) and downstream molecular consequences behind long-term potentiation (LTP) ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(8):e21769]

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Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

Anitha Govind, Okunola Jeyifous, Theron Russell, Zola Yi, Aubrey Weigel, Abhijit Ramaprasad, Luke Newell, William Ramos, Fernando Valbuena, Jason Casler, Jing-Zhi Yan, Benjamin Glick, Geoffrey Swanson, Jennifer Lippincott-Schwartz, William Green,

<h4>ABSTRACT</h4> Activity-driven changes in the neuronal surface glycoproteome are known to occur with synapse formation, plasticity and related diseases, but their mechanistic basis and significance are unclear. Here, we observed that N -glycans on surface glycoproteins of dendrites shift from immature to mature forms containing sialic acid in response to ... Read more >>

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Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex.

Si-Qiang Ren, Wen Yao, Jing-Zhi Yan, Chunhui Jin, Jia-Jun Yin, Jianmin Yuan, Shui Yu, Zaohuo Cheng,

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. At the early stages of AD development, the soluble β-amyloid (Aβ) induces synaptic dysfunction, perturbs the excitation/inhibition balance of neural circuitries, and in turn alters the normal neural network activity leading to cognitive decline, but the underlying mechanisms ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):302]

Cited: 15 times

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Geldanamycin inhibits Fas signaling pathway and protects neurons against ischemia.

Xiao-Hui Yin, Yan-Ling Han, Ying Zhuang, Jing-Zhi Yan, Chong Li,

The inhibitor of Heat shock proteins 90, geldanamycin (GA), has been reported neuroprotective against both global and focal brain ischemia. To understand the mechanisms underlies the neuroprotection effect of GA, we investigated the relationship between GA pretreatment and Fas signaling pathway in rat global brain ischemia/reperfusion model in the present ... Read more >>

Neurosci Res (Neuroscience research)
[2017, 124:33-39]

Cited: 4 times

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PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway.

Xiao-Hui Yin, Jing-Zhi Yan, Guo Yang, Li Chen, Xiao-Feng Xu, Xi-Ping Hong, Shi-Liang Wu, Xiao-Yu Hou, GuangYi Zhang,

Respecting the selective inhibition of peptides on protein-protein interactions, they might become potent methods in ischemic stroke therapy. In this study, we investigated the effect of PDZ1 inhibitor peptide on ischemic neuron apoptosis and the relative mechanism. Results showed that PDZ1 inhibitor peptide, which significantly disrupted GluK2-PSD-95 interaction, efficiently protected ... Read more >>

Brain Res (Brain research)
[2016, 1637:64-70]

Cited: 4 times

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A selective M1 and M3 receptor antagonist, penehyclidine hydrochloride, prevents postischemic LTP: involvement of NMDA receptors.

Teng-Fei Ma, Li Zhou, Yun Wang, Shou-Jun Qin, Yuan Zhang, Bin Hu, Jing-Zhi Yan, Xing Ma, Cheng-Hua Zhou, Shu-Ling Gu,

Our previous and other studies have confirmed that a selective M1 and M3 receptor antagonist, Penehyclidine hydrochloride (PHC), has neuroprotection activity in cerebral ischemia. However, the precise mechanisms of protection of PHC are still elusive. In this study we analyzed PHC-mediated neuroprotection on a model of brain ischemia (oxygen and ... Read more >>

Synapse (Synapse (New York, N.Y.))
[2013, 67(12):865-874]

Cited: 7 times

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Depolarization induces NR2A tyrosine phosphorylation and neuronal apoptosis.

Yong Liu, Jing-Zhi Yan, Ying-Hui Gu, Wei Wang, Yan-Yan Zong, Xiao-Yu Hou, Guang-Yi Zhang,

<h4>Background</h4>Cytosol Ca2+ overload plays a vital role in ischemic neuronal damage, which is largely contributed by the Ca2+ influx through L-type voltage-gated calcium channels (L-VGCCs) and N-methyl-D-aspartate (NMDA) type glutamate receptors. In this article, L-VGCCs were activated by depolarization to investigate the cross-talk between NMDA receptors and L-VGCCs.<h4>Methods</h4>Depolarization was induced ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2011, 38(6):880-886]

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Knock-down of postsynaptic density protein 95 expression by antisense oligonucleotides protects against apoptosis-like cell death induced by oxygen-glucose deprivation in vitro.

