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Author Jiawei Gong

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Vertically Ordered Mesoporous Silica-Nanochannel Film-Equipped Three-Dimensional Macroporous Graphene as Sensitive Electrochemiluminescence Platform.

Jiawei Gong, Hongliang Tang, Xuan Luo, Huaxu Zhou, Xueting Lin, Kailong Wang, Fei Yan, Fengna Xi, Jiyang Liu,

Three-dimensional (3D) electrochemiluminescence (ECL) platform with high sensitivity and good anti-fouling is highly desirable for direct and sensitive analysis of complex samples. Herein, a novel ECL-sensing platform is demonstrated based on the equipment of vertically ordered mesoporous silica-nanochannel films (VMSF) on monolithic and macroporous 3D graphene (3DG). Through electrografting of ... Read more >>

Front Chem (Frontiers in chemistry)
[2021, 9:770512]

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Three-dimensional macroscopic graphene supported vertically-ordered mesoporous silica-nanochannel film for direct and ultrasensitive detection of uric acid in serum.

Xiaoqi Zhu, Lingli Xuan, Jiawei Gong, Junjie Liu, Xiaobo Wang, Fengna Xi, Jie Chen,

Direct, rapid and sensitive detection of physiologically-relevant active small molecules (ASMs) in complex biological samples is highly desirable. Herein, we present an electrochemical sensing platform by combining three-dimensional macroscopic graphene (3DG) and vertically-ordered mesoporous silica-nanochannel film (VMSF), which is able to directly detect ASMs in complex samples with high sensitivity ... Read more >>

Talanta (Talanta)
[2022, 238(Pt 1):123027]

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Sensitive Detection of Sulfide Ion Based on Fluorescent Ionic Liquid-Graphene Quantum Dots Nanocomposite.

Guanhua Qiu, Yaoqi Han, Xiaoqi Zhu, Jiawei Gong, Tao Luo, Chang Zhao, Junjie Liu, Jiyang Liu, Xiang Li,

Sulfide ions (S<sup>2-</sup>) that are widely distributed in biological and industrial fields are extremely toxic and pose great harms to both ecological environment and human health. However, fluorescent sensors toward S<sup>2-</sup> ions commonly use S<sup>2-</sup>-recovered fluorescence of fluorophore that is first quenched mainly by metal ions. Fluorescent probe which enables ... Read more >>

Front Chem (Frontiers in chemistry)
[2021, 9:658045]

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Molecular characterization of miRNA genes and their expression in Dimocarpus longan Lour.

Yuling Lin, Yan Chen, Youjing Zeng, Shuting Zhang, Zihao Zhang, YuKun Chen, Jiawei Gong, Zhongxiong Lai,

<h4>Main conclusion</h4>A genome-wide analysis of longan miRNA genes was conducted, and full-length pri-miRNA transcripts were cloned. Bioinformatics and expression analyses contributed to the functional characterization of longan miRNA genes. MicroRNAs are important for the post-transcriptional regulation of target genes. However, little is known about the transcription and regulation of miRNA ... Read more >>

Planta (Planta)
[2021, 253(2):41]

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MiR-7 mediates mitochondrial impairment to trigger apoptosis and necroptosis in Rhabdomyosarcoma.

Lin Yang, Delin Kong, Mei He, Jiawei Gong, Yuzhe Nie, Sheng Tai, Chun-Bo Teng,

<h4>Background</h4>Rhabdomyosarcoma (RMS) is a pediatric cancer with rhabdomyoblastic phenotype and mitochondria act as pivotal regulators of its growth and progression. While miR-7-5p (miR-7) is reported to have a tumor-suppressive role, little is yet known about its antitumor activity in RMS.<h4>Methods</h4>The effects of miR-7 on RMS were analyzed both in vitro ... Read more >>

Biochim Biophys Acta Mol Cell Res (Biochimica et biophysica acta. Molecular cell research)
[2020, 1867(12):118826]

Cited: 4 times

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Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Yanqing Song, Tingting Hu, Huan Gao, Jinghui Zhai, Jiawei Gong, Yueming Zhang, Lina Tao, Jingmeng Sun, Zhiyuan Li, Xiaoyu Qu,

Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb Astragalus membranaceus, alleviated CDDP-induced AKI. To explore the mechanism, we performed a metabolomics study to ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2021, 183:114299]

Cited: 1 time

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[Toxicity reduction of human islet amyloid polypeptide by Trim-Away technique in insulinoma cells].

