Full Text Journal Articles by
Author Jie Mei Wang

Advertisement

Find full text journal articles






A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.

Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J Monks,

Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction, (E)-1,1-dimethyl-2-(5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl) guanidine (IMZ), ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21645]

Cited: 0 times

View full text PDF listing >>



Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina.

Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena J Steinle,

Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction in a common mouse model of type 2 diabetes, the db/db mouse. Retinal lysates ... Read more >>

J Diabetes Clin Res (Journal of diabetes and clinical research)
[2020, 2(1):12-15]

Cited: 0 times

View full text PDF listing >>



Advertisement

Insulin signal transduction is impaired in the type 2 diabetic retina

Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena Steinle,

Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction in a common mouse model of type 2 diabetes, the db/db mouse. Retinal lysates ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the KATP/MAPK pathway.

Yihan Wang, Leo M Hall, Marisa Kujawa, Hainan Li, Xiang Zhang, Megan O'Meara, Tomomi Ichinose, Jie-Mei Wang,

Endothelial dysfunction is a key risk factor in diabetes-related multiorgan damage. Methylglyoxal (MGO), a highly reactive dicarbonyl generated primarily as a by-product of glycolysis, is increased in both type 1 and type 2 diabetic patients. MGO can rapidly bind with proteins, nucleic acids, and lipids, resulting in structural and functional ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2019, 317(1):C68-C81]

Cited: 4 times

View full text PDF listing >>



Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

Hainan Li, Megan O'Meara, Xiang Zhang, Kezhong Zhang, Berhane Seyoum, Zhengping Yi, Randal J Kaufman, Terrence J Monks, Jie-Mei Wang,

Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived ... Read more >>

Diabetes (Diabetes)
[2019, 68(6):1287-1302]

Cited: 4 times

View full text PDF listing >>



Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.

Shukkur M Farooq, Yuning Hou, Hainan Li, Megan O'Meara, Yihan Wang, Chunying Li, Jie-Mei Wang,

<h4>Background</h4>G protein-coupled receptor 35 (GPR35) is an orphan receptor and is vastly expressed in immune cells and gastrointestinal cells, suggesting the potential physiological importance of GPR35 in these cells. Here, we tested the hypothesis that the lack of GPR35 expression in the colon mucosa exacerbates the severity of dextran sulfate ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2018, 63(11):2910-2922]

Cited: 6 times

View full text PDF listing >>



Isolation and Primary Culture of Mouse Aortic Endothelial Cells.

Jie-Mei Wang, Alex F Chen, Kezhong Zhang,

The vascular endothelium is essential to normal vascular homeostasis. Its dysfunction participates in various cardiovascular disorders. The mouse is an important model for cardiovascular disease research. This study demonstrates a simple method to isolate and culture endothelial cells from the mouse aorta without any special equipment. To isolate endothelial cells, ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (118):]

Cited: 16 times

View full text PDF listing >>



MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.

Hainan Li, Jenny Liu, Yihan Wang, Zhiyao Fu, Maik Hüttemann, Terrence J Monks, Alex F Chen, Jie-Mei Wang,

Bone marrow-derived progenitor cells (BMPCs) are potential candidates for autologous cell therapy in tissue repair and regeneration because of their high angiogenic potential. However, increased progenitor cell apoptosis in diabetes directly limits their success in the clinic. MicroRNAs are endogenous noncoding RNAs that regulate gene expression at the posttranscriptional level, ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2017, 313(4):E391-E401]

Cited: 5 times

View full text PDF listing >>



Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes.

Jie-Mei Wang, Kezhong Zhang,

Bone-marrow derived vascular precursors are an important endogenous repair reservoir for vascular repair and neovascularization [1]. Therapies of stem/progenitor cells targeting on angiogenesis are considered hopeful solutions for tissue repair and regeneration. However, the dysfunction of patient-derived progenitor cells has been implicated in diabetes [2], which limited the efficacy of ... Read more >>

Genom Data (Genomics data)
[2016, 7:86-87]

Cited: 1 time

View full text PDF listing >>



MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.

