Full Text Journal Articles by
Author Jill A Macoska

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Chromatin binding of FOXA1 is promoted by LSD1-mediated demethylation in prostate cancer.

Shuai Gao, Sujun Chen, Dong Han, Zifeng Wang, Muqing Li, Wanting Han, Anna Besschetnova, Mingyu Liu, Feng Zhou, David Barrett, My Phu Luong, Jude Owiredu, Yi Liang, Musaddeque Ahmed, Jessica Petricca, Susan Patalano, Jill A Macoska, Eva Corey, Sen Chen, Steven P Balk, Housheng Hansen He, Changmeng Cai,

FOXA1 functions as a pioneer transcription factor by facilitating the access to chromatin for steroid hormone receptors, such as androgen receptor and estrogen receptor1-4, but mechanisms regulating its binding to chromatin remain elusive. LSD1 (KDM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K4me1/2)5,6, but also ... Read more >>

Nat Genet (Nature genetics)
[2020, 52(10):1011-1017]

Cited: 0 times

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Causal Inference Engine: a platform for directional gene set enrichment analysis and inference of active transcriptional regulators.

Saman Farahmand, Corey O'Connor, Jill A Macoska, Kourosh Zarringhalam,

Inference of active regulatory mechanisms underlying specific molecular and environmental perturbations is essential for understanding cellular response. The success of inference algorithms relies on the quality and coverage of the underlying network of regulator-gene interactions. Several commercial platforms provide large and manually curated regulatory networks and functionality to perform inference ... Read more >>

Nucleic Acids Res (Nucleic acids research)
[2019, 47(22):11563-11573]

Cited: 0 times

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Prostate Transition Zone Fibrosis is Associated with Clinical Progression in the MTOPS Study.

Jill A Macoska, Kristen S Uchtmann, Glen E Leverson, Kevin T McVary, William A Ricke,

PURPOSE:Medications targeting androgen receptor activity (eg finasteride) or smooth muscle contractility (eg doxazosin) do not resolve lower urinary tract symptoms indicative of lower urinary tract dysfunction in an important subgroup of men. Recently fibrosis has been implicated as another pathobiology contributing to male lower urinary tract symptoms but to our ... Read more >>

J Urol (The Journal of urology)
[2019, 202(6):1240-1247]

Cited: 1 time

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Forkhead domain mutations in FOXA1 drive prostate cancer progression.

Shuai Gao, Sujun Chen, Dong Han, David Barrett, Wanting Han, Musaddeque Ahmed, Susan Patalano, Jill A Macoska, Housheng Hansen He, Changmeng Cai,

Cell Res. (Cell research)
[2019, 29(9):770-772]

Cited: 3 times

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Inhibition of the CXCL12/CXCR4 axis prevents periurethral collagen accumulation and lower urinary tract dysfunction in vivo.

Jill A Macoska, Zunyi Wang, Johanna Virta, Nicholas Zacharias, Dale E Bjorling,

BACKGROUND:Several studies show that prostatic fibrosis is associated with male lower urinary tract dysfunction (LUTD). Development of fibrosis is typically attributed to signaling through the transforming growth factor β (TGF-β) pathway, but our laboratory has demonstrated that in vitro treatment of human prostatic fibroblasts with the C-X-C motif chemokine ligand ... Read more >>

Prostate (The Prostate)
[2019, 79(7):757-767]

Cited: 2 times

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TMPRSS2-ERG activates NO-cGMP signaling in prostate cancer cells.

Feng Zhou, Shuai Gao, Dong Han, Wanting Han, Sujun Chen, Susan Patalano, Jill A Macoska, Housheng Hansen He, Changmeng Cai,

The aberrant activation of the ERG oncogenic pathway due to the TMPRSS2-ERG gene fusion is the major event that contributes to prostate cancer (PCa) development. However, the critical downstream effectors that can be therapeutically targeted remain to be identified. In this study, we have found that the expression of the ... Read more >>

Oncogene (Oncogene)
[2019, 38(22):4397-4411]

Cited: 2 times

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Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature.

Diego Almanza, Mehrnaz Gharaee-Kermani, Alisa Zhilin-Roth, Jose A Rodriguez-Nieves, Cory Colaneri, Todd Riley, Jill A Macoska,

BACKGROUND:Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma. AIMS:In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcriptional alterations in mouse fatty liver signified risk for the development of ... Read more >>

Dig. Dis. Sci. (Digestive diseases and sciences)
[2019, 64(5):1257-1269]

Cited: 1 time

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Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts.

