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Author Jin H Song


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Endothelial eNAMPT Amplifies Preclinical Acute Lung Injury: Efficacy of an eNAMPT-Neutralising mAb.

Hector Quijada, Tadeo Bermudez, Carrie L Kempf, Daniel G Valera, Alexander N Garcia, Sara M Camp, Jin H Song, Evelyn Franco, Jessica K Burt, Belinda Sun, Joseph B Mascarenhas, Kimberlie Burns, Amir Gaber, Radu C Oita, Vivian Reyes Hernon, Christy Barber, Liliana Moreno-Vinasco, Xiaoguang Sun, Anne E Cress, Diego Martin, Zhonglin Liu, Ankit A Desai, Viswanathan Natarajan, Jeffrey R Jacobson, Steven M Dudek, Christian Bime, Saad Sammani, Joe G N Garcia,

RATIONALE:The SARS-CoV-2/COVID-19 pandemic has highlighted the serious unmet need for effective therapies that reduce ARDS mortality. We explored whether extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a ligand for Toll-like receptor 4 and a master regulator of innate immunity and inflammation, is a potential ARDS therapeutic target. METHODS:Wild type C57BL/6J or endothelial cell ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, :]

Cited: 0 times

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Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.

Sathish K R Padi, Neha Singh, Jeremiah J Bearss, Virginie Olive, Jin H Song, Marina Cardó-Vila, Andrew S Kraft, Koichi Okumura,

The Pim and AKT serine/threonine protein kinases are implicated as drivers of cancer. Their regulation of tumor growth is closely tied to the ability of these enzymes to mainly stimulate protein synthesis by activating mTORC1 (mammalian target of rapamycin complex 1) signaling, although the exact mechanism is not completely understood. ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(41):20505-20510]

Cited: 2 times

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Oncologic Outcome and Morbidity in the Elderly Rectal Cancer Patients After Preoperative Chemoradiotherapy and Total Mesorectal Excision: A Multi-institutional and Case-matched Control Study.

Soo-Y Sung, Hong S Jang, Sung H Kim, Jae U Jeong, Songmi Jeong, Jin H Song, Mi J Chung, Hyeon M Cho, Hyung J Kim, Jun-Gi Kim, In K Lee, Jong H Lee,

OBJECTIVE:To determine the toxicity and oncologic outcome of neoadjuvant chemoradiotherapy (CRT) followed by curative total mesorectal excision (TME) in the elderly (≥70 yrs) and younger (<70 yrs) rectal cancer patients. BACKGROUND:Sufficient data for elderly rectal cancer patients who received definitive trimodality have not been accumulated yet. PATIENTS AND METHODS:A total ... Read more >>

Ann. Surg. (Annals of surgery)
[2019, 269(1):108-113]

Cited: 2 times

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Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase.

Jin H Song, Neha Singh, Libia A Luevano, Sathish K R Padi, Koichi Okumura, Virginie Olive, Stephen M Black, Noel A Warfel, David W Goodrich, Andrew S Kraft,

Cancer resistance to PI3K inhibitor therapy can be in part mediated by increases in the PIM1 kinase. However, the exact mechanism by which PIM kinase promotes tumor cell resistance is unknown. Our study unveils the pivotal control of redox signaling by PIM kinases as a driver of this resistance mechanism. ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2018, 17(12):2710-2721]

Cited: 7 times

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Pim1 kinase regulates c-Kit gene translation.

Ningfei An, Bo Cen, Houjian Cai, Jin H Song, Andrew Kraft, Yubin Kang,

BACKGROUND:Receptor tyrosine kinase, c-Kit (CD117) plays a pivotal role in the maintenance and expansion of hematopoietic stem/progenitor cells (HSPCs). Additionally, over-expression and/or mutational activation of c-Kit have been implicated in numerous malignant diseases including acute myeloid leukemia. However, the translational regulation of c-Kit expression remains largely unknown. METHODS AND RESULTS:We ... Read more >>

Exp Hematol Oncol (Experimental hematology & oncology)
[2016, 5:31]

Cited: 5 times

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Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset.

