Full Text Journal Articles by
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Development and characterization of starch films prepared by extrusion blowing: The synergistic plasticizing effect of water and glycerol

Wei Gao, Jie Zhu, Xuemin Kang, Bin Wang, Pengfei Liu, Bo Cui, A M Abd El-Aty,

Herein, we have investigated the synergistic plasticizing effect of water (W) and glycerol (G) on the physicochemical and structural properties of starch-based films prepared by extrusion blowing. Fourier transform infrared spectroscopy (FT-IR) revealed that glycerol could act as a typical plasticizer in the presence of sufficient amounts of water (approximately ... Read more >>

Lebensm Wiss Technol (Lebensmittel-Wissenschaft + [i.e. und] Technologie.)
[2021, 148:Not Available]

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Increased Oxidative Stress Contributes to Impaired CD56dimCD57+ NK Cells in Patients With Systemic Lupus Erythematosus

Zhimin Lu, Yao Tian, Ziran Bai, Jiaqing Liu, Yan Zhang, Jingjing Qi, Minli Jin, Jie Zhu, Xia Li,

<h4>Background: </h4> Systemic lupus erythematosus(SLE) is characterized by loss of immune tolerance and imbalance of immune cell subsets. NK cells contribute to regulate both the innate and adaptive immune response. In this study, we aimed to detect peripheral NK cell subsets in SLE patients, investigate their cytotoxic effect on activated ... Read more >>

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Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway.

Xiaoyan Feng, Weiwei Ma, Jie Zhu, Wei Jiao, Yuhai Wang,

Traumatic brain injury (TBI) is a major public health problem and a major cause of mortality and disability that imposes a substantial economic burden worldwide. Dexmedetomidine (DEX), a highly selective α‑2‑adrenergic receptor agonist that functions as a sedative and analgesic with minimal respiratory depression, has been reported to alleviate early ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 24(3):]

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Effect of capsular tension ring on optical and multifunctional lens position outcomes: a systematic review and a meta-analysis.

Tangshou Xie, Xi Liu, Jie Zhu, Xiuyun Li,

<h4>Aim</h4>To evaluate the effect of capsular tension rings with multifunctional lens position and optical outcomes.<h4>Methods</h4>We defined multifunctional lens as more than improving vision, but also to restore visual quality. PubMed, EMBASE, Cochrane Library and Scopus were searched for English-language articles published up to November 11, 2020. Randomized controlled trials and ... Read more >>

Int Ophthalmol (International ophthalmology)
[2021, :]

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Observation on the effect of painting therapy on bad emotion in children with functional gastrointestinal diseases.

Hongxia Kai, Li Cao, Yajun Li, Jie Zhu, Dawei Zhu, Ling Qi,

Minerva Pediatr (Torino) (Minerva pediatrics)
[2021, :]

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Research on the Geothermal Resource Exploration in Igneous Rock Areas by Comprehensive Geophysical Methods

Jie Zhu, Sheng Jin, Sanxi Peng, Yang Yang, Tianyu Zhang, Weizu Zeng,

Geothermal resource has considerable development potential and utilization value. In order to have a clearer understanding and understanding of geothermal resources, it is very important to carry out geological exploration of geothermal resources before mining. In Igneous rocks, ground water is heated by deep magmatic rocks and Igneous rocks to ... Read more >>

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High Plasma Llevels of Aβ1-42 Affect Monocytes and Macrophages via Biphasic Effects on Myeloid-Derived Suppressor Cells and Granulocyte-Monocyte Progenitors in Mouse Models of Alzheimer’s Disease

Chunrong Li, Kangding Liu, Jie Zhu, Feiqi Zhu,

Backgroud : Microglia play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Plasma Aβ 1-42 levels significantly increase 15 years before the onset of dominantly inherited AD. The effects of high plasma levels of Aβ 1-42 on monocytes and macrophages, the hematogenous counterparts of microglia, remain unclear. <h4>Methods: ... Read more >>

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Post-infection cognitive impairments in a cohort of elderly patients with COVID-19.

