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RIP1 promotes proliferation through G2/M checkpoint progression and mediates cisplatin-induced apoptosis and necroptosis in human ovarian cancer cells.

Xue-Lian Zheng, Jiao-Jiao Yang, Yan-Yun Wang, Qin Li, Ya-Ping Song, Min Su, Jin-Ke Li, Lin Zhang, Zhi-Ping Li, Bin Zhou, Yong Lin,

Receptor-interacting protein 1 (RIP1, also known as RIPK1) is not only a tumor-promoting factor in several cancers but also mediates either apoptosis or necroptosis in certain circumstances. In this study we investigated what role RIP1 plays in human ovarian cancer cells. We showed that knockout (KO) of RIP1 substantially suppressed ... Read more >>

Acta Pharmacol. Sin. (Acta pharmacologica Sinica)
[2020, :]

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Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a mendelian randomization study.

Xiao-Ling Gao, Zhi-Mei Jia, Fang-Fang Zhao, Dong-Dong An, Bei Wang, Er-Jing Cheng, Yan Chen, Jian-Nan Gong, Dai Liu, Ya-Qiong Huang, Jiao-Jiao Yang, Shu-Juan Wang,

Although observational studies have reported a positive association between obstructive sleep apnea syndrome (OSAS) and breast cancer (BC) risk, causality remains inconclusive. We aim to explore whether OSAS is associated with etiology of BC by conducting a two-sample Mendelian randomization (MR) study in a Chinese population and Asian population from ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(5):4082-4092]

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Overinhibition mediated by parvalbumin interneurons might contribute to depression-like behavior and working memory impairment induced by lipopolysaccharide challenge.

Mu-Huo Ji, Ling Zhang, Ming-Jie Mao, Hui Zhang, Jiao-Jiao Yang, Li-Li Qiu,

Systemic inflammation induces cognitive impairments via unclear mechanisms. Accumulating evidence has demonstrated that a subset of neurons that express parvalbumin (PV) play a critical role in regulation of cognitive and emotional behavior. Thus, the aim of the present study was to test whether disruption of PV interneuron mediates systemic inflammation-induced ... Read more >>

Behav. Brain Res. (Behavioural brain research)
[2020, 383:112509]

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CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced bone metabolism disorder and destruction in rats.

Zhan-Jun Dou, Xiao-Ling Gao, Yan-Li Jia, Jie Chen, Jiao-Jiao Yang, Yan Chen, Shu-Jie Wu, Tao Liu, Mei-Ting Wang, Chong Yang, Na Zhang, Bei Wang,

OBJECTIVE:The endocannabinoid system (ECS) regulates bone turn-over and remodeling. Chronic intermittent hypoxia (CIH) occurring during obstructive sleep apnea (OSA) may lead to disorders of the ECS and bone metabolism abnormalities. This study aimed to investigate whether or not the cannabinoid receptor 1 (CB1R) antagonist rimonabant (Ri) alleviates bone metabolism abnormalities ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

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Intergenerational Effects of Sevoflurane in Young Adult Rats.

Ling-Sha Ju, Jiao-Jiao Yang, Ning Xu, Jia Li, Timothy E Morey, Nikolaus Gravenstein, Christoph N Seubert, Barry Setlow, Anatoly E Martynyuk,

BACKGROUND:Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects of sevoflurane to future offspring. As germ cells are susceptible to reprogramming by environmental factors across the lifespan, the authors hypothesized that sevoflurane administered to adult rats could induce ... Read more >>

Anesthesiology (Anesthesiology)
[2019, 131(5):1092-1109]

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Mixed adenoneuroendocrine carcinoma of the liver: A rare case report.

Jiao-Jiao Yang, Zhi-Ping Li, Chun-Li Luo, Yan Du, Qiu-Yang Lu, Na Li, He Li, Tian-Ping Yu, Xing-Ming Huang,

A 55-year-old woman presented with chest and back pain of unknown cause. Contrast-enhanced computed tomography revealed two low-density tumors, sized 4.6 and 4.4 cm, in the hepatic caudate and left inner lobes, respectively. There are multiple enlarged lymph nodes around the abdominal aorta, hepatogastric ligament and gastrosplenic ligament. At the ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2020, 12(2):148-154]

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[Electroacupuncture of Multiple Acupoints Is Significantly Superior to That of Single Acupoint in Improving Sleep by Regulating Serum Sleep-promoting and Awakening-promoting Factors in Insomnia Rats].