Jing-Zhi Yan, Yong Liu, Yan-Yan Zong, Guang-Yi Zhang,

<h4>Objective</h4>Postsynaptic density protein 95 (PSD-95) plays important roles in the regulation of glutamate signaling, such as that of N-methyl-D-aspartate receptors (NMDARs). In this study, the functional roles of PSD-95 in tyrosine phosphorylation of NMDAR subunit 2A (NR2A) and in apoptosis-like cell death induced by oxygen-glucose deprivation (OGD) in cultured rat ... Read more >>

Neurosci Bull (Neuroscience bulletin)
[2012, 28(1):69-76]

Cited: 1 time

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Role of glycine receptors in glycine-induced LTD in hippocampal CA1 pyramidal neurons.

Rong-Qing Chen, Shan-Hui Wang, Wen Yao, Jing-Jing Wang, Fang Ji, Jing-Zhi Yan, Si-Qiang Ren, Zheng Chen, Su-Yi Liu, Wei Lu,

Glycine in the hippocampus can exert its effect on both synaptic NMDA receptors (NMDARs) and extrasynaptic functional glycine receptors (GlyRs) via distinct binding sites. Previous studies have reported that glycine induces long-term potentiation (LTP) through the activation of synaptic NMDARs. However, little is known about the potential role of the ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2011, 36(9):1948-1958]

Cited: 24 times

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Protein kinase C promotes N-methyl-D-aspartate (NMDA) receptor trafficking by indirectly triggering calcium/calmodulin-dependent protein kinase II (CaMKII) autophosphorylation.

Jing-Zhi Yan, Zhuo Xu, Si-Qiang Ren, Bin Hu, Wen Yao, Shan-Hui Wang, Su-Yi Liu, Wei Lu,

Regulation of neuronal NMDA receptor (NMDAR) is critical in synaptic transmission and plasticity. Protein kinase C (PKC) promotes NMDAR trafficking to the cell surface via interaction with NMDAR-associated proteins (NAPs). Little is known, however, about the NAPs that are critical to PKC-induced NMDAR trafficking. Here, we showed that calcium/calmodulin-dependent protein ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2011, 286(28):25187-25200]

Cited: 36 times

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Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses.

Yi Peng, Jiang Zhao, Qin-Hua Gu, Rong-Qing Chen, Zhuo Xu, Jing-Zhi Yan, Shan-Hui Wang, Su-Yi Liu, Zheng Chen, Wei Lu,

Although an increasing number of studies have demonstrated the plasticity of NMDA receptor-mediated synaptic transmission, little is known about the molecular mechanisms that underlie this neurologically important process. In a study of NMDAR-mediated synaptic responses in hippocampal Schaffer-CA1 synapses whose AMPA receptor (AMPAR) activity is totally blocked, we uncovered differences ... Read more >>

Hippocampus (Hippocampus)
[2010, 20(5):646-658]

Cited: 37 times

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Metaplastic regulation of long-term potentiation/long-term depression threshold by activity-dependent changes of NR2A/NR2B ratio.

Zhuo Xu, Rong-Qing Chen, Qin-Hua Gu, Jing-Zhi Yan, Shan-Hui Wang, Su-Yi Liu, Wei Lu,

In vivo experience induces changes in synaptic NMDA receptor (NMDAR) subunit components, which are correlated with subsequent modifications of synaptic plasticity. However, little is known about how these subunit changes regulate the induction threshold of subsequent plasticity. At hippocampal Schaffer collateral-CA1 synapses, we first examined whether a recent history of ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2009, 29(27):8764-8773]

Cited: 60 times

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Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6.PSD-95.MLK3 pathway.

Shu-Qun Hu, Jie Zhu, Dong-Sheng Pei, Yan-Yan Zong, Jing-Zhi Yan, Xiao-Yu Hou, Guang-Yi Zhang,

Recent studies have shown that kainate (KA) receptors are involved in neuronal cell death induced by seizure, which is mediated by the GluR6.PSD-95.MLK3 signaling module and subsequent JNK activation. In our previous studies, we demonstrated the neuroprotective role of a GluR6 c-terminus containing peptide against KA or cerebral ischemia-induced excitotoxicity ... Read more >>

J Neurosci Res (Journal of neuroscience research)
[2009, 87(16):3626-3638]

Cited: 7 times

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Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.

