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Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song,

<h4>Context</h4>Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.<h4>Objective</h4>This study estimates the protective effect of HQH against CYP-induced nephrotoxicity in rats.<h4>Materials and methods</h4>Four groups of 10 Sprague-Dawley ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1425-1431]

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Rational Design of Li-Wicking Hosts for Ultrafast Fabrication of Flexible and Stable Lithium Metal Anodes.

Jian Chang, Hong Hu, Jian Shang, Ruopian Fang, Dahua Shou, Chuan Xie, Yuan Gao, Yu Yang, Qiu Na Zhuang, Xi Lu, Yao Kang Zhang, Feng Li, Zijian Zheng,

The ever-increasing development of flexible and wearable electronics has imposed unprecedented demand on flexible batteries of high energy density and excellent mechanical stability. Rechargeable lithium (Li) metal battery shows great advantages in terms of its high theoretical energy density. However, the use of Li metal anode for flexible batteries faces ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2021, :e2105308]

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SD-Net: joint surgical gesture recognition and skill assessment.

Jinglu Zhang, Yinyu Nie, Yao Lyu, Xiaosong Yang, Jian Chang, Jian Jun Zhang,

<h4>Purpose</h4>Surgical gesture recognition has been an essential task for providing intraoperative context-aware assistance and scheduling clinical resources. However, previous methods present limitations in catching long-range temporal information, and many of them require additional sensors. To address these challenges, we propose a symmetric dilated network, namely SD-Net, to jointly recognize surgical ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, 16(10):1675-1682]

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Erratum: MicroRNA-374 targets JAM-2 regulates the growth and metastasis of human pancreatic cancer cells.

Wei Li, Nan Tang, Jing Tao, Zhongchao Zhu, Lei Liu, Qi Fang, Jian Chang,

[This corrects the article on p. 6454 in vol. 11, PMID: 31737197.]. ... Read more >>

Am J Transl Res (American journal of translational research)
[2021, 13(8):9912-9913]

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Vanadium Nitride Quantum Dots/Holey Graphene Matrix Boosting Adsorption and Conversion Reaction Kinetics for High-Performance Lithium-Sulfur Batteries.

Fu Li, Mengjie Zhang, Wenyan Chen, Xin Cai, Huashang Rao, Jian Chang, Yueping Fang, Xinhua Zhong, Yu Yang, Zhuohong Yang, Xiaoyuan Yu,

Lithium-sulfur batteries (LSBs) have been considered as potential next-generation energy storage systems due to their high specific energy of 2600 Wh kg<sup>-1</sup> and 2800 Wh L<sup>-1</sup>. Nevertheless, the practical application of LSBs still faces several hazards, including the shuttle effect of soluble lithium polysulfides, low electrical conductivities of solid sulfur ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2021, 13(26):30746-30755]

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Hyperporous magnetic catalyst foam for highly efficient and stable adsorption and reduction of aqueous organic contaminants.

Yu Yang, Zhuangzhuang Chu, Qiyao Huang, Yongtao Li, Bin Zheng, Jian Chang, Zhuohong Yang,

The facile and low-cost fabrication of free-standing magnetic catalysts with high catalytic efficiency, rapid reaction rate and excellent recoverability has been pursued for various catalysis applications, e.g., treating aqueous organic 4-nitrophenol pollutants. Here, we design and fabricate a free-standing nickel-coated hyperporous polymer foam (Ni-HPF) with adjustable shapes and sizes, hierarchical ... Read more >>

J Hazard Mater (Journal of hazardous materials)
[2021, 420:126622]

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Efficacy and Safety of IL-2 injection for the treatment of childhood solid tumors or lymphoma with malignant pleural effusion, ascites and pericardial effusion

Yu-Tong Zhang, Xiao-dan Zhong, Yan-li Gao, Jian Chang,

<h4>Background: </h4> Currently, no available coherent management protocol exists for pediatric cancers associated with pleural effusion, ascites, and pericardial effusion. This study aimed to retrospectively present our experience in treating pediatric cancer patients with pleural effusion, ascites, and pericardial effusion using interleukin-2 (IL-2) and dexamethasone (DEX) intracavitary injections. <h4>Methods: </h4> ... Read more >>

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A transport channel-regulated MXene membrane via organic phosphonic acids for efficient water permeation.

Ming Yi, Frédéric Héraly, Jian Chang, Atefeh Khorsand Kheirabad, Jiayin Yuan, Yan Wang, Miao Zhang,

A series of organic phosphonic acids (OPAs) were applied as multifunctional spacers to enlarge the inner space of carbide MXene (Ti3C2Tx) laminates. A synergistic improvement in permeance, rejection and stability is achieved via introducing OPA to create pillared laminates. This strategy provides a universal way to regulate transport channels of ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(51):6245-6248]

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Development of a High-Resolution Melting Curve Analysis to Differentiate Candida parapsilosis Complex Species.

Ya Kun Shao, Juan Xu, Jie Gong, Jian Min Chang,

Biomed Environ Sci (Biomedical and environmental sciences : BES)
[2021, 34(6):478-482]

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Nanomechanics of Lignin-Cellulase Interactions in Aqueous Solutions.

