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Apelin‑36 protects against lipopolysaccharide‑induced acute lung injury by inhibiting the ASK1/MAPK signaling pathway.

Qiong He, Yuqiao Wang, Hua Yang, Jianmin Wang, Jia Zhang, Danni Liu,

Apelin‑36 is able to mediate a range of effects on various diseases, and is upregulated in lipopolysaccharide (LPS)‑induced acute lung injury (ALI). However, to the best of our knowledge, whether apelin‑36 is able to regulate LPS‑induced ALI has yet to be investigated. The present study aimed to investigate the role ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 23(1):]

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Opportunities for Antigen Discovery in Metastatic Breast Cancer.

Ashwani K Sood, Michael Nemeth, Jianmin Wang, Yun Wu, Shipra Gandhi,

Immune checkpoint inhibitor-based immunotherapy (ICI) of breast cancer is currently efficacious in a fraction of triple negative breast cancers (TNBC) as these cancers generally carry high tumor mutation burden (TMB) and show increased tumor infiltration by CD8+ T cells. However, most estrogen receptor positive breast cancers (ERBC) have low TMB ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:570049]

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A novel miR-7156-3p-HOXD13 axis modulates glioma progression by regulating tumor cell stemness.

Junfeng Zhang, Mengsheng Deng, Haipeng Tong, Wei Xue, Yu Guo, Jianmin Wang, Lizhao Chen, Shunan Wang,

Malignant glioma is the most common brain tumor in adults. Despite the great advances in anti-glioma treatments which have led to significant improvement in clinical outcomes, tumor recurrence remains the major cause of mortality. Increased cancer cell stemness and invasiveness are correlated with glioma progression. By searching the Cancer Genome ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2020, 16(16):3200-3209]

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A novel electrochemical biosensor based on peptidoglycan and platinum-nickel-copper nano-cube for rapid detection of Gram-positive bacteria.

Daobin Han, Yurong Yan, Xintong Bian, Jianmin Wang, Min Zhao, Xiaolei Duan, Liangsheng Kong, Wei Cheng, Shijia Ding,

A novel non-enzyme electrochemical biosensor for the rapid detection of Gram-positive bacteria has been constructed that relys on a stable and efficient combination between the peptidoglycan layer and platinum-nickel-copper nanocubes (Pt-Ni-Cu NCs). Briefly, bacteria were first captured by a specific antibody. Then, the electrochemical signal materials (Pt-Ni-Cu NCs) were bound ... Read more >>

Mikrochim Acta (Mikrochimica acta)
[2020, 187(11):607]

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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.

Daniel K Wells, Marit M van Buuren, Kristen K Dang, Vanessa M Hubbard-Lucey, Kathleen C F Sheehan, Katie M Campbell, Andrew Lamb, Jeffrey P Ward, John Sidney, Ana B Blazquez, Andrew J Rech, Jesse M Zaretsky, Begonya Comin-Anduix, Alphonsus H C Ng, William Chour, Thomas V Yu, Hira Rizvi, Jia M Chen, Patrice Manning, Gabriela M Steiner, Xengie C Doan, , Taha Merghoub, Justin Guinney, Adam Kolom, Cheryl Selinsky, Antoni Ribas, Matthew D Hellmann, Nir Hacohen, Alessandro Sette, James R Heath, Nina Bhardwaj, Fred Ramsdell, Robert D Schreiber, Ton N Schumacher, Pia Kvistborg, Nadine A Defranoux,

Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, there are no reference data to compare these approaches, and the parameters governing tumor epitope immunogenicity remain unclear. Here, we assembled a global consortium wherein each participant predicted immunogenic ... Read more >>

Cell (Cell)
[2020, 183(3):818-834.e13]

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Transcriptome analysis reveals potential immune function-related regulatory genes/pathways of female Lubo goat submandibular glands at different developmental stages.

