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Correction: Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode.

Theoneste Muyizere, Yajun Zheng, Hongni Liu, Jia Zhao, Jin Li, Xianming Lu, Daniel E Austin, Zhiping Zhang,

Correction for 'Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode' by Theoneste Muyizere et al., Analyst, 2020, 145, 34-45. ... Read more >>

Analyst (The Analyst)
[2020, 145(7):2811]

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A protein nanocomposite for ultra-fast, efficient and non-irritating skin decontamination of nerve agents.

Jiapeng Wang, Yao Li, Jingyi Huang, Wanhua Li, Yuan Luo, Xin Sui, Jin Li, Yongan Wang, Jun Yang,

In recent assassinations reported in London and Malaysia, nerve agents were used to cause death, by skin poisoning. Skin decontamination is the ultimate and most important defense against nerve agent poisoning, because no effective antidote currently exists. However, almost no existing material can achieve effective and rapid decontamination without irritating ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(7):4400-4409]

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Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration.

Yuanhao Zhang, Mingjiao Chen, Zhaobo Dai, Hongliang Cao, Jin Li, Weian Zhang,

Bone tissue engineering based on stem cells, growth factors and bioactive scaffolds presents an appealing but challenging approach for rehabilitation of patients with bone defects. A versatile system with the capability for easy operation and precise protein delivery in specific locations is attractive for enhancing bone regeneration. Here, we develop ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(2):682-693]

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Metal salt assisted electrospray ionization mass spectrometry for the soft ionization of GAP polymers in negative ion mode.

Theoneste Muyizere, Yajun Zheng, Hongni Liu, Jia Zhao, Jin Li, Xianming Lu, Daniel E Austin, Zhiping Zhang,

Glycidyl azide polymers (GAP) are one of the most important energetic polymers, but it is still a challenge to elucidate their structures using mass spectrometry due to their fragility upon ionization. Herein we developed a soft metal salt assisted electrospray ionization (MSAESI) to characterize directly GAP polymers using mass spectrometry. ... Read more >>

Analyst (The Analyst)
[2019, 145(1):34-45]

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ROCK inhibitor modified intraocular lens as an approach for inhibiting the proliferation and migration of lens epithelial cells and posterior capsule opacification.

Lei Lin, Quankui Lin, Jin Li, Yuemei Han, Pingjun Chang, Fan Lu, Yun-E Zhao,

Lens epithelial cells (LECs) in the capsule play a critical role in posterior capsule opacification (PCO) formation following cataract surgery. Cytoskeleton remodeling and the related ROCK pathway are quite important during cell migration and proliferation, but their role in LECs is still unclear. This study aimed to explore the mechanism ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(10):4208-4217]

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Circulating Myeloid-derived Suppressor Cells Facilitate Invasion of Thyroid Cancer Cells by Repressing miR-486-3p.

Li Chen, Li Xiong, Shubing Hong, Jin Li, Zijun Huo, Yudong Li, Shuwei Chen, Quan Zhang, Ruiying Zhao, Julian A Gingold, Xiaonan Zhu, Weiming Lv, Yanbing Li, Shuang Yu, Haipeng Xiao,

BACKGROUND:Myeloid-derived suppressor cells (MDSCs) have become increasingly recognized as facilitators of tumor development. However, the role of MDSCs in papillary thyroid carcinoma (PTC) progression has not been clearly explored. OBJECTIVE:We aimed to evaluate the levels and function of circulating MDSCs in PTC. METHODS:The proportion of circulating polymorphonuclear (PMN)-MDSCs and mononuclear-MDSCs ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(8):]

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Bamboo-Shaped Carbon Nanotubes on Coal Fly Ash Cenospheres for Pb(II) Adsorption.

Xiaomin Zhang, Jin Li, Bo He, Heng Li, Chao Qi, Liang Zhang, Yongjun Peng, Yue Li,

The structural defects of bamboo-shaped carbon nanotubes (B-CNTs) provide abundant active sites for ion adsorption during wastewater treatment. However, a suitable supporting material for the growth of B-CNTs growth is less reported. In this paper, the catalytic growth of B-CNTs on the cenospheres (CSs) of coal fly ash was studied. ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2020, 20(8):5089-5095]

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Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study.

Yanfeng Jiang, Kexun Zhang, Zhen Zhu, Mei Cui, Yanpeng An, Yingzhe Wang, Chen Suo, Min Fan, Li Jin, Weizhong Tian, Xingdong Chen,

Metabolomics provides a promising tool for understanding the pathophysiology and identifying biomarkers of atherosclerosis. We aimed to estimate the associations between circulating metabolites and subclinical atherosclerosis in a Chinese cohort. The baseline serum levels of 38 metabolites of 489 individuals were measured using nuclear magnetic resonance. Associations between metabolites and ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12:]

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Direct evidence of active SARS-CoV-2 replication in the intestine.

