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Analysis of β-lactoglobulin-epigallocatechin gallate interactions: the antioxidant capacity and effects of polyphenols under different heating conditions in polyphenolic-protein interactions.

Xuejiao Qie, Yao Chen, Wei Quan, Zhaojun Wang, Maomao Zeng, Fang Qin, Jie Chen, Zhiyong He,

The interaction and antioxidant capacity between epigallocatechin gallate (EGCG) and β-lactoglobulin (β-Lg) under thermal treatments at 25-121 °C were investigated in this study. Fluorescence spectroscopy analysis showed that EGCG complexed with β-Lg mainly via non-covalent interactions and the binding affinity of EGCG to β-Lg was enhanced with heat treatment. EGCG ... Read more >>

Food Funct (Food & function)
[2020, 11(5):3867-3878]

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Exosomal miRNA-486-5p derived from rheumatoid arthritis fibroblast-like synoviocytes induces osteoblast differentiation through the Tob1/BMP/Smad pathway.

Jie Chen, Mao Liu, Xiao Luo, Lihui Peng, Zixia Zhao, Chengsong He, Yue He,

The pathogenesis of rheumatoid arthritis (RA) is related to the inhibition of osteoblast differentiation. Exosomes secreted from RA fibroblast-like synoviocytes (RA-FLSs-exos) are associated with the pathogenesis of RA and microRNAs (miRNAs) being crucial for RA progression. Accordingly, the aim of the present study is to elucidate the effect of RA-FLS-derived ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(12):3430-3442]

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Env diversity-dependent protection of the attenuated equine infectious anaemia virus vaccine.

Yuezhi Lin, Xue-Feng Wang, Yuhong Wang, Cheng Du, Huiling Ren, Cong Liu, Dantong Zhu, Jie Chen, Lei Na, Diqiu Liu, Zhibiao Yang, Xiaojun Wang,

Lentiviruses harbour high genetic variability for efficient evasion from host immunity. An attenuated equine infectious anaemia (EIA) vaccine was developed decades ago in China and presented remarkably robust protection against EIA. The vaccine was recently proven to have high genomic diversity, particular in env. However, how and to what extent ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1309-1320]

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Effects of amides from pungent spices on the free and protein-bound heterocyclic amine profiles of roast beef patties by UPLC–MS/MS and multivariate statistical analysis

Chaoyi Xue, Zhiyong He, Fang Qin, Jie Chen, Maomao Zeng,

Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), principal component analysis (PCA) and orthogonal projection to latent structure-discriminant analysis (OPLS-DA) were used to explore the effects of the amide components (capsaicin, sanshoamide, piperine) of pungent spices widely consumed in China (chili pepper, Sichuan pepper and black pepper) on the profiles of 17 ... Read more >>

Food Res. Int. (Food research international (Ottawa, Ont.))
[2020, 135:Not Available]

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Revealing the switching mechanisms of an off-on-off fluorescent logic gate system.

Weijie Chi, Jie Chen, Qinglong Qiao, Ying Gao, Zhaochao Xu, Xiaogang Liu,

A deep understanding of fluorescence on-off and off-on switching mechanisms is the foundation for rationally designing highly effective molecular logic gate components and systems. These mechanisms, however, are often subtle to perceive and interpret, as multiple effects may contribute to the change of fluorescence signals. Herein, we systematically investigated the ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(30):16798-16803]

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Correction to: Expression of the immune checkpoint VISTA in breast cancer.

Liju Zong, Shengwei Mo, Shuangni Yu, Yuncan Zhou, Ming Zhang, Jie Chen, Yang Xiang,

The original version of this article unfortunately contained a mistake. The correct information is given below. ... Read more >>

Cancer Immunol. Immunother. (Cancer immunology, immunotherapy : CII)
[2020, 69(8):1447]

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Disorder limits the coherent phonon transport in two-dimensional phononic crystal structures.