Saif Affas, Frank-Mattias Schäfer, Khalid Algarrahi, Vivian Cristofaro, Maryrose P Sullivan, Xuehui Yang, Kyle Costa, Bryan Sack, Mehrnaz Gharaee-Kermani, Jill A Macoska, Gokhan Gundogdu, Catherine Seager, Carlos R Estrada, Joshua R Mauney,

IMPACT STATEMENT:The search for an ideal "off-the-shelf" biomaterial for augmentation cystoplasty remains elusive and current scaffold configurations are hampered by mechanical and biocompatibility restrictions. In addition, preclinical evaluations of potential scaffold designs for bladder repair are limited by the lack of tractable large animal models of obstructive bladder disease that ... Read more >>

Tissue Eng Part A (Tissue engineering. Part A)
[2019, 25(11-12):855-866]

Cited: 1 time

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Androgen receptor variants: another twist in the plot.

Jill A Macoska,

Oncotarget (Oncotarget)
[2017, 8(10):16100]

Cited: 0 times

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Preface to the human microbiome in urologic health and disease.

Daniel A Shoskes, Jill A Macoska,

(Annals of translational medicine)
[2017, 5(2):27]

Cited: 0 times

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A novel nonsense mutation in androgen receptor confers resistance to CYP17 inhibitor treatment in prostate cancer.

Dong Han, Shuai Gao, Kevin Valencia, Jude Owiredu, Wanting Han, Eric de Waal, Jill A Macoska, Changmeng Cai,

The standard treatment for prostate cancer (PCa) is androgen deprivation therapy (ADT) that blocks transcriptional activity of androgen receptor (AR). However, ADT invariably leads to the development of castration-resistant PCa (CRPC) with restored activity of AR. CRPC can be further treated with CYP17 inhibitors to block androgen synthesis pathways, but ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(4):6796-6808]

Cited: 4 times

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Androgen Receptor Tumor Suppressor Function Is Mediated by Recruitment of Retinoblastoma Protein.

Shuai Gao, Yanfei Gao, Housheng Hansen He, Dong Han, Wanting Han, Amy Avery, Jill A Macoska, Xiaming Liu, Sen Chen, Fen Ma, Shaoyong Chen, Steven P Balk, Changmeng Cai,

Although well characterized as a transcriptional activator that drives prostate cancer (PCa) growth, androgen receptor (AR) can function as a transcriptional repressor, and high-level androgens can suppress PCa proliferation. The molecular basis for this repression activity remains to be determined. Genes required for DNA replication are highly enriched among androgen-repressed ... Read more >>

Cell Rep (Cell reports)
[2016, 17(4):966-976]

Cited: 19 times

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CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling.

José A Rodríguez-Nieves, Susan C Patalano, Diego Almanza, Mehrnaz Gharaee-Kermani, Jill A Macoska,

Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS). Although inflammation and abnormal smooth muscle contractions are known to play key roles in the development of LUTS, tissue fibrosis may also be ... Read more >>

PLoS ONE (PloS one)
[2016, 11(7):e0159490]

Cited: 7 times

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Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion.

Mehrnaz Gharaee-Kermani, Bethany B Moore, Jill A Macoska,

Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models. It represses collagen deposition in the vasculature, heart, lung, kidney, liver, and esophagus in animal models and may have some utility as ... Read more >>

PLoS ONE (PloS one)
[2016, 11(7):e0158357]

Cited: 8 times

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Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent.

Lesa A Begley, Sathish Kasina, Rajal B Shah, Jill A Macoska,

A key difference between normal and malignant prostate cells in vitro and in vivo is that both alleles of PTEN are largely intact in normal benign prostate glands and cultured epithelial cells, whereas one or both alleles of PTEN are mutant or deleted in the majority of prostate tumors and ... Read more >>

(American journal of clinical and experimental urology)
[2015, 3(2):91-99]

Cited: 6 times

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Promising molecular targets and biomarkers for male BPH and LUTS.

Mehrnaz Gharaee-Kermani, Jill A Macoska,

Benign prostatic hyperplasia (BPH) is a major health concern for aging men. BPH is associated with urinary voiding dysfunction and lower urinary tract symptoms (LUTS), which negatively affects quality of life. Surgical resection and medical approaches have proven effective for improving urinary flow and relieving LUTS but are not effective ... Read more >>

Curr Urol Rep (Current urology reports)
[2013, 14(6):628-637]

Cited: 9 times

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Complex cellular composition of solitary fibrous tumor of the prostate.