Sathish K R Padi, Libia A Luevano, Ningfei An, Ritu Pandey, Neha Singh, Jin H Song, Jon C Aster, Xue-Zhong Yu, Shikhar Mehrotra, Andrew S Kraft,

New approaches are needed for the treatment of patients with T-cell acute lymphoblastic leukemia (T-ALL) who fail to achieve remission with chemotherapy. Analysis of the effects of pan-PIM protein kinase inhibitors on human T-ALL cell lines demonstrated that the sensitive cell lines expressed higher PIM1 protein kinase levels, whereas T-ALL ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(18):30199-30216]

Cited: 9 times

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PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.

Noel A Warfel, Alva G Sainz, Jin H Song, Andrew S Kraft,

Intratumoral hypoxia is a significant obstacle to the successful treatment of solid tumors, and it is highly correlated with metastasis, therapeutic resistance, and disease recurrence in cancer patients. As a result, there is an urgent need to develop effective therapies that target hypoxic cells within the tumor microenvironment. The Proviral ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2016, 15(7):1637-1647]

Cited: 10 times

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Insulin receptor substrate 1 is a substrate of the Pim protein kinases.

Jin H Song, Sathish K R Padi, Libia A Luevano, Mark D Minden, Daniel J DeAngelo, Gary Hardiman, Lauren E Ball, Noel A Warfel, Andrew S Kraft,

The Pim family of serine/threonine protein kinases (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative phosphorylation. Drugs targeting the Pim protein kinases are being tested in phase I/II clinical trials for the treatment of hematopoietic malignancies. The goal of these ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(15):20152-20165]

Cited: 10 times

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Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.

Marina Y Zemskova, Jin H Song, Bo Cen, Javier Cerda-Infante, Viviana P Montecinos, Andrew S Kraft,

The PIM1 oncogene is over-expressed in human prostate cancer epithelial cells. Importantly, we observe that in human hyperplastic and cancerous prostate glands PIM1 is also markedly elevated in prostate fibroblasts, suggesting an important role for this kinase in epithelial/stromal crosstalk. The ability of PIM1 to regulate the biologic activity of ... Read more >>

Cell Signal (Cellular signalling)
[2015, 27(1):135-146]

Cited: 10 times

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Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors.

Shilpak Chatterjee, Krishnamurthy Thyagarajan, Pravin Kesarwani, Jin H Song, Myroslawa Soloshchenko, Jianing Fu, Stefanie R Bailey, Chenthamarkshan Vasu, Andrew S Kraft, Chrystal M Paulos, Xue-Zhong Yu, Shikhar Mehrotra,

T cells of the T helper (Th)17 subset offer promise in adoptive T-cell therapy for cancer. However, current protocols for ex vivo programming of Th17 cells, which include TGFβ exposure, increase the expression of CD39 and CD73, two cell surface ATP ectonucleotidases that reduce T-cell effector functions and promote immunosuppression. ... Read more >>

Cancer Res (Cancer research)
[2014, 74(21):6048-6059]

Cited: 21 times

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Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.

Jagadish Kummetha Venkata, Ningfei An, Robert Stuart, Luciano J Costa, Houjian Cai, Woodrow Coker, Jin H Song, Kiwana Gibbs, Terri Matson, Elizabeth Garrett-Mayer, Zhuang Wan, Besim Ogretmen, Charles Smith, Yubin Kang,

Sphingolipid metabolism is being increasingly recognized as a key pathway in regulating cancer cell survival and proliferation. However, very little is known about its role in multiple myeloma (MM). We investigated the potential of targeting sphingosine kinase 2 (SK2) for the treatment of MM. We found that SK2 was overexpressed ... Read more >>

Blood (Blood)
[2014, 124(12):1915-1925]

Cited: 38 times

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The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling.

