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Analysis of Chinese patients with sporadic Creutzfeldt-Jakob disease.

Jing Yang, Haiyan Kuang, Qiong Wang, Jiao Liu, Xueping Chen, Huifang Shang,

Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, incurable, and fatal neurodegenerative disorder. The objective of this study was to describe the clinical features and survival time of Chinese sCJD patients, and to explore the associations between clinical data and survival. In this study, we analysed the clinical data of 21 ... Read more >>

Prion (Prion)
[2020, 14(1):137-142]

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Selenium alleviates lipopolysaccharide-induced endometritis via regulating the recruitment of TLR4 into lipid rafts in mice.

Yu Chen, Yi-Fan Zhao, Jing Yang, Hong-Yuan Jing, Wan Liang, Miao-Yu Chen, Mei Yang, Ying Wang, Meng-Yao Guo,

Selenium (Se) is an essential trace element for living organisms and plays diverse biological roles. Endometritis is a common reproductive disorder in dairy cows, causing huge economic losses. In this study, we explored the effects of Se on lipopolysaccharide (LPS)-induced endometritis in mice and expounded its underlying mechanism of action. ... Read more >>

Food Funct (Food & function)
[2020, 11(1):200-210]

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Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.

Manling Hu, Jing Yang, Linlin Qu, Xuqian Deng, Zhiguang Duan, Rongzhan Fu, Lihua Liang, Daidi Fan,

Ginsenoside Rk1 is a substance derived from ginseng and exhibits various activities such as anti-diabetic, anti-inflammatory and anti-cancer effects; however, its anti-tumor effect and target signaling mechanism in lung adenocarcinoma are not well understood. Here, we show that Rk1, a natural drug product, can function as an antitumor modulator that ... Read more >>

Food Funct (Food & function)
[2020, 11(1):456-471]

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Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans.

Qin-Li Wan, Xiaodie Fu, Xiao Meng, Zhenhuan Luo, Wenyu Dai, Jing Yang, Chongyang Wang, Hao Wang, Qinghua Zhou,

Hypotaurine, an important sulfur-containing and nonpeptidic amino acid, is a precursor of taurine and an antioxidant. Our previous study indicated that hypotaurine levels are associated with the ageing of Caenorhabditis elegans (C. elegans). However, whether hypotaurine plays a role in the lifespan regulation of C. elegans and the mechanism remains ... Read more >>

Food Funct (Food & function)
[2020, 11(1):347-357]

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The terahertz dynamics interfaces to ion-lipid interaction confined in phospholipid reverse micelles.

Jing Yang, Chao Tang, Yadi Wang, Chao Chang, Jianbing Zhang, Jun Hu, Junhong Lü,

The terahertz dynamics of water nanodroplets confined in phospholipid reverse micelles have been developed as a probe to explore the interactions of metal ions with lipid membrane interfaces. The terahertz absorption coefficients of reverse micelles vary greatly with different Cu2+ concentrations and with different headgroups. The results proved that the ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(100):15141-15144]

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Solid-state transformation of TMA-magadiite into zeolite omega and detailed insights into the crystallization process.

Tianming Lv, Yu Wang, Shoulei Zhang, Zhe Feng, Jiqi Zheng, Jing Yang, Xin Liu, Xiaoyu Liu, Changgong Meng,

Herein, we have studied the crystallization of zeolite omega by the solid-state transformation of TMA-magadiite at 100 °C for 12 h. The samples prepared at different times were subjected to XRD, SEM, IR, Raman and solid MAS NMR analyses to investigate the crystallization behaviors and changes in the medium-range structure ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(45):16974-16985]

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A halogen ion-selective phosphorescence turn-on probe based on induction of Pt-Pt interactions.

Jing Yang, Lili Sun, Liang Hao, Gang-Gang Yang, Zhi-Cong Zou, Qian Cao, Liang-Nian Ji, Zong-Wan Mao,

Square-planar cyclometalated platinum(ii) complexes have been found to serve as turn-on phosphorescent probes selectively for biological halogen ions. This is based on the halogen ion induced self-assembly of Pt(ii) compounds in aqueous media, resulting in intermolecular Pt-Pt interaction associated emission. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(75):11191-11194]

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Acetylenic carbon-rich frameworks on copper foam as conjugated polymer photocathodes for efficient and stable water reduction.

Xue Zhou, Jing Yang, Zhonghai Zhang,

In this communication, a carbon-rich poly(1,3,5-triethynylbenzene) (PTEB) nanofiber is synthesized via a Cu-surface mediated Glaser polycondensation on a copper foam (CF) surface. The PTEB/CF based photocathodes present a record-high and stable photocurrent density of -1.09 mA cm-2, more than 100 times higher than the previously reported results. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(70):10396-10399]

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Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy.