Yu-Hui Liu, Ye-Ran Wang, Qing-Hua Wang, Yang Chen, Xian Chen, Ying Li, Yuan Cen, Cheng Xu, Tian Hu, Xu-Dong Liu, Ling-Li Yang, Si-Jing Li, Xue-Fei Liu, Chun-Mei Liu, Jie Zhu, Wei Li, Li-Li Zhang, Juan Liu, Yan-Jiang Wang,

<h4>Background</h4>Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly patients recovered from COVID-19.<h4>Methods</h4>This cross-sectional study recruited 1539 COVID-19 inpatients aged ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2021, 16(1):48]

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Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function.

Wei Lin, Xiao Qian, Li-Kun Yang, Jie Zhu, Dan Wang, Chun-Hua Hang, Yuhai Wang, Tao Chen,

Epilepsy is a neurological disorder which is characterized by brain hyper-excitability and manifests as seizure. Due to its complicated pathogenesis, treatment for epilepsy still remains a huge challenge for neurology in the whole world. MciroRNA-134 (miR-134) is one kind of miRNAs which was firstly found abundant in synapses. In this ... Read more >>

Epilepsy Res (Epilepsy research)
[2021, 176:106722]

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Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells.

Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu,

Tumor microenvironments are characterized not only in terms of chemical composition, but also by physical properties such as stiffness, which influences morphology, proliferation, and fate of tumor cells. However, the underlying mechanisms between matrix stiffness and the apoptosis-autophagy balance remain largely unexplored. In this study, we cultured human breast cancer ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 172:590-603]

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Polybasic patches in both C2 domains of Synaptotagmin-1 are required for evoked neurotransmitter release

Zhenyong Wu, Lu Ma, Nicholas Courtney, Jie Zhu, Yongli Zhang, Edwin Chapman, Erdem Karatekin,

<h4>ABSTRACT</h4> Synaptotagmin-1 (Syt1) is a vesicular calcium sensor required for synchronous neurotransmitter release. It is composed of a single-pass transmembrane domain linked to two tandem C2 domains (C2A and C2B) that bind calcium, acidic lipids, and SNARE proteins that drive fusion of the synaptic vesicle with the plasma membrane. Despite ... Read more >>

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Hypoxia-related lncRNAs to build prognostic classifier and reveal the immune characteristics of EGFR wild type and low expression of PD-L1 squamous and adenocarcinoma NSCLC.

Fang Zhao, Min Wang, Jie Zhu,

<h4>Background</h4>Recently, the development and application of targeted therapies like tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) have achieved remarkable survival benefits in non-small cell lung cancer (NSCLC) treatment. However, epidermal growth factor receptor (EGFR) wild type and low expression of programmed death-ligand 1 (PD-L1) NSCLC remain unmanageable. Few ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice.

Jie Zhu, Shi-Feng Chu, Ye Peng, Dan-Dan Liu, Chen Chen, Wen-Xuan Jian, Hong-Shuo Sun, Zhong-Ping Feng, Zhao Zhang, Nai-Hong Chen,

Newborns suffering from hypoxia-ischemia (HI) brain injury still lack effective treatment. Proline-rich tyrosine kinase 2 (Pyk2) is a non-receptor tyrosine kinase, which is highly correlated with transient ischemic brain injury in adult. In this study, we investigated the role of Pyk2 in neonatal HI brain injury. HI was induced in ... Read more >>

Acta Pharmacol Sin (Acta pharmacologica Sinica)
[2021, :]

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High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.

Jie Zhu, Wenjuan Yang, Xiangda Zhou, Dorina Zöphel, Leticia Soriano-Baguet, Denise Dolgener, Christopher Carlein, Chantal Hof, Renping Zhao, Shandong Ye, Eva C Schwarz, Dirk Brenner, Leticia Prates Roma, Bin Qu,

Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown. Here we used primary ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:689337]

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ARID1A Variations in Cholangiocarcinoma: Clinical Significances and Molecular Mechanisms.