Jie-Mei Wang, Jun Tao, Dan-Dan Chen, Jing-Jing Cai, Kaikobad Irani, Qinde Wang, Hong Yuan, Alex F Chen,

<h4>Objective</h4>Vascular precursor cells with angiogenic potentials are important for tissue repair, which is impaired in diabetes mellitus. MicroRNAs are recently discovered key regulators of gene expression, but their role in vascular precursor cell-mediated angiogenesis in diabetes mellitus is unknown. We tested the hypothesis that the microRNA miR-27b rescues impaired bone ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2014, 34(1):99-109]

Cited: 61 times

View full text PDF listing >>



Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus.

Ok-Nam Bae, Jie-Mei Wang, Seung-Hoon Baek, Qingde Wang, Hong Yuan, Alex F Chen,

<h4>Objective</h4>Circulating angiogenic cells play an essential role in angiogenesis but are dysfunctional in diabetes mellitus characterized by excessive oxidative stress. We hypothesize that oxidative stress-mediated upregulation of thrombospondin-2 (TSP-2), a potent antiangiogenic protein, contributes to diabetic bone marrow-derived angiogenic cell (BMAC) dysfunction.<h4>Approach and results</h4>BMACs were isolated from adult male type ... Read more >>

Arterioscler Thromb Vasc Biol (Arteriosclerosis, thrombosis, and vascular biology)
[2013, 33(8):1920-1927]

Cited: 26 times

View full text PDF listing >>



Thrombospondin-1/CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic hedgehog pathway suppression.

Jie-Mei Wang, Jeffery S Isenberg, Timothy R Billiar, Alex F Chen,

Refractory wounds in diabetic patients present a significant clinical problem. Sonic hedgehog (SHH), a morphogenic protein central to wound repair, is deficient in diabetes. Regulation of SHH in wound healing is poorly understood. We hypothesize that thrombospondin-1 (TSP-1), through its receptor CD36, contributes to the SHH signaling defect in bone ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2013, 305(12):E1464-72]

Cited: 15 times

View full text PDF listing >>



Statistical virtual eye model based on wavefront aberration.

Jie-Mei Wang, Chun-Ling Liu, Yi-Ning Luo, Yi-Guang Liu, Bing-Jie Hu,

Wavefront aberration affects the quality of retinal image directly. This paper reviews the representation and reconstruction of wavefront aberration, as well as the construction of virtual eye model based on Zernike polynomial coefficients. In addition, the promising prospect of virtual eye model is emphasized. ... Read more >>

Int J Ophthalmol (International journal of ophthalmology)
[2012, 5(5):620-624]

Cited: 2 times

View full text PDF listing >>



Impaired endothelial progenitor cell activity is associated with reduced arterial elasticity in patients with essential hypertension.

Zhen Yang, Long Chen, Chen Su, Wen-Hao Xia, Yan Wang, Jie-Mei Wang, Fei Chen, Yuan-Yuan Zhang, Fang Wu, Shi-Yue Xu, Xiao-Lin Zhang, Jun Tao,

Endothelial dysfunction is related to reduced arterial elasticity in patients with essential hypertension. Circulating endothelial progenitor cells (EPCs), an important endogenous repair approach for endothelial injury, is altered in hypertensive patients. However, the association between alteration in circulating EPCs and hypertension-related reduced arterial elasticity has not been reported. The purpose ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2010, 32(7):444-452]

Cited: 22 times

View full text PDF listing >>



Berberine-induced decline in circulating CD31+/CD42- microparticles is associated with improvement of endothelial function in humans.