Mehrnaz Gharaee-Kermani, Rohit Mehra, Dan R Robinson, John T Wei, Jill A Macoska,

Solitary fibrous tumors (SFTs) of the prostate are a rare type of spindle cell neoplasm that can demonstrate either a benign or malignant phenotype. SFTs represent a clinical challenge along with other spindle cell lesions of the prostate in terms of both diagnosis and treatment. The present study shows, for ... Read more >>

Am. J. Pathol. (The American journal of pathology)
[2014, 184(3):732-739]

Cited: 8 times

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Prostatic fibrosis, lower urinary tract symptoms, and BPH.

Jose A Rodriguez-Nieves, Jill A Macoska,

Lower urinary tract symptoms (LUTS)--constituting a spectrum disorder that encompasses weak stream, nocturia, and sensations of incomplete emptying and intermittent or hesitant urination--are indicative of lower urinary tract dysfunction (LUTD). LUTD is a progressive disease that can lead to bladder dysfunction if left untreated or treated ineffectively. Sequelae include urinary ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2013, 10(9):546-550]

Cited: 38 times

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Obesity-induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model.

Mehrnaz Gharaee-Kermani, Jose A Rodriguez-Nieves, Rohit Mehra, Chad A Vezina, Aruna V Sarma, Jill A Macoska,

BACKGROUND:Progressive aging- and inflammation-associated fibrosis effectively remodels the extracellular matrix (ECM) to increase prostate tissue stiffness and reduce urethral flexibility, resulting in urinary flow obstruction and lower urinary tract symptoms (LUTS). In the current study, we sought to test whether senescence-accelerated mouse prone (SAMP)6 mice, which were reported to develop ... Read more >>

Prostate (The Prostate)
[2013, 73(10):1123-1133]

Cited: 36 times

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CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis.

Mehrnaz Gharaee-Kermani, Sathish Kasina, Bethany B Moore, Dafydd Thomas, Rohit Mehra, Jill A Macoska,

Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to the etiology of LUTS. Fibrosis can generally be regarded as an errant wound-healing ... Read more >>

PLoS One (PloS one)
[2012, 7(11):e49278]

Cited: 31 times

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Prostatic fibrosis is associated with lower urinary tract symptoms.

Jinjin Ma, Mehrnaz Gharaee-Kermani, Lakshmi Kunju, John M Hollingsworth, Jeremy Adler, Ellen M Arruda, Jill A Macoska,

Current therapies for male lower urinary tract symptoms secondary to prostate enlargement prevent hormonal effects on prostate growth and inhibit smooth muscle contraction to ease bladder neck and urethral pressure. However, lower urinary tract symptoms can be refractory to these therapies, suggesting that additional biological processes not addressed by them ... Read more >>

J Urol (The Journal of urology)
[2012, 188(4):1375-1381]

Cited: 57 times

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CCL11 (eotaxin-1): a new diagnostic serum marker for prostate cancer.

Manisha Agarwal, Chang He, Javed Siddiqui, John T Wei, Jill A Macoska,

The recent recommendation of the U.S. Preventive Services Task Force against PSA-based screening for prostate cancer was based, in part, on the lack of demonstrated diagnostic utility of serum PSA values in the low, but detectable range to successfully predict prostate cancer. Though controversial, this recommendation reinforced the critical need ... Read more >>

Prostate (The Prostate)
[2013, 73(6):573-581]

Cited: 26 times

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Developmental, cellular and molecular biology of benign prostatic hyperplasia.

William A Ricke, Jill A Macoska, Gerald R Cunha,

Differentiation (Differentiation; research in biological diversity)
[2011, 82(4-5):165-167]

Cited: 2 times

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Chemokines and BPH/LUTS.

Jill A Macoska,

A wealth of published studies indicate that a variety of chemokines are actively secreted by the prostatic microenvironment consequent to disruptions in normal tissue homeostasis due to the aging process or inflammatory responses. The accumulation of senescent stromal fibroblasts, and, possibly, epithelial cells, may serve as potential driving forces behind ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2011, 82(4-5):253-260]

Cited: 22 times

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The PCa Tumor Microenvironment.

Joseph L Sottnik, Jian Zhang, Jill A Macoska, Evan T Keller,

The tumor microenvironment (TME) is a very complex niche that consists of multiple cell types, supportive matrix and soluble factors. Cells in the TME consist of both host cells that are present at tumor site at the onset of tumor growth and cells that are recruited in either response to ... Read more >>

(Cancer microenvironment : official journal of the International Cancer Microenvironment Society)
[2011, 4(3):283-297]

Cited: 11 times

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