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Free Wanderer Powder regulates AMPA receptor homeostasis in chronic restraint stress-induced rat model of depression with liver-depression and spleen-deficiency syndrome.

Shengyan Xi, Guangxin Yue, Yueyun Liu, Yanan Wang, Yingkun Qiu, Zhigeng Li, Pei Ma, Tiegang Liu, Youming Jiang, Yuan Liang, Qun Liu, Jing Shi, Jiaxu Chen, Lifeng Yue,

Free Wanderer Powder (FWP) is a classic formula for depression with digestive dysfunctions, i.e., liver-depression and spleen-deficiency syndrome (LDSDS) in Chinese Medicine. But its protective mechanism has not been fully clarified. Here a chronic restraint stress (CRS) induced rat model showed depression with LDSDS in food intake, metabolism, and behaviour ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(19):19563-19584]

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Prognostic and Immunological Role of mRNA ac4C Regulator NAT10 in Pan-Cancer: New Territory for Cancer Research?

Chuanxi Yang, Tingting Wu, Jing Zhang, Jinghui Liu, Kun Zhao, Wei Sun, Jing Shi, Xiangqing Kong,

Abstract BackgroundNAT10 (also known as human N-acetyltransferase-like protein) is a critical gene that regulates N4-acetylcytidine formation in RNA, similar to the multiple regulators of N6-methyladenosine. However, the underlying functions and mechanisms of NAT10 in tumor progression and immunology are unclear.MethodsIn this study, we systematically analyzed the pan-cancer expression and correlations ... Read more >>

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Traumatic brain injuries and problem gambling in youth: Evidence from a population-based study of secondary students in Ontario, Canada.

Nigel E Turner, Steven Cook, Jing Shi, Tara Elton-Marshall, Hayley Hamilton, Gabriela Ilie, Christine M Wickens, André J McDonald, Nico Trajtenberg, Michael D Cusimano, Robert E Mann,

Traumatic brain injury (TBI) is characterized by a change in brain function after an external force or sudden movement to the head. TBI is associated with risk-taking, impulsivity, psychological distress, substance abuse, and violent crime. Previous studies have also linked problem gambling to TBI, but these studies have not controlled ... Read more >>

PLoS One (PloS one)
[2020, 15(10):e0239661]

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Association between temperature changes and uveitis onset in mainland China.

Handan Tan, Su Pan, Zhenyu Zhong, Jing Shi, Weiting Liao, Guannan Su, Aize Kijlstra, Peizeng Yang,

BACKGROUND:Some uveitis subtypes show seasonal patterns. Whether these patterns are caused by seasonally varying temperatures or by other climatic factors remains unknown. This ecological research aimed to quantify the association between climate variability and uveitis onset. METHODS:We combined data from the largest database of uveitis cases with surface climate data ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2020, :]

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CueR activates transcription through a DNA distortion mechanism.

Chengli Fang, Steven J Philips, Xiaoxian Wu, Kui Chen, Jing Shi, Liqiang Shen, Juncao Xu, Yu Feng, Thomas V O'Halloran, Yu Zhang,

The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshaping promoter DNA. To address the question ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

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Prognostic Value and Influence of Receptor Conversion on Treatment Regimen in Metastatic Breast Cancer at the First Time of Recurrence.

Jiming Shen, Lu Xu, Jing Shi, Lei Zhao, Sha Shi, Jing Feng, Xu Han, Yu Shi, Qiaochu Wei, Dongni Wang, Mingfang Sun, Xiaoyi Mi, Yue Apos E Teng,

PURPOSE:At the first time of metastatic breast cancer recurrence, conversion of the receptors status may occur between primary lesions and metastatic lesions, including the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Whether the decision of the treatment regimen is based on the primary ... Read more >>

Oncol Res Treat (Oncology research and treatment)
[2020, :1-8]

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Arterial embolism caused by a peripherally inserted central catheter in a very premature infant: A case report and literature review

