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Author Jihong Liu

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Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems.

Luling Wu, Jihong Liu, Ping Li, Bo Tang, Tony D James,

In this tutorial review, we will explore recent advances for the design, construction and application of two-photon excited fluorescence (TPEF)-based small-molecule probes. The advantages of TPEF-based probes include deep tissue penetration and minimal photo-damage. We discuss the underlying two-photon (TP) fluorophores including hemicyanine and design strategies such as Förster resonance ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2021, 50(2):702-734]

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An artificial intelligence process of immunoassay for multiple biomarkers based on logic gates.

Wenjie Liu, Jihong Liu, Ao Huang, Shuo Shi, Tianming Yao,

We present a universal platform to synchronously analyze the possible existing state of two protein biomarkers. This platform is based on the integration of three logic gates: NAND, OR and NOT. These logic gates were constructed by the principle of immune recognition and fluorescence quenching between fluorescein labelled antibodies/antigens and ... Read more >>

Analyst (The Analyst)
[2021, 146(3):889-895]

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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer.

Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu,

<h4>Objective</h4>To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).<h4>Methods</h4>We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e40]

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Stress and Depressive Symptoms Are Not Associated with Overall Diet Quality, But Are Associated with Aspects of Diet Quality in Pregnant Women in South Carolina.

Alycia K Boutté, Gabrielle M Turner-McGrievy, Sara Wilcox, Jihong Liu, Jan M Eberth, Andrew T Kaczynski,

<h4>Background</h4>Poor mental health may hinder diet quality in pregnancy.<h4>Objective</h4>This study 1) examined whether stress and depressive symptoms are associated with diet quality (via Healthy Eating Index [HEI] 2015 total scores and dietary intake of food groups/nutrients that align with HEI-2015 components) and 2) tested race as a moderator in the ... Read more >>

J Acad Nutr Diet (Journal of the Academy of Nutrition and Dietetics)
[2021, :]

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Association of provider advice and gestational weight gain in twin pregnancies: a cross-sectional electronic survey.

Kara M Whitaker, Meghan Baruth, Rebecca A Schlaff, Christopher P Connolly, Jihong Liu, Sara Wilcox,

<h4>Background</h4>Little is known about patient-provider communication on gestational weight gain among women pregnant with twins, a growing population at high risk for adverse maternal and neonatal outcomes. We examined if women's report of provider advice on gestational weight gain was consistent with the Institute of Medicine (IOM) weight gain guidelines ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2020, 20(1):417]

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In Situ Observation of mtDNA Damage during Hepatic Ischemia-Reperfusion.

Wen Zhang, Simin Bi, Ping Li, Jihong Liu, Chunmiao Zhou, Xin Wang, Wei Zhang, Hui Wang, Bo Tang,

Hepatic ischemia-reperfusion (IR) injury is a severe pathophysiological event during liver surgery or transplantation and could lead to liver failure or even death. The energy supply of mitochondria plays an essential role in preventing IR injury. Mitochondrial DNA (mtDNA) is involved in maintaining the balance of energy by participating in ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(14):5782-5788]

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Neurodevelopment correlates with gut microbiota in a cross-sectional analysis of children at 3 years of age in rural China.

Sarah E Rothenberg, Qiurong Chen, Jian Shen, Yanfen Nong, Hua Nong, Eva P Trinh, Fred J Biasini, Jihong Liu, Xiaoyun Zeng, Yunfeng Zou, Fengxiu Ouyang, Susan A Korrick,

We investigated cross-sectional associations between children's neurodevelopment and their gut microbiota composition. Study children (36 months of age) lived in rural China (n = 46). Neurodevelopment was assessed using the Bayley Scales of Infant Development, 2nd Edition, yielding the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI). Children's gut microbiota was assessed ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):7384]

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Associations of maternal stress and/or depressive symptoms with diet quality during pregnancy: a narrative review.

Alycia K Boutté, Gabrielle M Turner-McGrievy, Sara Wilcox, Jihong Liu, Jan M Eberth, Andrew T Kaczynski,

<h4>Background</h4>Pregnancy can be a stressful time for many women; however, it is unclear if higher stress and depressive symptoms are associated with poorer diet quality during pregnancy.<h4>Objective</h4>The aims for this narrative review were to (1) synthesize findings of original, peer-reviewed studies that examined associations of stress and/or depressive symptoms with ... Read more >>

Nutr Rev (Nutrition reviews)
[2021, 79(5):495-517]

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Persistent Bacterial Coinfection of a COVID-19 Patient Caused by a Genetically Adapted Pseudomonas aeruginosa Chronic Colonizer.