Aili Wang, Tianle Chao, Zhibin Ji, Rong Xuan, Shuang Liu, Maosen Guo, Guizhi Wang, Jianmin Wang,

Background:The submandibular glands, as major salivary glands, participate in rumen digestion in goats. Sialic acid, lysozyme, immunoglobulin A (IgA), lactoferrin and other biologically active substances secreted in the submandibular glands were reported in succession, which suggests that the submandibular gland may have immune functions in addition to participating in digestion. ... Read more >>

PeerJ (PeerJ)
[2020, 8:e9947]

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Defective Fe3+ self-doped spinel ZnFe2O4 with oxygen vacancies for highly efficient photoelectrochemical water splitting.

Jianmin Wang, Yunan Wang, Xinchao Xv, Yan Chen, Xi Yang, Jun Zhou, Song Li, Feng Cao, Gaowu Qin,

Defective Fe3+ self-doped spinel ZnFe2O4 with abundant oxygen vacancies, (Zn1-xFex)Fe2O4-y, was successfully synthesized via a simple spin-coating method and subsequent hydrogen reduction treatment. It displays a photocurrent density of 0.22 mA cm-2 at 1.23 (V vs. RHE), which is 11 times higher than that of pure ZnFe2O4. The largely enhanced ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2019, 48(31):11934-11940]

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A highly sensitive electrochemiluminescence immunosensor for h-FABP determination based on self-enhanced luminophore coupled with ultrathin 2D nickel metal-organic framework nanosheets.

Xiufeng Gan, Daobin Han, Jianmin Wang, Ping Liu, Xingrong Li, Qingyuan Zheng, Yurong Yan,

In this work, a novel ECL immunosensor based on self-enhanced luminophore and ultrathin 2D nickel MOF nanosheets was fabricated for sensitive and specific detection of h-FABP. Initially, the porous ultrathin Ni-TCPP (Fe) nanosheets with high specific surface area and plentiful active sites were newly synthesized, which could enhance ECL signal ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2021, 171:112735]

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Hazardous wastes treatment technologies.

Yu Han Yu, Jenn Fang Su, Yujen Shih, Jianmin Wang, Po Yen Wang, Chin Pao Huang,

A review of the literature published in 2019 on topics related to hazardous waste management in water, soils, sediments, and air. The review covered treatment technologies applying physical, chemical, and biological principles for the remediation of contaminated water, soils, sediments, and air. PRACTICAL POINTS: This report provides a review of ... Read more >>

Water Environ Res (Water environment research : a research publication of the Water Environment Federation)
[2020, :]

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Dynamic prediction of relapse in patients with acute leukemias after allogeneic transplantation: Joint model for minimal residual disease.

Aijie Huang, Qi Chen, Yang Fei, Ziwei Wang, Xiong Ni, Lei Gao, Li Chen, Jie Chen, Weiping Zhang, Jianmin Yang, Jianmin Wang, Xiaoxia Hu,

INTRODUCTION:Relapse remains the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (alloHSCT) in leukemia. Numerous investigations have demonstrated that minimal residual disease (MRD) before or after alloHSCT is prognostic of relapse risk. These MRD data were collected at specific checkpoints and could not dynamically predict the relapse ... Read more >>

Int J Lab Hematol (International journal of laboratory hematology)
[2020, :]

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Identification of regulatory networks and hub genes controlling mammary gland development and lactation in dairy goats during the late lactation, dry period, and late gestation stages

Rong Xuan, Tianle Chao, Xiaodong Zhao, Aili Wang, Yunpeng Chu, Qing Li, Yilin Zhao, Zhibin Ji, Jianmin Wang,

Abstract Background From the late lactation to late gestation stages, the mammary gland tissue of goats undergoes a process from involution to remodeling and then to high differentiation of mammary gland tissue. From the perspective of lactation, this is a continuous development process of the goat mammary gland from ... Read more >>

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Quantifying the effect of nano-TiO2 on the toxicity of lead on C. dubia using a two-compartment modeling approach.

Xuesong Liu, Jianmin Wang, Yue-Wern Huang,

Nanoparticles (NPs) can significantly influence toxicity imposed by toxic metals. However, this impact has not been quantified. In this research, we investigated the effect of nano-TiO2 on lead (Pb) accumulation and the resultant toxicity using water flea Ceriodaphnia dubia (C. dubia) as the testing organism. We used a two-compartment modeling approach, ... Read more >>

Chemosphere (Chemosphere)
[2020, 263:127958]

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Implementation of long solids retention time activated sludge process for rural residential community.