Yi-Fei Huang, Yan-Ling Hu, Xing-Li Wan, Hong Cheng, Yao-Hua Wu, Xiao-Yan Yang, Jing Shi,

BACKGROUND Extremely premature infants have poor vascular conditions. Operators often choose deep veins such as the femoral vein and axillary vein to peripherally insert central catheters, and these vessels are often accompanied by arteries; thus, it is easy to mistakenly enter the artery. CASE SUMMARY The case of an extremely ... Read more >>

(World journal of clinical cases)
[2020, 8(18):4259-4265]

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Dose-response association of the ZJU index and fatty liver disease risk: A large cohort in China.

Xue Li, Pei Qin, Liming Cao, Yanmei Lou, Jing Shi, Ping Zhao, Changyi Wang, Jianping Ma, Shan Xu, Xiaolin Peng, Hongen Chen, Dan Zhao, Fulan Hu, Yashuang Zhao,

AIMS:To investigate the sex-specific association between the ZJU index and risk of fatty liver disease in a large Chinese cohort. METHODS:Totally 28,729 adults without fatty liver disease at baseline and who completed at least one follow-up of annual examinations between 2009 and 2016 were included in this study. Cox proportional ... Read more >>

J. Gastroenterol. Hepatol. (Journal of gastroenterology and hepatology)
[2020, :]

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The profile of hematinic deficiencies in patients with oral lichen planus: a case-control study.

Zhe-Xuan Bao, Xiao-Wen Yang, Jing Shi, Yu-Feng Wang,

BACKGROUND:Oral lichen planus (OLP) is a relatively common mucocutaneous disorder, and its causative factors and pathogenesis are not fully understood. Existing studies on the association between hematinic deficiencies and OLP are limited and inconsistent. The aim of this study was to assess the hematinic deficiencies in a cohort of OLP ... Read more >>

BMC Oral Health (BMC oral health)
[2020, 20(1):252]

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Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.

Yingran Liang, Bin Zheng, Jinghan Li, Jing Shi, Li Chu, Xue Han, Xi Chu, Xuan Zhang, Jianping Zhang,

Arsenic trioxide (ATO) is an excellent therapy for acute promyelocytic leukemia; however, its use is limited due to its cardiotoxicity. Crocin (CRO) possesses abundant pharmacological and biological properties, including antioxidant, anti-inflammatory, and anti-apoptotic. This study examined the cardioprotective effects of crocin and explored their mechanistic involvement in ATO-induced cardiotoxicity. Forty-eight ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 131:110713]

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Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K/AKT pathway.

Panpan Liu, Yurun Xue, Bin Zheng, Yingran Liang, Jianping Zhang, Jing Shi, Xi Chu, Xue Han, Li Chu,

Arsenic trioxide (ATO)-induced renal toxicity through oxidative stress and apoptosis restricts the therapeutic action of acute myelogenous leukemia. Crocetin (Crt) possesses antioxidant and antiapoptosis properties, and has certain renal protective effects, but it has not been reported that it has protective effect on renal injury caused by ATO. The current ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2020, 88:106959]

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Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.

Mengying Li, Panpan Liu, Yucong Xue, Yingran Liang, Jing Shi, Xue Han, Jianping Zhang, Xi Chu, Li Chu,

The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway. Adult rats were ... Read more >>

Oncol Rep (Oncology reports)
[2020, 44(5):2306-2316]

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Arterial embolism caused by a peripherally inserted central catheter in a very premature infant: A case report and literature review.

Yi-Fei Huang, Yan-Ling Hu, Xing-Li Wan, Hong Cheng, Yao-Hua Wu, Xiao-Yan Yang, Jing Shi,

BACKGROUND:Extremely premature infants have poor vascular conditions. Operators often choose deep veins such as the femoral vein and axillary vein to peripherally insert central catheters, and these vessels are often accompanied by arteries; thus, it is easy to mistakenly enter the artery. CASE SUMMARY:The case of an extremely premature infant ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(18):4259-4265]

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[Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial].