Peitao Zheng, Li Xiang, Jian Chang, Qiaojia Lin, Lei Xie, Tu Lan, Jing Liu, Zhenggang Gong, Tian Tang, Li Shuai, Xiaolin Luo, Nairong Chen, Hongbo Zeng,

Efficient enzymatic hydrolysis of cellulose in lignocellulose to glucose is one of the most critical steps for the production of biofuels. The nonproductive adsorption of lignin to expensive cellulase highly impedes the development of biorefinery. Understanding the lignin-cellulase interaction mechanism serves as a vital basis for reducing such nonproductive adsorption ... Read more >>

Biomacromolecules (Biomacromolecules)
[2021, 22(5):2033-2042]

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Retrospective analysis of pediatric hepatoblastoma with tumor rupture: experience from a single center

Yu-Tong Zhang, Yu-fei Zhao, Dian-fei Yang, Jian Chang,

<h4>Background: </h4> Hepatoblastoma (HB) tumor rupture is currently considered as a high-risk factor in some risk-stratification systems. This study aimed to investigate the value of HB tumor rupture in predicting the poor prognosis of child patients. <h4>Methods: </h4> The clinical data from children with high-risk HB or HB tumor rupture ... Read more >>

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Ultratough and ultrastrong graphene oxide hybrid films via a polycationitrile approach.

Jian Chang, Miao Zhang, Qiang Zhao, Liangti Qu, Jiayin Yuan,

Graphene oxide (GO) is a classic two dimensional (2D) building block that can be used to develop high-performance materials for numerous applications, particularly in the energy and environmental fields. Currently, the precise assembly of GO nanosheets into macroscopic nanohybrids of superior strength and toughness is desirable, and faces challenges and ... Read more >>

Nanoscale Horiz (Nanoscale horizons)
[2021, 6(4):341-347]

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Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets.

Xiaodan Zhong, Ying Tao, Jian Chang, Yutong Zhang, Hao Zhang, Linyu Wang, Yuanning Liu,

<h4>Background</h4>The prognostic value of immune-related genes and lncRNAs in neuroblastoma has not been elucidated, especially in subgroups with different outcomes. This study aimed to explore immune-related prognostic signatures.<h4>Materials and methods</h4>Immune-related prognostic genes and lncRNAs were identified by univariate Cox regression analysis in the training set. The top 20 C-index genes ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:631546]

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The status of anxiety state among cancer patients and their relatives during coronavirus disease 2019 (COVID-19) in Hubei, China.

Shengli Yang, Huang Yao, Yating Song, Chengrong Shu, Mengni Chen, Guoliang Pi, Min Jin, Renwang Chen, Qiushuang Wang, Jian Chang, Zhigang Zuo, Jianli Hu,

<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) epidemic, tumor patients and their families might suffer from greater psychological stress as a result of anxiety or other psychological disorders. We conducted an online study during the epidemic to explore the mental state of tumor patients and their families during this extraordinary time.<h4>Methods</h4>A ... Read more >>

Ann Palliat Med (Annals of palliative medicine)
[2021, 10(4):4601-4611]

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microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.

Jian Chang, Hanjun Li, Zhongchao Zhu, Pei Mei, Weimin Hu, Xingcheng Xiong, Jing Tao,

<h4>Aim</h4>Given the fact that tumor-associated macrophage-derived extracellular vesicles (EVs) are attributable to tumor aggressiveness, this research intends to decode the mechanism of M2 macrophage-derived EVs in the differentiation and activities of pancreatic cancer (PaCa) stem cells via delivering microRNA (miR)-21-5p.<h4>Methods</h4>Polarized M2 macrophages were induced, from which EVs were collected and ... Read more >>

Cell Biol Toxicol (Cell biology and toxicology)
[2021, :]

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Rational Design of Adenylate Kinase Thermostability through Coevolution and Sequence Divergence Analysis.

Jian Chang, Chengxin Zhang, Huaqiang Cheng, Yan-Wen Tan,

Protein engineering is actively pursued in industrial and laboratory settings for high thermostability. Among the many protein engineering methods, rational design by bioinformatics provides theoretical guidance without time-consuming experimental screenings. However, most rational design methods either rely on protein tertiary structure information or have limited accuracies. We proposed a primary-sequence-based ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(5):]

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Circular RNA CDR1as promotes tumor progression by regulating miR-432-5p/E2F3 axis in pancreatic cancer.

Xingcheng Xiong, Jiarui Feng, Xiao Yang, Hanjun Li, Qiao Shi, Jing Tao, Jian Chang,

<h4>Background</h4>Pancreatic cancer (PC), characterized with high growth rate and metastatic rate. It's urgently necessary to explore new mechanism of PC. Circular RNA/miRNA/mRNA network was widely reported to participate in the cancer progression.<h4>Methods</h4>In this research, circular RNA CDR1as (circCDR1as) was identified by microarray analysis and detected in pancreatic cancer (PC) tissues ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):112]

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Pathways of Developing High-Energy-Density Flexible Lithium Batteries.