Li-Na Qiao, Qiao-Ling Gao, Lian-Hong Tan, Yi-Nan Shi, Yan-Shu Jiang, Jiao-Jiao Yang, Yong-Sheng Yang,

OBJECTIVE:To observe the effect of electroacupuncture (EA) stimulation of single and multiple acupoints on sleep and concentrations of interlukin-1 β(IL-1 β), brain-derived neurotrophic factor (BDNF), prostaglandin D2(PGD2) and melatonin (MLT, sleep-promoting factors) and corticosterone (CORT, awakening-promoting factor) in the serum in insomnia rats, so as to explore its efficacy difference ... Read more >>

Zhen Ci Yan Jiu (Zhen ci yan jiu = Acupuncture research)
[2018, 43(10):651-656]

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Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea.

Jiao-Jiao Yang, Shu-Juan Wang, Xiaoling Gao, Bei Wang, Yan-Ting Dong, Yang Bai, Yan Chen, Jian-Nan Gong, Ya-Qiong Huang, Dong-Dong An,

BACKGROUND Studies have shown that intermittent hypoxia mimics obstructive sleep apnea in causing pulmonary inflammation, but the mechanism is not yet clear.TLR-4 is a recognized proinflammatory factor, so the purpose of this study was to assess the function of TLR-4 in pulmonary inflammation induced by chronic intermittent hypoxia simulating obstructive ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2018, 24:7152-7161]

Cited: 2 times

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Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome.

Yan Qiao, Bei Wang, Jiao-Jiao Yang, Yan-Feng Fan, Qian Guo, Zhan-Jun Dou, Ya-Qiong Huang, Ting-Ting Feng, Shu-Juan Wang, Dong-Dong An, Xiao-Ling Gao,

Background:Obstructive sleep apnea syndrome (OSAS) is prevalent in obesity and is associated with many metabolic abnormalities. The relationship between OSAS and bone metabolism is still unclear. The aim of this study was to investigate the relationship between the severity of OSAS and bone metabolic markers. Methods:A total of 119 obese ... Read more >>

Chin. Med. J. (Chinese medical journal)
[2018, 131(16):1898-1903]

Cited: 1 time

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Upregulation of microRNA-335-5p reduces inflammatory responses by inhibiting FASN through the activation of AMPK/ULK1 signaling pathway in a septic mouse model.

Xiao-Ling Gao, Jian-Qiang Li, Yan-Ting Dong, Er-Jing Cheng, Jian-Nan Gong, Yi-Li Qin, Ya-Qiong Huang, Jiao-Jiao Yang, Shu-Juan Wang, Dong-Dong An,

Sepsis, as a systemic inflammatory response syndrome (SIRS) subtype, is generally characterized by infection. Emerging evidence has highlighted dysregulated microRNAs (miRNAs) are involved in the progression of sepsis. The aim of the study was to investigate the effects of miR-335-5p on inflammatory responses in a septic mouse model. The hypothesis ... Read more >>

Cytokine (Cytokine)
[2018, 110:466-478]

Cited: 4 times

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Effects of RNA interference-mediated silencing of toll-like receptor 4 gene on proliferation and apoptosis of human breast cancer MCF-7 and MDA-MB-231 cells: An in vitro study.

Xiao-Ling Gao, Jiao-Jiao Yang, Shu-Juan Wang, Yan Chen, Bei Wang, Er-Jing Cheng, Jian-Nan Gong, Yan-Ting Dong, Dai Liu, Xiang-Li Wang, Ya-Qiong Huang, Dong-Dong An,

Breast cancer is known as the most prevalent cancer in women worldwide, and has an undeniable negative impact on public health, both physically, and mentally. This study aims to investigate the effects of toll-like receptor 4 (TLR4) gene silencing on proliferation and apoptosis of human breast cancer cells to explore ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2018, 234(1):433-442]

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[Effects of Electroacupuncture on Activities of Satellite Glial Cells of Dorsal Root Ganglia in Rats with Neck Incision Pain].

Li-Na Qiao, Lian-Hong Tan, Jiao-Jiao Yang, Qiao-Ling Gao, Jiang Zhu, Pei-Jing Rong, Bing Zhu, Yong-Sheng Yang, Jun-Ling Liu,

OBJECTIVE:To observe the effect of electroacupuncture (EA) stimulation of "Futu"(LI 18), etc. on activities of satellite glial cells (SGCs) in the dorsal root ganglia (DRG) in rats with neck-incision pain so as to explore its mechanism underlying reduction of post-surgical pain of thyroidectomy. METHODS:Male SD rats were randomly divided into ... Read more >>

Zhen Ci Yan Jiu (Zhen ci yan jiu = Acupuncture research)
[2017, 42(4):283-289]

Cited: 1 time

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Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.

Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N Seubert, Timothy E Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E Martynyuk,

The majority of studies evaluating neurocognition in humans who had procedures under anesthesia early in life found long-term deficits even though the typical anesthesia duration normalized to the human life span is much shorter than that shown to induce developmental abnormalities in rodents. Therefore, we studied whether subsequent environmental stressors ... Read more >>

Psychoneuroendocrinology (Psychoneuroendocrinology)
[2017, 81:96-104]

Cited: 4 times

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The Combination of Long-term Ketamine and Extinction Training Contributes to Fear Erasure by Bdnf Methylation.

Ling-Sha Ju, Jiao-Jiao Yang, Lei Lei, Jiang-Yan Xia, Dan Luo, Mu-Huo Ji, Anatoly E Martynyuk, Jian-Jun Yang,

A combination of antidepressant drugs and psychotherapy exhibits more promising efficacy in treating fear disorders than either treatment alone, but underlying mechanisms of such treatments remain largely unknown. Here we investigated the role of DNA methylation of the brain-derived neurotrophic factor (Bdnf) gene in the therapeutic effects of ketamine in ... Read more >>

Front Cell Neurosci (Frontiers in Cellular Neuroscience)
[2017, 11:100]

Cited: 2 times

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Sex comb on midleg like-2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors.

Jiao-Jiao Yang, Hua Huang, Ming-Bing Xiao, Feng Jiang, Wen-Kai Ni, Yi-Fei Ji, Cui-Hua Lu, Run-Zhou Ni,

Sex comb on midleg like-2 (SCML2) is a polycomb-group protein that encodes transcriptional repressors essential for appropriate development in the fly and in mammals. On the basis of previous findings, the present study aimed to explore the possibility of developing SCML2 into a new diagnostic marker for gastroenteropancreatic neuroendocrine tumors ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2017, 14(2):1749-1755]

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[Transcutaneous Electrostimulation of Auricular Otopoints Reduces Epileptic Attack Possibly by Suppressing Hippocampal Gliocyte Proliferation and Regulating IL-6 and IL-10 Expression in Chronic Temporal Lobe Epilepsy Rats].

Li-Na Qiao, Hai-Long Yang, Lian-Hong Tan, Jiao-Jiao Yang, Qiao-Ling Gao, Sheng-Hong Zhou, Yong-Chen Zhang, Yong-Sheng Yang,

To observe the effect of transcutaneous otopoint electrostimulaiton (TCOES) on seizure frequency, immunoreactivity of hippocampal gliocytes and expression of proinflammatory cytokine interleukin-6(IL-6) and anti-inflammatory cytokine IL-10 in chronic temporal lobe epilepsy (CTLE) rats, so as to investigate its antiepileptic mechanism.Thirty-six SD rats were randomly divided into control, model and TCOES ... Read more >>

Zhen Ci Yan Jiu (Zhen ci yan jiu = Acupuncture research)
[2017, 42(3):189-196]

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[Effects of Transcutaneous Electrostimulation of Auricular Points on Behavior and Hippocampal IL-1 β and TNF-α Expression in Temporal Lobe Epilepsy Rats].

Hai-Long Yang, Li-Na Qiao, Lian-Hong Tan, Jiao-Jiao Yang, Zhong Chen, Yong-Chen Zhang, Yong-Sheng Yang,

To observe the effect of transcutaneous otopoint electrostimulation (TCOES) on behavior and expression of hippocampal interleukin-1 β (IL-1 β) and tumor necrosis factor-α (TNF-α) expression in lithium-pilocarpine induced chronic spontaneous temporal lobe epilepsy (TLE) rats, so as to investigate its antiepileptic mechanism.Thirty-six SD rats were randomly divided into control, model ... Read more >>

Zhen Ci Yan Jiu (Zhen ci yan jiu = Acupuncture research)
[2016, 41(4):283-290]

Cited: 0 times

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Role of histone acetylation in long-term neurobehavioral effects of neonatal Exposure to sevoflurane in rats.

Min Jia, Wen-Xue Liu, Jiao-Jiao Yang, Ning Xu, Ze-Min Xie, Ling-Sha Ju, Mu-Huo Ji, Anatoly E Martynyuk, Jian-Jun Yang,

Human studies, and especially laboratory studies, provide evidence that early life exposure to general anesthesia may affect neurocognitive development via largely unknown mechanisms. We explored whether hippocampal histone acetylation had a role in neurodevelopmental effects of sevoflurane administered to neonatal rats. Male Sprague-Dawley rats were exposed to 3% sevoflurane or ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2016, 91:209-220]

Cited: 10 times

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Impact of length of red blood cells transfusion on postoperative delirium in elderly patients undergoing hip fracture surgery: A cohort study.