Bo Cen, Ying Xiong, Jin H Song, Sandeep Mahajan, Rachel DuPont, Kristen McEachern, Daniel J DeAngelo, Jorge E Cortes, Mark D Minden, Allen Ebens, Alice Mims, Amanda C LaRue, Andrew S Kraft,

MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell migration and invasion. Here, we describe a previously unrecognized mechanism that promotes MET expression in multiple tumor cell types. The levels of the Pim-1 protein kinase show a positive correlation with the ... Read more >>

Mol. Cell. Biol. (Molecular and cellular biology)
[2014, 34(13):2517-2532]

Cited: 31 times

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Pim kinase inhibitors sensitize prostate cancer cells to apoptosis triggered by Bcl-2 family inhibitor ABT-737.

Jin H Song, Andrew S Kraft,

Pim serine/threonine kinases contribute to prostate tumorigenesis and therapeutic resistance, yet Pim kinase inhibitors seem to have only limited effects on prostate cancer cell survival. Because overexpression of Bcl-2 family members are implicated in chemotherapeutic resistance in prostate cancer, we investigated the cooperative effects of Pim kinase inhibition with ABT-737, ... Read more >>

Cancer Res (Cancer research)
[2012, 72(1):294-303]

Cited: 37 times

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The BH3 mimetic ABT-737 induces cancer cell senescence.

Jin H Song, Karthikeyan Kandasamy, Marina Zemskova, Ying-Wei Lin, Andrew S Kraft,

ABT-737, a small molecule cell-permeable Bcl-2 antagonist that acts by mimicking BH3 proteins, induces apoptotic cell death in multiple cancer types. However, when incubated with this agent many solid tumor cell lines do not undergo apoptosis. The current study reveals a novel mechanism whereby ABT-737 when added to apoptosis-resistant cancer ... Read more >>

Cancer Res (Cancer research)
[2011, 71(2):506-515]

Cited: 27 times

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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.

Ying-Wei Lin, Zanna M Beharry, Elizabeth G Hill, Jin H Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D Aplan, Jon C Aster, Charles D Smith, Andrew S Kraft,

The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions. We demonstrate that SMI-4a, a novel benzylidene-thiazolidine-2, 4-dione small molecule inhibitor of the Pim kinases, kills a wide ... Read more >>

Blood (Blood)
[2010, 115(4):824-833]

Cited: 61 times

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Targeted quantitative mass spectrometric identification of differentially expressed proteins between Bax-expressing and deficient colorectal carcinoma cells.

Peng Wang, Andy Lo, J Bryce Young, Jin H Song, Raymond Lai, Norman M Kneteman, Chunhai Hao, Liang Li,

Bax, a Bcl-2 interacting protein, plays a central role in several stimuli-induced apoptosis pathways through its functional and physical interactions with various biologically important proteins. Identification of the Bax-modulating protein network should be useful to further our understanding of Bax-mediated apoptosis. For the first time, we performed proteome-wide quantification and ... Read more >>

J. Proteome Res. (Journal of proteome research)
[2009, 8(7):3403-3414]

Cited: 11 times

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ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.

Jin H Song, Karthikeyan Kandasamy, Andrew S Kraft,

Because Bcl-2 family members inhibit the ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis, we investigated whether ABT-737, a small molecule Bcl-2 inhibitor, enhances TRAIL killing. We demonstrate that a combination of ABT-737 and TRAIL induced significant cell death in multiple cancer types, including renal, prostate, and ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2008, 283(36):25003-25013]

Cited: 45 times

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Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells.

Jin H Song, Margaret C L Tse, Anita Bellail, Surasak Phuphanich, Fadlo Khuri, Norman M Kneteman, Chunhai Hao,

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is capable of inducing apoptosis in non-small cell lung carcinoma (NSCLC). However, many of the human NSCLC cell lines are resistant to TRAIL, and TRAIL treatment of the resistant cells leads to the activation of nuclear factor-kappaB (NF-kappaB) and extracellular signal-regulated kinase 1/2 (ERK1/2). ... Read more >>

Cancer Res. (Cancer research)
[2007, 67(14):6946-6955]

Cited: 83 times

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Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis.