Qun Qian, Lifang Fan, Weicheng Liu, Jin Li, Junqiu Yue, Mingwei Wang, Xianliang Ke, Yan Yin, Quanjiao Chen, Congqing Jiang,

BACKGROUND:Currently, there is no direct evidence to prove the active SARS-CoV-2 replication in the intestinal tract and relevant pathological changes in the colon and rectum. We investigated the presence of virions and pathological changes in surgical rectal tissues of a clinically confirmed COVID-19 patient with rectal adenocarcinoma. METHODS:Here, the clinical ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Molecular Structure Modulated Trap Distribution and Carrier Migration in Fluorinated Epoxy Resin.

Jin Li, Yufan Wang, Zhaoyu Ran, Hang Yao, Boxue Du, Tatsuo Takada,

Surface charge accumulation on epoxy insulators is one of the most serious problems threatening the operation safety of the direct current gas-insulated transmission line (GIL), and can be efficiently inhibited by the surface modification technology. This paper investigated the mechanisms of fluorination modulated surface charge behaviors of epoxy resin through ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(13):]

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Recurrent Neural Reinforcement Learning for Counterfactual Evaluation of Public Health Interventions on the Spread of Covid-19 in the world

Qiyang Ge, Zixin Hu, Kai Zhang, Shudi Li, Wei Lin, Li Jin, Momiao Xiong,

As the Covid-19 pandemic soars around the world, there is urgent need to forecast the expected number of cases worldwide and the length of the pandemic before receding and implement public health interventions for significantly stopping the spread of Covid-19. Widely used statistical and computer methods for modeling and forecasting ... Read more >>

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Genome Wide Characterization and Comparative Analysis of Simple Sequence Repeats in Cucurbita Genomes

Lei Zhu, Hua yu Zhu, Yan man Li, Xiang bin Wu, Jin tao Li, Zhen li Zhang, Yan jiao Wang, Jian bin Hu, Sen Yang, Yong qiang Li, Shou ru Sun, Lu Ming Yang,

Abstract Background The Cucurbita genus contains important economic crops in the world, while limited molecular markers have been developed in the past years. Simple sequence repeats (SSR) markers are powerful tools for the study of genetic mapping construction, genetic diversity analysis and genome wide association. The availability of pumpkin genome ... Read more >>

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One additional shot of brachial plexus block equates to less postoperative pain for younger children with elbow surgeries.

Jin Li, Saroj Rai, Ruikang Liu, Ruijing Xu, Pan Hong,

BACKGROUND:Postoperative pain in children has always been inadequately evaluated. This study aims to evaluate the postoperative pain response using an additional dose of brachial plexus block (BPB) for younger children receiving elbow surgeries under general anesthesia (GA). METHODS:This retrospective case-control study included pediatric patients (3-10 years) who underwent surgeries for elbow ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2020, 15(1):246]

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Overexpression of TC2N is associated with poor prognosis in gastric cancer

Jianbo Xu, Xinde Ou, Jin Li, Qinbo Cai, Kaiyu Sun, Jingning Ye, Jianjun Peng,

Abstract Background Tac2-N (TC2N) is a tandem C2 domain-containing protein, acting as a novel oncogene or suppressor in different kinds of cancers. However, the status of TC2N expression and its significance in gastric cancer (GC) is still unclear. The present study is aimed to elucidate the clinicopathological significance and ... Read more >>

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Distal third femoral shaft fractures in school-aged children: A comparative study of elastic stable intramedullary nail and external fixator.

Jin Li, Saroj Rai, Renhao Ze, Xin Tang, Ruikang Liu, Pan Hong,

Internal fixation such as elastic stable intramedullary(ESIN) nail and submuscular plate (SMP) is gaining popularity for femoral shaft fractures in school-aged children. However, external fixation (ExFix) might be a valuable option for the distal third femoral shaft fractures, where the fracture heals rapidly, but it is crucial to avoid angular ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(27):e21053]

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Volatile organic compounds analysis as a potential novel screening tool for colorectal cancer: A systematic review and meta-analysis.

Wenchuan Zhou, Jinxin Tao, Jin Li, Shaoyu Tao,

The purpose of this meta-analysis was to assess the usefulness of volatile organic compounds (VOC) as a potential novel biomarker for colorectal cancer (CRC).We systematically searched PubMed, Embase, Web of Science, and Cochrane Library databases for observational studies (published before November 25th, 2019; no language restrictions) comparing the VOC analysis ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(27):e20937]

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Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function

Casey Gailey, Eric Wang, Li Jin, Sean Ahmadi, David Brautigan, Xudong Li, Wenhao Xu, Zheng Fu,

Abstract Background Kinesin family member 3A (KIF3A) is a molecular motor protein in the heterotrimeric kinesin-2 complex that drives anterograde intraflagellar transport. This process plays a pivotal role in both biogenesis and maintenance of the primary cilium that supports tissue development. Ciliogenesis associated kinase 1 (CILK1) phosphorylates human KIF3A at ... Read more >>

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Enhancement of pollutants removal from saline wastewater through simultaneous anammox and denitrification (SAD) process with glycine betaine addition.