Shiqian Hu, Zhongwei Zhang, Pengfei Jiang, Weijun Ren, Cuiqian Yu, Junichiro Shiomi, Jie Chen,

Recently, increasing efforts are being made to control thermal transport via coherent phonons in periodic phononic structures; however, the direct observation of coherent phonon transport is experimentally very difficult at ambient temperature, and the importance of coherent phonons to the total thermal conductivity has not been critically assessed to date. ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(24):11839-11846]

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Chemotherapeutic tumor microparticles elicit a neutrophil response targeting malignant pleural effusions.

Pingwei Xu, Ke Tang, Jingwei Ma, Huafeng Zhang, Dianheng Wang, Liyan Zhu, Jie Chen, Keke Wei, Jincheng Liu, Haiqing Fang, Liang Tang, Yi Zhang, Jing Xie, Yuying Liu, Rui Meng, Li Liu, Xiaorong Dong, Kunyu Yang, Gang Wu, Fei Ma, Bo Huang,

Malignant pleural effusion (MPE) is a frequent complication of various cancers and often leads to a poor quality of life, prognosis, and life expectancy, and its management remains palliative. New approaches that can effectively treat MPE are highly desirable. Here, we show that methotrexate (MTX)-packaging, tumor cell-derived microparticles (MTX-MP) act ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2020, :]

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Evaluation of different proton pump inhibitors combined with bismuth quadruple regimens in Helicobacter pylori eradication.

Lian-Di Kan, Jie Chen, Yue-Ting Huang, Yang Qiu, Xin-Lu Yu, Hong-Mei Fang, Qin Chen, Liu-Cheng Li,

To evaluate the efficacy and economics of different proton pump inhibitors (PPIs) combined with bismuth quadruple regimens for Helicobacter pylori (Hp) eradication, a retrospective analysis method was used to collect Hp-positive patients who were treated with a bismuth-containing quadruple regimen (PPIs + amoxicillin + furazolidone + colloid pectin bismuth) from the outpatient department of gastroenterology in ... Read more >>

Clin. Exp. Med. (Clinical and experimental medicine)
[2020, :]

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Analysis of Operation Procedure and Effect for Emergency Surgery in General Hospital During Novel Coronavirus Pneumonia Period

Yuchen Liu, Minggang Wang, Yingmo Shen, Jie Chen,

Abstract Background Novel coronavirus pneumonia(NCP) outbreak in Wuhan, China in early 2020, resulted in over 80 thousand infections in China. At present, NCP has an explosive growth in the world. Surgeons could refuse selective operation during the outbreak, but they must face the emergency operation. We hope to avoid the ... Read more >>

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Three-Way Decisions Community Detection Model Based on Weighted Graph Representation.

Jie Chen, Yang Li, Shu Zhao, Xiangyang Wang, Yanping Zhang,

Community detection is of great significance to the study of complex networks. Community detection algorithm based on three-way decisions (TWD) forms a multi-layered community structure by hierarchical clustering and then selects a suitable layer as the community detection result. However, this layer usually contains overlapping communities. Based on the idea ... Read more >>

(Rough Sets)
[0, 12179:153-165]

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Analysis of pathological changes and related factors in liver tissue of HBeAg-negative patients with low HBsAg levels.

Li Liu, Chunyun Liu, Junyi Li, Yingrong Du, Jie Chen, Hui Wang, Huimin Li, Lixian Chang,

The relationship between pathological changes in liver tissue and the level of hepatitis B surface antigen (HBsAg) remains unclear. This study aimed to analyze the pathological changes in liver tissue and its related factors in patients with low-level HBsAg in order to provide a basis for judging the condition of ... Read more >>

Clin. Exp. Med. (Clinical and experimental medicine)
[2020, :]

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Analysis of mRNAs and ncRNAs and Prediction Competing Endogenous RNA Networks in Colorectal Cancer Chemo-Resistance by Whole-Transcriptome Sequencing