Dong Han, Quan-Guang Zhang, Yong-Liu, Chong Li, Yan-Yan Zong, Chang-Zhou Yu, Wei Wang, Jing-Zhi Yan, Guang-Yi Zhang,

In this study, we investigated whether the increase of inhibitory gamma-amino butyric acid (GABA) signal suppresses the excitatory glutamate signal induced by cerebral ischemia and the underlying mechanisms. In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, ... Read more >>

FEBS Lett (FEBS letters)
[2008, 582(9):1298-1306]

Cited: 16 times

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Lithium suppressed Tyr-402 phosphorylation of proline-rich tyrosine kinase (Pyk2) and interactions of Pyk2 and PSD-95 with NR2A in rat hippocampus following cerebral ischemia.

Juan Ma, Guang-Yi Zhang, Yong Liu, Jing-Zhi Yan, Zhi-Bin Hao,

It has been indicated that Pyk2/Src signaling pathway is involved in modulation of N-methyl-D-aspartate-type (NMDA) glutamate receptor activity. Lithium protects against glutamate-induced excitotoxicity in cultured neurons and in animal models of diseases. The neuroprotection against excitotoxicity afforded by lithium is time-dependent, requiring treatment for 6-7 days for maximal effect. In ... Read more >>

Neurosci Res (Neuroscience research)
[2004, 49(4):357-362]

Cited: 26 times

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Suppression of postsynaptic density protein 95 by antisense oligonucleotides diminishes postischemic pyramidal cell death in rat hippocampal CA1 subfield.

Xiao-Yu Hou, Guang-Yi Zhang, De-Guang Wang, Qiu-Hua Guan, Jing-Zhi Yan,

Our previous investigation has shown that postsynaptic density protein 95 (PSD-95) is critical for the Src family kinases-mediated tyrosine phosphorylation of N-methyl-d-aspartate receptor subunit 2A (NR2A) in the postischemic hippocampus. To clarify the roles of PSD-95 in the ischemic brain damage, histological method was performed to examine the effects of ... Read more >>

Neurosci Lett (Neuroscience letters)
[2005, 385(3):230-233]

Cited: 10 times

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Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.

Dong-Sheng Pei, Xiao-Tian Wang, Yong Liu, Ya-Feng Sun, Qiu-Hua Guan, Wei Wang, Jing-Zhi Yan, Yan-Yan Zong, Tian-Le Xu, Guang-Yi Zhang,

It is well documented that N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors play a pivotal role in ischaemic brain injury. Recent studies have shown that kainate (KA) receptors are involved in neuronal cell death induced by seizure, which is mediated by the GluR6*PSD-95*MLK3 signalling module and subsequent c-Jun N-terminal kinase (JNK) activation. ... Read more >>

Brain (Brain : a journal of neurology)
[2006, 129(Pt 2):465-479]

Cited: 77 times

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Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus.

Yong Liu, Guang-Yi Zhang, Jing-Zhi Yan, Tian-Le Xu,

Effects of suppressing the protein expression of Pyk2 on increased tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor subunit 2A (NR2A) after brain ischemia in rat hippocampus were studied with immunoprecipitation and immunoblot. Transient (15 min) brain ischemia and reperfusion (I/R) was induced by four-vessel occlusion in Sprague-Dawley (SD) rats. I/R led ... Read more >>

Neurosci Lett (Neuroscience letters)
[2005, 379(1):55-58]

Cited: 8 times

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Increased tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels and interactions among Src/Fyn, PSD-95 and alpha(1C) in rat hippocampus after transient brain ischemia.

Xiao Yu Hou, Guang Yi Zhang, Jing Zhi Yan, Yong Liu,

It has been reported that the Src family kinases-mediated tyrosine phosphorylation of alpha(1C) subunits of L-type voltage-gated calcium channels (L-VGCCs) potentiates the channel currents. In this study, we evaluated the alterations in the tyrosine phosphorylation level of alpha(1C) and in the interactions involving Src/Fyn, alpha(1C) and PSD-95 in the hippocampus ... Read more >>

Brain Res (Brain research)
[2003, 979(1-2):43-50]

Cited: 11 times

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Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia.

Xiao-Yu Hou, Guang-Yi Zhang, Jing-Zhi Yan, Min Chen, Yong Liu,

Recent studies have indicated that tyrosine phosphorylation of NMDA receptor subunit 2A (NR2A) by Src family kinases (Src, Fyn, etc.) up-regulates NMDA receptors activity and postsynaptic density protein 95 kDa (PSD95) may mediate the regulation. To investigate whether the above processes are involved in brain ischemia-induced enhancement of NMDA receptors ... Read more >>

Brain Res (Brain research)
[2002, 955(1-2):123-132]

Cited: 42 times

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