Yu Chen, Rui-Qing Wang, Jing-Xuan Liu, Zi-di Zhang, Ye-Juan Jia, Jiu-Heng Lv, Jing Shi, Jing Xu, Chun-Sheng Jia,

OBJECTIVE:To compare the clinical efficacy between moxibustion and acupuncture for knee osteoarthritis (KOA), and to observe the effect on serum tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), superoxide dismutase (SOD) and malondialdehyde (MDA). METHODS:A total of 60 patients with KOA were randomized into a moxibustion group (30 cases, 2 cases dropped off) and ... Read more >>

Zhongguo Zhen Jiu (Zhongguo zhen jiu = Chinese acupuncture & moxibustion)
[2020, 40(9):913-917]

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Comparison Between 7 Osteoporotic Vertebral Compression Fractures Treatments: Systematic Review and Network Meta-analysis.

Minmin Chang, Chenchen Zhang, Jing Shi, Jian Liang, Xin Yuan, Honghao Huang, Dong Li, Binbin Yang, Shujie Tang,

BACKGROUND:Vertebroplasty (VP), kyphoplasty (KP), SpineJack system (SJ), radiofrequency kyphoplasty (RFK), Kiva system (Kiva), Sky kyphoplasty system (SK), and conservative treatment are widely used in the treatment of osteoporotic vertebral compression fractures (OVCFs). However, it is still unknown which is the best intervention. The aim of the current study was to ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Resting-state functional connectivity of neural circuits associated with primary and secondary rewards in patients with bipolar disorder.

Jing Shi, Hua Guo, Sijia Liu, Wei Xue, Fengmei Fan, Hongzhen Fan, Huimei An, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan,

OBJECTIVE:We used resting-state functional connectivity (rsFC) to evaluate the integrity of the neural circuits associated with primary and secondary rewards in bipolar disorder (BD) with different mood phases. METHODS:Sixty patients with BD [21 patients with depressive episode of BD (BDD) and 41 patients with maniac episode of BD (BDM)] and ... Read more >>

Soc Cogn Affect Neurosci (Social cognitive and affective neuroscience)
[2020, 15(7):755-763]

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Blockade of IDO-kynurenine-AhR pathway promotes cell apoptosis in carboxyamidotriazole-induced tumor cell dormancy-apoptosis oscillation

Jing Shi, Qingzhu Wang, Lixing Yang, Qin Liu, Rui Ju, Lei Guo, Caiying Ye, Dechang Zhang,

Abstract Background: Some cancer cells may reshape their genetic make-up, adopt a special metabolism mode and undergo dormancy to endure drug attacks. Blocking survival signals in dormant cancer cells that survive a certain anticancer therapy and eradicating them while dormant may help prevent tumor recurrence and metastasis. Methods: Two colorectal ... Read more >>

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Decreased serum NCAM is positively correlated with hippocampal volumes and negatively correlated with positive symptoms in first-episode schizophrenia patients.

Huimei An, Jun Qin, Hongzhen Fan, Fengmei Fan, Shuping Tan, Zhiren Wang, Jing Shi, Fude Yang, Yunlong Tan, Xu-Feng Huang,

BACKGROUND:Neural cell adhesion molecule (NCAM) plays an important role in neurodevelopmental processes and regulates hippocampal plasticity. This study investigated the relationship between the serum NCAM concentrations and hippocampal volume and psychotic symptoms in first-episode drug naïve schizophrenia (FES) patients. METHODS:Forty-four FES patients and forty-four healthy controls (HC) were recruited in ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, 131:108-113]

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Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.

Meng-Jia Zhu, Jing Shi, Yong Chen, Guobing Huang, Xiong-Wei Zhu, Sam Zhang, Xian-Feng Huang, Guo-Qiang Song, Han-Ting Zhang, Heng-Ming Ke, James M O'Donnell, Li-Qun Wang, Ying Xu,

RATIONALE:Currently available PDE2 inhibitors have poor brain penetration that limits their therapeutic utility in the treatment of depression. Hcyb1 is a novel selective PDE2 inhibitor that was introduced more lipophilic groups with polar functionality to the scaffold pyrazolopyrimidinone to improve the blood-brain barrier (BBB) penetration. Our previous study suggested that ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2020, 237(11):3215-3224]

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Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Carotid Intima-Media Thickness: A Cohort Study in China.