Jiawei Gong, De Lin Kong, Lin Yang, Yu Zhe Nie, Yang Liang, Chun Bo Teng,

Human islet amyloid polypeptide (hIAPP, also known as amylin) is a co-secreting protein of insulin in human pancreatic β-cells. It is encapsulated in vesicles and secreted out of the cells with insulin. hIAPP can promote insulin secretion and regulate blood glucose homeostasis in the body under the normal physiological conditions. ... Read more >>

Yi Chuan (Yi chuan = Hereditas)
[2020, 42(6):586-598]

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Genome-wide identification and expression profiling of microRNAs genes during SE and in different organs/tissues in Dimocarpus longan Lour.

Yuling Lin, Yan Chen, Youjing Zeng, Shuting Zhang, Zihao Zhang, Jiawei Gong, Zhongxiong Lai,

<h4>Background: </h4> MicroRNAs (miRNAs) is a conserved class of single-stranded noncoding RNAs, which regulate growth and development, hormone response, and stress responses in plant. Longan (Dimocarpus longan Lour.) is an important fruit tree with medicinal value and considerable economic value. However, there is no research on genome-wide identification of miRNAs ... Read more >>

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Simvastatin induces breast cancer cell death through oxidative stress up-regulating miR-140-5p.

Fuliang Bai, Ze Yu, Xin Gao, Jiawei Gong, Lizhi Fan, Feifei Liu,

Statins, a class of hyperlipidemic drugs, are widely used cholesterol lowering drugs that selectively inhibit 3-hydroxy-3-methylglutaryl CoA reductase, which is the rate-limiting enzyme in cholesterol biosynthesis, leading to decreasing of cholesterol biosynthesis. Statins exert anti-tumoral effects on various cancer, including breast cancer. However, the molecular mechanisms for the actions were ... Read more >>

Aging (Albany NY) (Aging)
[2019, 11(10):3198-3219]

Cited: 18 times

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In situ silk fibroin-mediated crystal formation of octacalcium phosphate and its application in bone repair.

Fengxuan Han, Yuanbin Hu, Jiaying Li, Jiawei Gong, Qianping Guo, Caihong Zhu, Xuesong Zhu, Huilin Yang, Bin Li,

The development of an ideal scaffold material is critical for the repair of bone defects. Being an important precursor of the mineralized matrix of bone tissue, octacalcium phosphate (OCP) has been considered a promising bone substitute. However, its application is largely limited due to the thermodynamical instability and poor processability ... Read more >>

Mater Sci Eng C Mater Biol Appl (Materials science & engineering. C, Materials for biological applications)
[2019, 95:1-10]

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ICP-MS determination of serum aluminum in monkeys subcutaneously administered an alhydrogel-formulated drug candidate.

Wenkui Li, Jiawei Gong, Chuan Wang, Zhongping John Lin, Jimmy Flarakos,

<label>AIM</label>To develop and validate an inductively coupled plasma-mass spectrometry method for quantitative bioanalysis of aluminum (Al) in monkey serum in support of a GLP TOX study with alhydrogel-formulated drug candidate.<label>METHODS & RESULTS</label>The method was linear over a dynamic range of 10-1000 ng/ml using a 50-μl sample volume. The intra-/inter-run precision (%CV) ... Read more >>

Bioanalysis (Bioanalysis)
[2017, 9(23):1873-1881]

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Identification of beta-lactamase inhibitory peptide using yeast two-hybrid system.

Wei Sun, Youjia Hu, Jiawei Gong, Chunbao Zhu, Baoquan Zhu,

Random oligonucleotide fragments were designed and amplified by PCR and fused with the activating domain of pGAD424 to construct a random peptide library. The DNA fragment encoding beta-lactamase was fused with the binding domain of pGBT9(+2). Subsequently, using yeast two-hybrid system we found two positive clones encoding peptides P1 and ... Read more >>

Biochemistry (Mosc) (Biochemistry. Biokhimiia)
[2005, 70(7):753-760]

Cited: 6 times

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