Full Text Journal Articles by
Author Jianghong Yan

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Tubeimoside I improves survival of mice in sepsis by inhibiting inducible nitric oxide synthase expression.

Minghao Luo, Suxin Luo, Zhe Cheng, Xiyang Yang, Dingyi Lv, Xingbing Li, Yongzheng Guo, Chang Li, Jianghong Yan,

Sepsis is a disease with high mortality rate worldwide and inducible nitric oxide (iNOS) induced vascular hyporeactivity plays a key role in it. There is no effective drug to treat vascular hyporeactivity specifically. Tubeimoside I (TBM) is a triterpenoid saponin isolated from Rhizoma Bolbostemmatis. In this study, we found that ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2020, 126:110083]

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Role of the Nucleotide-Binding Domain-Like Receptor Protein 3 Inflammasome in the Endothelial Dysfunction of Early Sepsis.

Minghao Luo, Jiayu Meng, Jianghong Yan, Feifei Shang, Ting Zhang, Dingyi Lv, Chang Li, Xiyang Yang, Suxin Luo,

Endothelial dysfunction is responsible for multiple organ failure and the high mortality rate of sepsis. Nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome plays an essential role in the progression of sepsis. However, the role of NLRP3 inflammasome in the endothelial dysfunction of sepsis has not been fully elucidated. In this ... Read more >>

Inflammation (Inflammation)
[2020, :]

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CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia.

Fei-Fei Shang, Li Luo, Jianghong Yan, Qiubo Yu, Yongzheng Guo, Yuchen Wen, Xiao-Li Min, Ling Jiang, Xiang He, Wei Liu,

Phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3] is a phosphorylated derivative of phosphatidylinositol 4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], which recruit and activate AKT in the plasma membrane (PM) to promote cellular survival. ORP5 anchors at the endoplasmic reticulum (ER)-PM contact sites and acts as a PI(4)P and PI(4,5)P2/phosphatidylserine (PS) exchanger. Here, a lipidomics analysis ... Read more >>

Redox Biol (Redox biology)
[2020, :101459]

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Inducible nitric oxide synthase contributes to insulin resistance and cardiac dysfunction after burn injury in mice.

Yongzheng Guo, Yuehua You, Dingyi Lv, Jianghong Yan, Fei-Fei Shang, Xiaowen Wang, Cheng Zhang, Qingdan Fan, Suxin Luo,

AIMS:Cardiac dysfunction is a major cause of multi-organ dysfunction in critical care units following severe burns. The purpose of this study was to investigate the role of inducible nitric oxide synthase (iNOS) in cardiac dysfunction in burned mice. MATERIALS AND METHODS:Wild-type and iNOS-knockout mice were subjected to 30% total body ... Read more >>

Life Sci. (Life sciences)
[2019, 239:116912]

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Tubeimoside-I sensitizes colorectal cancer cells to chemotherapy by inducing ROS-mediated impaired autophagolysosomes accumulation.

Jianghong Yan, Xiaoyun Dou, Jing Zhou, Yuanfeng Xiong, Ling Mo, Longhao Li, Yunlong Lei,

BACKGROUND:Tubeimoside-I (TBM), a plant-derived bioactive compound, shows antitumor activity in different tumors and can enhance the efficacy of chemotherapeutic agents. However, the detail mechanism underlying remains to be elucidated. METHODS:The cytotoxic potential of TBM towards CRC cells was examined by CCK8 assay, colony formation, LDH release assay, flow cytometry method ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2019, 38(1):353]

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A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice.

Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu, Wuyang Zhu,

BACKGROUND:Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity in an inactivated aluminum-adjuvanted rabies vaccine for dogs has been identified using mouse and dog models. ... Read more >>

Virol. J. (Virology journal)
[2018, 15(1):174]

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Identification of an unknown glycoprotein from whole cell lysate using conA and mass spectrometry.