Qian Cao, Jing Yang, Hang Zhang, Liang Hao, Gang-Gang Yang, Liang-Nian Ji, Zong-Wan Mao,

We have proposed a facile and cheap cancer therapeutic strategy by in-cell synthesizing theranostic Zn Schiff base complexes with nuclear targeting and DNA damaging capability. The in-cell synthesis can be traced via a green-to-blue fluorescence shift, and the subsequent cytoplasm-to-nucleus translocation realizes cancer-specific therapy both in vitro and in vivo. ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(54):7852-7855]

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Aptamer-based regulation of transcription circuits.

Linqiang Pan, Yingxin Hu, Taoli Ding, Chun Xie, Zhiyu Wang, Zhekun Chen, Jing Yang, Cheng Zhang,

We propose synthetic DNA/RNA transcription circuits based on specific aptamer recognition. By mimicking transcription factor regulation, combined with specific enzyme/DNA aptamer binding, multiple biomolecules including DNA, RNA, polymerase, restriction enzymes and methylase were used as regulators. In addition, multi-level cascading networks and methylation-switch circuits were also established. This regulation strategy ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2019, 55(51):7378-7381]

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Polyamide nanofilms synthesized via controlled interfacial polymerization on a "jelly" surface.

Zhao-Yu Ma, Xi Zhang, Chang Liu, Shun-Ni Dong, Jing Yang, Guang-Peng Wu, Zhi-Kang Xu,

A thermal-sensitive "jelly" was used to control the diffusion of a diamine monomer for synthesizing polyamide free-standing nanofilms with an adjustable thickness of 5-35 nm. The reduced reaction rate of the interfacial polymerization at the hexane-"jelly" interface made the synthesized nanofilms show high water permeation flux and suitable salt rejection, ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, :]

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Role of the SDF-1/CXCR4 signaling pathway in cartilage and subchondral bone in temporomandibular joint osteoarthritis induced by overloaded functional orthopedics in rats

jing yang, Yazhen Li, Ying Liu, Qiang Zhang, Qi Zhang, Junbo Chen, Xiao Yan, Xiao Yuan,

Abstract Objectives To: (i) use a mandibular-advancement appliance in rats to investigate the role of the stromal cell-derived factor/ CXC receptor 4 (SDF-1/CXCR4) signaling pathway in temporomandibular joint osteoarthritis (TMJ OA) induced by overloaded functional orthopedics (OFO); (ii) provide a cellular and molecular basis for efficacious treatment of skeletal class-II ... Read more >>

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Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection during late pregnancy: A Report of 18 patients from Wuhan, China

Lu Zhang, Lan Dong, Lei Ming, Min Wei, Jun Li, Ruheng Hu, Jing Yang,

Abstract Background: Compared with Severe Acute Respiratory Syndrome(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with ... Read more >>

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Intra-Pancreatic Insulin Nourishes Cancer Cells: Do Insulin-Receptor Antagonists such as PGG and EGCG Play a Role?

Lijuan Hu, Xijuan Chen, Shuai Qiu, Jing Yang, Hongyi Liu, Jie Zhang, Dapeng Zhang, Feng Wang,

Harboring insulin-producing cells, the pancreas has more interstitial insulin than any other organ. In vitro, insulin activates both insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) to stimulate pancreatic cancer cells. Whether intra-pancreatic insulin nourishes pancreatic cancer cells in vivo remains uncertain. In the present studies, we transplanted human ... Read more >>

Am. J. Chin. Med. (The American journal of Chinese medicine)
[2020, :1-15]

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Associations of hypertension with the severity and fatality of SARS-CoV-2 infection: A meta-analysis.

Jingqi Zhang, Jing Wu, Xiaohua Sun, Hong Xue, Jianguo Shao, Weihua Cai, Yang Jing, Ming Yue, Chen Dong,

Epidemiol. Infect. (Epidemiology and infection)
[2020, :1-19]

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Anodic Oxidation Strategy toward Structure-Optimized V2O3 Cathode via Electrolyte Regulation for Zn-Ion Storage.

Hao Luo, Bo Wang, Fei Wang, Jing Yang, Fangdong Wu, Yu Ning, Yu Zhou, Dianlong Wang, Huakun Liu, Shixue Dou,

The lack of suitable cathodes is one of the key reasons that impede the development of aqueous zinc-ion batteries. Because of the inherently unsuitable structure and inferior physicochemical properties, the low-valent V2O3 as Zn2+ host could not be effectively discharged. Herein, we demonstrate that V2O3 (theoretical capacity up to 715 ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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Jab1 promotes gastric cancer tumorigenesis via non-ubiquitin proteasomal degradation of p14ARF.

Lin Wang, Wen-Qi Du, Min Xie, Man-Ru Liu, Fu-Chun Huo, Jing Yang, Dong-Sheng Pei,

BACKGROUND:Jab1 has been reported to regulate various proteins in signal transduction pathways and be implicated in carcinogenesis or tumor progression. However, the precise role and molecular mechanism of Jab1 in gastric tumorigenesis have not yet been fully elucidated. METHODS:Jab1 staining in gastric cancer tissues and paired non-cancerous tissues was measured ... Read more >>

Gastric Cancer (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association)
[2020, :]

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Pharmacokinetics and Bioequivalence of Clopidogrel Hydrogen Sulfate Tablet in Fed and Fasted Conditions: An Open-Label, Randomized, Semireplicated Crossover Study in Healthy Chinese Volunteers.