Jiuxin Qu, Zhao Cai, Yumei Liu, Xiangke Duan, Shuhong Han, Jihong Liu, Yuao Zhu, Zhaofang Jiang, Yingdan Zhang, Chao Zhuo, Yang Liu, Yingxia Liu, Lei Liu, Liang Yang,

<i>Pseudomonas aeruginosa</i> is a biofilm-forming opportunistic pathogen which causes chronic infections in immunocompromised patients and leads to high mortality rate. It is identified as a common coinfecting pathogen in COVID-19 patients causing exacerbation of illness. In our hospital, <i>P. aeruginosa</i> is one of the top coinfecting bacteria identified among COVID-19 ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2021, 11:641920]

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Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial.

Tingyan Shi, Jianqing Zhu, Yanling Feng, Dongsheng Tu, Yuqin Zhang, Ping Zhang, Huixun Jia, Xiao Huang, Yunlang Cai, Sheng Yin, Rong Jiang, Wenjuan Tian, Wen Gao, Jihong Liu, Huijuan Yang, Xi Cheng, Rongyu Zang,

<h4>Background</h4>The benefits of secondary cytoreduction for platinum-sensitive relapsed ovarian cancer are still widely debated. We aimed to assess the efficacy of secondary cytoreduction plus chemotherapy versus chemotherapy alone in this patient population.<h4>Methods</h4>This multicentre, open-label, randomised, controlled, phase 3 trial (SOC-1), was done in four primarily academic centres in China (two ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(4):439-449]

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ITGB2 as a Novel Biomarker Correlating With Prognosis and Immune Infiltrates in Ovarian Cancer

chanyuan li, Ting Wan, Ting Deng, Junya Cao, He Huang, Jihong Liu,

<h4>Background: </h4> Epithelial ovarian cancer is nowadays one of the malignancies in women, this study aimed to identify novel biomarkers to predict prognosis and immunotherapy efficacy. <h4>Methods:</h4> The differentially expressed genes (DEGs) obtained from online database Gene Expression Omnibus (GEO)were screened via GEO2R and Venn diagram software, gene enrichment was ... Read more >>

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Optimizing Management to Reduce the Mortality of COVID-19: Experience From a Designated Hospital for Severely and Critically Ill Patients in China.

Wei Zhu, Huaqiu Zhang, Yong Li, Zeyang Ding, Zhuo Liu, Yajun Ruan, Huan Feng, Ganxun Li, Bo Liu, Fan He, Ning Zhou, Jiangang Jiang, Zhixiang Wen, Gang Xu, Jianping Zhao, Bixiang Zhang, Daowen Wang, Zhouping Tang, Hui Wang, Jihong Liu,

<b>Background:</b> The coronavirus disease 2019 (COVID-19) has swept through the world at a tremendous speed, and there is still limited data available on the treatment for COVID-19. The mortality of severely and critically ill COVID-19 patients in the Optical Valley Branch of Tongji Hospital was low. We aimed to analyze ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:582764]

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Nomograms to Predict the Density of Tumor-Infiltrating Lymphocytes in Patients With High-Grade Serous Ovarian Cancer.

Danian Dai, Lili Liu, He Huang, Shangqiu Chen, Bo Chen, Junya Cao, Xiaolin Luo, Feng Wang, Rongzhen Luo, Jihong Liu,

<h4>Background</h4>Tumor-infiltrating lymphocytes (TILs) have important roles in predicting tumor therapeutic responses and progression, however, the method of evaluating TILs is complicated. We attempted to explore the association of TILs with clinicopathological characteristics and blood indicators, and to develop nomograms to predict the density of TILs in patients with high-grade serous ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:590414]

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Excitation of high-quality orbital angular momentum vortex beams in an adiabatically helical-twisted single-mode fiber.

Kaili Ren, Liyong Ren, Jian Liang, Li Yang, Jie Xu, Dongdong Han, Yongkai Wang, Jihong Liu, Jun Dong, Hanyu He, Wenfei Zhang,

A novel method to control the parameters of a chiral fiber grating structure is proposed. Mode couplings are controlled in real time during the twisting fabrication process. This chiral grating structure can satisfy the phase-matching condition for generating high-quality orbital angular momentum (OAM) beams, with an order mode of conversion ... Read more >>

Opt Express (Optics express)
[2021, 29(6):8441-8450]

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Identification of gene co-expression networks and key genes regulating flavonoid accumulation in apple (Malus × domestica) fruit skin