Ken Campbell, Jianmin Wang, Robert Tucker, Chris Struemph,

Most rural communities in the United States are facing increasingly rigorous effluent criteria, especially ammonia, for their wastewater treatment facilities. A new baffled bioreactor (BBR) technology, which employs a preanoxic activated sludge process operated with a long solids retention time (SRT), was installed in a small community in Missouri to ... Read more >>

Water Environ Res (Water environment research : a research publication of the Water Environment Federation)
[2020, :]

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Clonality and antigen-specific responses shape the prognostic effects of tumor-infiltrating T cells in ovarian cancer.

Takemasa Tsuji, Kevin H Eng, Junko Matsuzaki, Sebastiano Battaglia, J Brian Szender, Anthony Miliotto, Sacha Gnjatic, Wiam Bshara, Carl D Morrison, Shashikant Lele, Ryan O Emerson, Jianmin Wang, Song Liu, Harlan Robins, Amit A Lugade, Kunle Odunsi,

CD8+ tumor-infiltrating lymphocytes (TILs) are not all specific for tumor antigens, but can include bystander TILs that are specific for cancer-irrelevant epitopes, and it is unknown whether the T-cell repertoire affects prognosis. To delineate the complexity of anti-tumor T-cell responses, we utilized a computational method for de novo assembly of ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(27):2669-2683]

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The impact of donor full-length KIR2DS4 in the development of acute and chronic GVHD after unrelated allogeneic HSCT.

Kang An, Benshang Li, Changying Luo, Jianmin Wang, Chengjuan Luo, Jing Chen,

BACKGROUND:Killer Ig-like receptor 2DS4 (KIR2DS4) is the most prevalent activating killer Ig-like receptor gene. It is divergent and encodes either full-length or deleted allele variants. The studies of donor killer KIR2DS4 in unrelated allogeneic hematopoietic stem cell transplantations were limited. METHODS:KIR and HLA genotyping were determined in 75 pairs of ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, 24(6):e13728]

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Recapitulation of prostate tissue cell type-specific transcriptomes by an in vivo primary prostate tissue xenograft model.

Nelson T Gross, Jianmin Wang, Michael V Fiandalo, Eduardo Cortes Gomez, Anica Watts, Alejandro S Godoy, Gary J Smith, Yue Wu,

Studies of the normal functions and diseases of the prostate request in vivo models that maintain the tissue architecture and the multiple-cell type compartments of human origin in order to recapitulate reliably the interactions of different cell types. Cell type-specific transcriptomes are critical to reveal the roles of each cell ... Read more >>

PLoS One (PloS one)
[2020, 15(6):e0233899]

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Suppression of Hematopoietic Primitive Cells in Patients with Secondary Failure of Platelet Recovery after Acute Graft-versus-Host Disease.

Aijie Huang, Xiaoming Zhao, Meizhang Li, Gusheng Tang, Yang Fei, Roujia Wang, Lei Gao, Xiong Ni, Weiping Zhang, Jianmin Yang, Xiaoxia Hu, Jianmin Wang,

Secondary failure of platelet recovery (SFPR) can occur after allogeneic hematopoietic stem cell transplantation (alloHSCT), and 20% of cases are related to acute graft-versus-host disease (aGVHD). The underlying mechanisms of this association are unclear, however. The aim of the present study was to investigate the potential mechanisms of SFPR secondary ... Read more >>

Biol Blood Marrow Transplant (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2020, 26(10):1840-1854]

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Enhanced Potency of a Broad H7N9-Neutralizing Antibody HNIgGA6 Through Structure-Based Design.

Cong Chen, Zuliang Liu, Liguo Liu, Jianmin Wang, Qi Jin,

H7N9 influenza virus was first isolated in 2013 and has caused five epidemic waves among humans to date. Treatment opinions are currently limited. Previously, we characterized a human neutralizing antibody, HNIgGA6, by isolating rearranged heavy- and light-chain genes from convalescent patients. The mAb disrupts viral attachment to the cellular receptor ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1313]

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Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.