Tong Pei, Jing Yang, Chaoying Hu, Xiaoping Chen, Shili Gong, Xiao Hu, Lin Li, Lan Zhang,

Clopidogrel is an antiplatelet drug with high intraindividual variability in systemic exposure and efficacy. It has been used for treating atherosclerosis and acute coronary syndrome and in preventing stent restenosis and thrombotic complications after stent implantation in clinical practice for nearly 20 years. In this study we aimed to evaluate ... Read more >>

Clin Pharmacol Drug Dev (Clinical pharmacology in drug development)
[2020, :]

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The effect of Ginkgolide B combined with fluconazole against drug-resistant Candida albicans based on common resistance mechanisms.

Yiman Li, Jing Yang, Xiuyun Li, Shan Su, Xueqi Chen, Shujuan Sun, Yuanyuan Li,

The number of invasive fungal infections has dramatically increased over the recent years, leading to high morbidity and mortality of immunocompromised patients. Candida albicans (C. albicans) has been recorded as the most frequent cause of life-threatening disseminated candidiasis among invasive fungal infections. In the recent decades, the resistance of C. ... Read more >>

Int. J. Antimicrob. Agents (International journal of antimicrobial agents)
[2020, :106030]

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Dynamic alteration of dendrites and dendritic spines in the hippocampus and microglia in mouse brain tissues after kainate-induced status epilepticus.

Lingling Xie, Tianyi Li, Xiaojie Song, Hong Sun, Jie Liu, Jing Yang, Wenjie Zhao, Li Chen, Hengsheng Chen, Benke Liu, Wei Han, Chen Yang, Li Jiang,

Purpose: To study the alteration of microglial subtypes, the representative markers of microglia, and the morphology of dendrites and dendritic spines after acute status epilepticus (SE) and during recurrent seizures. Methods: A mouse kainate-induced SE model was used. Dendrites and dendritic spines of granule neurons in the dentate gyrus (DG)subregion ... Read more >>

Int. J. Neurosci. (The International journal of neuroscience)
[2020, :1-18]

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Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance.

Dandan Wang, Letian Zhang, Ajin Hu, Yuxiang Wang, Yan Liu, Jing Yang, Ningning Du, Xiuli An, Congying Wu, Congrong Liu,

Epithelial ovarian cancer (EOC) is one of the leading causes of death from gynecologic cancers and peritoneal dissemination is the major cause of death in patients with EOC. Although the loss of 4.1N is associated with increased risk of malignancy, its association with EOC remains unclear. To explore the underlying ... Read more >>

Protein Cell (Protein & cell)
[2020, :]

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Research Progress of Coronavirus Based on Bibliometric Analysis.

Fei Zhai, Yuxuan Zhai, Chuang Cong, Tingyan Song, Rongwu Xiang, Tianyi Feng, Zhengxuan Liang, Ya Zeng, Jing Yang, Jie Yang, Jiankun Liang,

BACKGROUND:COVID-19 has become one of the most serious global epidemics in the 21st Century. This study aims to explore the distribution of research capabilities of countries, institutions, and researchers, and the hotspots and frontiers of coronavirus research in the past two decades. In it, references for funding support of urgent ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(11):]

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Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells.

Zhiqiang Liu, Huan Liu, Jin He, Pei Lin, Qiang Tong, Jing Yang,

The suppression of bone formation is a hallmark of multiple myeloma. Myeloma cells inhibit osteoblastogenesis from mesenchymal stem cells (MSCs), which can also differentiate into adipocytes. We investigated myeloma-MSC interactions and the effects of such interactions on the differentiation of MSCs into adipocytes or osteoblasts using single-cell RNA sequencing, in ... Read more >>

Sci Signal (Science signaling)
[2020, 13(633):]

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A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast.

Yi Li, Caiping Tian, Keke Liu, Ying Zhou, Jing Yang, Peng Zou,

The engineered ascorbate peroxidase (APEX) is a powerful tool for the proximity-dependent labeling of proteins and RNAs in live cells. Although widely use in mammalian cells, APEX applications in microorganisms have been hampered by the poor labeling efficiency of its biotin-phenol (BP) substrate. In this study, we sought to address ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2020, :]

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Effects of nonlinear frequency compression on Mandarin speech and sound-quality perception in hearing-aid users.

Xueqing Chen, Yanyan You, Jing Yang, Jinyu Qian, Qian Lu, Volker Kuehnel, Julia Rehmann, Bo Liu, Li Xu,

Objective: The purpose of the present study was to examine the effects of NLFC fitting in hearing aids and auditory acclimatisation on speech perception and sound-quality rating in hearing-impaired, native Mandarin-speaking adult listeners.Design: Mandarin consonant, vowel and tone recognition were tested in quiet and sentence recognition in noise (speech-shaped noise ... Read more >>

Int J Audiol (International journal of audiology)
[2020, :1-10]

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