Tiyu Ding, Ruiping Zhang, Hengtao Zhang, Zhe Zhou, Chonghuai Liu, Mengmeng Wu, Huan Wang, Haiqing Dong, Jihong Liu, Jia-Long Yao, Zhenli Yan,

Anthocyanin provides a red color for apple and health benefit for human. To better understand the molecular mechanisms of regulating apple color formation, we analyzed 27 transcriptomes of fruit skin from three cultivars ‘Huashuo’ (red-skinned), ‘Hongcuibao’ (red-skinned), and ‘Golden Delicious’ (yellow-skinned) at 0, 2, and 6 days after bag removal. ... Read more >>

Plant Sci (Plant science.)
[2021, 304:Not Available]

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A Behavioral Lifestyle Intervention to Limit Gestational Weight Gain in Pregnant Women with Overweight and Obesity.

Jihong Liu, Sara Wilcox, Ellen Wingard, Gabrielle Turner-McGrievy, Brent Hutto, Judith Burgis,

<h4>Objective</h4>This study aimed to evaluate the effects of an antenatal behavioral lifestyle intervention on total gestational weight gain (GWG) and perinatal outcomes.<h4>Methods</h4>Pregnant women with overweight and obesity in South Carolina were recruited into a theory-based randomized controlled trial (n = 112 intervention, n = 105 standard care), which was designed to target weight self-monitoring, ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2021, 29(4):672-680]

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An Open-label, Multicenter, Single-arm, Phase II Study of Fluzoparib in Patients with Germline BRCA1/2 Mutation and Platinum-sensitive Recurrent Ovarian Cancer.

Ning Li, Hualei Bu, Jihong Liu, Jianqing Zhu, Qi Zhou, Li Wang, Rutie Yin, Xiaohua Wu, Shuzhong Yao, Kangsheng Gu, Hui Zhang, Guiling Li, Hongming Pan, Qiang Wu, Ruifang An, Xinfeng Yang, Yaping Zhu, Xiaoping Wan, Wei Duan, Jianping Xiong, Hongyan Guo, Ge Lou, Jing Wang, Wenjing Hu, Xin Zhang, Yuanguang Meng, Ben Zhang, Yuting Wang, Quanren Wang, Lingying Wu,

<h4>Purpose</h4>Fluzoparib (PARP inhibitor) showed promising antitumor activity for advanced ovarian cancer in a phase I study. This study aimed to assess the efficacy and safety of fluzoparib in patients with germline <i>BRCA1/2</i>-mutated recurrent ovarian cancer.<h4>Patients and methods</h4>This open-label, multicenter, single-arm, phase II study enrolled patients with platinum-sensitive recurrent ovarian cancer ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, :]

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Effectiveness of High-risk Human Papillomavirus Testing for Cervical Cancer Screening in China: A Multicenter, Open-label, Randomized Clinical Trial.

Junji Zhang, Yuqian Zhao, Yi Dai, Le Dang, Li Ma, Chunxia Yang, Yang Li, Linghua Kong, Lihui Wei, Shulan Zhang, Jihong Liu, Minrong Xi, Long Chen, Xianzhi Duan, Qing Xiao, Guzhalinuer Abulizi, Guonan Zhang, Ying Hong, Xiaohong Gao, Qi Zhou, Xing Xie, Li Li, Mayinuer Niyazi, Zhifen Zhang, Jiyu Tuo, Yiling Ding, Manfei Si, Fei Chen, Li Song, Youlin Qiao, Jinghe Lang,

<h4>Importance</h4>Evidence is needed regarding the introduction of high-risk human papillomavirus (hrHPV) testing into China's national cervical cancer screening program.<h4>Objective</h4>To evaluate hrHPV testing as a new screening modality for the national program.<h4>Design, setting, and participants</h4>This population-based, multicenter, open-label, randomized clinical trial took place across 20 primary health care centers in urban ... Read more >>

JAMA Oncol (JAMA oncology)
[2021, 7(2):263-270]

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Rational design of a fluorescent probe for the detection of LAP and its application in drug-induced liver injury.

Tao Liu, Manman Tian, Jiayue Wang, Xiangge Tian, Jihong Liu, Lei Feng, Xiaochi Ma, Jingnan Cui,

Drug-induced liver injury (DILI) has become a common adverse effect in routine clinical practice, which would further cause the disorder of enzymatic system that respond to multiple pathological progresses. Leucine aminopeptidase (LAP) is regarded as a biomarker in the early course of various liver diseases, in this work, a fluorescent ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 251:119362]

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Healthy Food Density is Not Associated With Diet Quality Among Pregnant Women With Overweight/Obesity in South Carolina.