Pei Qin, Jing Shi, Liming Cao, Xue Li, Yanmei Lou, Changyi Wang, Jianping Ma, Li Wang, Xiaolin Peng, Hongen Chen, Shan Xu, Ping Zhao, Dongsheng Hu, Fulan Hu,

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio may carry additional information and has been suggested as a better predictor for atherosclerosis progression and cardiovascular disease (CVD) than LDL-C and HDL-C alone. Therefore, we aim to explore the association between LDL-C/HDL-C ratio and high carotid intima-media thickness (CIMT) risk ... Read more >>

Lipids (Lipids)
[2020, :]

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Pleural Fluid GSDMD is a Novel Biomarker for the Early Differential Diagnosis of Pleural Effusion

Pu Li, Jing Shi, Lijing Zhou, Bo Wang, Lijun Zhang, Liang Duan, Qin Hu, Xiaolan Zhou, Yuan Yuan, Dandan Li, Hong Chen, Qing Zhao, Xuemei Peng, Weixian Chen,

Abstract Introduction: To accurate differential diagnosis of pleural effusion (PE) is still a big challenge. Gasdermin D (GSDMD), controlling pyroptosis in cells, has multiple physiological functions. The diagnostic role of GSDMD in PE remains unknown. Methods: Sandwich ELISA kits that we developed were applied to measure the level of GSDMD ... Read more >>

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Hydroxychloroquine use and progression or prognosis of COVID-19: a systematic review and meta-analysis.

Yanxiang Zang, Xuejie Han, Meijiao He, Jing Shi, Yue Li,

Hydroxychloroquine (HCQ) has been implicated in antiviral activity in vitro against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is still controversy about whether HCQ should be used for coronavirus disease 2019 (COVID-19) patients due to the conflicting results in different clinical trials. To systematically assess the benefits and ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2020, :]

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Aberrant driving behaviors by tourists: a study of drivers in China.

Ling Luo, Jing Shi,

The motivation of this research is to understand tourists' aberrant driving behaviors while traveling by car and explore the factors related to these behaviors. A questionnaire that measures driving behaviors, driving attitudes, driving skills, and personal attributes was implemented via the Internet. Through factor analysis, a four-factor structure of tourists' ... Read more >>

Accid Anal Prev (Accident; analysis and prevention)
[2020, 146:105738]

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LncRNA CCAT1 Enhances Chemoresistance in Hepatocellular Carcinoma by Targeting QKI-5

Jing Shi, Cao Guo, Junli Ma,

Abstract Background: A major reason for treatment failure of cancer is acquisition of drug resistance. The specific mechanisms underlying hepatocellular carcinoma (HCC) chemoresistance need to be fully elucidated. lncRNAs involve in drug resistance in some cancers, however, the exact functions of lncRNA colon cancer-associated transcript 1 (CCAT1) in oxaliplatin resistance ... Read more >>

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Maternal intake of caffeinated products and birth defects: a systematic review and meta-analysis of observational studies.

Yan Yue, Wenxing Li, Jun Tang, Yan Zeng, Tao Xiong, Xia Qiu, Jing Shi, Hua Wang, Bin Xia, Lili Luo, Yi Qu, Dezhi Mu,

Caffeinated products are frequently consumed by women of childbearing age worldwide. It still unclear that whether maternal intake of caffeine associated with an increased risk of birth defects. We searched the databases of PubMed, Embase, the Cochrane Library, and Web of Science for eligible studies through July 2020. All studies ... Read more >>

Crit Rev Food Sci Nutr (Critical reviews in food science and nutrition)
[2020, :1-15]

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