Zhuang-Yun Zhang, Da-Peng Gao, Jiao-Jiao Yang, Xiao-ru Sun, Hui Zhang, Jian Hu, Zhi-Yong Fang, Jian-Jun Yang, Mu-Huo Ji,

The purpose of the present study was to test whether older red blood cells (RBCs) transfusion results in an increased risk of postoperative delirium (POD) and various in-hospital postoperative complications in elderly patients undergoing hip fracture surgery.Patients (≥65 years) who underwent hip fracture surgery were enrolled, 179 patients were divided ... Read more >>

Injury (Injury)
[2016, 47(2):408-412]

Cited: 4 times

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[Traditional Chinese medicine pairs (III)--effect of extract of Ginseng Radix et Rhizoma and Puerariae Lobatae Radix on intestinal absorption in rats].

Yi-hang Chen, Meng-xuan Li, Zhao-qing Meng, Jiao-jiao Yang, Wen-zhe Huang, Zhen-zhong Wang, Yue-sheng Wang, Wei Xiao,

This study focused on the intestinal absorption of traditional Chinese medicines (TCM) to reveal the scientific connotation of the compatibility of TCM pairs. The single pass intestinal perfusion (SPIP) was used in rats to compare the absorption of single extracts from Puerariae Lobatae Radix, single extracts from Ginseng Radix et ... Read more >>

Zhongguo Zhong Yao Za Zhi (Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica)
[2015, 40(15):3094-3099]

Cited: 0 times

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Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, attenuates postoperative cognitive dysfunction in aging mice.

Min Jia, Wen-Xue Liu, He-Liang Sun, Yan-Qing Chang, Jiao-Jiao Yang, Mu-Huo Ji, Jian-Jun Yang, Chen-Zhuo Feng,

Postoperative cognitive dysfunction (POCD) is a recognized clinical entity characterized with cognitive deficits after anesthesia and surgery, especially in aged patients. Previous studies have shown that histone acetylation plays a key role in hippocampal synaptic plasticity and memory formation. However, its role in POCD remains to be determined. Here, we ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2015, 8:52]

Cited: 7 times

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NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice.

Li-Li Qiu, Mu-Huo Ji, Hui Zhang, Jiao-Jiao Yang, Xiao-Ru Sun, Hui Tang, Jing Wang, Wen-Xue Liu, Jian-Jun Yang,

Microglial activation plays a key role in the development of postoperative cognitive dysfunction (POCD). Nox2, one of the main isoforms of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in the central nervous system, is a predominant source of reactive oxygen species (ROS) overproduction in phagocytes including microglia. We therefore hypothesized that ... Read more >>

Brain Behav. Immun. (Brain, Behavior, and Immunity)
[2016, 51:109-118]

Cited: 22 times

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Environmental Enrichment Ameliorates Neonatal Sevoflurane Exposure-Induced Cognitive and Synaptic Plasticity Impairments.

Mu-huo Ji, Xing-ming Wang, Xiao-ru Sun, Hui Zhang, Ling-sha Ju, Li-li Qiu, Jiao-jiao Yang, Min Jia, Jing Wu, Jianjun Yang,

Early exposure to sevoflurane, an inhalation anesthetic, induces neurodegeneration in the developing brain and subsequent long-term neurobehavioral abnormalities. Here, we investigated whether an enriched environment could mitigate neonatal sevoflurane exposure-induced long-term cognitive and synaptic plasticity impairments. Male C57BL/6 mice were exposed to 3 % sevoflurane 2 h daily for 3 ... Read more >>

J. Mol. Neurosci. (Journal of molecular neuroscience : MN)
[2015, 57(3):358-365]

Cited: 4 times

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Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice.

Mu-Huo Ji, Li-Li Qiu, Jiao-Jiao Yang, Hui Zhang, Xiao-Ru Sun, Si-Hai Zhu, Wei-Yan Li, Jian-Jun Yang,

Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available. Herein, the authors investigated whether curcumin can prevent ... Read more >>

Neurotoxicology (Neurotoxicology)
[2015, 46:155-164]

Cited: 21 times

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Comparison of restrictive and liberal transfusion strategy on postoperative delirium in aged patients following total hip replacement: a preliminary study.

Yun-Xia Fan, Fang-Fang Liu, Min Jia, Jiao-Jiao Yang, Jin-Chun Shen, Guang-Ming Zhu, Si-Hai Zhu, Wei-Yan Li, Jian-Jun Yang, Mu-Huo Ji,

Few studies have examined the association between perioperative blood transfusion and postoperative delirium (POD) in aged patients undergoing total hip replacement surgery. In this prospective study, 186 patients older than 65 years undergoing elective unilateral total hip replacement surgery were enrolled. Of those, 94 patients were randomly assigned to the ... Read more >>

Arch Gerontol Geriatr (Archives of Gerontology and Geriatrics)
[2014, 59(1):181-185]

Cited: 18 times

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