Fei Yao, Chuanren Zhou, Qiyou Huang, Xiaoying Huang, Jie Chen, Yanling Zhou, Qiang Wang, Qingming Wu,

Abstract Background: Chemo-resistance is a major clinical obstacle to the treatment of colorectal cancer (CRC), mRNAs and non-coding RNAs (ncRNAs) have been reported to modulate the development of chemo-resistance. However, the profiles of mRNAs and ncRNAs as well as competing endogenous RNA (ceRNA) networks in CRC chemo-resistance are still unclear, ... Read more >>

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The study on the treatment of Xuebijing injection (XBJ) in adults with severe or critical Corona Virus Disease 2019 and the inhibitory effect of XBJ against SARS-CoV-2.

Qinhai Ma, Minshan Qiu, Hongxia Zhou, Jie Chen, Xue Yang, Zhenxuan Deng, Liping Chen, Jinchao Zhou, Yuping Liao, Qimin Chen, Qianwei Zheng, Lihua Cai, Lihan Shen, Zifeng Yang,

Pharmacol. Res. (Pharmacological research)
[2020, :105073]

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Single cell RNA sequencing identifies an early monocyte gene signature in acute respiratory distress syndrome.

Yale Jiang, Brian R Rosborough, Jie Chen, Sudipta Das, Georgios D Kitsios, Bryan J McVerry, Rama K Mallampalli, Janet S Lee, Anuradha Ray, Wei Chen, Prabir Ray,

Acute respiratory distress syndrome (ARDS) results from overwhelming pulmonary inflammation. Prior bulk RNA sequencing provided limited insights into ARDS pathogenesis. We used single cell RNA sequencing to probe ARDS at a higher resolution. PBMCs of patients with pneumonia and sepsis with early ARDS were compared with those of sepsis patients ... Read more >>

JCI Insight (JCI insight)
[2020, 5(13):]

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Association of Plasma Lactate Level With 28-day Mortality in Non-elderly and Elderly Sepsis Patients: A Retrospective Cohort Study Based on the Mimic-III Database

Yihua Dong, Xiaoyang Miao, Yufeng Hu, Yueyue Huang, Jie Chen, Yingru Lu, Jingye Pan,

Abstract Purpose: The objective of this study is to assess the clinical usefulness of lactate as a predictor of 28-day mortality and the relationship between lactate and 28-day mortality in non-elderly (<65 years) and elderly (≥65 years) sepsis patients who were admitted to an intensive care unit (ICU). Methods: This ... Read more >>

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SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection.

Ling Li, Haiya Wu, Qingmei Li, Jie Chen, Kaifeng Xu, Jinfu Xu, Xiao Su,

Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of TBK1 and interferon pathway and the expression of SOCS3 is closely correlated with symptoms of influenza patients. However, whether deletion of Socs3 in the lung epithelial cells would affect influenza lung replication and inflammation in vivo is unknown. To ... Read more >>

Mol. Immunol. (Molecular immunology)
[2020, 125:51-62]

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Muscle-derived TRAIL negatively regulates myogenic differentiation.

Dongwook Kim, Nilmani Singh, Rachel J Waldemer-Streyer, Mee-Sup Yoon, Jie Chen,

TNF-related apoptosis-inducing ligand (TRAIL) is known to induce apoptosis in cancer cells, although non-apoptotic functions have also been reported for this cytokine in various cell types. TRAIL and its receptor TRAIL-R2 are expressed in skeletal muscles, but a potential role of muscle-derived TRAIL in myogenesis has not been explored. Here ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2020, :112165]

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Family support is beneficial to the management and prognosis of patients with obstructive sleep apnoea.

