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Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury.

Jian Kang, Chenglin Zhang, Zhongzheng Zhi, Yingjie Wang, Jingdong Liu, Furong Wu, Guanghui Xu,

We aimed to evaluate the therapeutic effects of exosomes, which were collected from human neuroepithelial stem cells (HNESCs) treated by miR-29b mimics, on the treatment of spinal cord injury (SCI). Computational analysis, real-time PCR, Western blot analysis and TUNEL assay, a BBB score system, the Nissl staining and IHC assay ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):627-638]

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CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer.

Elaine Sanij, Katherine M Hannan, Jiachen Xuan, Shunfei Yan, Jessica E Ahern, Anna S Trigos, Natalie Brajanovski, Jinbae Son, Keefe T Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J Deans, Kum Kum Khanna, Linda Mileshkin, Grant A McArthur, John Soong, Els M J J Berns, Ross D Hannan, Clare L Scott, Karen E Sheppard, Richard B Pearson,

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX-5461, the first-in-class inhibitor of RNA polymerase I transcription of ribosomal RNA genes (rDNA), induces replication stress and activates the DNA damage response. CX-5461 co-operates with ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):2641]

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Surface Enhanced Raman Spectroscopy Based Biosensor with a Microneedle Array for Minimally Invasive In Vivo Glucose Measurements.

Jian Ju, Chao-Mao Hsieh, Yao Tian, Jian Kang, Ruining Chia, Hao Chang, Yanru Bai, Chenjie Xu, Xiaomeng Wang, Quan Liu,

To monitor blood glucose levels reliably, diabetic patients usually have to undergo frequent fingerstick tests to draw out fresh blood, which is painful and inconvenient with the potential risk of cross contamination especially when the lancet is reused or not properly sterilized. This work reports a novel surface-enhanced Raman spectroscopy ... Read more >>

ACS Sens (ACS sensors)
[2020, :]

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Do underlying cardiovascular diseases have any impact on hospitalised patients with COVID-19?

Jixiang Zhang, Shimin Lu, Xiaoli Wang, Xuemei Jia, Jiao Li, Hongbo Lei, Zhengru Liu, Fei Liao, Mengyao Ji, Xiaoguang Lv, Jian Kang, Shan Tian, Jingjing Ma, Dandan Wu, Yang Gong, Yu Xu, Weiguo Dong,

OBJECTIVES:An outbreak of the highly contagious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has sickened thousands of people in China. The purpose of this study was to explore the early clinical characteristics of COVID-19 patients with cardiovascular disease (CVD). METHODS:This is a retrospective analysis of patients with COVID-19 from a ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, :]

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Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos.

Yile Wang, Yanhe Li, Deji Luan, Jian Kang, Rongjun He, Yong Zhang, Fusheng Quan,

The histone variant H3.3 is an important maternal factor in fertilization of oocytes and reprogramming of somatic cell nuclear transfer (SCNT) embryos. As a crucial replacement histone, maternal H3.3 is involved in chromatin remodeling and zygote genome activation. Litte is, however, known about the replacement of H3.3 in the bovine ... Read more >>

Theriogenology (Theriogenology)
[2020, 154:43-52]

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Prevention of COVID-19 in patients with inflammatory bowel disease in Wuhan, China.

Ping An, Mengyao Ji, Haixia Ren, Juan Su, Nik Sheng Ding, Jian Kang, Anning Yin, Qian Zhou, Linyong Shen, Liang Zhao, Xiaoda Jiang, Yong Xiao, Wei Tan, Xiaoguang Lv, Jiao Li, Shuzhong Liu, Jing Zhou, Hongbin Chen, Yaqing Xu, Jun Liu, Mingkai Chen, Jiwang Cao, Zhongyin Zhou, Lei Shen, Shiyun Tan, Honggang Yu, Weiguo Dong, Yijuan Ding,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2020, 5(6):525-527]

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ATP antagonizes the crowding-induced destabilization of the human eye-lens protein γS-crystallin.

Yuan He, Jian Kang, Jianxing Song,

In lens, αβγ-crystallins accounting for ∼90% of ocular proteins with concentrations >400 mg/ml need to remain soluble for the whole life-span and their aggregation can lead to cataract. Mysteriously, despite being a metabolically-quiescent organ, lens maintains ATP concentrations of 3-7 mM. Very recently, ATP was proposed to hydrotropically prevent aggregation of crystallins ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and Biophysical Research Communications)
[2020, 526(4):1112-1117]

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ERCP during the pandemic of COVID-19 in Wuhan, China.

Ping An, Xu Huang, Xinyue Wan, Yong Xiao, Jun Zhang, Jian Kang, Jun Liu, Dan Hu, Yang Wang, Haixia Ren, Di Chen, Xuefen Wang, Zhongyin Zhou, Honggang Yu,

Gastrointest. Endosc. (Gastrointestinal endoscopy)
[2020, :]

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Overexpression of PGC7 in donor cells maintains the DNA methylation status of imprinted genes in goat embryos derived from somatic cell nuclear transfer technology.