Peng Wang, Jin H Song, Doyoun K Song, Jing Zhang, Chunhai Hao,

The molecular mechanism underlying chemotherapy-induced apoptosis is often debated because of contradicting reports of its signaling pathway. The focus of this ongoing debate is on the requirement of a death receptor and its role in subsequent activation of caspase-8. Understanding the precise mechanism responsible for apoptosis and identifying molecules targeted ... Read more >>

Cell. Signal. (Cellular signalling)
[2006, 18(9):1528-1535]

Cited: 31 times

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Genomic alterations in human malignant glioma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy.

Yueh-Chun Li, Ching-Cherng Tzeng, Jin H Song, Fuu-Jen Tsia, Lie-Jiau Hsieh, Shu-Ju Liao, Chang-Hai Tsai, Erwin G Van Meir, Chunhai Hao, Chyi-Chyang Lin,

PURPOSE: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently under clinical development as a cancer therapeutic agent. Many human malignant glioma cells, however, are resistant to TRAIL treatment. We, therefore, investigated the genomic alterations in TRAIL-resistant malignant glioma cells. EXPERIMENTAL DESIGN: Seven glioma cell lines and two primary cultures were ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2006, 12(9):2716-2729]

Cited: 15 times

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Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.

Jin H Song, Anita Bellail, Margaret C L Tse, V Wee Yong, Chunhai Hao,

Human astrocytes express Fas yet are resistant to Fas-induced apoptosis. Here, we report that calcium/calmodulin-dependent protein kinase II (CaMKII) is constitutively activated in human astrocytes and protects the cells from apoptotic stimulation by Fas agonist. Once stimulated, Fas recruits Fas-associated death domain and caspase-8 for the assembly of the death-inducing ... Read more >>

J. Neurosci. (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2006, 26(12):3299-3308]

Cited: 56 times

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Modulation of TRAIL signaling complex.

Chunhai Hao, Jin H Song, Urosh Vilimanovich, Norman M Kneteman,

Vitam. Horm. (Vitamins and hormones)
[2004, 67:81-99]

Cited: 9 times

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TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol 3-kinase/Akt through the short form of cellular FLIP and Bcl-2.

Salima J Alladina, Jin H Song, Sandra T Davidge, Chunhai Hao, Alexander S Easton,

Apoptosis of vascular endothelial cells plays a central role in angiogenesis and atherosclerosis. This study investigates the molecular mechanisms of endothelial apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) following inhibition of phosphatidylinositol 3-kinase (PI3K). It examines downstream regulation and activation of the extrinsic and intrinsic pathways.By flow cytometry, ... Read more >>

J. Vasc. Res. (Journal of vascular research)
[2005, 42(4):337-347]

Cited: 47 times

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Interferon gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent kinase 5 activator via activation of ERK1/2 pathway.

Jin H Song, Chen Xu Wang, Doyoun K Song, Peng Wang, Ashfaq Shuaib, Chunhai Hao,

Interferon gamma (IFN-gamma) is a cytokine predominantly involved in antiproliferative and antiviral responses, immune surveillance, and tumor suppression. However, it has been shown that IFN-gamma is also involved in central nervous system development. Here we studied the underlying mechanism for IFN-gamma-induced neuronal differentiation using the human neuroblastoma Paju cell line. ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2005, 280(13):12896-12901]

Cited: 66 times

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TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice.

Chunhai Hao, Jin H Song, Belinda Hsi, Jamie Lewis, Doyoun K Song, Kenneth C Petruk, David L J Tyrrell, Norman M Kneteman,

Tumor necrosis factor (TNF) family ligand TNF-alpha and Fas ligand (FasL) can trigger apoptosis in solid tumors, but their clinical usage has been limited by hepatotoxicity. TNF-related apoptosis-inducing ligand (TRAIL) is a newly identified member of the TNF family, and its clinical application currently is under a similar debate. Here, ... Read more >>

Cancer Res. (Cancer research)
[2004, 64(23):8502-8506]

Cited: 84 times

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