Jie-mei Wang, Zhen Yang, Ming-guo Xu, Long Chen, Yan Wang, Chen Su, Jun Tao,

Elevated circulating endothelial microparticles (EMPs) are associated with endothelial dysfunction. This study is to investigate whether berberine-induced fall in circulating EMPs facilitates improvement of endothelial function in healthy subjects. Fourteen healthy subjects received 1-month berberine therapy (1.2 g/d) and 11 healthy subjects served as control. Circulating EMPs were measured by ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2009, 614(1-3):77-83]

Cited: 22 times

View full text PDF listing >>



Berberine-induced upregulation of circulating endothelial progenitor cells is related to nitric oxide production in healthy subjects.

Ming-Guo Xu, Jie-Mei Wang, Long Chen, Yan Wang, Zhen Yang, Jun Tao,

OBJECTIVES: Berberine (BR) has a beneficial effect on endothelial function by increasing nitric oxide (NO), as NO plays a pivotal role in the regulation of endothelial progenitor cell (EPC) mobilization and function. The aim of the present study was to investigate whether BR-induced upregulation of circulating EPCs is related to ... Read more >>

Cardiology (Cardiology)
[2009, 112(4):279-286]

Cited: 27 times

View full text PDF listing >>



Increased brachial-ankle pulse wave velocity is associated with impaired endothelial function in patients with coronary artery disease.

Dong-hong Liu, Yan Wang, Xin-xue Liao, Ming-guo Xu, Jie-mei Wang, Zhen Yang, Long Chen, Ming-de Lü, Kun Lu, Jun Tao,

<h4>Background</h4>Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave ... Read more >>

Chin Med J (Engl) (Chinese medical journal)
[2006, 119(22):1866-1870]

Cited: 9 times

View full text PDF listing >>



[Fluid shear stress upregulated endothelial nitric oxide synthase gene expression and nitric oxide formation in human endothelial progenitor cells].

Zhen Yang, Jun Tao, Jie-Mei Wang, Chang Tu, Ming-Guo Xu, Yan Wang, Long Chen, Chu-Fan Luo, An-Li Tang, Hong Ma,

<h4>Objective</h4>To observe the effect of fluid shear stress on the eNOS gene expression and NO production in endothelial progenitor cells (EPCs).<h4>Methods</h4>The peripheral blood mononuclear cells from healthy volunteers were inducted into EPCs and divided into stationary group (0 dyn/cm(2), 1 dyn/cm(2) = 0.1 Pa), low-flow shear stress group (5 dyn/cm(2)), ... Read more >>

Zhonghua Xin Xue Guan Bing Za Zhi (Zhonghua xin xue guan bing za zhi)
[2007, 35(4):359-362]

Cited: 0 times

View full text PDF listing >>



C-Reactive protein-induced endothelial microparticle generation in HUVECs is related to BH4-dependent NO formation.

Jie-Mei Wang, Yan Wang, Jun-Yi Huang, Zhen Yang, Long Chen, Li-Chun Wang, An-Li Tang, Zhou-Fen Lou, Jun Tao,

<h4>Background</h4>C-reactive protein (CRP) has been proven to facilitate endothelial injury via reduced NO production. Endothelial microparticles (EMPs) have emerged as a novel marker of endothelial injury.<h4>Methods</h4>In vitro cultured human umbilical vein endothelial cells (HUVECs) were incubated with CRP (20 mg/l) for 24 h. The numbers of EMPs with CD31- and ... Read more >>

J Vasc Res (Journal of vascular research)
[2007, 44(3):241-248]

Cited: 42 times

View full text PDF listing >>



In vitro shear stress modulates antithrombogenic potentials of human endothelial progenitor cells.

Zhen Yang, Jie-mei Wang, Li-chun Wang, Long Chen, Chang Tu, Chu-fang Luo, An-li Tang, Sheng-Ming Wang, Jun Tao,

<h4>Background</h4>Recent study suggested that endothelial progenitor cells (EPCs), a novel therapeutic approach for endothelial dysfunction, present limited antithrombogenic potentials. However, few attempts have been done to improve the antithrombogenic potentials of EPCs. Our previous study proved that in vitro shear stress contributes to the increase in t-PA production by human ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2007, 23(2):121-127]

Cited: 17 times

View full text PDF listing >>



[A study of association between age-related circulating endothelial progenitor cells and arterial elasticity].