Shankun Zhao, Youwen Xu, Weizhou Wu, Pan Wang, Yichao Wang, Hao Jiang, Jie Zhu,

Cholangiocarcinoma (CCA), a high mortality malignant carcinoma characterized by advanced disease and frequent recurrence, constitutes a major challenge for treatment and prognosis. AT-rich interaction domain 1A (<i>ARID1A</i>) variation is a distinct genetic entity in CCA, getting mounting concerns recently. Here, we comprehensively reviewed the clinical significance and molecular mechanisms of ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:693295]

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Multistage-responsive nanovehicle to improve tumor penetration for dual-modality imaging-guided photodynamic-immunotherapy.

Yi Feng, Xiaoxue Xie, Hanxi Zhang, Qingqing Su, Geng Yang, Xiaodan Wei, Ningxi Li, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Guixue Wang, Hong Yang, Yiyao Liu,

The exploration of an intelligent multifunctional imaging-guided therapeutic platform is of great significance because of its ideal delivery efficiency and controlled release. In this work, a tumor microenvironment (TME)-responsive nanocarrier (denoted as [email protected]) is designed for on-demand, sequentially release of a short D-peptide antagonist of programmed cell death-ligand 1 (named ... Read more >>

Biomaterials (Biomaterials)
[2021, 275:120990]

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Zinc finger antiviral protein (ZAP) inhibits small ruminant morbillivirus replication in vitro.

Aoxing Tang, Jingyu Tang, Qiuhong Miao, Jie Zhu, Hongyuan Guo, Chuncao Liu, Chunchun Meng, Chuanfeng Li, Zongyan Chen, Guangqing Liu,

Small ruminant morbillivirus (SRMV) is a highly contagious and economically important viral disease of small domestic and wild ruminants. Difficulty with its stable proliferation in ovis aries-derived cells has led to a relative lag in the study of its natural immunity and pathogenesis. Here we report the antiviral properties of ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2021, 260:109163]

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Disruption of the Interfacial Membrane Leads to Magnaporthe oryzae Effector Re-location and Lifestyle Switch During Rice Blast Disease.

Kiersun Jones, Jie Zhu, Cory B Jenkinson, Dong Won Kim, Mariel A Pfeifer, Chang Hyun Khang,

To cause the devastating rice blast disease, the hemibiotrophic fungus <i>Magnaporthe oryzae</i> produces invasive hyphae (IH) that are enclosed in a plant-derived interfacial membrane, known as the extra-invasive hyphal membrane (EIHM), in living rice cells. Little is known about when the EIHM is disrupted and how the disruption contributes to ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:681734]

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Prediction of drug efficacy from transcriptional profiles with deep learning.

Jie Zhu, Jingxiang Wang, Xin Wang, Mingjing Gao, Bingbing Guo, Miaomiao Gao, Jiarui Liu, Yanqiu Yu, Liang Wang, Weikaixin Kong, Yongpan An, Zurui Liu, Xinpei Sun, Zhuo Huang, Hong Zhou, Ning Zhang, Ruimao Zheng, Zhengwei Xie,

Drug discovery focused on target proteins has been a successful strategy, but many diseases and biological processes lack obvious targets to enable such approaches. Here, to overcome this challenge, we describe a deep learning-based efficacy prediction system (DLEPS) that identifies drug candidates using a change in the gene expression profile ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2021, :]

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Water-stable zirconium-based metal-organic frameworks armed polyvinyl alcohol nanofibrous membrane with enhanced antibacterial therapy for wound healing.

Jie Zhu, Weiwang Qiu, Chengjian Yao, Chun Wang, Dequn Wu, Shravan Pradeep, Jianyong Yu, Zijian Dai,

Inadequate water-stability and antibacterial activity limit the biomedical application of polyvinyl alcohol (PVA)-based membranes in moist environments. In this work, we propose a strategy to improve the water-stability of PVA membranes via metal complexation and heat treatment. We report a simple routine where the zirconium-based UiO-66-NH<sub>2</sub> metal-organic frameworks (MOFs) are ... Read more >>

J Colloid Interface Sci (Journal of colloid and interface science)
[2021, 603:243-251]

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Recognition memory for pictures in children with ADHD: an event-related potential study.