Yufei Wang, Qingqing Liu, Jian Kang, Yong Zhang, Fusheng Quan,

Abnormal methylation of imprinted genes is commonly observed in the embryos cloned by somatic cell nuclear transfer (SCNT) procedure and is one of the primary reasons for their abnormal development and high mortality. Primordial germ cell 7 (PGC7), a developmentally regulated gene highly expressed in primordial germ cells, maintains the ... Read more >>

Theriogenology (Theriogenology)
[2020, 151:86-94]

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Acute mediastinitis associated with tracheobronchial tuberculosis and aspergillosis: a case report and literature review.

Chao-Nan Liang, Hong-Wen Zhao, Jian Kang, Gang Hou, Yan Yin,

Acute mediastinitis (AM) is a rare but life-threatening disease. Here, we report a case of AM secondary to endobronchial tuberculosis (EBTB) and pseudomembranous Aspergillus tracheobronchitis (PMATB) co-infection. EBTB was confirmed by tissue culture for Mycobacterium tuberculosis and GeneXpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) detection (simultaneous detection of M. tuberculosis and ... Read more >>

J. Int. Med. Res. (The Journal of international medical research)
[2020, 48(5):300060520918469]

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Clinical study for external washing by traditional Chinese medicine in the treatment of multiple infectious wounds of diabetic foot: Study protocol clinical trial (SPIRIT compliant).

Yuan Zhang, Haipo Yuan, Jian Kang, Hongyan Xie, Xinhua Long, Luguang Qi, Chunguang Xie, Guangming Gong,

BACKGROUND:Diabetic foot (DF) is among the most serious complications of type 2 diabetes. DF infection (DFI) is a key factor in the deterioration and development of DF, so controlling infection plays an important role in the treatment of the disease. Traditional Chinese medicine foot bath has been widely used in ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(17):e19841]

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Learning Convolutional Sparse Coding on Complex Domain for Interferometric Phase Restoration.

Jian Kang, Danfeng Hong, Jialin Liu, Gerald Baier, Naoto Yokoya, Begum Demir,

Interferometric phase restoration has been investigated for decades and most of the state-of-the-art methods have achieved promising performances for InSAR phase restoration. These methods generally follow the nonlocal filtering processing chain, aiming at circumventing the staircase effect and preserving the details of phase variations. In this article, we propose an ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2020, :]

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Bayesian modeling of dependence in brain connectivity data.

Shuo Chen, Yishi Xing, Jian Kang, Peter Kochunov, L Elliot Hong,

Brain connectivity studies often refer to brain areas as graph nodes and connections between nodes as edges, and aim to identify neuropsychiatric phenotype-related connectivity patterns. When performing group-level brain connectivity alternation analyses, it is critical to model the dependence structure between multivariate connectivity edges to achieve accurate and efficient estimates ... Read more >>

Biostatistics (Biostatistics (Oxford, England))
[2020, 21(2):269-286]

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Use of the Highly Biocompatible Au [email protected] Nanoparticles as a New Contrast Agent for In Vivo Computed Tomography Scan Imaging.

Yan Gao, Jian Kang, Zhen Lei, Yankun Li, Xifan Mei, Guannan Wang,

In recent years, contrast agents have been widely used in imaging technology to improve quality. Nanoparticles have better in vivo detection capability than conventional molecular scale contrast agents. In this study, a new type of Au [email protected] nanoparticles ([email protected]) with a strong X-ray absorption coefficient was synthesized as a contrast ... Read more >>

Nanoscale Res Lett (Nanoscale research letters)
[2020, 15(1):53]

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Traditional Chinese medicine Shenqi compound to improve lower extremity atherosclerosis of patients with type 2 diabetes by affecting blood glucose fluctuation: Study protocol for a randomized controlled multicenter trial.

Qianru Zhu, Jian Kang, Gang Xu, Jinyao Li, Hui Zhou, Ya Liu,

BACKGROUND:Clinical and basic research supports that blood glucose fluctuation is an important predictor of diabetic vascular disease and an etiology of lower extremity atherosclerosis, which is an important pathological basis for lower extremity vascular diseases. Previous Chinese National Natural Science Foundation trials (No. 81503566) have reported that the traditional Chinese ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(11):e19501]

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Oncogene-induced senescence: From biology to therapy.

Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan,

Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism, arresting cell cycle progression upon oncogene-activating genomic alterations. The discovery and characterization of the senescence-associated secretome unveiled a rich additional complexity to the senescence phenotype, including extrinsic impacts on the microenvironment and engagement of the immune response. Emerging evidence suggests that ... Read more >>

Mech. Ageing Dev. (Mechanisms of ageing and development)
[2020, 187:111229]

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Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

Jian Kang, Shu-Qing Liu, Yi-Fan Song, Meng-Ru Wang, Yao-Juan Chu, Ya-Min Shi, Feng-Yan Zhang, Lin Zhu,

Abstract Background: Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. ... Read more >>

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Mutation in myostatin 3'UTR promotes C2C12 myoblast proliferation and differentiation by blocking the translation of MSTN.