Jun Tao, Yan Wang, Zhen Yang, Chang Tu, Ming-guo Xu, Jie-mei Wang, Qiang Wang, Qin-yi Zeng, Guo-wei Chen, Hong Ma,

<h4>Objective</h4>Reduced arterial elasticity is a hallmark of aging in healthy humans independently of diseases and endothelial-cell injury and dysfunction may be responsible for this fall in arterial elasticity. We hypothesized that circulating endothelial progenitor cells (EPCs) are involved in endothelial repair and that lack of EPCs contributes to impaired arterial ... Read more >>

Zhonghua Xin Xue Guan Bing Za Zhi (Zhonghua xin xue guan bing za zhi)
[2005, 33(4):347-350]

Cited: 2 times

View full text PDF listing >>



Effects of fluid shear stress on eNOS mRNA expression and NO production in human endothelial progenitor cells.

Jun Tao, Zhen Yang, Jie-Mei Wang, Chang Tu, Shi-Rong Pan,

The increases in physiological levels of fluid shear stress have beneficial effects on vascular homeostasis. Endothelial progenitor cells (EPCs) play an important role in the maintenance of endothelial integrity. We hypothesized that shear stress-mediated vascular protection is related to the upregulation of endothelial nitric oxide synthase expression in EPCs. The ... Read more >>

Cardiology (Cardiology)
[2006, 106(2):82-88]

Cited: 30 times

View full text PDF listing >>



[Change in endothelial progenitor cells and endothelial function in patients with unstable angina pectoris].

Chang Tu, Jun Tao, Yan Wang, Zhen Yang, Dong-hong Liu, Ming-guo Xu, Jie-mei Wang, Qun-ying Zeng, Guo-wei Chen, Hong Ma,

<h4>Objective</h4>To investigate the relationship between endothelial progenitors cells (EPCs) and endothelium-dependent vasodilation in patients with unstable angina pectoris.<h4>Methods</h4>Thirty patients with unstable angina pectoris (UAP) and thirty control subjects were recruited. Flow-mediated dilation (FMD) in the brachial artery was evaluated by using ultrasound Doppler flow method. The number of circulating EPCs ... Read more >>

Zhonghua Xin Xue Guan Bing Za Zhi (Zhonghua xin xue guan bing za zhi)
[2005, 33(11):1014-1017]

Cited: 0 times

View full text PDF listing >>



Shear stress contributes to t-PA mRNA expression in human endothelial progenitor cells and nonthrombogenic potential of small diameter artificial vessels.

Zhen Yang, Jun Tao, Jie-Mei Wang, Chang Tu, Ming-Guo Xu, Yan Wang, Shi-Rong Pan,

Seeding endothelial progenitor cells (EPCs) onto the surface of vascular grafts has been proved to be a promising strategy to improve nonthrombogenic potentials of small diameter artificial vessels. Here, we investigated whether in vitro shear stress modulates the tissue-type plasminogen activator (t-PA) secretion and mRNA expression in human EPCs and ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2006, 342(2):577-584]

Cited: 37 times

View full text PDF listing >>



[Fluid shear stress regulates secretion of tissue-type plasminogen activator in human endothelial progenitor cells].

Zhen Yang, Jun Tao, Chang Tu, Ming-guo Xu, Yan Wang, Jie-mei Wang, Shi-rong Pan,

<h4>Objective</h4>In order to investigate the role of shear stress in the regulation of endothelial function, we assessed here effects of shear stress on tissue-type plasminogen activator in human endothelial progenitor cells (EPCs).<h4>Methods</h4>The peripheral blood mononuclear cells were separated from healthy adult and inducted into EPCs, which were identified by double ... Read more >>

Zhonghua Xin Xue Guan Bing Za Zhi (Zhonghua xin xue guan bing za zhi)
[2005, 33(9):840-842]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0369 s