Weiqiang Zhu, Jin Li, Bo Wang, Guanghao Chen,

Enhanced pollutants removal from saline wastewater was investigated in simultaneous anammox and denitrification (SAD) process with glycine betaine (GB) addition. Long-term operation indicated the optimal GB dose was around 0.4 mM, which enhanced both anammox and denitrifying activity by 30% and 45%, respectively. The total nitrogen and organic removal rates were ... Read more >>

Bioresour. Technol. (Bioresource technology)
[2020, 315:123784]

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Genetic Reconstruction and Forensic Analysis of Chinese Shandong and Yunnan Han Populations by Co-Analyzing Y Chromosomal STRs and SNPs.

Caiyong Yin, Kaiyuan Su, Ziwei He, Dian Zhai, Kejian Guo, Xueyun Chen, Li Jin, Shilin Li,

Y chromosomal short tandem repeats (Y-STRs) have been widely harnessed for forensic applications, such as pedigree source searching from public security databases and male identification from male-female mixed samples. For various populations, databases composed of Y-STR haplotypes have been built to provide investigating leads for solving difficult or cold cases. ... Read more >>

Genes (Basel) (Genes)
[2020, 11(7):]

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De novo design of Au36(SR)24 nanoclusters.

Xu Liu, Wen Wu Xu, Xinyu Huang, Endong Wang, Xiao Cai, Yue Zhao, Jin Li, Min Xiao, Chunfeng Zhang, Yi Gao, Weiping Ding, Yan Zhu,

The discovery of atomically precise nanoclusters is generally unpredictable, and the rational synthesis of nanoclusters guided by the theoretical design is still in its infancy. Here we present a de novo design of Au36(SR)24 nanoclusters, from theoretical prediction to experimental synthesis and characterization of their physicochemical properties. The crystal structure ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):3349]

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Structural Oscillation Revealed in Gold Nanoparticles.

Nan Xia, Jinyun Yuan, Lingwen Liao, Wenhao Zhang, Jin Li, Haiteng Deng, Jinlong Yang, Zhikun Wu,

Oscillation is an intriguing phenomenon in nature. However, structural oscillation has not yet been found in semiconducting nanoparticles, primarily due to the difficulty of structural resolution at the atomic level. The emergence of gold nanoclusters (ultrasmall nanoparticles) has provided an excellent opportunity to address some challenging issues in the nanoparticle ... Read more >>

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2020, :]

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Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy.

Yu Yang, Xiaoqi Sun, Jun Xu, Cheng Cui, Hoda Safari Yazd, Xiaoshu Pan, Yujie Zhu, Xigao Chen, Xiaowei Li, Jin Li, Weihong Tan,

Adoptive T cell immunotherapy, such as chimeric antigen receptor (CAR) T cell therapy, has proven to be highly efficient in the treatment of hematologic malignancies. But it's challenged by complicated ex vivo engineering, systemic side effects, and low exprssion of tumor specific antigen, espcially in soild tumor. In this paper, ... Read more >>

ACS Nano (ACS nano)
[2020, :]

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JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.

Jun-Jie Chen, Yan-Lin Ren, Chuan-Jun Shu, Yi Zhang, Min-Juan Chen, Jin Xu, Jin Li, Ai-Ping Li, Dong-Yin Chen, Jing-Dong He, Yong-Qian Shu, Jian-Wei Zhou,

BACKGROUND:Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and drug resistance. Tumor angiogenesis plays an important role in the development of gastric cancer and is a challenge in the treatment of gastric cancer. METHODS:Mouse xenograft models ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):118]

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Serum GDF11 is closely related to metabolic syndrome in a Chinese cohort.

Bo Xu, Yan Huang, Rong Zhang, Mengyang Tang, Zhen He, Li Jin, Yicen Zong, Cheng Hu, Weiping Jia,

AIMS:Despite increasing interest in growth differentiation factor 11 (GDF11) based on its involvement in age-related disorders, clinical implications-especially for metabolic diseases-remain unclear. Therefore, we assessed the association between serum GDF11 levels and metabolic disturbance in the Chinese population. MATERIALS AND METHODS:Three hundred eighty-one subjects from the Shanghai Nicheng Cohort Study ... Read more >>

J Diabetes Investig (Journal of diabetes investigation)
[2020, :]

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Genome-wide profiling of circulating tumor DNA depicts landscape of copy number alterations in pancreatic cancer with liver metastasis.

Tao Wei, Jian Zhang, Jin Li, Qi Chen, Xiao Zhi, Wei Tao, Jingjiao Ma, Jiaqi Yang, Yu Lou, Tao Ma, Xiang Li, Qi Zhang, Wei Chen, Risheng Que, Shunliang Gao, Xueli Bai, Tingbo Liang,

Cell-free DNA (cfDNA) offers an alternative to tissue biopsies for genomic profiling in tumors. Here, we sought to evaluate copy number alterations in PDAC through whole-genome sequencing (WGS) of cfDNA and determine their clinical significance. Using shallow WGS across 90 plasma samples from 70 pancreatic cancer patients, we detected somatic ... Read more >>

Mol Oncol (Molecular oncology)
[2020, :]

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