Alycia K Boutté, Gabrielle M Turner-McGrievy, Jan M Eberth, Sara Wilcox, Jihong Liu, Andrew T Kaczynski,

<h4>Objective</h4>Examine the association and moderating effect of residential location (urban/rural) on the relationship between neighborhood healthy food density and diet quality.<h4>Design</h4>Cross-sectional analysis of baseline data from the Health in Pregnancy and Postpartum study, a randomized trial designed to prevent excessive gestational weight gain.<h4>Participants</h4>Pregnant women in South Carolina with prepregnancy overweight/obesity ... Read more >>

J Nutr Educ Behav (Journal of nutrition education and behavior)
[2021, 53(2):120-129]

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Safety and Effectiveness of Dapoxetine On Demand in Chinese Men With Premature Ejaculation: Results of a Multicenter, Prospective, Open-Label Phase IV Study.

Jing Peng, Lin Yang, Long Liu, Renyuan Zhou, Jihong Liu, Ningchen Li, Liming Li, Yongguang Jiang, Yuqiang Liu, Zhaohui Zhu, Xiaodong Zhang, Guowei Shi, Suyog Jain, Emmanuele A Jannini, Zhichao Zhang,

<h4>Introduction</h4>Dapoxetine on demand has been approved for premature ejaculation (PE) management in China; however, studies on the efficacy and safety of this treatment in the Chinese population are scarce.<h4>Aim</h4>The aim of this study was to evaluate the safety and effectiveness of dapoxetine 30 mg and 60 mg on demand in Chinese men ... Read more >>

Sex Med (Sexual medicine)
[2021, 9(2):100296]

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Variations in health behaviors among pregnant women during the COVID-19 pandemic.

Kara M Whitaker, Peiyin Hung, Anthony J Alberg, Nicole L Hair, Jihong Liu,

<h4>Purpose</h4>To examine changes in lifestyle behaviors early in the COVID-19 pandemic among pregnant women.<h4>Materials and methods</h4>A cross-sectional internet-based survey was completed by 706 pregnant women (mean age 29.6 years ± 3.2) residing in the United States in May 2020 to assess self-reported changes in diet, physical activity, and sleep during ... Read more >>

Midwifery (Midwifery)
[2021, 95:102929]

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The clinical characteristics and prognosis of COVID-19 patients with cerebral stroke: A retrospective study of 113 cases from one single-centre.

Xiaolong Yao, Shengwen Liu, Junwen Wang, Kai Zhao, Xiaobing Long, Xuejun He, Huicong Kang, Yiping Yang, Xiaopeng Ma, Pengjie Yue, Kai Shu, Zhouping Tang, Ting Lei, Jihong Liu, Wei Wang, Huaqiu Zhang,

To explore the clinical characteristics and prognosis of COVID-19 patients with cerebral stroke. A total of 2,474 COVID-19 patients from February 10th to March 24th, 2020 were admitted and treated in two branches (Optic Valley and Sino-French New City branch) of the Tongji Hospital. Data on the clinical characteristics, laboratory ... Read more >>

Eur J Neurosci (The European journal of neuroscience)
[2021, 53(4):1350-1361]

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Regulation of Brassinosteroid Signaling and Salt Resistance by SERK2 and Potential Utilization for Crop Improvement in Rice.

Nana Dong, Wenchao Yin, Dapu Liu, Xiaoxing Zhang, Zhikun Yu, Wei Huang, Jihong Liu, Yanzhao Yang, Wenjing Meng, Mei Niu, Hongning Tong,

The complex roles of the steroid hormone brassinosteroids (BRs) in many different yield- and stress-related traits make it difficult to utilize the hormones for crop improvement. Here, we show that SERK2 as a BR signaling component is a potentially useful candidate for BR manipulation in rice. We generated multiple mutant ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2020, 11:621859]

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Minimally invasive surgery vs laparotomy for early stage cervical cancer: A propensity score-matched cohort study.

Danian Dai, He Huang, Yanling Feng, Ting Wan, Zhimin Liu, Chongjie Tong, Jihong Liu,

<h4>Objective</h4>To compare the long-term oncologic outcomes of minimally invasive surgery (MIS) vs laparotomy for patients with stage IB (2018 FIGO) cervical cancer.<h4>Methods</h4>A matched retrospective study of cervical cancer patients who underwent MIS or laparotomy at Sun Yat-sen University Cancer Center from January 2012 to December 2015 was carried out. Patients ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(24):9236-9245]

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