Luxing Ge, Xiangchen Dong, Xutong Gong, Jian Kang, Yong Zhang, Fusheng Quan,

The point mutation in myostatin (MSTN) can produce the Texel sheep double muscle phenotype. However, whether other species have the same mode of action as MSTN and whether breeding materials can be obtained through cross-species genetic editing remain unclear. The mutation in the mouse MSTN 3'UTR could create a target ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2020, 154:634-643]

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Efficacy and Safety of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler in Chinese Patients with COPD: A Subgroup Analysis of KRONOS.

Chen Wang, Ting Yang, Jian Kang, Rongchang Chen, Li Zhao, Huijie He, Pryseley N Assam, Rong Su, Eric Bourne, Shaila Ballal, Kiernan DeAngelis, Paul Dorinsky,

INTRODUCTION:This pre-specified subgroup analysis evaluated the efficacy and safety of budesonide/glycopyrrolate/formoterol fumarate metered dose inhaler (BGF MDI) triple therapy versus corresponding dual therapies in the China subgroup of the phase III, double-blind KRONOS study in patients with moderate to very severe chronic obstructive pulmonary disease (COPD). METHODS:Patients were randomized 2:2:1:1 to ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(4):1591-1607]

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Effects of spatial elements and sound sources on sound field in Main Hall of Chinese Buddhist temple.

Dongxu Zhang, Ruipeng Lai, Mei Zhang, Jian Kang,

In Chinese Han Buddhist temples, the Main Hall is the paramount indoor religious location, for which acoustic quality is very important for several Buddhist rites held within; however, the sound field in the Main Hall has not yet been analyzed scientifically. By combining sound field measurement with acoustic simulation, this ... Read more >>

J. Acoust. Soc. Am. (The Journal of the Acoustical Society of America)
[2020, 147(3):1516]

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HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization.

Meng-Lu Li, Xin-Ming Su, Yuan Ren, Xuan Zhao, Ling-Fei Kong, Jian Kang,

BACKGROUND:This study was to investigate of the mechanism by which histone deacetylase (HDAC) 8 inhibitor ameliorated airway hyperresponsiveness (AHR) and allergic airway inflammation. METHODS:Mice were sensitized and then treated with budesonide (BUD) or PCI-34051 (PCI) prior to exposing to normal saline (NS) or ovalbumin (OVA). The raw264.7 cells were treated ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):62]

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The therapeutic effect of bone marrow-derived mesenchymal stem cells on osteoarthritis is improved by the activation of the KDM6A/SOX9 signaling pathway caused by exposure to hypoxia.

Zhongzheng Zhi, Chenglin Zhang, Jian Kang, Yingjie Wang, Jingdong Liu, Furong Wu, Guanghui Xu,

Abnormal expression of KDM6A and SOX9 is a key factor in the pathogenesis of osteoarthritis (OA). Cellular treatments of OA with articular cartilage chondrocytes (ACCs) and bone marrow mesenchymal stem cells (BMSCs) are promising, but their underlying mechanisms remain to be explored. The pellet size, weight and sulfated glycosaminoglycan/DNA content ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2020, :]

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miR-1323 Promotes Cell Migration in Lung Adenocarcinoma by Targeting Cbl-b and Is an Early Prognostic Biomarker.

Huan Zhao, Chunlei Zheng, Yizhe Wang, Kezuo Hou, Xianghong Yang, Yang Cheng, Xiaofang Che, Shilin Xie, Shuo Wang, Tieqiong Zhang, Jian Kang, Yunpeng Liu, Dianzhu Pan, Xiujuan Qu, Xuejun Hu, Yibo Fan,

Purpose: MicroRNAs are known to regulate cellular processes in non-small cell lung cancer (NSCLC) cells and predict prognosis. However, identification of specific microRNAs in NSCLC as potential therapeutic targets is controversial. We aim to determine the clinical significance of miR-1323 in the prognosis of patients with lung cancer and the ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:181]

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Fluorochromic polymer films containing ultrasmall silver nanoclusters.

Libing Wang, Huan Chen, Qiyan Yin, Jian Kang, Ben Liu, Gengsheng Weng, Jie He,

Fluorochromic materials that change their emission properties in response to their environment are of interest for the development of sensors, optical data storage and light-emitting materials. A thermally fluorochromic elastic polymer film that exhibits remarkable fluorochromism (from red to yellow) and enhancement of fluorescence intensity after thermal treatment (>120 °C) ... Read more >>

Nanotechnology (Nanotechnology)
[2020, 31(24):245703]

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Combination of high-resolution accurate mass spectrometry and network pharmacology provides a new method for the chemical constituents' study and target prediction in vivo of Garcinia multiflora.

Zhuolun Li, Lihua Zuo, Yingying Shi, Dongsong Tian, Liwei Liu, Yantao Yang, Lin Zhou, Xiaojian Zhang, Jian Kang, Xiaojiang Hao, Chunmao Yuan, Zhi Sun,

Garcinia multiflora is a kind of evergreen tree which is widely distributed in the south of China. However, few researches focused on the constituents in different parts of G. multiflora as well as their potential targets and pathways in vivo. To clarify the chemical constituents of G. multiflora rapidly and ... Read more >>

J Sep Sci (Journal of separation science)
[2020, 43(5):978-986]

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