Chen Zhang, Fei Ye, Jianmin Wang, Ping He, Ming Lei, Longbin Huang, Anbang Huang, Pingming Tang, Hongjun Lin, Yuting Liao, Yong Liang, Jia Ni, Pangke Yan,

In the present work, a novel series of trifluoromethyl-substituted tetrahydropyran derivatives were rationally designed and synthesized as potent DPP-4 inhibitors with significantly improved duration time of action over current commercially available DPP-4 inhibitors. The incorporation of the trifluoromethyl group on the 6-position of the tetrahydropyran ring of omarigliptin with the ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2020, 63(13):7108-7126]

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Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

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Pathophysiology of Hip Disorders in Patients with Mucopolysaccharidosis IVA.

Zhigang Wang, Yunlan Xu, Enze Jiang, Jianmin Wang, Shunji Tomatsu, Kaiying Shen,

Patients with mucopolysaccharidoses IVA (MPS IVA) have a progressive accumulation of the specific glycosaminoglycans (GAGs): chondroitin-6-sulfate (C6S) and keratan sulfate (KS), leading to the degeneration of the cartilage matrix and its connective tissue perturbing the regular microarchitecture of cartilage and successively distorting bone ossification and growth. Impaired cartilage quality and ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2020, 10(5):]

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An Approach for Process Model Extraction by Multi-grained Text Classification

Schahram Dustdar, Eric Yu, Camille Salinesi, Dominique Rieu, Vik Pant, Chen Qian, Lijie Wen, Akhil Kumar, Leilei Lin, Li Lin, Zan Zong, Shu’ang Li, Jianmin Wang,

Process model extraction (PME) is a recently emerged interdiscipline between natural language processing (NLP) and business process management (BPM), which aims to extract process models from textual descriptions. Previous process extractors heavily depend on manual features and ignore the potential relations between clues of different text granularities. In this paper, ... Read more >>

(Advanced Information Systems Engineering32nd International Conference, CAiSE 2020, Grenoble, France, June 8–12, 2020, Proceedings)
[2020, 12127:268-282]

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Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants.

Tao Li, Yumin Zhang, Ying Liu, Xudong Li, Guanglong Hao, Qinghui Han, Lynnette M A Dirk, A Bruce Downie, Yong-Ling Ruan, Jianmin Wang, Guoying Wang, Tianyong Zhao,

Raffinose and its precursor galactinol accumulate in plant leaves during abiotic stress. RAFFINOSE SYNTHASE (RAFS) catalyzes raffinose formation by transferring a galactosyl group of galactinol to sucrose. However, whether RAFS contributes to plant drought tolerance and, if so, by what mechanism remains unclear. In this study, we report that expression ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, 295(23):8064-8077]

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Effects and Mechanism of lncRNA CRNDE on Sepsis-Induced Acute Kidney Injury.

Shen Wu, Hengyi Qiu, Qiao Wang, Zheng Cao, Jianmin Wang,

Objective:To investigate the effects of lncRNA CRNDE on sepsis-associated acute kidney injury in the human kidney 2 cell line and explore the potential mechanisms. Methods:HK-2 cells were treated with lipopolysaccharides to induce injuries. The expression of CRNDE and miR-146a in HK-2 cells were altered by a transient transfection assay. Cell ... Read more >>

Anal Cell Pathol (Amst) (Analytical cellular pathology (Amsterdam))
[2020, 2020:8576234]

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Genome‑wide integrated analysis demonstrates widespread functions of lncRNAs in mammary gland development and lactation in dairy goats.

Zhibin Ji, Tianle Chao, Zhaohua Liu, Lei Hou, Jin Wang, Aili Wang, Jie Zhou, Rong Xuan, Guizhi Wang, Jianmin Wang,

BACKGROUND:The mammary gland is a unique organ for milk synthesis, secretion and storage, and it undergoes cyclical processes of development, differentiation, lactation and degeneration. At different developmental periods, the biological processes governing mammary gland physiology and internal environmental homeostasis depend on a complex network of genes and regulatory factors. Emerging ... Read more >>

BMC Genomics (BMC genomics)
[2020, 21(1):254]

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