Jianghong Yan, Shupeng Hu, Xiudan Xu, Dezhang Zhao, Mingjun Wu, Suxin Luo, Yong Xia,

Medical laboratory technology major was set up to meet rapid development of science and medical research technology in 2013. Students majoring in medical laboratory had learnt a lot of techniques distributed among different specialized courses. But, they did not understand why they had to learn these techniques and how they ... Read more >>

Biochem Mol Biol Educ (Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology)
[2018, 46(4):373-381]

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Integration sites of human papillomavirus 18 in esophageal cancer samples.

Shuying Li, Zhanjun Liu, Jianghong Yan, Shangbo Sun, Xiaoli Hou, Dianqing Liu, Ke Zhang, Jin-Tao Li,

To investigate the association between human papillomavirus (HPV) infection and esophageal cancer, genomic DNA was isolated from 189 samples obtained from patients with esophageal carcinoma, and HPV DNA was identified using the polymerase chain reaction (PCR) with the following specific primers: My09/11 for HPV L1 and HPV18 E6 for HPV18. ... Read more >>

Oncol Lett (Oncology letters)
[2018, 15(5):7438-7442]

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Analysis of human papilloma virus type 52 integration status in exfoliated cervical cells.

Ke Zhang, Zhanjun Liu, Ji Li, Juan Li, Jianghong Yan, Yunchuan Su, Shuying Li, Jintao Li,

To explore the significance of human papilloma virus type 52 (HPV52) infection and its integration in cells within cervical lesions, the expression levels of HPV52 were detected using polymerase chain reaction (PCR). The copy numbers of HPV52 E2, HPV52 E6 and the reference gene β-actin were determined by quantitative PCR ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2017, 14(6):5817-5824]

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Measurement of O-GlcNAcylated endothelial nitric oxide synthase by using 2',5'-ADP-Sepharose pull-down assay.

Yang Long, Jianghong Yan, Suxin Luo, Zhenguo Liu, Yong Xia,

Endothelial nitric oxide synthase (eNOS) plays central roles in cardiovascular regulation and disease. eNOS function is critically affected by O-linked N-acetylglucosamine (O-GlcNAc) modification. The present method for measuring O-GlcNAcylated eNOS relies on immunoprecipitation. Such method exhibits low detection efficiency and is also costly. We here report a simplified assay by ... Read more >>

Anal. Biochem. (Analytical biochemistry)
[2017, 537:8-12]

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Role of systemic injection of rabies immunoglobulin in rabies vaccination.

Weichen Wu, Shuqing Liu, Pengcheng Yu, Xiaoyan Tao, Xuexin Lu, Jianghong Yan, Qian Wang, Zongshen Zhang, Wuyang Zhu,

To determine the role of systemic injection of rabies immunoglobulin (RIG) in rabies vaccination, we analyzed the level of antibody against rabies virus in the serum of mice that received various doses of RIG combined with rabies vaccine. Our results indicate that systemic injection of RIG does not contribute detectably ... Read more >>

Arch. Virol. (Archives of virology)
[2017, 162(6):1701-1703]

Cited: 1 time

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[Advances in Application of Rabies Immunoglobulin].

Weichen Wu, Jingxia Luo, Weixian Liang, Jianghong Yan, Wuyang Zhu, Xinjun Lv,

China has the second highest number of rabies cases worldwide. There are millions of category III rabies exposure cases in China every year, which are treated with rabies immunoglobulin(RIG)and the rabies vaccine. The price of RIG is relatively expensive, and the application of RIG is relatively complicated. The rate of ... Read more >>

Bing Du Xue Bao (Bing du xue bao = Chinese journal of virology)
[2016, 32(5):666-670]

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N-Glycosylation of Gel1 or Gel2 is vital for cell wall β-glucan synthesis in Aspergillus fumigatus.

Wan Zhao, Yang Lü, Haomiao Ouyang, Hui Zhou, Jianghong Yan, Ting Du, Cheng Jin,

Fungal cell wall is a dynamic structure that communicates with and protects the cell from outside stress. In Aspergillus fumigatus, the cell wall β-glucans are mainly elongated by β-1,3-glucanosyltransferases Gels, which consist of seven family members (Gel1-7) utilizing β-1,3-glucan chains as substrates. Previously, we have shown that the mutant deficient ... Read more >>

Glycobiology (Glycobiology)
[2013, 23(8):955-968]

Cited: 5 times

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