Qinhong Xu, Haofen Xie, Yuqing Lin, Yao Yao, Zhixue Ye, Jie Chen, Shan Yang, Ye Wang,

BACKGROUND:This study aimed to explore the correlations between continuous positive airway pressure (CPAP) treatment-related self-efficacy and family support among patients with obstructive sleep apnoea (OSA) to provide a basis for improving patients' CPAP treatment compliance. METHODS:From May to Dec 2017, a cross-sectional study was conducted in the emergency wards, otorhinolaryngology ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2020, :]

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Decomposing Urban and Rural Disparities of Preventable ED Visits Among Patients With Alzheimer's Disease and Related Dementias: Evidence of the Availability of Health Care Resources.

Nianyang Wang, Asmaa Albaroudi, Jie Chen,

PURPOSE:The purpose of this study was to examine the urban and rural differences in the frequency of preventable Emergency Department (ED) visits among Alzheimer's Disease and Related Dementias (ADRD) patients, with a focus on the availability of health care resources in urban and rural areas. METHODS:Linked datasets of 2015 State ... Read more >>

J Rural Health (The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association)
[2020, :]

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A novel bacterial β-N-acetyl glucosaminidase from Chitinolyticbacter meiyuanensis possessing transglycosylation and reverse hydrolysis activities.

Alei Zhang, Xiaofang Mo, Ning Zhou, Yingying Wang, Guoguang Wei, Jie Chen, Kequan Chen, Pingkai Ouyang,

Background:N-Acetyl glucosamine (GlcNAc) and N-Acetyl chitooligosaccharides (N-Acetyl COSs) exhibit many biological activities, and have been widely used in the pharmaceutical, agriculture, food, and chemical industries. Particularly, higher N-Acetyl COSs with degree of polymerization from 4 to 7 ((GlcNAc)4-(GlcNAc)7) show good antitumor and antimicrobial activity, as well as possessing strong stimulating ... Read more >>

Biotechnol Biofuels (Biotechnology for Biofuels)
[2020, 13:115]

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Antifatigue and antihypoxia activities of oligosaccharides and polysaccharides from Codonopsis pilosula in mice.

Qi Xie, Yuting Sun, Lanlan Cao, Liangni Chen, Jie Chen, Xuemei Cheng, Changhong Wang,

Codonopsis pilosula is a traditional Chinese medicine and food supplement that is widely used in China. This study aimed to investigate the antifatigue and antihypoxia activities of different extracts and fractions from C. pilosula, including ethanol extract (ETH), water extract (WAT), polysaccharides (POL), inulin (INU) and oligosaccharides (OLI). Different extracts ... Read more >>

Food Funct (Food & function)
[2020, :]

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Retraction Note: Interactions between Th1 cells and Tregs affect regulation of hepatic fibrosis in biliary atresia through the IFN-γ/STAT1 pathway.

Jie Wen, Ying Zhou, Jun Wang, Jie Chen, Wenbo Yan, Jin Wu, Junkai Yan, Kejun Zhou, Yongtao Xiao, Yang Wang, Qiang Xia, Wei Cai,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, 27(7):2295]

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SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7.

Jie Chen, Yunzhi Dang, Weibo Feng, Chenyang Qiao, Danfei Liu, Tongyue Zhang, Yijun Wang, Dean Tian, Daiming Fan, Yongzhan Nie, Kaichun Wu, Limin Xia,

The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited. Therefore, it is still imperative to fully elucidate the mechanisms underlying GC metastasis. Here, we report a novel role of SRY-box transcription factor 18 (SOX18), a member of the SOX family, in promoting GC metastasis. The elevated expression ... Read more >>

Oncogene (Oncogene)
[2020, :]

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Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic nephropathy

Xue-hong Zhou, Shu-yan Liu, Lin Feng, Bo Yang, Yong-feng Li, Xiao-qing Wang, Jie Chen, Hui-hui Wang,

Abstract Background :Diagnosing diabetic nephropathy is important to prevent long-term kidney damage and determine the prognosis of patients with diabetes. Since some kidney injury biomarkers increase in the early stages of diabetic nephropathy, this study investigated the clinical significance of combined detection of urine orosomucoid and retinol binding protein for ... Read more >>

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