Jian Chang, Qiyao Huang, Yuan Gao, Zijian Zheng,

Flexible lithium-based batteries (FLBs) enable the seamless implementation of power supply to flexible and wearable electronics. They not only enhance the energy capacity by fully utilizing the available space but also revolutionize the form factors of future device design. To date, how to simultaneously acquire high energy density and excellent ... Read more >>

Adv Mater (Advanced materials (Deerfield Beach, Fla.))
[2021, 33(46):e2004419]

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Solid Tumor Complicated With Venous Thromboembolism: A 10-Year Retrospective Cross-Sectional Study.

Miao Peng, Shengli Yang, Guiling Li, Tao Zhang, Xiaojuan Qin, Chen Shi, Jian Chang, Mengni Chen, Chen Chen, Bingjie Li, Sihang Cao, Ting Li, Renwang Chen, Prapti Bakhshi, Min Jin, Gang Wu, Jianli Hu,

Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT) occurs more frequently in cancer patients than in the general population. A retrospective cross-sectional study was carried out in patients with solid tumor complicated with VTE admitted to the Cancer Center, Union Hospital, Tongji Medical College, Huazhong University ... Read more >>

Clin Appl Thromb Hemost (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2021, 27:1076029620975484]

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Mental Health of Front-Line Chinese Medical Staff During the COVID-19 Outbreak

Yan Wang, Xi-Xi Wang, Xiao-Jin Zhang, Yue Leng, Yue Zhang, Jian Chang, Fang Fang, Kristine Yaffe, Yun-Cheng Wu,

Background: Coronavirus disease 2019 (COVID-19) has affected over 100 countries thus far. The increasing number of patients might lead to enormous changes in psychological status of medical staff. <br><br>Aims: The aim of this study was to understand the psychological status of medical staff during the COVID-19 outbreak. ... Read more >>

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Ultra-low NA step-index large mode area Yb-doped fiber with a germanium doped cladding for high power pulse amplification.

Raghuraman Sidharthan, Di Lin, Kang Jie Lim, Huizi Li, Serene Huiting Lim, Chen Jian Chang, Yue Men Seng, Song Liang Chua, Yongmin Jung, David J Richardson, Seongwoo Yoo,

High concentration rare earth doped, large mode area (LMA) step-index fibers, which feature a very high cladding absorption per unit length at the pump wavelength, high efficiency, and excellent beam quality, are ideal for high power pulsed fiber lasers/amplifiers where large effective mode areas and short device lengths are crucial ... Read more >>

Opt Lett (Optics letters)
[2020, 45(14):3828-3831]

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Minimizing Material Consumption of 3D Printing with Stress-Guided Optimization

Anzong Zheng, Shaojun Bian, Ehtzaz Chaudhry, Jian Chang, Habibollah Haron, Lihua You, Jianjun Zhang,

3D printing has been widely used in daily life, industry, architecture, aerospace, crafts, art, etc. Minimizing 3D printing material consumption can greatly reduce the costs. Therefore, how to design 3D printed objects with less materials while maintain structural soundness is an important problem. The current treatment is to use thin ... Read more >>

(Computational Science – ICCS 202020th International Conference, Amsterdam, The Netherlands, June 3–5, 2020, Proceedings, Part V)
[2020, 12141:588-603]

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The combination of serum NLR and D-dimer levels at diagnosis predicts overall survival in metastatic pancreatic cancer

Pei Mei, Qiong Gong, Yu-Ping Rong, Jian Chang, Qi Fang, Jing Tao,

<h4>Background: </h4> Many studies have confirmed that the systemic inflammatory response and hypercoagulable state of the patient are related to the occurrence and development of various tumors, including pancreatic cancer. The aim of this research was to combine blood inflammatory factors and D-dimer into a new prognostic scoring system.Methods We ... Read more >>

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Novel treatment of refractory / recurrent pulmonary hepatoblastoma.

Yu-Tong Zhang, Jian Chang, Yun-Ming Yao, Ya-Nan Li, Xiao-Dan Zhong, Zi-Ling Liu,

BACKGROUND:There is no consensus about how to manage pulmonary metastasis in patients with hepatoblastoma. We reviewed a treatment with a combination of oxaliplatin, vincristine, and topotecan (OVT) paired with radiofrequency ablation (RFA) of 12 patients with multiple refractory / recurrent pulmonary hepatoblastoma. METHODS:The medical records from patients with ≤21 years of ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(3):324-329]

Cited: 1 time

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Free nitrous acid-based suppression of sulfide production in sewer sediments: In-situ effect mechanism.

Zhiqiang Zuo, Min Zheng, Jian Chang, Daheng Ren, Xia Huang, Zhiguo Yuan, Yanchen Liu,

Sulfide production control in gravity sewer sediments is more complex and difficult due to the greater spatial complexity of biological processes as a result of the abundant microflora inside the sediments. In this study, a promising and cost-effective free nitrous acid (FNA)-based suppression strategy for sulfide production in sewer sediments ... Read more >>

Sci Total Environ (The Science of the total environment)
[2020, 715:136871]

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