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Author Jiahe Guo

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LncRNA-412.25 activates the LIF/STAT3 signaling pathway in ovarian granulosa cells of Hu sheep by sponging miR-346.

Xiaolei Yao, Mohamed AbdFatah El-Samahy, Xiaodan Li, Yongjin Bao, Jiahe Guo, Fan Yang, Zhibo Wang, Kang Li, Yanli Zhang, Feng Wang,

Although long non-coding RNAs (lncRNAs) are reported to regulate follicular development and reproductive disease pathogenesis, the underlying mechanisms have not been elucidated. In this study, lncRNA expression profiling of different-sized healthy follicles from Hu sheep with different prolificacy revealed 50 613 lncRNAs. Numerous lncRNAs were differentially expressed among different comparison groups. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(9):e22467]

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Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived mesenchymal stem cells via miR-143-3p/ADD3 axis

Hewei Xiong, Sen Ren, Jing Chen, Xiaofan Yang, Yutian Liu, Zhao Xu, Jiahe Guo, Tao Jiang, Meng Yuan, Yang Liu, Guolei Zhang, Wenqing Li, Hans-Günther Machens, Zhenbing Chen,

<h4>Background: </h4> Senescent adipose-derived stem cells (ASCs) exhibit reduced therapeutic efficacy during wound healing. Transcriptional regulation factors including long non-coding RNAs (lncRNAs) reportedly play essential roles in stem cell aging. However, the mechanisms by which lncRNAs influence mesenchymal stem cell aging have not been investigated. Methods The lncRNA senescence-associated ... Read more >>

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