Chaoqun Wang, Huijuan Shen, Jie Zhu, Ni Manman, Lina Liao, Kaihua Jiang, Xuan Dong,

<h4>Objective</h4>Children with ADHD are reported to accompany by various degrees of recognition memory cognitive deficits. We aimed to investigate age-related changes of the amplitude in event-related potential recordings on recognition memory in Chinese children with ADHD and to provide theoretical basis of neuro-electrophysiology for the cognition development of children.<h4>Method</h4>ERP and ... Read more >>

Int J Neurosci (The International journal of neuroscience)
[2021, :1-12]

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Shear stress triggered circular dorsal ruffles formation to facilitate cancer cell migration.

Xiang Qin, Yuehui Zhang, Yuchen He, Kang Chen, Yixi Zhang, Ping Li, Ying Jiang, Shun Li, Tingting Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu,

Circular dorsal ruffles (CDRs) are a kind of special ring-shaped membrane structure rich in F-actin, it is highly involved in the invasion-metastasis of tumor. Shear stress is one of the biophysical elements that affects the fate of tumor cells. However, how shear stress contributes to the CDRs formation is still ... Read more >>

Arch Biochem Biophys (Archives of biochemistry and biophysics)
[2021, 709:108967]

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Deep-learning models for the detection and incidence prediction of chronic kidney disease and type 2 diabetes from retinal fundus images.

Kang Zhang, Xiaohong Liu, Jie Xu, Jin Yuan, Wenjia Cai, Ting Chen, Kai Wang, Yuanxu Gao, Sheng Nie, Xiaodong Xu, Xiaoqi Qin, Yuandong Su, Wenqin Xu, Andrea Olvera, Kanmin Xue, Zhihuan Li, Meixia Zhang, Xiaoxi Zeng, Charlotte L Zhang, Oulan Li, Edward E Zhang, Jie Zhu, Yiming Xu, Daniel Kermany, Kaixin Zhou, Ying Pan, Shaoyun Li, Iat Fan Lai, Ying Chi, Changuang Wang, Michelle Pei, Guangxi Zang, Qi Zhang, Johnson Lau, Dennis Lam, Xiaoguang Zou, Aizezi Wumaier, Jianquan Wang, Yin Shen, Fan Fan Hou, Ping Zhang, Tao Xu, Yong Zhou, Guangyu Wang,

Regular screening for the early detection of common chronic diseases might benefit from the use of deep-learning approaches, particularly in resource-poor or remote settings. Here we show that deep-learning models can be used to identify chronic kidney disease and type 2 diabetes solely from fundus images or in combination with ... Read more >>

Nat Biomed Eng (Nature biomedical engineering)
[2021, 5(6):533-545]

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Efficacy of a combined Er:YAG laser and Nd:YAG laser in non-surgical treatment for severe periodontitis.

Jie Zhu, Rong Wei, Xiaodan Lv, Chunna Qu,

Severe periodontitis is challenging to treat. The aim of this study was to evaluate the efficacy of a combined Er:YAG laser (ERL) and Nd:YAG laser (NDL) in non-surgical treatment for severe periodontitis. One week after supragingival scaling, 32 systemically healthy patients with stage III or IV periodontitis were randomly divided into ... Read more >>

Lasers Med Sci (Lasers in medical science)
[2021, :]

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Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease.

Xiao-Ying Sun, Ling-Jie Li, Quan-Xiu Dong, Jie Zhu, Ya-Ru Huang, Sheng-Jie Hou, Xiao-Lin Yu, Rui-Tian Liu,

<h4>Background</h4>Tau pathology is a hallmark of Alzheimer's disease (AD) and other tauopathies. During disease progression, abnormally phosphorylated forms of tau aggregate and accumulate into neurofibrillary tangles, leading to synapse loss, neuroinflammation, and neurodegeneration. Thus, targeting of tau pathology is expected to be a promising strategy for AD treatment.<h4>Methods</h4>The effect of ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2021, 18(1):131]

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